JP2021505542A5 - - Google Patents
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- Publication number
- JP2021505542A5 JP2021505542A5 JP2020529321A JP2020529321A JP2021505542A5 JP 2021505542 A5 JP2021505542 A5 JP 2021505542A5 JP 2020529321 A JP2020529321 A JP 2020529321A JP 2020529321 A JP2020529321 A JP 2020529321A JP 2021505542 A5 JP2021505542 A5 JP 2021505542A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)[C@@](C(N[C@@](CCCNC(N)=O)C(Nc1ccc(CO)cc1)=O)=O)N* Chemical compound CC(C)[C@@](C(N[C@@](CCCNC(N)=O)C(Nc1ccc(CO)cc1)=O)=O)N* 0.000 description 20
- HYSPJPGXSALJRR-DHIFEGFHSA-N CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(COC(Oc(cc2)ccc2[N+]([O-])=O)=O)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O Chemical compound CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(COC(Oc(cc2)ccc2[N+]([O-])=O)=O)cc1)=O)=O)NC(CCCCCN(C(C=C1)=O)C1=O)=O HYSPJPGXSALJRR-DHIFEGFHSA-N 0.000 description 3
- VEGGTWZUZGZKHY-GJZGRUSLSA-N CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(CO)cc1)=O)=O)N Chemical compound CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(CO)cc1)=O)=O)N VEGGTWZUZGZKHY-GJZGRUSLSA-N 0.000 description 2
- JGHPPNLZKDOBQX-UHFFFAOYSA-N CC1C(CC2)C2CC1 Chemical compound CC1C(CC2)C2CC1 JGHPPNLZKDOBQX-UHFFFAOYSA-N 0.000 description 2
- OLFJKHKGMAHRPW-QINSGFPZSA-N CCC/C=C(/Nc(cccc1)c1[IH]CC)\N(C)C Chemical compound CCC/C=C(/Nc(cccc1)c1[IH]CC)\N(C)C OLFJKHKGMAHRPW-QINSGFPZSA-N 0.000 description 2
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N CCCC[C@@H](C(O)=O)N Chemical compound CCCC[C@@H](C(O)=O)N LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 2
- JDFXJJLFADUZIY-UHFFFAOYSA-N CON(C(CC1)=O)C1=O Chemical compound CON(C(CC1)=O)C1=O JDFXJJLFADUZIY-UHFFFAOYSA-N 0.000 description 2
- ACBQROXDOHKANW-UHFFFAOYSA-N [O-][N+](c(cc1)ccc1OC(Oc(cc1)ccc1[N+]([O-])=O)=O)=O Chemical compound [O-][N+](c(cc1)ccc1OC(Oc(cc1)ccc1[N+]([O-])=O)=O)=O ACBQROXDOHKANW-UHFFFAOYSA-N 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023152281A JP7787859B2 (ja) | 2017-11-30 | 2023-09-20 | 薬物リンカー化合物の調製のためのプロセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762593104P | 2017-11-30 | 2017-11-30 | |
| US62/593,104 | 2017-11-30 | ||
| PCT/US2018/063070 WO2019108797A1 (en) | 2017-11-30 | 2018-11-29 | Process for the preparation of drug linker compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023152281A Division JP7787859B2 (ja) | 2017-11-30 | 2023-09-20 | 薬物リンカー化合物の調製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505542A JP2021505542A (ja) | 2021-02-18 |
| JP2021505542A5 true JP2021505542A5 (https=) | 2022-01-06 |
| JP7402159B2 JP7402159B2 (ja) | 2023-12-20 |
Family
ID=66665808
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529321A Active JP7402159B2 (ja) | 2017-11-30 | 2018-11-29 | 薬物リンカー化合物の調製のためのプロセス |
| JP2023152281A Active JP7787859B2 (ja) | 2017-11-30 | 2023-09-20 | 薬物リンカー化合物の調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023152281A Active JP7787859B2 (ja) | 2017-11-30 | 2023-09-20 | 薬物リンカー化合物の調製のためのプロセス |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11612666B2 (https=) |
| EP (1) | EP3717016A4 (https=) |
| JP (2) | JP7402159B2 (https=) |
| KR (2) | KR20250024092A (https=) |
| CN (2) | CN111417408B (https=) |
| AU (1) | AU2018375412B2 (https=) |
| BR (1) | BR112020010503A2 (https=) |
| CA (1) | CA3082165A1 (https=) |
| EA (1) | EA202091340A1 (https=) |
| IL (1) | IL274757B2 (https=) |
| MA (1) | MA51870A (https=) |
| MX (2) | MX2020005565A (https=) |
| SG (1) | SG11202004698RA (https=) |
| WO (1) | WO2019108797A1 (https=) |
| ZA (1) | ZA202003037B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7167163B2 (ja) * | 2019-05-20 | 2022-11-08 | 煙台邁百瑞国際生物医薬股▲ふん▼有限公司 | 抗体－薬物コンジュゲートの中間体のワンポット合成法による製造プロセス |
| CN110945009B (zh) * | 2019-10-23 | 2023-10-31 | 烟台迈百瑞国际生物医药股份有限公司 | 一种寡肽连接子中间体及其制备方法 |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| CN115873066A (zh) * | 2022-07-27 | 2023-03-31 | 吉林省博大伟业制药有限公司 | 一种抗体偶联药物连接子的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US7498298B2 (en) * | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| WO2007031734A1 (en) * | 2005-09-14 | 2007-03-22 | Ucb Pharma S.A. | Comb polymers |
| MX2009002855A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales. |
| ES2569483T3 (es) * | 2007-06-21 | 2016-05-11 | Amgen Inc. | Métodos para sintetizar cinacalcet y sales del mismo |
| KR102356286B1 (ko) * | 2011-05-27 | 2022-02-08 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도 |
| US9981046B2 (en) * | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
| SI2941432T1 (en) * | 2012-12-07 | 2018-07-31 | Vertex Pharmaceuticals Incorporated | 2-AMINO-6-FLUORO-N- (5-FLUORO-4- (4- (4- (OXETHAN-3-YL) PIPERAZIN-1-CARBONYL) PIPERIDIN-1-YLIPRIDIN-3-YL) 1,5 ALFA) PYRIMIDINE-3-CARBOXAMIDE AS ATR KINAZE INHIBITOR |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| GB201416960D0 (en) * | 2014-09-25 | 2014-11-12 | Antikor Biopharma Ltd | Biological materials and uses thereof |
| US9533483B2 (en) | 2014-09-26 | 2017-01-03 | Kimberly-Clark Worldwide, Inc. | Apparatus for and method of shaping and applying a segment to a moving web |
-
2018
- 2018-11-29 CN CN201880077478.0A patent/CN111417408B/zh active Active
- 2018-11-29 MA MA051870A patent/MA51870A/fr unknown
- 2018-11-29 BR BR112020010503-1A patent/BR112020010503A2/pt active Search and Examination
- 2018-11-29 MX MX2020005565A patent/MX2020005565A/es unknown
- 2018-11-29 AU AU2018375412A patent/AU2018375412B2/en active Active
- 2018-11-29 KR KR1020257002801A patent/KR20250024092A/ko active Pending
- 2018-11-29 JP JP2020529321A patent/JP7402159B2/ja active Active
- 2018-11-29 SG SG11202004698RA patent/SG11202004698RA/en unknown
- 2018-11-29 CN CN202410349991.8A patent/CN118271394A/zh active Pending
- 2018-11-29 EA EA202091340A patent/EA202091340A1/ru unknown
- 2018-11-29 WO PCT/US2018/063070 patent/WO2019108797A1/en not_active Ceased
- 2018-11-29 KR KR1020207018586A patent/KR102762352B1/ko active Active
- 2018-11-29 US US16/768,027 patent/US11612666B2/en active Active
- 2018-11-29 IL IL274757A patent/IL274757B2/en unknown
- 2018-11-29 CA CA3082165A patent/CA3082165A1/en active Pending
- 2018-11-29 EP EP18883925.2A patent/EP3717016A4/en active Pending
-
2020
- 2020-05-22 ZA ZA2020/03037A patent/ZA202003037B/en unknown
- 2020-07-13 MX MX2023009372A patent/MX2023009372A/es unknown
-
2023
- 2023-01-31 US US18/162,432 patent/US20240042052A1/en not_active Abandoned
- 2023-09-20 JP JP2023152281A patent/JP7787859B2/ja active Active
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