JP2021167329A5 - - Google Patents
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- Publication number
- JP2021167329A5 JP2021167329A5 JP2021109873A JP2021109873A JP2021167329A5 JP 2021167329 A5 JP2021167329 A5 JP 2021167329A5 JP 2021109873 A JP2021109873 A JP 2021109873A JP 2021109873 A JP2021109873 A JP 2021109873A JP 2021167329 A5 JP2021167329 A5 JP 2021167329A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cell
- nucleic acid
- permeable
- phosphorothioate nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202006P | 2015-08-06 | 2015-08-06 | |
| US62/202,006 | 2015-08-06 | ||
| JP2018506182A JP7104462B2 (ja) | 2015-08-06 | 2016-08-05 | 細胞透過性タンパク質－抗体コンジュゲートおよび使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506182A Division JP7104462B2 (ja) | 2015-08-06 | 2016-08-05 | 細胞透過性タンパク質－抗体コンジュゲートおよび使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021167329A JP2021167329A (ja) | 2021-10-21 |
| JP2021167329A5 true JP2021167329A5 (https=) | 2021-12-09 |
| JP7260596B2 JP7260596B2 (ja) | 2023-04-18 |
Family
ID=57943680
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506182A Active JP7104462B2 (ja) | 2015-08-06 | 2016-08-05 | 細胞透過性タンパク質－抗体コンジュゲートおよび使用方法 |
| JP2021109873A Active JP7260596B2 (ja) | 2015-08-06 | 2021-07-01 | 細胞透過性タンパク質－抗体コンジュゲートおよび使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506182A Active JP7104462B2 (ja) | 2015-08-06 | 2016-08-05 | 細胞透過性タンパク質－抗体コンジュゲートおよび使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11661463B2 (https=) |
| EP (1) | EP3331543A4 (https=) |
| JP (2) | JP7104462B2 (https=) |
| CN (2) | CN108135958B (https=) |
| AR (1) | AR105642A1 (https=) |
| TW (1) | TW201718023A (https=) |
| WO (1) | WO2017024238A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3331543A4 (en) * | 2015-08-06 | 2019-03-20 | City of Hope | Cell-pollenizing protein antibody conjugates and methods of use |
| CN108866635B (zh) * | 2017-05-09 | 2021-11-26 | 安升（上海）医药科技有限公司 | 多特异性蛋白药物及其文库、以及制备方法和应用 |
| JP7295838B2 (ja) * | 2017-07-13 | 2023-06-21 | シティ・オブ・ホープ | ホスホロチオエートコンジュゲートペプチド及びその使用方法 |
| EP3730150A4 (en) * | 2017-12-22 | 2021-10-06 | Rophibio, Inc. | ANTI-STAT3 BISPECIFIC ANTIBODY WITH CELL-PENETRATING ABILITY AND THIS PHARMACEUTICAL COMPOSITION |
| KR102526768B1 (ko) * | 2017-12-22 | 2023-04-27 | 주식회사 로피바이오 | 세포 내 침투능을 갖는 항 stat3 이중특이 항체 |
| KR102256985B1 (ko) | 2019-06-25 | 2021-06-03 | 주식회사 로피바이오 | 항 stat3 특이 항체 및 이를 포함하는 약학적 조성물 |
| EP4153762A4 (en) * | 2020-05-22 | 2025-05-07 | City of Hope | Phosphorothioate nucleic acid conjugates with DNA-editing enzymes |
| WO2024091824A1 (en) | 2022-10-26 | 2024-05-02 | Ada Forsyth Institute, Inc. | Differentiation and reprogramming of chondrocyte |
| EP4634373A1 (en) | 2022-12-16 | 2025-10-22 | University of Rochester | Repairment of barrier dysfunction in esophagus |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| WO1992000373A1 (en) | 1990-06-29 | 1992-01-09 | Biosource Genetics Corporation | Melanin production by transformed microorganisms |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| JP2594486B2 (ja) | 1991-01-15 | 1997-03-26 | アルコン ラボラトリーズ インコーポレイテッド | 局所的眼薬組成物 |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| US6210671B1 (en) | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| HK1044159A1 (zh) | 1998-12-01 | 2002-10-11 | 蛋白质设计实验室股份有限公司 | 抗γ-干扰素的人化抗体 |
| AU2006325030B2 (en) | 2005-12-16 | 2012-07-26 | Cellectis | Cell penetrating peptide conjugates for delivering nucleic acids into cells |
| US20100239504A1 (en) * | 2007-07-17 | 2010-09-23 | The General Hospital Corporation | Imaging nucleic acid binding proteins |
| EP2090584A1 (en) | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
| CA2721183C (en) | 2008-04-11 | 2019-07-16 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| JP2013541510A (ja) | 2010-08-31 | 2013-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規の単一の化学物質、およびオリゴヌクレオチドの送達方法 |
| WO2013101690A1 (en) | 2011-12-29 | 2013-07-04 | modeRNA Therapeutics | Modified mrnas encoding cell-penetrating polypeptides |
| KR101567576B1 (ko) * | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| CN105658230B (zh) * | 2013-08-29 | 2020-04-21 | 希望之城 | 细胞穿透缀合物及其使用方法 |
| UY36519A (es) | 2015-01-16 | 2016-08-31 | Hope City | Anticuerpos de penetración celular |
| EP3331543A4 (en) * | 2015-08-06 | 2019-03-20 | City of Hope | Cell-pollenizing protein antibody conjugates and methods of use |
-
2016
- 2016-08-05 EP EP16833941.4A patent/EP3331543A4/en active Pending
- 2016-08-05 CN CN201680058266.9A patent/CN108135958B/zh active Active
- 2016-08-05 WO PCT/US2016/045817 patent/WO2017024238A1/en not_active Ceased
- 2016-08-05 JP JP2018506182A patent/JP7104462B2/ja active Active
- 2016-08-05 US US15/750,814 patent/US11661463B2/en active Active
- 2016-08-05 CN CN202210151646.4A patent/CN114306627A/zh active Pending
- 2016-08-05 TW TW105124954A patent/TW201718023A/zh unknown
- 2016-08-08 AR ARP160102425A patent/AR105642A1/es unknown
-
2021
- 2021-07-01 JP JP2021109873A patent/JP7260596B2/ja active Active
-
2023
- 2023-04-11 US US18/298,933 patent/US20230250196A1/en not_active Abandoned
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