JP2021500861A - 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 - Google Patents
共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 Download PDFInfo
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- JP2021500861A JP2021500861A JP2020517377A JP2020517377A JP2021500861A JP 2021500861 A JP2021500861 A JP 2021500861A JP 2020517377 A JP2020517377 A JP 2020517377A JP 2020517377 A JP2020517377 A JP 2020517377A JP 2021500861 A JP2021500861 A JP 2021500861A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023120385A JP2023145589A (ja) | 2017-09-27 | 2023-07-25 | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762564249P | 2017-09-27 | 2017-09-27 | |
| US62/564,249 | 2017-09-27 | ||
| PCT/US2018/053247 WO2019067805A1 (en) | 2017-09-27 | 2018-09-27 | NEW PLATFORMS FOR CO-STIMULATION, NEW CAR DESIGNS AND OTHER IMPROVEMENTS FOR ADOPTIVE CELL THERAPY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023120385A Division JP2023145589A (ja) | 2017-09-27 | 2023-07-25 | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500861A true JP2021500861A (ja) | 2021-01-14 |
| JP2021500861A5 JP2021500861A5 (https=) | 2021-11-04 |
Family
ID=65902679
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517377A Pending JP2021500861A (ja) | 2017-09-27 | 2018-09-27 | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
| JP2023120385A Pending JP2023145589A (ja) | 2017-09-27 | 2023-07-25 | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023120385A Pending JP2023145589A (ja) | 2017-09-27 | 2023-07-25 | 共刺激のための新規のプラットフォーム、新規のcar設計、および養子細胞療法のための他の増強 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12570711B2 (https=) |
| EP (1) | EP3687553A4 (https=) |
| JP (2) | JP2021500861A (https=) |
| KR (1) | KR20200071079A (https=) |
| CN (1) | CN111629734A (https=) |
| AU (2) | AU2018338647B2 (https=) |
| BR (1) | BR112020005938A2 (https=) |
| CA (1) | CA3075806A1 (https=) |
| EA (1) | EA202090839A1 (https=) |
| IL (1) | IL273201B2 (https=) |
| MX (1) | MX2020004185A (https=) |
| SG (1) | SG11202002321YA (https=) |
| WO (1) | WO2019067805A1 (https=) |
| ZA (2) | ZA202002046B (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4400516A1 (en) | 2014-12-15 | 2024-07-17 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| DK3368571T5 (da) | 2015-10-30 | 2024-09-30 | Univ California | Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf |
| US20200172601A1 (en) | 2017-06-22 | 2020-06-04 | University Of Maryland, Baltimore | Broadly neutralizing antibodies against hiv |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| BR112020006643A2 (pt) * | 2017-10-03 | 2020-09-24 | Juno Therapeutics Inc | moléculas de ligação específica ao hpv |
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| WO2019173801A1 (en) * | 2018-03-09 | 2019-09-12 | Atreca, Inc. | Nucleic acids encoding anti-hiv antibodies |
| MX2020012927A (es) | 2018-06-01 | 2021-03-25 | Univ Southern California | Diversos dominios de enlace de antigenos, nuevas plataformas y otras mejoras para terapia celular. |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2020095248A1 (en) * | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Anti-ptk7 immune cell cancer therapy |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| US12419913B2 (en) | 2019-02-08 | 2025-09-23 | Dna Twopointo, Inc. | Modification of CAR-T cells |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス,インコーポレーテッド | T細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| CA3132202A1 (en) * | 2019-04-08 | 2020-10-15 | Phanes Therapeutics, Inc. | Humanized anti-dll3 chimeric antigen receptors and uses thereof |
| EP3962519A1 (en) | 2019-05-01 | 2022-03-09 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods |
| JP7562103B2 (ja) * | 2019-05-31 | 2024-10-07 | 国立大学法人信州大学 | Alkを標的とするキメラ抗原受容体発現細胞 |
| CA3146019A1 (en) | 2019-07-17 | 2021-01-21 | Nanjing Legend Biotech Co., Ltd. | Anti-dll3 chimeric antigen receptors and uses thereof |
| US12606612B2 (en) | 2019-07-31 | 2026-04-21 | The Wistar Institute Of Anatomy And Biology | Multivalent DNA antibody constructs and use thereof |
| WO2021035170A1 (en) * | 2019-08-21 | 2021-02-25 | Precision Biosciences, Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| JP7748935B2 (ja) * | 2019-08-27 | 2025-10-03 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | IL13Rα2陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成CAR |
| WO2021046205A1 (en) * | 2019-09-04 | 2021-03-11 | Tmunity Therapeutics Inc. | Adoptive cell therapy and methods of dosing thereof |
| EP4025598A1 (en) * | 2019-09-06 | 2022-07-13 | Eli Lilly and Company | Proteins comprising t-cell receptor constant domains |
| CN110483621A (zh) * | 2019-09-19 | 2019-11-22 | 河南省农业科学院 | 天然免疫库筛选识别环丙沙星单链抗体的核心序列及应用 |
| WO2021062313A1 (en) * | 2019-09-26 | 2021-04-01 | Board Of Regents, The University Of Texas System | Immunogenic egfr peptide compositions and their use in the treatment of cancer |
| EP3808765A1 (en) * | 2019-10-14 | 2021-04-21 | ETH Zurich | Cell line for tcr discovery and engineering and methods of use thereof |
| CN110903401A (zh) * | 2019-11-20 | 2020-03-24 | 浙江大学 | 一种靶向cd19的二代嵌合抗原受体及其表达载体与应用 |
| EP4077398A4 (en) * | 2019-12-16 | 2024-04-10 | Legend Biotech Ireland Limited | SINGLE DOMAIN ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS TARGETTING BCMA AND METHODS OF USE THEREOF |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| IL295074A (en) * | 2020-02-04 | 2022-09-01 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Methods and compositions for stimulation of t cells with a chimeric receptor receptor by hapten-labeled cells |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン-4抗体コンジュゲートおよびその使用 |
| CA3174575A1 (en) | 2020-03-02 | 2021-09-10 | The Regents Of The University Of California | Chimeric antigen receptors and related methods and compositions for the treatment of cancer |
| WO2021188454A1 (en) * | 2020-03-16 | 2021-09-23 | Marengo Therapeutics, Inc. | Engineered cell compositions and methods of use thereof |
| JP2023518049A (ja) | 2020-03-16 | 2023-04-27 | ユニバーシティ オブ サザン カリフォルニア | 新規な抗原結合ドメインおよびそれを組み込んだ合成抗原受容体 |
| GB202004371D0 (en) * | 2020-03-26 | 2020-05-13 | Glaxosmithkline Ip Dev Ltd | CAR constructs |
| US20240252641A1 (en) * | 2020-05-05 | 2024-08-01 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using cd70 specific fusion proteins |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| CA3196549A1 (en) * | 2020-11-04 | 2022-05-12 | Bahram Valamehr | Engineered ipsc and immune effector cells for heterogenous tumor control |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| WO2022122709A1 (en) * | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CN112500497B (zh) * | 2020-12-14 | 2021-06-08 | 南京凯地医疗技术有限公司 | Cltx-nkg2d双特异性嵌合抗原受体细胞及其制备方法和应用 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| WO2023019144A1 (en) * | 2021-08-10 | 2023-02-16 | The Regents Of The University Of California | Hla-a2-specific regulatory t cells |
| US12576135B2 (en) * | 2021-09-29 | 2026-03-17 | Chimera Bioengineering, Inc. | Compositions and methods for anti-TnMUC1 gold CAR t-cells |
| CN115881221B (zh) * | 2021-09-29 | 2025-12-16 | 上海市免疫学研究所 | 一种冠状病毒转录组鉴定分析方法及分析系统 |
| CN116102658B (zh) * | 2021-11-09 | 2025-04-29 | 四川大学华西医院 | 基于gas6构建的嵌合抗原受体免疫细胞制备及其应用 |
| KR102739632B1 (ko) | 2022-02-09 | 2024-12-05 | 한림대학교 산학협력단 | 항-cd20 키메릭 항원 수용체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 제조 방법 |
| WO2023192992A2 (en) * | 2022-03-31 | 2023-10-05 | The Wistar Institute Of Anatomy And Biology | Bispecific natural killer engagers that target siglec-7 |
| CN116058334B (zh) * | 2022-11-21 | 2023-08-08 | 中国人民解放军军事科学院军事医学研究院 | 一种可视化gvhd动物模型的构建方法及其应用 |
| CN115558021B (zh) * | 2022-12-01 | 2023-03-17 | 山东大学 | 一种转录因子、重组细胞及其在制备肿瘤治疗药物的应用 |
| WO2024226829A2 (en) * | 2023-04-26 | 2024-10-31 | Yale University | Enpp3-binding molecules, compositions formed therefrom, and methods of use thereof for the treatment of cancer |
| CN116445402B (zh) * | 2023-05-09 | 2025-04-25 | 中国科学院生态环境研究中心 | 红系祖细胞的扩增培养基、扩增培养方法及应用 |
| TW202521564A (zh) * | 2023-08-14 | 2025-06-01 | 美商英特利亞醫療公司 | 用於基於細胞之療法的cd70 car-t組合物及方法 |
| WO2025084880A1 (ko) * | 2023-10-20 | 2025-04-24 | 주식회사 이온셀 | Ct83 항원에 결합하는 car-t 세포 및 이의 용도 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN118620059B (zh) * | 2024-02-21 | 2025-08-15 | 北京永泰瑞科生物科技有限公司 | 一种t细胞抗原受体及其制备方法和其应用 |
| CN118130793B (zh) * | 2024-02-26 | 2025-07-29 | 赣南医科大学 | 视网膜母细胞瘤的生物标志物cdk12及其应用 |
| WO2025215183A1 (en) * | 2024-04-11 | 2025-10-16 | Universität Heidelberg | Anti-cll1 binding agents |
| WO2025255267A1 (en) * | 2024-06-05 | 2025-12-11 | Dynamic Cell Therapies, Inc. | Engineered receptors for activation of regulatory t-cells |
| CN119823962A (zh) * | 2025-01-08 | 2025-04-15 | 浙江大学 | 一种cnb突变体及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012503019A (ja) * | 2008-09-22 | 2012-02-02 | ベイラー カレッジ オブ メディスン | Cd40およびパターン認識受容体アダプターを誘発することによる免疫応答を生成するための方法および組成物 |
| JP2013525305A (ja) * | 2010-04-16 | 2013-06-20 | ベリカム ファーマシューティカルズ, インコーポレイテッド | 固形腫瘍を処置するための方法 |
| WO2016120216A1 (en) * | 2015-01-26 | 2016-08-04 | Cellectis | mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS |
| WO2016154143A1 (en) * | 2015-03-20 | 2016-09-29 | Georgia State University Research Foundation, Inc. | Compositions and methods for treating copd and other inflammatory conditions |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708871A (en) | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| CA2406864A1 (en) | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| CA2666667C (en) | 2006-10-19 | 2023-06-20 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| WO2011060076A1 (en) | 2009-11-10 | 2011-05-19 | Amgen Inc. | Anti-c-mpl antibodies |
| EP2694549B1 (en) | 2011-04-08 | 2018-08-15 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer |
| CN107058101B (zh) | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| WO2014160030A2 (en) | 2013-03-13 | 2014-10-02 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
| JP6346266B2 (ja) * | 2013-03-21 | 2018-06-20 | サンガモ セラピューティクス, インコーポレイテッド | 操作されたジンクフィンガータンパク質ヌクレアーゼを使用するt細胞受容体遺伝子の標的化された破壊 |
| WO2015107545A1 (en) | 2013-12-18 | 2015-07-23 | Dharmesh Mahendrabhai Shah | Water soluble salts of dasatinib hydrate |
| CN106459990B (zh) | 2014-02-07 | 2021-06-01 | 麦克马斯特大学 | 三功能t细胞抗原偶联物及其制备方法和用途 |
| US10934346B2 (en) * | 2014-02-14 | 2021-03-02 | Bellicum Pharmaceuticals, Inc. | Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12 |
| EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| EP3322801A1 (en) * | 2015-07-15 | 2018-05-23 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| EP3842450A1 (en) * | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Antibody/t-cell receptor chimeric constructs and uses thereof |
| WO2017076308A1 (zh) * | 2015-11-04 | 2017-05-11 | 广州市香雪制药股份有限公司 | 识别ny-eso-1抗原短肽的tcr |
| CN105647871A (zh) * | 2016-01-27 | 2016-06-08 | 苏州佰通生物科技有限公司 | 一种可异体移植的嵌合抗原受体t细胞及制备方法 |
| WO2017172981A2 (en) | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| CA3018253A1 (en) | 2016-03-31 | 2017-10-05 | University Of Southern California | A highly sensitive and specific luciferase based reporter assay for antigen detection |
| US11377637B2 (en) * | 2016-04-15 | 2022-07-05 | Memorial Sloan Kettering Cancer Center | Transgenic T cell and chimeric antigen receptor T cell compositions and related methods |
| WO2017192536A1 (en) * | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
| US11377875B2 (en) | 2016-09-19 | 2022-07-05 | Level Home, Inc. | Deadbolt position sensing |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| MX2020012927A (es) | 2018-06-01 | 2021-03-25 | Univ Southern California | Diversos dominios de enlace de antigenos, nuevas plataformas y otras mejoras para terapia celular. |
| WO2020028444A1 (en) * | 2018-07-30 | 2020-02-06 | University Of Southern California | Improving the efficacy and safety of adoptive cellular therapies |
-
2018
- 2018-09-27 MX MX2020004185A patent/MX2020004185A/es unknown
- 2018-09-27 CA CA3075806A patent/CA3075806A1/en active Pending
- 2018-09-27 KR KR1020207012047A patent/KR20200071079A/ko not_active Ceased
- 2018-09-27 AU AU2018338647A patent/AU2018338647B2/en active Active
- 2018-09-27 SG SG11202002321YA patent/SG11202002321YA/en unknown
- 2018-09-27 JP JP2020517377A patent/JP2021500861A/ja active Pending
- 2018-09-27 WO PCT/US2018/053247 patent/WO2019067805A1/en not_active Ceased
- 2018-09-27 EP EP18863755.7A patent/EP3687553A4/en active Pending
- 2018-09-27 US US16/651,907 patent/US12570711B2/en active Active
- 2018-09-27 EA EA202090839A patent/EA202090839A1/ru unknown
- 2018-09-27 CN CN201880073056.6A patent/CN111629734A/zh active Pending
- 2018-09-27 IL IL273201A patent/IL273201B2/en unknown
- 2018-09-27 BR BR112020005938-2A patent/BR112020005938A2/pt unknown
-
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- 2020-05-04 ZA ZA2020/02046A patent/ZA202002046B/en unknown
-
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- 2022-05-24 ZA ZA2022/05717A patent/ZA202205717B/en unknown
-
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- 2023-07-25 JP JP2023120385A patent/JP2023145589A/ja active Pending
-
2025
- 2025-08-28 AU AU2025223797A patent/AU2025223797A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012503019A (ja) * | 2008-09-22 | 2012-02-02 | ベイラー カレッジ オブ メディスン | Cd40およびパターン認識受容体アダプターを誘発することによる免疫応答を生成するための方法および組成物 |
| JP2013525305A (ja) * | 2010-04-16 | 2013-06-20 | ベリカム ファーマシューティカルズ, インコーポレイテッド | 固形腫瘍を処置するための方法 |
| WO2016120216A1 (en) * | 2015-01-26 | 2016-08-04 | Cellectis | mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS |
| WO2016154143A1 (en) * | 2015-03-20 | 2016-09-29 | Georgia State University Research Foundation, Inc. | Compositions and methods for treating copd and other inflammatory conditions |
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