JP2021501198A5 - - Google Patents
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- JP2021501198A5 JP2021501198A5 JP2020543247A JP2020543247A JP2021501198A5 JP 2021501198 A5 JP2021501198 A5 JP 2021501198A5 JP 2020543247 A JP2020543247 A JP 2020543247A JP 2020543247 A JP2020543247 A JP 2020543247A JP 2021501198 A5 JP2021501198 A5 JP 2021501198A5
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- 150000001875 compounds Chemical class 0.000 claims 47
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 10
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 10
- 210000000130 stem cell Anatomy 0.000 claims 7
- 102000036693 Thrombopoietin Human genes 0.000 claims 6
- 108010041111 Thrombopoietin Proteins 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 3
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 3
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 3
- 239000007640 basal medium Substances 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000012526 feed medium Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000004700 fetal blood Anatomy 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- -1 -OH Chemical group 0.000 claims 1
- SJODITPGMMSNRF-UHFFFAOYSA-N 2-aminofluoren-9-one Chemical compound C1=CC=C2C(=O)C3=CC(N)=CC=C3C2=C1 SJODITPGMMSNRF-UHFFFAOYSA-N 0.000 claims 1
- CNCFLCLXJBPMIR-UHFFFAOYSA-N 2-fluorofluoren-9-one Chemical compound C1=CC=C2C(=O)C3=CC(F)=CC=C3C2=C1 CNCFLCLXJBPMIR-UHFFFAOYSA-N 0.000 claims 1
- AJEAHBZZHSLIQP-UHFFFAOYSA-N 2-nitrofluoren-9-one Chemical compound C1=CC=C2C(=O)C3=CC([N+](=O)[O-])=CC=C3C2=C1 AJEAHBZZHSLIQP-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101001052849 Homo sapiens Tyrosine-protein kinase Fer Proteins 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102100024537 Tyrosine-protein kinase Fer Human genes 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002923 oximes Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023198957A JP2024015035A (ja) | 2017-10-27 | 2023-11-24 | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762578297P | 2017-10-27 | 2017-10-27 | |
| US62/578,297 | 2017-10-27 | ||
| US201762583328P | 2017-11-08 | 2017-11-08 | |
| US62/583,328 | 2017-11-08 | ||
| PCT/US2018/057783 WO2019084452A1 (en) | 2017-10-27 | 2018-10-26 | COMPOSITIONS AND METHODS FOR PRODUCING EXPANDED HEMATOPOIETIC STEM CELLS USING FLUORENE DERIVATIVES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023198957A Division JP2024015035A (ja) | 2017-10-27 | 2023-11-24 | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021501198A JP2021501198A (ja) | 2021-01-14 |
| JP2021501198A5 true JP2021501198A5 (https=) | 2021-12-02 |
Family
ID=66247033
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543247A Pending JP2021501198A (ja) | 2017-10-27 | 2018-10-26 | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
| JP2023198957A Pending JP2024015035A (ja) | 2017-10-27 | 2023-11-24 | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023198957A Pending JP2024015035A (ja) | 2017-10-27 | 2023-11-24 | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11459293B2 (https=) |
| EP (1) | EP3700334B1 (https=) |
| JP (2) | JP2021501198A (https=) |
| KR (1) | KR102770289B1 (https=) |
| CN (1) | CN111885914B (https=) |
| AU (1) | AU2018354418B2 (https=) |
| CA (1) | CA3079959A1 (https=) |
| IL (1) | IL273978B2 (https=) |
| WO (1) | WO2019084452A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102488238B1 (ko) * | 2018-12-13 | 2023-01-13 | 동우 화인켐 주식회사 | 양자점, 이를 포함하는 양자점 발광다이오드, 양자점 필름, 광 변환 수지 조성물, 상기 광 변환 수지 조성물을 이용하여 형성되는 컬러필터, 광 변환 적층기재 및 상기 컬러필터 또는 상기 광 변환 적층기재를 포함하는 화상표시장치 |
| AU2020265737A1 (en) * | 2019-05-01 | 2021-12-02 | Immunebridge Inc. | Methods of making oligopotent and unipotent precursors |
| CA3138280A1 (en) * | 2019-05-01 | 2020-11-05 | Transfusion Health, Llc | Compositions and methods of making expanded hematopoietic stem cells using derivatives of carbazole |
| CN114787342A (zh) * | 2019-12-16 | 2022-07-22 | 广州辑因医疗科技有限公司 | 扩增造血干细胞的小分子化合物及其组合 |
| CN111019886B (zh) * | 2019-12-18 | 2023-02-03 | 卓越细胞工程(香港)有限公司 | 新的干性因子和其用于培养胚胎干细胞的方法或培养体系 |
Family Cites Families (41)
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| GB1120461A (en) * | 1964-07-06 | 1968-07-17 | Manuf Prod Pharma | Derivatives of fluoreno-[1,9-ef]1,4-diazepine-1-oxide |
| GB1314899A (en) * | 1970-07-28 | 1973-04-26 | Sterling Winthrop Group Ltd | Thiosemicarbazones processes for their preparations and compositions incorporating them |
| US3947593A (en) * | 1973-06-15 | 1976-03-30 | Richardson-Merrell Inc. | Pharmaceutically useful bis-amine derivatives |
| EP0005288A1 (en) * | 1978-04-21 | 1979-11-14 | Chimac Societe Anonyme | Derivatives of 1-amino-fluoren-9-one and their use as herbicides |
| DK575387A (da) * | 1986-11-04 | 1988-05-05 | Otsuka Pharma Co Ltd | Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser |
| JP2622197B2 (ja) * | 1990-03-01 | 1997-06-18 | 三共株式会社 | １３−エーテル置換ミルベマイシン誘導体 |
| WO1994005276A1 (en) * | 1992-09-08 | 1994-03-17 | Morgan Lee R | Cytotoxic compounds |
| JP2807860B2 (ja) * | 1993-06-18 | 1998-10-08 | 大塚製薬株式会社 | フルオレノン誘導体 |
| AU700386B2 (en) * | 1995-10-16 | 1999-01-07 | Kyowa Hakko Kogyo Co. Ltd. | Triciclic compounds |
| CO5170528A1 (es) * | 1999-05-28 | 2002-06-27 | Smithkline Beecham Corp | Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8 |
| US20020035104A1 (en) * | 2000-08-18 | 2002-03-21 | Genentech, Inc. | Integrin receptor inhibitors |
| BRPI0116728B1 (pt) * | 2001-01-05 | 2018-10-30 | Pfizer Inc. | anticorpos para receptor de fator de crescimento i semelhante à insulina |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| BRPI0410439A (pt) * | 2003-05-19 | 2006-06-06 | Irm Llc | compostos e composições imunossupressoras |
| WO2005032598A1 (en) * | 2003-10-02 | 2005-04-14 | The General Hospital Corporation | Polybiotin compounds for magnetic resonance imagining and drug delivery |
| US20080161419A1 (en) * | 2004-02-20 | 2008-07-03 | Shinobu Akuzawa | Prophylactic Antimigraine Agents |
| EP1755574A4 (en) | 2004-04-06 | 2009-05-13 | Semafore Pharmaceuticals Inc | PTEN INHIBITORS |
| KR100775738B1 (ko) * | 2004-09-24 | 2007-11-09 | 주식회사 엘지화학 | 새로운 유기 발광 소자 재료 및 이를 이용한 유기 발광소자(10) |
| WO2007016762A1 (en) * | 2005-08-10 | 2007-02-15 | Quest Pharmatech Inc. | Perylenequinone derivatives and uses thereof |
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| CN101506154B (zh) * | 2006-08-21 | 2015-06-17 | 辛塔制药公司 | 用于治疗增生性疾病的化合物 |
| EP2148569B1 (en) * | 2007-04-23 | 2014-07-16 | Stowers Institute for Medical Research | Methods and compositions for hematopoeitic stem cell self-renewal |
| AU2008287542C1 (en) * | 2007-06-01 | 2015-01-22 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| JP5645658B2 (ja) * | 2007-07-10 | 2014-12-24 | カーネギー メロン ユニバーシティー | 核磁気共鳴技術のための細胞標識を製造するための組成物及び方法 |
| AU2008305581C1 (en) * | 2007-09-26 | 2014-12-11 | Celgene Corporation | 6-, 7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same |
| FR2929276B1 (fr) * | 2008-04-01 | 2010-04-23 | Servier Lab | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN101418269B (zh) * | 2008-09-27 | 2010-12-01 | 大连理工大学 | 一种链霉菌及其在还原芳香酮中的应用 |
| US20100310456A1 (en) * | 2009-06-04 | 2010-12-09 | General Electric Company | Imaging of myelin basic protein |
| JP5761718B2 (ja) * | 2009-08-07 | 2015-08-12 | 国立大学法人東京農工大学 | 新規糖転移酵素、新規糖転移酵素遺伝子および新規糖供与体化合物 |
| JP5984217B2 (ja) | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| MX344772B (es) * | 2011-01-28 | 2017-01-06 | Univ Kentucky Res Found | Analogos de estilbeno y metodos para tratar cancer. |
| CN102174320A (zh) * | 2011-03-17 | 2011-09-07 | 上海大学 | 具有扭曲结构的蓝色电致发光材料及其制备方法 |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| CN103086859B (zh) * | 2011-11-08 | 2015-11-11 | 清华大学 | 2,4-二羟基-5,6-取代-1-卤代苯衍生物、其合成方法及其应用 |
| US9552457B2 (en) * | 2012-02-27 | 2017-01-24 | British Columbia Cancer Agency Branch | Reprogramming effector protein interactions to correct epigenetic defects in cancer |
| US20140135359A1 (en) * | 2012-11-12 | 2014-05-15 | Louis C. Martineau | Methods of designing, preparing, and using novel protonophores |
| EP3074001A1 (en) * | 2013-11-27 | 2016-10-05 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Piperidine and piperazine derivatives and their use in treating viral infections and cancer |
| CA2946446C (en) * | 2014-04-22 | 2020-11-03 | Universite De Montreal | Pyrido-pyrrolo-pyrimidine and pyrido-indole compounds, pharmaceutical compositions containing same and their use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
| CN104557862B (zh) * | 2014-12-15 | 2017-05-17 | 苏州云轩医药科技有限公司 | 具有Wnt信号通路抑制活性的杂环化合物 |
| US20200155609A1 (en) | 2017-05-22 | 2020-05-21 | Transfusion Health Llc | Compositions and methods of making expanded hematopoietic stem cells using pten inhibitors |
-
2018
- 2018-10-26 AU AU2018354418A patent/AU2018354418B2/en active Active
- 2018-10-26 CA CA3079959A patent/CA3079959A1/en active Pending
- 2018-10-26 JP JP2020543247A patent/JP2021501198A/ja active Pending
- 2018-10-26 EP EP18870471.2A patent/EP3700334B1/en active Active
- 2018-10-26 KR KR1020207014934A patent/KR102770289B1/ko active Active
- 2018-10-26 IL IL273978A patent/IL273978B2/en unknown
- 2018-10-26 WO PCT/US2018/057783 patent/WO2019084452A1/en not_active Ceased
- 2018-10-26 US US16/758,396 patent/US11459293B2/en active Active
- 2018-10-26 CN CN201880083616.6A patent/CN111885914B/zh active Active
-
2022
- 2022-08-18 US US17/820,874 patent/US20230112489A1/en active Pending
-
2023
- 2023-11-24 JP JP2023198957A patent/JP2024015035A/ja active Pending
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