JP2021511344A - 癌を治療する組成物および方法 - Google Patents

癌を治療する組成物および方法 Download PDF

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Publication number
JP2021511344A
JP2021511344A JP2020540459A JP2020540459A JP2021511344A JP 2021511344 A JP2021511344 A JP 2021511344A JP 2020540459 A JP2020540459 A JP 2020540459A JP 2020540459 A JP2020540459 A JP 2020540459A JP 2021511344 A JP2021511344 A JP 2021511344A
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cancer
compound
antibody
administered
subject
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Japanese (ja)
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JPWO2019144098A5 (https=
JP2021511344A5 (https=
Inventor
チーホン・ジャオ
ジョセフ・ファルニョーリ
ムラリ・グルラジャン
スーザン・ウィー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2021511344A5 publication Critical patent/JP2021511344A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2020540459A 2018-01-22 2019-01-22 癌を治療する組成物および方法 Pending JP2021511344A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862620209P 2018-01-22 2018-01-22
US62/620,209 2018-01-22
PCT/US2019/014489 WO2019144098A1 (en) 2018-01-22 2019-01-22 Compositions and methods of treating cancer

Publications (3)

Publication Number Publication Date
JP2021511344A true JP2021511344A (ja) 2021-05-06
JPWO2019144098A5 JPWO2019144098A5 (https=) 2022-02-24
JP2021511344A5 JP2021511344A5 (https=) 2022-02-24

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US (2) US20190224205A1 (https=)
EP (1) EP3743076A1 (https=)
JP (1) JP2021511344A (https=)
KR (1) KR20200112904A (https=)
CN (1) CN111629731A (https=)
AU (1) AU2019209435A1 (https=)
BR (1) BR112020014574A2 (https=)
CA (1) CA3088542A1 (https=)
EA (1) EA202091751A1 (https=)
IL (1) IL276203A (https=)
MX (1) MX2020007526A (https=)
SG (1) SG11202006823XA (https=)
WO (1) WO2019144098A1 (https=)

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US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
JP2023538533A (ja) 2020-08-07 2023-09-08 ブリストル－マイヤーズ スクイブ カンパニー 線維症の処置のための、ｃｃｒ２／５拮抗剤と組み合わせたｆｇｆ２１

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JP2013507444A (ja) * 2009-10-13 2013-03-04 ブリストル−マイヤーズ スクイブ カンパニー Ｎ−（（１Ｒ，２Ｓ，５Ｒ）−５−（ＴＥＲＴ−ブチルアミノ）−２−（（Ｓ）−３−（７−ＴＥＲＴ−ブチルピラゾロ［１，５−ａ］［１，３，５］トリアジン−４−イルアミノ）−２−オキソピロリジン−１−イル）シクロヘキシル）アセトアミド、ケモカイン受容体活性のデュアルモジュレーター、結晶形および製造方法

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Also Published As

Publication number Publication date
EP3743076A1 (en) 2020-12-02
US20220160718A1 (en) 2022-05-26
CA3088542A1 (en) 2019-07-25
AU2019209435A1 (en) 2020-09-17
SG11202006823XA (en) 2020-08-28
MX2020007526A (es) 2020-09-09
US20190224205A1 (en) 2019-07-25
WO2019144098A1 (en) 2019-07-25
KR20200112904A (ko) 2020-10-05
CN111629731A (zh) 2020-09-04
IL276203A (en) 2020-09-30
EA202091751A1 (ru) 2020-11-06
BR112020014574A2 (pt) 2020-12-08

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