JP2021501321A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021501321A5 JP2021501321A5 JP2020523788A JP2020523788A JP2021501321A5 JP 2021501321 A5 JP2021501321 A5 JP 2021501321A5 JP 2020523788 A JP2020523788 A JP 2020523788A JP 2020523788 A JP2020523788 A JP 2020523788A JP 2021501321 A5 JP2021501321 A5 JP 2021501321A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- plates
- plate
- spacer
- smartphone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 claims description 252
- 238000000034 method Methods 0.000 claims description 140
- 125000006850 spacer group Chemical group 0.000 claims description 105
- 239000012530 fluid Substances 0.000 claims description 41
- 210000001519 tissue Anatomy 0.000 claims description 38
- 238000004458 analytical method Methods 0.000 claims description 36
- 239000000243 solution Substances 0.000 claims description 32
- 238000012546 transfer Methods 0.000 claims description 31
- 238000001514 detection method Methods 0.000 claims description 26
- 210000004369 blood Anatomy 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 23
- 210000004027 cell Anatomy 0.000 claims description 23
- 210000002939 cerumen Anatomy 0.000 claims description 21
- 206010050337 Cerumen impaction Diseases 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 238000003825 pressing Methods 0.000 claims description 19
- 239000000975 dye Substances 0.000 claims description 17
- 238000010295 mobile communication Methods 0.000 claims description 16
- 210000003097 mucus Anatomy 0.000 claims description 13
- 210000002751 lymph Anatomy 0.000 claims description 12
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 206010036790 Productive cough Diseases 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 10
- 210000003802 sputum Anatomy 0.000 claims description 10
- 208000024794 sputum Diseases 0.000 claims description 10
- 239000012192 staining solution Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 210000003608 fece Anatomy 0.000 claims description 9
- 238000011002 quantification Methods 0.000 claims description 9
- 238000003860 storage Methods 0.000 claims description 9
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 claims description 8
- -1 Jenna Dye 1899 Chemical compound 0.000 claims description 8
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 239000002981 blocking agent Substances 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 239000002357 osmotic agent Substances 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 241001494479 Pecora Species 0.000 claims description 7
- 230000002496 gastric effect Effects 0.000 claims description 7
- 210000004251 human milk Anatomy 0.000 claims description 7
- 235000020256 human milk Nutrition 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 7
- 210000004915 pus Anatomy 0.000 claims description 7
- 210000003296 saliva Anatomy 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 239000012188 paraffin wax Substances 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 210000004243 sweat Anatomy 0.000 claims description 6
- 210000001138 tear Anatomy 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 208000005228 Pericardial Effusion Diseases 0.000 claims description 4
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 4
- 210000003567 ascitic fluid Anatomy 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 claims description 4
- 210000004211 gastric acid Anatomy 0.000 claims description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 150000002484 inorganic compounds Chemical class 0.000 claims description 4
- 229910010272 inorganic material Inorganic materials 0.000 claims description 4
- 229960000907 methylthioninium chloride Drugs 0.000 claims description 4
- 235000013336 milk Nutrition 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- AFAIELJLZYUNPW-UHFFFAOYSA-N pararosaniline free base Chemical compound C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=N)C=C1 AFAIELJLZYUNPW-UHFFFAOYSA-N 0.000 claims description 4
- 210000004912 pericardial fluid Anatomy 0.000 claims description 4
- 210000004910 pleural fluid Anatomy 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 239000002516 radical scavenger Substances 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- 238000001574 biopsy Methods 0.000 claims description 3
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 210000000845 cartilage Anatomy 0.000 claims description 3
- 210000002808 connective tissue Anatomy 0.000 claims description 3
- 210000000981 epithelium Anatomy 0.000 claims description 3
- 210000003722 extracellular fluid Anatomy 0.000 claims description 3
- 230000002550 fecal effect Effects 0.000 claims description 3
- 210000004700 fetal blood Anatomy 0.000 claims description 3
- 230000001605 fetal effect Effects 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 230000000762 glandular Effects 0.000 claims description 3
- 210000004880 lymph fluid Anatomy 0.000 claims description 3
- 244000005706 microflora Species 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 210000002826 placenta Anatomy 0.000 claims description 3
- 230000028327 secretion Effects 0.000 claims description 3
- JKYKXTRKURYNGW-UHFFFAOYSA-N 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C(O)C(S(O)(=O)=O)=C2 JKYKXTRKURYNGW-UHFFFAOYSA-N 0.000 claims description 2
- IICCLYANAQEHCI-UHFFFAOYSA-N 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 IICCLYANAQEHCI-UHFFFAOYSA-N 0.000 claims description 2
- ALJHHTHBYJROOG-UHFFFAOYSA-N 7-(dimethylamino)phenothiazin-3-one Chemical compound C1=CC(=O)C=C2SC3=CC(N(C)C)=CC=C3N=C21 ALJHHTHBYJROOG-UHFFFAOYSA-N 0.000 claims description 2
- YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 claims description 2
- 108700012813 7-aminoactinomycin D Proteins 0.000 claims description 2
- MPVDXIMFBOLMNW-ISLYRVAYSA-N 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid Chemical compound OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1\N=N\C1=CC=CC=C1 MPVDXIMFBOLMNW-ISLYRVAYSA-N 0.000 claims description 2
- CKLBXIYTBHXJEH-UHFFFAOYSA-J 75881-23-1 Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cu+2].[N-]1C(N=C2C3=CC=C(CSC(N(C)C)=[N+](C)C)C=C3C(N=C3C4=CC=C(CSC(N(C)C)=[N+](C)C)C=C4C(=N4)[N-]3)=N2)=C(C=C(CSC(N(C)C)=[N+](C)C)C=C2)C2=C1N=C1C2=CC(CSC(N(C)C)=[N+](C)C)=CC=C2C4=N1 CKLBXIYTBHXJEH-UHFFFAOYSA-J 0.000 claims description 2
- QFIIYGZAUXVPSZ-UHFFFAOYSA-N 8-(2,4-dihydroxy-6-methylanilino)-2-(2,4-dihydroxy-6-methylphenyl)imino-7-hydroxy-1,9-dimethyldibenzofuran-3-one Chemical compound CC1=CC(=CC(=C1NC2=C(C3=C(C=C2O)OC4=CC(=O)C(=NC5=C(C=C(C=C5C)O)O)C(=C43)C)C)O)O QFIIYGZAUXVPSZ-UHFFFAOYSA-N 0.000 claims description 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 239000004214 Fast Green FCF Substances 0.000 claims description 2
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- XXACTDWGHQXLGW-UHFFFAOYSA-M Janus Green B chloride Chemical compound [Cl-].C12=CC(N(CC)CC)=CC=C2N=C2C=CC(\N=N\C=3C=CC(=CC=3)N(C)C)=CC2=[N+]1C1=CC=CC=C1 XXACTDWGHQXLGW-UHFFFAOYSA-M 0.000 claims description 2
- WWKGVZASJYXZKN-UHFFFAOYSA-N Methyl violet 2B Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[N+](C)C)C=C1 WWKGVZASJYXZKN-UHFFFAOYSA-N 0.000 claims description 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 2
- 239000004218 Orcein Substances 0.000 claims description 2
- 238000001069 Raman spectroscopy Methods 0.000 claims description 2
- 208000036071 Rhinorrhea Diseases 0.000 claims description 2
- 206010039101 Rhinorrhoea Diseases 0.000 claims description 2
- FHNINJWBTRXEBC-UHFFFAOYSA-N Sudan III Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC(C=C1)=CC=C1N=NC1=CC=CC=C1 FHNINJWBTRXEBC-UHFFFAOYSA-N 0.000 claims description 2
- 108010076830 Thionins Proteins 0.000 claims description 2
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- DEXKHGVSCDMMLD-UHFFFAOYSA-N [ClH]1N=CC=C1 Chemical compound [ClH]1N=CC=C1 DEXKHGVSCDMMLD-UHFFFAOYSA-N 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000000980 acid dye Substances 0.000 claims description 2
- RZUBARUFLYGOGC-MTHOTQAESA-L acid fuchsin Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=C(N)C(C)=CC(C(=C\2C=C(C(=[NH2+])C=C/2)S([O-])(=O)=O)\C=2C=C(C(N)=CC=2)S([O-])(=O)=O)=C1 RZUBARUFLYGOGC-MTHOTQAESA-L 0.000 claims description 2
- DGOBMKYRQHEFGQ-UHFFFAOYSA-L acid green 5 Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 DGOBMKYRQHEFGQ-UHFFFAOYSA-L 0.000 claims description 2
- CQPFMGBJSMSXLP-UHFFFAOYSA-M acid orange 7 Chemical compound [Na+].OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 CQPFMGBJSMSXLP-UHFFFAOYSA-M 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 239000012190 activator Substances 0.000 claims description 2
- 230000001464 adherent effect Effects 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- WLDHEUZGFKACJH-UHFFFAOYSA-K amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1N=NC1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-UHFFFAOYSA-K 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- KSCQDDRPFHTIRL-UHFFFAOYSA-N auramine O Chemical compound [H+].[Cl-].C1=CC(N(C)C)=CC=C1C(=N)C1=CC=C(N(C)C)C=C1 KSCQDDRPFHTIRL-UHFFFAOYSA-N 0.000 claims description 2
- QZKHGYGBYOUFGK-UHFFFAOYSA-L azocarmine B Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(S(=O)(=O)[O-])=CC=C1NC(C1=CC(=CC=C1C1=NC2=CC=CC=C22)S([O-])(=O)=O)=CC1=[N+]2C1=CC=CC=C1 QZKHGYGBYOUFGK-UHFFFAOYSA-L 0.000 claims description 2
- BDFZFGDTHFGWRQ-UHFFFAOYSA-N basic brown 1 Chemical compound NC1=CC(N)=CC=C1N=NC1=CC=CC(N=NC=2C(=CC(N)=CC=2)N)=C1 BDFZFGDTHFGWRQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940052223 basic fuchsin Drugs 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004820 blood count Methods 0.000 claims description 2
- DEGAKNSWVGKMLS-UHFFFAOYSA-N calcein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(O)=O)CC(O)=O)=C(O)C=C1OC1=C2C=C(CN(CC(O)=O)CC(=O)O)C(O)=C1 DEGAKNSWVGKMLS-UHFFFAOYSA-N 0.000 claims description 2
- BQRGNLJZBFXNCZ-UHFFFAOYSA-N calcein am Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=C(OC(C)=O)C=C1OC1=C2C=C(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(=O)C)C(OC(C)=O)=C1 BQRGNLJZBFXNCZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000012730 carminic acid Nutrition 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 210000000349 chromosome Anatomy 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- 230000005494 condensation Effects 0.000 claims description 2
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 238000009792 diffusion process Methods 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000003255 drug test Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000005401 electroluminescence Methods 0.000 claims description 2
- ZBQZBWKNGDEDOA-UHFFFAOYSA-N eosin B Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC([N+]([O-])=O)=C(O)C(Br)=C1OC1=C2C=C([N+]([O-])=O)C(O)=C1Br ZBQZBWKNGDEDOA-UHFFFAOYSA-N 0.000 claims description 2
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims description 2
- UKZQEOHHLOYJLY-UHFFFAOYSA-M ethyl eosin Chemical compound [K+].CCOC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 UKZQEOHHLOYJLY-UHFFFAOYSA-M 0.000 claims description 2
- IDAQSADEMXDTKN-UHFFFAOYSA-L ethyl green Chemical compound [Cl-].[Br-].C1=CC([N+](C)(C)CC)=CC=C1C(C=1C=CC(=CC=1)N(C)C)=C1C=CC(=[N+](C)C)C=C1 IDAQSADEMXDTKN-UHFFFAOYSA-L 0.000 claims description 2
- 235000019240 fast green FCF Nutrition 0.000 claims description 2
- 239000000834 fixative Substances 0.000 claims description 2
- 229940072686 floxin Drugs 0.000 claims description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 2
- 238000011331 genomic analysis Methods 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 230000003100 immobilizing effect Effects 0.000 claims description 2
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 claims description 2
- 229960003988 indigo carmine Drugs 0.000 claims description 2
- 235000012738 indigotine Nutrition 0.000 claims description 2
- 239000004179 indigotine Substances 0.000 claims description 2
- 238000004020 luminiscence type Methods 0.000 claims description 2
- 229940012189 methyl orange Drugs 0.000 claims description 2
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 210000003470 mitochondria Anatomy 0.000 claims description 2
- 230000002438 mitochondrial effect Effects 0.000 claims description 2
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 claims description 2
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 claims description 2
- XJCPMUIIBDVFDM-UHFFFAOYSA-M nile blue A Chemical compound [Cl-].C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4[O+]=C3C=C(N)C2=C1 XJCPMUIIBDVFDM-UHFFFAOYSA-M 0.000 claims description 2
- 229960002378 oftasceine Drugs 0.000 claims description 2
- 239000002751 oligonucleotide probe Substances 0.000 claims description 2
- 235000019248 orcein Nutrition 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 230000000737 periodic effect Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 229940127557 pharmaceutical product Drugs 0.000 claims description 2
- 238000005424 photoluminescence Methods 0.000 claims description 2
- 235000021395 porridge Nutrition 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 claims description 2
- CXZRDVVUVDYSCQ-UHFFFAOYSA-M pyronin B Chemical compound [Cl-].C1=CC(=[N+](CC)CC)C=C2OC3=CC(N(CC)CC)=CC=C3C=C21 CXZRDVVUVDYSCQ-UHFFFAOYSA-M 0.000 claims description 2
- INCIMLINXXICKS-UHFFFAOYSA-M pyronin Y Chemical compound [Cl-].C1=CC(=[N+](C)C)C=C2OC3=CC(N(C)C)=CC=C3C=C21 INCIMLINXXICKS-UHFFFAOYSA-M 0.000 claims description 2
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 claims description 2
- 229940081623 rose bengal Drugs 0.000 claims description 2
- 229930187593 rose bengal Natural products 0.000 claims description 2
- STRXNPAVPKGJQR-UHFFFAOYSA-N rose bengal A Natural products O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(I)=C(O)C(I)=C1OC1=C(I)C(O)=C(I)C=C21 STRXNPAVPKGJQR-UHFFFAOYSA-N 0.000 claims description 2
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
- YCUVUDODLRLVIC-VPHDGDOJSA-N sudan black b Chemical compound C1=CC(=C23)NC(C)(C)NC2=CC=CC3=C1\N=N\C(C1=CC=CC=C11)=CC=C1\N=N\C1=CC=CC=C1 YCUVUDODLRLVIC-VPHDGDOJSA-N 0.000 claims description 2
- 229940099373 sudan iii Drugs 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims description 2
- 210000004127 vitreous body Anatomy 0.000 claims description 2
- XOSXWYQMOYSSKB-UHFFFAOYSA-L water blue Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=C(N)C(C)=CC(C(=C2C=CC(C=C2)=NC=2C=CC(=CC=2)S([O-])(=O)=O)C=2C=CC(NC=3C=CC(=CC=3)S(O)(=O)=O)=CC=2)=C1 XOSXWYQMOYSSKB-UHFFFAOYSA-L 0.000 claims description 2
- 239000012491 analyte Substances 0.000 claims 9
- 238000000151 deposition Methods 0.000 claims 5
- 230000003204 osmotic effect Effects 0.000 claims 5
- 230000008021 deposition Effects 0.000 claims 2
- ZHAFUINZIZIXFC-UHFFFAOYSA-N [9-(dimethylamino)-10-methylbenzo[a]phenoxazin-5-ylidene]azanium;chloride Chemical compound [Cl-].O1C2=CC(=[NH2+])C3=CC=CC=C3C2=NC2=C1C=C(N(C)C)C(C)=C2 ZHAFUINZIZIXFC-UHFFFAOYSA-N 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 239000010891 toxic waste Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762577347P | 2017-10-26 | 2017-10-26 | |
| US62/577,347 | 2017-10-26 | ||
| PCT/US2018/057875 WO2019084515A1 (en) | 2017-10-26 | 2018-10-26 | DEVICES AND METHODS FOR COLORING TISSUES AND CELLS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021501321A JP2021501321A (ja) | 2021-01-14 |
| JP2021501321A5 true JP2021501321A5 (https=) | 2021-12-02 |
Family
ID=66246756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523788A Pending JP2021501321A (ja) | 2017-10-26 | 2018-10-26 | 組織および細胞染色のためのデバイスおよび方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11326989B2 (https=) |
| EP (1) | EP3700420B1 (https=) |
| JP (1) | JP2021501321A (https=) |
| CN (1) | CN112218577A (https=) |
| WO (1) | WO2019084515A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3837543A4 (en) * | 2018-08-16 | 2022-11-16 | Essenlix Corporation | CELL ANALYSIS IN BODY FLUID, ESPECIALLY BLOOD |
| US12169167B2 (en) * | 2019-01-15 | 2024-12-17 | Essenlix Corporation | Devices and methods for tissue and cell staining (II) |
| US11210554B2 (en) * | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| CN113795744B (zh) * | 2019-05-13 | 2025-03-18 | 通用表面增强光谱学有限公司 | 一种用于确定流体样品中的颗粒特性和/或用于确定流体样品的污染特性的方法 |
| WO2020247409A1 (en) * | 2019-06-02 | 2020-12-10 | Essenlix Corporation | Fast staining of biomaterials enhanced by image processing and artificial intelligence |
| WO2021011944A2 (en) * | 2019-07-18 | 2021-01-21 | Essenlix Corporation | Imaging based homogeneous assay |
| EP4193299B1 (en) * | 2020-08-04 | 2026-04-01 | PAIGE.AI, Inc. | Systems and methods to process electronic images to provide image-based cell group targeting |
| WO2022136848A1 (en) * | 2020-12-22 | 2022-06-30 | Oxford Immune Algorithmics Ltd | Wafer for carrying biological sample |
| WO2022159627A1 (en) * | 2021-01-20 | 2022-07-28 | Rebus Biosystems, Inc. | Spatial rna localization method |
| US12525320B2 (en) | 2021-03-16 | 2026-01-13 | Illumina, Inc. | Neural network parameter quantization for base calling |
| CN112986215B (zh) * | 2021-04-20 | 2022-08-02 | 江南大学 | 一种基于表面增强拉曼光谱技术检测牛奶中苯甲酸的方法 |
| CN113567217A (zh) * | 2021-07-27 | 2021-10-29 | 肖波 | 一种妇科荧光染色液 |
| CN114441271B (zh) * | 2021-12-27 | 2023-06-27 | 桂林优利特医疗电子有限公司 | 一种新型染色液的配置及染色方法 |
| CN114252324B (zh) * | 2022-03-02 | 2022-05-13 | 中国人民解放军军事科学院军事医学研究院 | 一种方便使用的多孔脑片孵育装置 |
| CN114624084A (zh) * | 2022-03-18 | 2022-06-14 | 深圳市贝安特医疗技术有限公司 | 一种病理组织切片染色试剂盒的制备、染色方法 |
| CN115372350A (zh) * | 2022-09-02 | 2022-11-22 | 中迅优检生物科技(江苏)有限公司 | 一种游离血红素单检双判方法 |
| WO2024057329A1 (en) * | 2022-09-16 | 2024-03-21 | Bhattacharyya Neha | Fluorometric sensory arrays for the detection of urinary bladder cancer-related vocs |
| WO2025158393A1 (en) * | 2024-01-24 | 2025-07-31 | The Regents Of The University Of Michigan | Cell typing with cell lasing |
| CN118670828A (zh) * | 2024-07-17 | 2024-09-20 | 甘肃农业大学 | 一种用于观察双子叶植物木质化程度石蜡切片的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3063985B2 (ja) * | 1989-08-10 | 2000-07-12 | 株式会社北里サプライ | 使い捨て検査用具 |
| JP3005480B2 (ja) * | 1996-02-15 | 2000-01-31 | アロカ株式会社 | 生物組織の処理装置 |
| FR2759166B1 (fr) * | 1997-01-31 | 1999-04-23 | Abx Sa | Reactif de coloration pour la determination de cellules sanguines |
| US6391568B1 (en) * | 1998-07-15 | 2002-05-21 | Lionheart Technologies, Inc. | Method for determining platelet reactivity in a whole blood sample |
| US6586259B1 (en) * | 1999-11-15 | 2003-07-01 | Pharmanetics Incorporated | Platelet/leukocyte interaction assay and reagent therefor |
| FR2821428B1 (fr) * | 2001-02-23 | 2004-08-06 | Abx Sa | Reactif et procede pour l'identification et le comptage de cellules biologiques |
| US7943093B2 (en) * | 2001-12-12 | 2011-05-17 | Erie Scientific Company | Cover slip |
| KR20080026113A (ko) * | 2005-05-24 | 2008-03-24 | 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 | 적혈구생성 자극 단백질의 생산을 위한 재조합 방법 |
| JP2008032420A (ja) * | 2006-07-26 | 2008-02-14 | National Institute Of Advanced Industrial & Technology | エバネッセント励起蛍光観察における背景蛍光を減弱する方法及び部材 |
| CN103328979B (zh) * | 2010-12-06 | 2015-10-07 | 丹麦达科有限公司 | 组合的组织学染色 |
| US9448151B2 (en) * | 2011-10-22 | 2016-09-20 | Lightintegra Technology Inc. | Apparatus and method for platelet monitoring and for assessing the quality of platelets |
| WO2013075736A1 (en) * | 2011-11-22 | 2013-05-30 | Luxcel Biosciences Limited | Device and method for rapid assay of multiple biological samples for oxygen consumption |
| WO2015175188A1 (en) * | 2014-05-14 | 2015-11-19 | General Electric Company | Microfluidic flow cell assemblies for imaging and method of use |
| WO2016042830A1 (ja) * | 2014-09-16 | 2016-03-24 | 富士フイルム株式会社 | 胎児染色体の解析方法 |
| US9891209B2 (en) * | 2015-05-29 | 2018-02-13 | C A Casyso Gmbh | Electrode assembly for measurement of platelet function in whole blood |
| CN113376364B (zh) * | 2015-08-10 | 2025-02-25 | 上海宜晟生物科技有限公司 | 步骤简化、小样品、快速、易使用的生物/化学分析装置和方法 |
| WO2017048871A1 (en) * | 2015-09-14 | 2017-03-23 | Essenlix Corp. | Device and system for analyzing a sample, particularly blood, as well as methods of using the same |
| MX392709B (es) | 2015-09-14 | 2025-03-24 | Essenlix Corp | Dispositivo y sistema para recolectar y analizar condensado de vapor, particularmente condensado de exhalación de la respiración y un método para usarlo. |
| KR20170099739A (ko) * | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법 |
| CA3052809A1 (en) | 2017-02-08 | 2018-08-23 | Essenlix Corporation | Qmax assays and applications |
| EP3723611A4 (en) * | 2017-12-14 | 2021-11-03 | Essenlix Corporation | ENHANCED OPTICAL TRANSMISSION SAMPLE HOLDER AND FOR ANALYSIS, ESPECIALLY FOR HEMOGLOBIN |
-
2018
- 2018-10-26 JP JP2020523788A patent/JP2021501321A/ja active Pending
- 2018-10-26 US US16/758,938 patent/US11326989B2/en active Active
- 2018-10-26 WO PCT/US2018/057875 patent/WO2019084515A1/en not_active Ceased
- 2018-10-26 CN CN201880083342.0A patent/CN112218577A/zh active Pending
- 2018-10-26 EP EP18871316.8A patent/EP3700420B1/en active Active
-
2022
- 2022-04-04 US US17/713,198 patent/US20230014031A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021501321A5 (https=) | ||
| Ates et al. | Integrated devices for non‐invasive diagnostics | |
| JP7219713B2 (ja) | Qmaxアッセイ法および用途(ii) | |
| JP7003158B2 (ja) | 圧縮開放流アッセイおよび使用 | |
| KR101982331B1 (ko) | 샘플 특히 혈액샘플을 분석하기 위한 장치와 시스템 및 그 사용 방법 | |
| JP2022048247A (ja) | 採取された体液に基づく健康をモニタリングためのシステムおよび方法 | |
| JP2021501321A (ja) | 組織および細胞染色のためのデバイスおよび方法 | |
| JP2020128995A5 (https=) | ||
| JP2020128999A5 (https=) | ||
| JP5948056B2 (ja) | 側方流動核酸検出器 | |
| EP3049560B1 (en) | Methods of using detectable arrays for diagnosis | |
| US20090289201A1 (en) | Combined visual/fluorescence analyte detection test | |
| Fang et al. | Self‐healing electronics for prognostic monitoring of methylated circulating tumor DNAs | |
| BR112012012342A2 (pt) | Dispositivo de fluxo lateral para detectar um analito em uma amostra, tira de teste universal, compressor de amostra, método de aplicação de uma amostra a uma tira de teste, método de acentuação de um sinal sobre um dispositivo de fluxo lateral e método de detecção de pelo menos um analito em uma amostra | |
| WO2014132150A1 (en) | Rapid identification of organisms in bodily fluids | |
| US20230084255A1 (en) | Test strip for detecting analyte in sample | |
| JP2676108B2 (ja) | 血液滴または任意の生物媒質に由来する液からの物質の免疫酵素的検出装置 | |
| CN205374467U (zh) | 一种早期炎症反应的荧光定量联合检测卡 | |
| WO2009152209A2 (en) | Combined visual/fluorescence analyte detection test | |
| CN108535485A (zh) | 一种定量检测血液中ca153的时间分辨荧光免疫层析试纸条及制备方法 | |
| US9535061B1 (en) | Multi-functional rapid diagnostic test device | |
| FI13179Y1 (fi) | Laite aivovamman havaitsemiseksi kohteessa | |
| US20100304397A1 (en) | Chromogenic test kit for detecting health conditions in saliva | |
| Cheng et al. | Development of a sampling collection device with diagnostic procedures | |
| Kight | Advancements in point-of-care diagnostic assays for non-invasive samples in resource constrained settings |