JP2021510528A5 - - Google Patents
Info
- Publication number
- JP2021510528A5 JP2021510528A5 JP2020539801A JP2020539801A JP2021510528A5 JP 2021510528 A5 JP2021510528 A5 JP 2021510528A5 JP 2020539801 A JP2020539801 A JP 2020539801A JP 2020539801 A JP2020539801 A JP 2020539801A JP 2021510528 A5 JP2021510528 A5 JP 2021510528A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- pharmaceutical composition
- sequence
- composition according
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18152133 | 2018-01-17 | ||
| EP18152133.7 | 2018-01-17 | ||
| PCT/EP2019/051128 WO2019141765A1 (en) | 2018-01-17 | 2019-01-17 | A modified raav capsid protein for gene therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021510528A JP2021510528A (ja) | 2021-04-30 |
| JP2021510528A5 true JP2021510528A5 (https=) | 2022-02-24 |
| JP7389040B2 JP7389040B2 (ja) | 2023-11-29 |
Family
ID=61022137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539801A Active JP7389040B2 (ja) | 2018-01-17 | 2019-01-17 | 遺伝子治療のための修飾ｒＡＡＶキャプシドタンパク質 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US12480138B2 (https=) |
| EP (1) | EP3740222B1 (https=) |
| JP (1) | JP7389040B2 (https=) |
| KR (1) | KR102919991B1 (https=) |
| CN (1) | CN112004544B (https=) |
| AU (1) | AU2019209595B2 (https=) |
| BR (1) | BR112020014625A2 (https=) |
| CA (1) | CA3087910C (https=) |
| DK (1) | DK3740222T5 (https=) |
| EA (1) | EA202091712A1 (https=) |
| ES (1) | ES2957622T3 (https=) |
| FI (1) | FI3740222T3 (https=) |
| HR (1) | HRP20231126T1 (https=) |
| HU (1) | HUE062774T2 (https=) |
| IL (1) | IL275838B2 (https=) |
| LT (1) | LT3740222T (https=) |
| MX (1) | MX2020006764A (https=) |
| MY (1) | MY202252A (https=) |
| PH (1) | PH12020551096A1 (https=) |
| PL (1) | PL3740222T3 (https=) |
| PT (1) | PT3740222T (https=) |
| RS (1) | RS64499B1 (https=) |
| SG (1) | SG11202006056RA (https=) |
| SI (1) | SI3740222T1 (https=) |
| SM (1) | SMT202300284T1 (https=) |
| WO (1) | WO2019141765A1 (https=) |
| ZA (1) | ZA202004980B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2865487T3 (es) | 2015-09-28 | 2021-10-15 | Univ North Carolina Chapel Hill | Métodos y composiciones para vectores virales que evaden los anticuerpos |
| EP3645021A4 (en) * | 2017-06-30 | 2021-04-21 | Intima Bioscience, Inc. | ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY |
| SI3740222T1 (sl) | 2018-01-17 | 2023-11-30 | Meiragtx Uk Ii Limited | Modificiran kapsidni protein raav za gensko terapijo |
| EP3774852A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Antibody-evading virus vectors |
| AU2019247748A1 (en) | 2018-04-03 | 2020-10-08 | Ginkgo Bioworks, Inc. | Antibody-evading virus vectors |
| MX2020010465A (es) | 2018-04-03 | 2021-01-08 | Vectores de virus para direccionamiento a tejidos oftalmicos. | |
| CN110437317B (zh) * | 2019-01-30 | 2023-05-02 | 上海科技大学 | 具有变异衣壳蛋白的腺相关病毒及其用途 |
| AR118465A1 (es) | 2019-03-21 | 2021-10-06 | Stridebio Inc | Vectores de virus adenoasociados recombinantes |
| MX2022000551A (es) * | 2019-07-15 | 2022-05-18 | Meiragtx Uk Ii Ltd | Proteínas de la cápside de aav modificadas para el tratamiento de una enfermedad artrítica. |
| JP2022551739A (ja) | 2019-10-17 | 2022-12-13 | ストライドバイオ，インコーポレイテッド | ニーマン・ピック病ｃ型の治療のためのアデノ随伴ウイルスベクター |
| US12611436B2 (en) | 2019-10-17 | 2026-04-28 | Sarepta Therapeutics, Inc. | AAV transfer cassette |
| CN110950934B (zh) * | 2019-12-31 | 2022-11-04 | 复旦大学 | 一种腺相关病毒衣壳蛋白、载体及其构建方法与应用 |
| BR112022016965A2 (pt) * | 2020-02-25 | 2022-12-06 | Childrens Medical Res Institute | Polipeptídeos e vetores de capsídeo do vírus adenoassociado |
| AU2021328475A1 (en) | 2020-08-19 | 2023-03-16 | Sarepta Therapeutics, Inc. | Adeno-associated virus vectors for treatment of Rett syndrome |
| GB202110014D0 (en) * | 2021-07-12 | 2021-08-25 | Cytiva Bioprocess R & D Ab | A method for separating adeno-associated virus capsids, compositions obtained by said method and uses thereof |
| KR20240095539A (ko) | 2021-10-08 | 2024-06-25 | 디노 테라퓨틱스, 인코포레이티드 | 캡시드 변이체 및 이의 사용 방법 |
| WO2024191778A1 (en) | 2023-03-10 | 2024-09-19 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2024213660A1 (en) | 2023-04-13 | 2024-10-17 | Meiragtx Uk Ii Limited | Inflammation-inducible promoters |
| CN119320802A (zh) * | 2023-07-17 | 2025-01-17 | 苏州吉恒基因科技有限公司 | 单链单极DNA重组腺相关病毒的cis包装元件、spAAV载体和应用 |
| AU2024332181A1 (en) | 2023-08-31 | 2026-02-12 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| TW202545971A (zh) | 2024-02-08 | 2025-12-01 | 美商戴諾治療公司 | 殼體多肽及其使用方法 |
| WO2026064442A2 (en) | 2024-09-18 | 2026-03-26 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003042361A2 (en) | 2001-11-09 | 2003-05-22 | Government Of The United States Of America, Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| WO2005021768A1 (en) * | 2003-09-01 | 2005-03-10 | Academisch Medisch Centrum | Aav vectors for in vivo gene therapy of rheumatoid arthritis |
| AU2010201278B2 (en) * | 2003-09-01 | 2012-11-15 | Academisch Medisch Centrum | AAV vectors for in vivo gene therapy of rheumatoid arthritis |
| US8529885B2 (en) * | 2003-09-01 | 2013-09-10 | Academisch Medisch Centrum | AAV vectors for in vivo gene therapy of rheumatoid arthritis |
| EP2311966A3 (en) | 2005-10-20 | 2012-09-05 | Amsterdam Molecular Therapeutics (AMT) B.V. | Improved AAV vectors produced in insect cells |
| US7588772B2 (en) * | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| CN103849629B (zh) | 2006-06-21 | 2017-06-09 | 尤尼克尔Ip股份有限公司 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
| WO2008024998A2 (en) | 2006-08-24 | 2008-02-28 | Virovek, Inc. | Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor |
| EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| DK2173888T3 (en) | 2007-07-26 | 2016-11-28 | Uniqure Ip Bv | Baculovirus vectors comprising repeating coding sequences WITH differential preferred codons |
| JP2011512156A (ja) | 2008-02-19 | 2011-04-21 | アムステルダム モレキュラー セラピューティクス ビー．ブイ． | 昆虫細胞におけるパルボウイルスｒｅｐ及びｃａｐタンパク質の発現の最適化 |
| WO2009154452A1 (en) | 2008-06-17 | 2009-12-23 | Amsterdam Molecular Therapeutics B.V. | Parvoviral capsid with incorporated Gly-Ala repeat region |
| EP2545165B1 (en) | 2010-03-11 | 2020-07-29 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
| JP6198278B2 (ja) | 2011-09-08 | 2017-09-20 | ユニキュアー アイピー ビー．ブイ． | Ａａｖ調製物からの混入ウイルスの除去 |
| WO2013174760A1 (en) * | 2012-05-25 | 2013-11-28 | Deutsches Krebsforschungszentrum | Optimized aav-vectors for high transduction rates in dendritic cells |
| EP3492597A3 (en) * | 2013-05-21 | 2019-08-28 | University of Florida Research Foundation, Inc. | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
| DE102014207498A1 (de) * | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| CN104107438A (zh) * | 2014-05-29 | 2014-10-22 | 中国人民解放军军事医学科学院基础医学研究所 | Spry2在制备预防和治疗类风湿性关节炎药物中的应用 |
| EP3204503A1 (en) | 2014-10-06 | 2017-08-16 | Arthrogen BV | Aav-based gene therapy |
| WO2016100575A1 (en) | 2014-12-16 | 2016-06-23 | Board Of Regents Of The University Of Nebraska | Gene therapy for juvenile batten disease |
| RU2771490C2 (ru) | 2016-01-13 | 2022-05-05 | Мериал, Инк. | Рекомбинантные aav векторы, экспрессирующие остеопротективные гены, включая has2 и лубрицин, пригодные при лечении остеоартрита и сходных заболеваний суставов у млекопитающих |
| JP7165410B2 (ja) | 2016-08-19 | 2022-11-04 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド | 組換え自己相補的アデノ随伴ウイルスを使用して疾患を治療するための方法及び組成物 |
| KR20190088561A (ko) | 2016-12-07 | 2019-07-26 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 인터류킨-1 수용체 길항제(IL-1RA) cDNA |
| EP3609542B1 (en) | 2017-04-11 | 2023-02-22 | Ruprecht-Karls-Universität Heidelberg | Adeno-associated virus library |
| BR112020003976A8 (pt) * | 2017-08-31 | 2023-03-28 | Benitec Biopharma Ltd | Vírus adeno-associado (aav) com domínio fosfolipase modificado |
| SI3740222T1 (sl) | 2018-01-17 | 2023-11-30 | Meiragtx Uk Ii Limited | Modificiran kapsidni protein raav za gensko terapijo |
| MX2022000551A (es) * | 2019-07-15 | 2022-05-18 | Meiragtx Uk Ii Ltd | Proteínas de la cápside de aav modificadas para el tratamiento de una enfermedad artrítica. |
-
2019
- 2019-01-17 SI SI201930613T patent/SI3740222T1/sl unknown
- 2019-01-17 US US16/962,748 patent/US12480138B2/en active Active
- 2019-01-17 AU AU2019209595A patent/AU2019209595B2/en active Active
- 2019-01-17 MX MX2020006764A patent/MX2020006764A/es unknown
- 2019-01-17 HU HUE19701080A patent/HUE062774T2/hu unknown
- 2019-01-17 ES ES19701080T patent/ES2957622T3/es active Active
- 2019-01-17 CA CA3087910A patent/CA3087910C/en active Active
- 2019-01-17 KR KR1020207023174A patent/KR102919991B1/ko active Active
- 2019-01-17 BR BR112020014625-0A patent/BR112020014625A2/pt unknown
- 2019-01-17 MY MYPI2020003653A patent/MY202252A/en unknown
- 2019-01-17 EA EA202091712A patent/EA202091712A1/ru unknown
- 2019-01-17 WO PCT/EP2019/051128 patent/WO2019141765A1/en not_active Ceased
- 2019-01-17 HR HRP20231126TT patent/HRP20231126T1/hr unknown
- 2019-01-17 IL IL275838A patent/IL275838B2/en unknown
- 2019-01-17 SG SG11202006056RA patent/SG11202006056RA/en unknown
- 2019-01-17 JP JP2020539801A patent/JP7389040B2/ja active Active
- 2019-01-17 LT LTEPPCT/EP2019/051128T patent/LT3740222T/lt unknown
- 2019-01-17 RS RS20230730A patent/RS64499B1/sr unknown
- 2019-01-17 SM SM20230284T patent/SMT202300284T1/it unknown
- 2019-01-17 PL PL19701080.4T patent/PL3740222T3/pl unknown
- 2019-01-17 PT PT197010804T patent/PT3740222T/pt unknown
- 2019-01-17 CN CN201980020100.1A patent/CN112004544B/zh active Active
- 2019-01-17 FI FIEP19701080.4T patent/FI3740222T3/fi active
- 2019-01-17 EP EP19701080.4A patent/EP3740222B1/en active Active
- 2019-01-17 DK DK19701080.4T patent/DK3740222T5/da active
-
2020
- 2020-07-17 PH PH12020551096A patent/PH12020551096A1/en unknown
- 2020-08-12 ZA ZA2020/04980A patent/ZA202004980B/en unknown
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