JP2021107373A - 下部尿路症状改善用組成物 - Google Patents
下部尿路症状改善用組成物 Download PDFInfo
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Abstract
Description
[1]産地が鹿児島県屋久島より南方の地域である長命草の抽出物及び該抽出物に含まれる成分からなる群から選ばれる少なくとも1種の有効成分を含有する、下部尿路症状改善用組成物。
[2]前記長命草は、産地が北緯30°及び赤道の間にある地域である、[1]に記載の組成物。
[3]前記抽出物はイソサミジンを実質的に含有しない抽出物であり、及び/又は、前記成分はイソサミジンとは異なる成分である、[1]〜[2]のいずれか1項に記載の組成物。
[4]下記一般式(1)
(1)
(式中、R11、R12及びR13は、それぞれ独立して、水素原子又はメチル基を表す)
で示される化合物(ただし、イソサミジンを除く);及び
下記一般式(2)
(2)
(式中、R14、R15及びR16は、それぞれ独立して、水素原子又はメチル基を表す)
で示される化合物からなる群から選ばれる少なくとも1種の有効成分を含有する、下部尿路症状改善用組成物。
[5]前記組成物は、畜尿症状、排尿症状、排尿後症状及び過活動膀胱からなる群より選ばれる少なくとも1種の下部尿路症状を改善するための組成物である、[1]〜[4]のいずれか1項に記載の組成物。
[6]前記組成物は、飲食品又は医薬品の形態にある下部尿路症状改善用組成物である、[1]〜[5]のいずれか1項に記載の組成物。
[7][1]〜[6]のいずれか1項に記載の組成物を、個体に投与することにより、該個体の下部尿路症状を改善する工程を含む、下部尿路症状の改善方法。
[8][1]〜[6]のいずれか1項に記載の組成物を、個体に投与することにより、該個体の膀胱収縮抑制を抑制する工程を含む、膀胱収縮を抑制する方法。
[9][1]〜[6]のいずれか1項に記載の組成物を製造するための、産地が屋久島より南方の地域である長命草の抽出物、産地が赤道及び北緯30°の間にある地域である長命草の抽出物及び上記一般式(1)〜(2)の化合物からなる群から選ばれる少なくとも1種の有効成分の使用。
沖縄県本島で採取した長命草の葉及び茎 174.1g(湿重量)を80%含水エタノール 1.5Lに浸漬することにより2日間抽出処理に供した。長命草の残渣を除くために吸引ろ過して得られた粗抽出物を減圧濃縮した。得られた濃縮物に水 60mL及び酢酸エチル 60mLを加えて、液−液分配に供した。酢酸エチル層を回収し、残った水層に酢酸エチル 60mLを加えて液−液分配に供することを2回繰り返した。
沖縄県本島で採取した長命草の葉及び茎の乾燥処理物、該乾燥処理物 10.0g及び該乾燥処理物を80%含水エタノールに浸漬する抽出処理に供して得られた80%エタノール抽出物の濃縮物に含まれる長命草A、長命草B・C、長命草D・E及び長命草Fの含有量を表1に示す。
沖縄県本島で採取した長命草の葉及び茎の乾燥処理を80%含水エタノールに浸漬する抽出処理に供して得られた80%エタノール抽出物の濃縮物を以下の条件のHPLCに供した。
カラム:Inertsil ODS−HL(4.6×250mm)
展開溶媒:60% CH3CN
検出UV:215nm
流速:1mL/min
リテンション・タイム:長命草F(16.8min)、イソサミジン(17.3min)
沖縄県西原町産長命草抽出物の摘出ラット膀胱の収縮に対する作用を評価した。
Claims (6)
- 産地が鹿児島県屋久島より南方の地域である長命草の抽出物及び該抽出物に含まれる成分からなる群から選ばれる少なくとも1種の有効成分を含有する、下部尿路症状改善用組成物。
- 前記長命草は、産地が北緯30°及び赤道の間にある地域である、請求項1に記載の組成物。
- 前記抽出物はイソサミジンを実質的に含有しない抽出物であり、及び/又は、前記成分はイソサミジンとは異なる成分である、請求項1〜2のいずれか1項に記載の組成物。
- 前記組成物は、畜尿症状、排尿症状、排尿後症状及び過活動膀胱からなる群より選ばれる少なくとも1種の下部尿路症状を改善するための組成物である、請求項1〜4のいずれか1項に記載の組成物。
- 前記組成物は、飲食品又は医薬品の形態にある下部尿路症状改善用組成物である、請求項1〜5のいずれか1項に記載の組成物。
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