JP2021075570A5 - - Google Patents
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- Publication number
- JP2021075570A5 JP2021075570A5 JP2021022476A JP2021022476A JP2021075570A5 JP 2021075570 A5 JP2021075570 A5 JP 2021075570A5 JP 2021022476 A JP2021022476 A JP 2021022476A JP 2021022476 A JP2021022476 A JP 2021022476A JP 2021075570 A5 JP2021075570 A5 JP 2021075570A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- cycloalkyl
- group
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 9
- 125000004103 aminoalkyl group Chemical group 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 9
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 150000001540 azides Chemical class 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 125000003368 amide group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000006207 intravenous dosage form Substances 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 0 C[C@]([C@]([C@]([C@]1O)N)O)O[C@]1O[C@](C[C@@](C([C@](C1)O)NC(**)=O)OC1(*)C[C@](CC(C(CC[C@](C[C@](CC(O[C@@](C)C1)=O)O)O)O)O)O)C=CC=CC=CC=CC=CC=CC=C[C@](C)[C@]1O Chemical compound C[C@]([C@]([C@]([C@]1O)N)O)O[C@]1O[C@](C[C@@](C([C@](C1)O)NC(**)=O)OC1(*)C[C@](CC(C(CC[C@](C[C@](CC(O[C@@](C)C1)=O)O)O)O)O)O)C=CC=CC=CC=CC=CC=CC=C[C@](C)[C@]1O 0.000 description 3
- GDFAOVXKHJXLEI-UHFFFAOYSA-N CC(C(O)=O)NC Chemical compound CC(C(O)=O)NC GDFAOVXKHJXLEI-UHFFFAOYSA-N 0.000 description 1
- ROIWAMOFUAFMRY-UHFFFAOYSA-N CC(C)(C)OC(CN(C)C)=O Chemical compound CC(C)(C)OC(CN(C)C)=O ROIWAMOFUAFMRY-UHFFFAOYSA-N 0.000 description 1
- AHZBIPPXGFSEJH-UHFFFAOYSA-N CC(C)OC(C(C)NC)=O Chemical compound CC(C)OC(C(C)NC)=O AHZBIPPXGFSEJH-UHFFFAOYSA-N 0.000 description 1
- VZKWZLGSRBOHIU-UHFFFAOYSA-N CCCN(C)CC(N1CCOCC1)=O Chemical compound CCCN(C)CC(N1CCOCC1)=O VZKWZLGSRBOHIU-UHFFFAOYSA-N 0.000 description 1
- IWNBQXFSYAIRCJ-UHFFFAOYSA-N CN(C)C1CN(C)CC1 Chemical compound CN(C)C1CN(C)CC1 IWNBQXFSYAIRCJ-UHFFFAOYSA-N 0.000 description 1
- ZAMXVCJJAQXCBT-UHFFFAOYSA-N CN(CC1)CC1F Chemical compound CN(CC1)CC1F ZAMXVCJJAQXCBT-UHFFFAOYSA-N 0.000 description 1
- UNHOPMIDKWXFMF-UHFFFAOYSA-N CN(CC1)CC1N Chemical compound CN(CC1)CC1N UNHOPMIDKWXFMF-UHFFFAOYSA-N 0.000 description 1
- XJZDIZQNHVHDKM-UHFFFAOYSA-N CN1CC(CC2)OC2C1 Chemical compound CN1CC(CC2)OC2C1 XJZDIZQNHVHDKM-UHFFFAOYSA-N 0.000 description 1
- ZFELWKKEFVPBJQ-UHFFFAOYSA-N CN1CCN(CCOC)CC1 Chemical compound CN1CCN(CCOC)CC1 ZFELWKKEFVPBJQ-UHFFFAOYSA-N 0.000 description 1
- JMGQDYJFBQGUDC-NTSWFWBYSA-N CN1[C@@H](C2)CO[C@H]2C1 Chemical compound CN1[C@@H](C2)CO[C@H]2C1 JMGQDYJFBQGUDC-NTSWFWBYSA-N 0.000 description 1
- UZFSSDLWBZWJRU-UHFFFAOYSA-N CNC(CCCC1)C1N Chemical compound CNC(CCCC1)C1N UZFSSDLWBZWJRU-UHFFFAOYSA-N 0.000 description 1
- VDIPNVCWMXZNFY-UHFFFAOYSA-N CNCCC(O)=O Chemical compound CNCCC(O)=O VDIPNVCWMXZNFY-UHFFFAOYSA-N 0.000 description 1
- UKYSWWLKULEJFA-UHFFFAOYSA-N CNCCCN1CCOCC1 Chemical compound CNCCCN1CCOCC1 UKYSWWLKULEJFA-UHFFFAOYSA-N 0.000 description 1
- OVHIPFZQRQQFGQ-UHFFFAOYSA-N CNCCNCCO Chemical compound CNCCNCCO OVHIPFZQRQQFGQ-UHFFFAOYSA-N 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N CNCCc1cnc[nH]1 Chemical compound CNCCc1cnc[nH]1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- DBGFNLVRAFYZBI-UHFFFAOYSA-N CNc1cnccc1 Chemical compound CNc1cnccc1 DBGFNLVRAFYZBI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147949P | 2015-04-15 | 2015-04-15 | |
| US62/147,949 | 2015-04-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553875A Division JP7240811B2 (ja) | 2015-04-15 | 2016-04-15 | アムホテリシンｂの誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021075570A JP2021075570A (ja) | 2021-05-20 |
| JP2021075570A5 true JP2021075570A5 (enExample) | 2021-07-26 |
Family
ID=57126898
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553875A Active JP7240811B2 (ja) | 2015-04-15 | 2016-04-15 | アムホテリシンｂの誘導体 |
| JP2021022476A Abandoned JP2021075570A (ja) | 2015-04-15 | 2021-02-16 | アムホテリシンｂの誘導体 |
| JP2022205228A Pending JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553875A Active JP7240811B2 (ja) | 2015-04-15 | 2016-04-15 | アムホテリシンｂの誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022205228A Pending JP2023030103A (ja) | 2015-04-15 | 2022-12-22 | アムホテリシンｂの誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9957290B2 (enExample) |
| EP (2) | EP3283171B1 (enExample) |
| JP (3) | JP7240811B2 (enExample) |
| CA (2) | CA3213127A1 (enExample) |
| ES (1) | ES2880029T3 (enExample) |
| PT (1) | PT3283171T (enExample) |
| WO (1) | WO2016168568A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110407898B (zh) | 2013-10-07 | 2023-12-01 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| MA39568A1 (fr) * | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| US9957290B2 (en) * | 2015-04-15 | 2018-05-01 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin B |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| KR102893040B1 (ko) * | 2018-09-07 | 2025-11-27 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 독성이 감소된 혼성 암포테리신 b 유도체 |
| AU2020325054A1 (en) * | 2019-08-08 | 2022-03-03 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| MX2022001678A (es) * | 2019-08-08 | 2022-05-18 | Univ Illinois | Derivados amidas hibridas de anfotericina b. |
| FR3112145A1 (fr) * | 2020-07-03 | 2022-01-07 | Nanotracks Diagnostics | Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations |
| WO2022003181A1 (fr) * | 2020-07-03 | 2022-01-06 | Nanotracks Diagnostics | Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée |
| WO2022035752A1 (en) * | 2020-08-10 | 2022-02-17 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin b |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8829592D0 (en) | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| EP0350164A3 (en) * | 1988-06-13 | 1991-07-24 | Beecham Group Plc | Amphotericin derivatives |
| EP0431870A1 (en) | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| GB9203476D0 (en) * | 1992-02-19 | 1992-04-08 | Smithkline Beecham Plc | Novel compounds |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US5606038A (en) | 1995-04-10 | 1997-02-25 | Competitive Technologies, Inc. | Amphiphilic polyene macrolide antibiotic compounds |
| PL180253B1 (pl) * | 1995-05-13 | 2001-01-31 | Politechnika Gdanska | Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL |
| US6664241B2 (en) * | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| WO2007096137A1 (en) * | 2006-02-23 | 2007-08-30 | Eth Zurich | Amphotericin derivatives |
| JP5240704B2 (ja) * | 2007-10-05 | 2013-07-17 | 国立大学法人群馬大学 | 新規蛍光化合物およびそれを用いた細胞内コレステロールの検出方法 |
| BR112014031060A2 (pt) | 2012-06-15 | 2017-06-27 | Blirt S A | composto de fórmula 1a; composição farmacêutica; uso do composto; método para tratamento de infecção fúngica em um paciente; produto de proteção de planta; método para tratamento de infecção fúngica em uma planta; produto de tratamento de edifício antifúngico; método para tratamento de um edifício; e composto para uso |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| CN110407898B (zh) | 2013-10-07 | 2023-12-01 | 伊利诺伊大学评议会 | 具有提高的治疗指数的两性霉素b衍生物 |
| WO2015164289A1 (en) * | 2014-04-21 | 2015-10-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of fungal infections |
| CA2981288C (en) | 2014-05-16 | 2022-12-06 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| MA39568A1 (fr) * | 2014-06-12 | 2017-09-29 | Shionogi & Co | Dérivé de macrolide de polyène |
| WO2016014779A1 (en) | 2014-07-23 | 2016-01-28 | The Board Of Trustees Of The University Of Illinois | Antifungal polyene macrolide derivatives with reduced mammalian toxicity |
| WO2016040779A1 (en) | 2014-09-12 | 2016-03-17 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of polyene macrolide antibiotics |
| JP6755859B2 (ja) | 2014-10-17 | 2020-09-16 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法 |
| WO2016112243A1 (en) | 2015-01-08 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Urea derivatives of amphotericin b derived from secondary amines |
| AU2016205187B2 (en) | 2015-01-08 | 2020-02-27 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin B |
| US9957290B2 (en) * | 2015-04-15 | 2018-05-01 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin B |
-
2016
- 2016-04-15 US US15/099,837 patent/US9957290B2/en active Active
- 2016-04-15 CA CA3213127A patent/CA3213127A1/en active Pending
- 2016-04-15 CA CA3021061A patent/CA3021061C/en active Active
- 2016-04-15 EP EP16780813.8A patent/EP3283171B1/en active Active
- 2016-04-15 PT PT167808138T patent/PT3283171T/pt unknown
- 2016-04-15 JP JP2017553875A patent/JP7240811B2/ja active Active
- 2016-04-15 WO PCT/US2016/027703 patent/WO2016168568A1/en not_active Ceased
- 2016-04-15 ES ES16780813T patent/ES2880029T3/es active Active
- 2016-04-15 EP EP21175661.4A patent/EP3929203A1/en active Pending
-
2018
- 2018-04-09 US US15/948,122 patent/US10597420B2/en active Active
-
2020
- 2020-02-25 US US16/800,694 patent/US10882883B2/en active Active
-
2021
- 2021-02-16 JP JP2021022476A patent/JP2021075570A/ja not_active Abandoned
-
2022
- 2022-12-22 JP JP2022205228A patent/JP2023030103A/ja active Pending
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