JP2021507677A5 - - Google Patents

Download PDF

Info

Publication number
JP2021507677A5
JP2021507677A5 JP2020517858A JP2020517858A JP2021507677A5 JP 2021507677 A5 JP2021507677 A5 JP 2021507677A5 JP 2020517858 A JP2020517858 A JP 2020517858A JP 2020517858 A JP2020517858 A JP 2020517858A JP 2021507677 A5 JP2021507677 A5 JP 2021507677A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
antigen
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020517858A
Other languages
English (en)
Japanese (ja)
Other versions
JP7438937B2 (ja
JP2021507677A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/062863 external-priority patent/WO2019108662A1/en
Publication of JP2021507677A publication Critical patent/JP2021507677A/ja
Publication of JP2021507677A5 publication Critical patent/JP2021507677A5/ja
Priority to JP2023191236A priority Critical patent/JP2024016204A/ja
Application granted granted Critical
Publication of JP7438937B2 publication Critical patent/JP7438937B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020517858A 2017-11-30 2018-11-28 抗ｔｒｋｂモノクローナル抗体および使用の方法 Active JP7438937B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023191236A JP2024016204A (ja) 2017-11-30 2023-11-09 抗ｔｒｋｂモノクローナル抗体および使用の方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762592657P 2017-11-30 2017-11-30
US62/592,657 2017-11-30
PCT/US2018/062863 WO2019108662A1 (en) 2017-11-30 2018-11-28 Anti-trkb monoclonal antibodies and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023191236A Division JP2024016204A (ja) 2017-11-30 2023-11-09 抗ｔｒｋｂモノクローナル抗体および使用の方法

Publications (3)

Publication Number Publication Date
JP2021507677A JP2021507677A (ja) 2021-02-25
JP2021507677A5 true JP2021507677A5 (https=) 2022-01-04
JP7438937B2 JP7438937B2 (ja) 2024-02-27

Family

ID=64665125

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020517858A Active JP7438937B2 (ja) 2017-11-30 2018-11-28 抗ｔｒｋｂモノクローナル抗体および使用の方法
JP2023191236A Pending JP2024016204A (ja) 2017-11-30 2023-11-09 抗ｔｒｋｂモノクローナル抗体および使用の方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023191236A Pending JP2024016204A (ja) 2017-11-30 2023-11-09 抗ｔｒｋｂモノクローナル抗体および使用の方法

Country Status (18)

Country Link
US (3) US11066474B2 (https=)
EP (1) EP3717514A1 (https=)
JP (2) JP7438937B2 (https=)
KR (1) KR20200090779A (https=)
CN (2) CN111372949B (https=)
AU (3) AU2018375340B2 (https=)
BR (1) BR112020006976A2 (https=)
CA (1) CA3083452A1 (https=)
CL (3) CL2020000855A1 (https=)
CO (1) CO2020004075A2 (https=)
EA (1) EA202090966A1 (https=)
IL (1) IL273538B2 (https=)
MA (1) MA51207A (https=)
MX (3) MX2020003550A (https=)
MY (1) MY203247A (https=)
PH (1) PH12020550409A1 (https=)
SG (1) SG11202002665UA (https=)
WO (1) WO2019108662A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793634B2 (en) 2017-06-09 2020-10-06 Boehringer Ingelheim International Gmbh Anti-TrkB antibodies
WO2019108662A1 (en) * 2017-11-30 2019-06-06 Regeneron Pharmaceuticals, Inc. Anti-trkb monoclonal antibodies and methods of use
IL310006A (en) * 2017-11-30 2024-03-01 Regeneron Pharma Non-human animals containing a humanized TRKB locus
JP7524158B2 (ja) * 2019-03-04 2024-07-29 公益財団法人東京都医学総合研究所 Ｔｒｋ断片をコードする核酸構築物、及びその利用
US12559560B2 (en) * 2020-01-30 2026-02-24 Fred Hutchinson Cancer Center Antibody-based compositions for targeting tropomyosin receptor kinase B (TrkB) isoforms
WO2023125485A1 (en) * 2021-12-28 2023-07-06 4B Technologies (Beijing) Co., Limited TrkB ANTIBODY AND APPLICATION THEREOF
TW202342494A (zh) 2022-03-30 2023-11-01 日商肽夢想股份有限公司 具有TrkB結合活性之肽複合物
CN120665203B (zh) * 2025-06-18 2026-03-27 广东优赛生物医药科技有限公司 一种药物组合物及其在治疗中枢性肥胖中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US6225282B1 (en) 1996-01-05 2001-05-01 Genentech, Inc. Treatment of hearing impairments
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2006133164A2 (en) 2005-06-06 2006-12-14 Wyeth Anti-trkb monoclonal antibodies and uses thereof
EP1988923A1 (en) * 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkb agonist
EP1988920A1 (en) 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkb antagonist
ES2398076T3 (es) 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. Anticuerpos de alta afinidad contra el receptor de IL-6 humano
WO2008058127A2 (en) 2006-11-09 2008-05-15 Irm Llc Agonist trkb antibodies and uses thereof
CA2672750A1 (en) * 2006-12-20 2008-07-03 Rinat Neuroscience Corporation Trkb agonists for treating autoimmune disorders
WO2009048605A1 (en) 2007-10-11 2009-04-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists
CA2712298C (en) 2008-01-17 2015-11-24 Irm Llc Improved anti-trkb antibodies
WO2010086828A2 (en) * 2009-02-02 2010-08-05 Rinat Neuroscience Corporation Agonist anti-trkb monoclonal antibodies
WO2011103667A1 (en) 2010-02-26 2011-09-01 6452728 Canada Inc. Agonistic antibodies to trkb receptors and uses thereof
GB2491106A (en) 2011-05-18 2012-11-28 Univ Basel Antibodies against tropomyosin-related kinase B receptors
US10080745B2 (en) 2013-11-25 2018-09-25 The Regents Of The University Of California Santa Cruz Piericidin bacterial inhibitors
ES2936810T3 (es) 2014-05-16 2023-03-22 Pfizer Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería
CA2993645A1 (en) 2015-07-28 2017-02-02 Otonomy, Inc. Trkb or trkc agonist compositions and methods for the treatment of otic conditions
CA3005491A1 (en) 2015-11-17 2017-05-26 Glaxosmithkline Intellectual Property Development Limited Binding agonists for treatment of neurological and other disorders
JP2019517787A (ja) * 2016-05-03 2019-06-27 ザ スクリプス リサーチ インスティテュート 神経変性障害の処置のためのＴｒｋＢアゴニスト抗体
US9914781B1 (en) 2016-11-08 2018-03-13 Glaxosmithkline Intellectual Property Development Limited Binding agonist for treatment of neurological and other disorders
EP4095161A1 (en) * 2017-03-15 2022-11-30 Tsinghua University Novel anti-trkb antibodies
WO2019108662A1 (en) * 2017-11-30 2019-06-06 Regeneron Pharmaceuticals, Inc. Anti-trkb monoclonal antibodies and methods of use

Similar Documents

Publication Publication Date Title
JP2021507677A5 (https=)
JP7790754B2 (ja) Ｃｄ３を標的とする抗体、二重特異性抗体及びその使用
RU2577228C2 (ru) Анти-il-17-антитела, способ их получения и способ применения
JP2017536414A5 (https=)
JP2018527908A (ja) Ｄｌｌ３及びｃｄ３に結合する二重特異性抗体構築物
JP2012525829A5 (https=)
JP2018530996A6 (ja) Ｃｄ７０及びｃｄ３に対する抗体構築物
JP7292526B2 (ja) 操作された抗ｉｌ－２抗体
JP2015535828A5 (https=)
JP2018530996A (ja) Ｃｄ７０及びｃｄ３に対する抗体構築物
RU2012107286A (ru) Высокоаффинные человеческие антитела к человеческому ангиопоэтину-2
CN106565840B (zh) 抗乙肝表面抗原的抗体及其用途
JP2013543384A5 (https=)
CN113480641B (zh) 用于治疗乙肝感染及相关疾病的抗体
JP7328324B2 (ja) Ｔｉｍ－３に対する抗体およびその使用
JP7679399B2 (ja) 抗ｆｌｔ３抗体及び組成物
IL273538B1 (en) Anti-trkb monoclonal antibodies and methods of use
KR20240016991A (ko) 항-nkg2a 항체 및 조성물
TW202313689A (zh) 抗pvrig/抗tigit雙特異性抗體和應用
JP2022507599A (ja) 安定性が向上した抗ｃ－ｍｅｔ抗体又はその抗原結合断片
US20230167188A1 (en) Anti-tumor necrosis factor receptor (tnfr2) antibodies and uses thereof
CN117396220A (zh) 抗nkg2d抗体及其用途
WO2022237819A1 (zh) 抗Siglec-15抗体及其用途
RU2841957C1 (ru) Сконструированные антитела против il-2
JP2026069499A (ja) Ｃｄ３を標的とする抗体、二重特異性抗体及びその使用