JP2021113185A5 - - Google Patents
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- JP2021113185A5 JP2021113185A5 JP2020204848A JP2020204848A JP2021113185A5 JP 2021113185 A5 JP2021113185 A5 JP 2021113185A5 JP 2020204848 A JP2020204848 A JP 2020204848A JP 2020204848 A JP2020204848 A JP 2020204848A JP 2021113185 A5 JP2021113185 A5 JP 2021113185A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- represented
- compounds
- kinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 30
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 claims 9
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 9
- 229940126657 Compound 17 Drugs 0.000 claims 9
- 229940126142 compound 16 Drugs 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 108091000080 Phosphotransferase Proteins 0.000 claims 6
- 238000001727 in vivo Methods 0.000 claims 6
- 230000003287 optical effect Effects 0.000 claims 6
- 102000020233 phosphotransferase Human genes 0.000 claims 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 5
- 230000005764 inhibitory process Effects 0.000 claims 4
- 229940043355 kinase inhibitor Drugs 0.000 claims 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 4
- 230000004410 intraocular pressure Effects 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000004683 Corneal Endothelial Cell Loss Diseases 0.000 claims 1
- 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 claims 1
- 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108091054455 MAP kinase family Proteins 0.000 claims 1
- 102000043136 MAP kinase family Human genes 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 101710109271 Mitogen-activated protein kinase 19 Proteins 0.000 claims 1
- 102000016349 Myosin Light Chains Human genes 0.000 claims 1
- 108010067385 Myosin Light Chains Proteins 0.000 claims 1
- 102100035044 Myosin light chain kinase, smooth muscle Human genes 0.000 claims 1
- 108010074596 Myosin-Light-Chain Kinase Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 150000001576 beta-amino acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962955683P | 2019-12-31 | 2019-12-31 | |
| US62/955,683 | 2019-12-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021113185A JP2021113185A (ja) | 2021-08-05 |
| JP2021113185A5 true JP2021113185A5 (cg-RX-API-DMAC10.html) | 2022-04-18 |
| JP7531379B2 JP7531379B2 (ja) | 2024-08-09 |
Family
ID=74556625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020204848A Active JP7531379B2 (ja) | 2019-12-31 | 2020-12-10 | βアミノ酸誘導体、これを含むキナーゼ阻害剤および医薬組成物ならびにその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11608319B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3845276B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP7531379B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN113121443B (cg-RX-API-DMAC10.html) |
| ES (1) | ES3015621T3 (cg-RX-API-DMAC10.html) |
| TW (1) | TWI777325B (cg-RX-API-DMAC10.html) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230038697A (ko) * | 2020-07-14 | 2023-03-21 | 우한 엘엘 사이언스 앤드 테크놀로지 디벨롭먼트 컴퍼니, 리미티드 | Rock 억제제 및 이의 제조 방법과 용도 |
| WO2025143152A1 (ja) | 2023-12-27 | 2025-07-03 | 全薬工業株式会社 | チアゾリル－ピラゾロ［１，５－ａ］ピリジン化合物、およびそのＭＹＬＫ４阻害剤としての使用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200306819A (en) * | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| CN101253152A (zh) * | 2005-09-02 | 2008-08-27 | 安斯泰来制药株式会社 | 作为rock抑制剂的酰胺衍生物 |
| US8504218B2 (en) | 2007-07-31 | 2013-08-06 | General Electric Company | Methods and systems for universal input output for vehicle control |
| JP2011507850A (ja) * | 2007-12-21 | 2011-03-10 | ザ スクリプス リサーチ インスティチュート | Ｒｈｏキナーゼインヒビターとしてのアニリドおよびアナログ |
| WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| WO2010126626A2 (en) * | 2009-05-01 | 2010-11-04 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| KR101768235B1 (ko) | 2009-07-28 | 2017-08-14 | 오노 야꾸힝 고교 가부시키가이샤 | 이환식 화합물 및 이의 의약 용도 |
| KR102074020B1 (ko) | 2012-07-13 | 2020-02-05 | 산텐 세이야꾸 가부시키가이샤 | 술폰아미드 화합물의 조합 |
| EP2961746B1 (en) * | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| AU2016264220A1 (en) | 2015-05-18 | 2018-01-04 | Translational Drug Development Llc | Heterocyclic compounds as kinase inhibitors |
| JP2019529359A (ja) * | 2016-08-19 | 2019-10-17 | アエリエ ファーマシューティカルズ インコーポレイテッド | ベータ−アミノ−イソキノリニルアミド化合物 |
| WO2018094362A1 (en) * | 2016-11-21 | 2018-05-24 | Translational Drug Development, Llc | Heterocyclic compounds as kinase inhibitors |
| CN111050766A (zh) * | 2017-07-21 | 2020-04-21 | 卡德门企业有限公司 | Rho相关含卷曲螺旋蛋白激酶的抑制剂 |
| US20210087184A1 (en) * | 2018-03-14 | 2021-03-25 | Aerie Pharmaceuticals, Inc. | Amino-benzoisothiazole and amino-benzoisothiadiazole amide compounds |
-
2020
- 2020-12-10 CN CN202011454931.0A patent/CN113121443B/zh active Active
- 2020-12-10 JP JP2020204848A patent/JP7531379B2/ja active Active
- 2020-12-10 TW TW109143679A patent/TWI777325B/zh active
- 2020-12-10 EP EP20213242.9A patent/EP3845276B1/en active Active
- 2020-12-10 US US17/117,615 patent/US11608319B2/en active Active
- 2020-12-10 ES ES20213242T patent/ES3015621T3/es active Active
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