JP2021513552A - 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物 - Google Patents

非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物 Download PDF

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JP2021513552A
JP2021513552A JP2020543742A JP2020543742A JP2021513552A JP 2021513552 A JP2021513552 A JP 2021513552A JP 2020543742 A JP2020543742 A JP 2020543742A JP 2020543742 A JP2020543742 A JP 2020543742A JP 2021513552 A JP2021513552 A JP 2021513552A
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drug
ibutamoren
ghs
effective amount
antagonist
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JP2021513552A5 (enExample
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オリバー ソーナー マイケル
オリバー ソーナー マイケル
ジー．スミス ロイ
ジー．スミス ロイ
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ルーモス ファーマ，インコーポレイティド
ルーモス ファーマ，インコーポレイティド
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Publication of JP2021513552A publication Critical patent/JP2021513552A/ja
Publication of JP2021513552A5 publication Critical patent/JP2021513552A5/ja
Priority to JP2023221157A priority Critical patent/JP2024028337A/ja
Priority to JP2025129927A priority patent/JP2025179056A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020543742A 2018-02-14 2019-02-14 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物 Withdrawn JP2021513552A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023221157A JP2024028337A (ja) 2018-02-14 2023-12-27 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物
JP2025129927A JP2025179056A (ja) 2018-02-14 2025-08-04 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862630361P 2018-02-14 2018-02-14
US62/630,361 2018-02-14
PCT/US2019/017964 WO2019161025A1 (en) 2018-02-14 2019-02-14 Compositions for the treatment of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

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JP2023221157A Division JP2024028337A (ja) 2018-02-14 2023-12-27 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物

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JP2021513552A true JP2021513552A (ja) 2021-05-27
JP2021513552A5 JP2021513552A5 (enExample) 2022-02-21

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JP2020543742A Withdrawn JP2021513552A (ja) 2018-02-14 2019-02-14 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物
JP2023221157A Pending JP2024028337A (ja) 2018-02-14 2023-12-27 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物
JP2025129927A Pending JP2025179056A (ja) 2018-02-14 2025-08-04 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物

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JP2023221157A Pending JP2024028337A (ja) 2018-02-14 2023-12-27 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物
JP2025129927A Pending JP2025179056A (ja) 2018-02-14 2025-08-04 非アルコール性脂肪性肝疾患及び非アルコール性脂肪性肝炎の治療のための組成物

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US (3) US20210059993A1 (enExample)
EP (3) EP4467158A3 (enExample)
JP (3) JP2021513552A (enExample)
KR (2) KR20240015742A (enExample)
CN (2) CN118453597A (enExample)
AU (2) AU2019222736B2 (enExample)
BR (1) BR112020016613A2 (enExample)
CA (1) CA3088177A1 (enExample)
EA (1) EA202091464A1 (enExample)
WO (1) WO2019161025A1 (enExample)

Cited By (1)

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JP2025535941A (ja) * 2022-11-03 2025-10-30 ルーモス ファーマ，インコーポレイテッド イブタモレンの圧縮型経口製剤

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WO2020205498A1 (en) * 2019-03-29 2020-10-08 The General Hospital Corporation Ghrh or analogues thereof for use in treatment of hepatic disease
CA3192690A1 (en) * 2020-09-18 2022-03-24 Seung Yong Seong Pharmaceutical composition for treating nonalcoholic steatohepatitis and liver fibrosis
KR20220132312A (ko) 2021-03-23 2022-09-30 한국과학기술원 간세포의 IFN-γR1 매개 지질생성작용 억제를 통한 비알코올성 지방간 질환의 치료 방법
WO2025193784A1 (en) * 2024-03-12 2025-09-18 Lumos Pharma, Inc. Pharmaceutical formulations for maintaining lean muscle mass during weight loss treatment
WO2025217521A1 (en) * 2024-04-12 2025-10-16 Jnana Therapeutics Inc. Treating chronic kidney disease with a combination of a slc6a19 inhibitor and a glp-1 agonist
CN119405782A (zh) * 2025-01-06 2025-02-11 山东大学 胰岛素样生长因子结合蛋白-1在制备治疗非酒精性脂肪性肝病药物中的应用

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Publication number Priority date Publication date Assignee Title
JP2025535941A (ja) * 2022-11-03 2025-10-30 ルーモス ファーマ，インコーポレイテッド イブタモレンの圧縮型経口製剤
JP7872443B2 (ja) 2022-11-03 2026-06-09 ルーモス ファーマ，インコーポレイテッド イブタモレンの圧縮型経口製剤

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AU2019222736A1 (en) 2020-07-30
AU2019222736B2 (en) 2024-08-01
CN111727041A (zh) 2020-09-29
BR112020016613A2 (pt) 2020-12-22
EA202091464A1 (ru) 2020-12-07
US20210059993A1 (en) 2021-03-04
KR20240015742A (ko) 2024-02-05
EP4467158A2 (en) 2024-11-27
WO2019161025A1 (en) 2019-08-22
EP4623929A3 (en) 2025-12-17
EP3781158A4 (en) 2022-03-16
KR20200121308A (ko) 2020-10-23
AU2024205599A1 (en) 2024-08-22
US20230381158A1 (en) 2023-11-30
EP3781158A1 (en) 2021-02-24
CN118453597A (zh) 2024-08-09
EP4623929A2 (en) 2025-10-01
US20250281470A1 (en) 2025-09-11
EP4467158A3 (en) 2025-02-19
JP2025179056A (ja) 2025-12-09
CA3088177A1 (en) 2019-08-22
JP2024028337A (ja) 2024-03-04

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