JP2021073194A5 - - Google Patents
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- JP2021073194A5 JP2021073194A5 JP2020218615A JP2020218615A JP2021073194A5 JP 2021073194 A5 JP2021073194 A5 JP 2021073194A5 JP 2020218615 A JP2020218615 A JP 2020218615A JP 2020218615 A JP2020218615 A JP 2020218615A JP 2021073194 A5 JP2021073194 A5 JP 2021073194A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- composition
- composition according
- weight
- hetre
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N Meglumine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 150000004885 piperazines Chemical class 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000000699 topical Effects 0.000 claims 1
Claims (6)
- １５−ヒドロキシ−８（Ｚ），１１（Ｚ），１３（Ｅ）−エイコサトリエン酸（１５−ＨＥＴｒＥ）の塩を含む組成物であって、１５−ＨＥＴｒＥの塩形態を、該組成物の全重量の約０．１重量％〜約２０重量％の量で含む、前記組成物。
- 前記塩が、リジン塩、ナトリウム塩、オルニチン塩、ピペラジン塩、またはメグルミン塩である、請求項１に記載の組成物。
- 賦形剤をさらに含む、請求項１に記載の組成物。
- 界面活性剤、保存剤、香味剤、共溶剤、粘度助剤、懸濁助剤、及び/または親油相のうちの１つ以上をさらに含む、請求項１に記載の組成物。
- 局所投与用に製剤化される、請求項１に記載の組成物。
- クリーム、ゲル、エマルション、油、またはローションとして製剤化される、請求項５に記載の組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904600P | 2013-11-15 | 2013-11-15 | |
| US61/904,600 | 2013-11-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019212877A Division JP6818851B2 (ja) | 2013-11-15 | 2019-11-26 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021073194A JP2021073194A (ja) | 2021-05-13 |
| JP2021073194A5 true JP2021073194A5 (ja) | 2021-11-25 |
Family
ID=52669635
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530882A Pending JP2016538288A (ja) | 2013-11-15 | 2014-11-17 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
| JP2019212877A Expired - Fee Related JP6818851B2 (ja) | 2013-11-15 | 2019-11-26 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
| JP2020218615A Pending JP2021073194A (ja) | 2013-11-15 | 2020-12-28 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530882A Pending JP2016538288A (ja) | 2013-11-15 | 2014-11-17 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
| JP2019212877A Expired - Fee Related JP6818851B2 (ja) | 2013-11-15 | 2019-11-26 | 多価不飽和ヒドロキシ脂肪酸の薬学的に許容される塩 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10017453B2 (ja) |
| EP (3) | EP3068757B1 (ja) |
| JP (3) | JP2016538288A (ja) |
| CN (2) | CN109232278A (ja) |
| ES (1) | ES2727387T3 (ja) |
| WO (1) | WO2015071766A1 (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016370626B2 (en) | 2015-12-18 | 2020-08-20 | Afimmune Limited | Compositions comprising 15-HEPE and methods of using the same |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| WO2022090482A1 (en) | 2020-10-30 | 2022-05-05 | Ds Biopharma Limited | Pharmaceutical compositions comprising 15-hetre and methods of use thereof |
Family Cites Families (48)
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|---|---|---|---|---|
| US3055923A (en) * | 1960-03-25 | 1962-09-25 | Baxter Laboratories Inc | Fatty acid salts |
| IE47777B1 (en) | 1978-01-23 | 1984-06-13 | Efamol Ltd | Pharmaceutical and dietary composition comprising gamma-linolenic acids |
| US5352700A (en) | 1988-01-14 | 1994-10-04 | Anders Frithz | Use of essential fatty acids for the preparation of a drug for the treatment of infantile seborrheic eczema |
| GB9111900D0 (en) | 1991-06-03 | 1991-07-24 | Efamol Holdings | Fatty acid compositions |
| JPH05186342A (ja) | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
| US5807884A (en) * | 1992-10-30 | 1998-09-15 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| GB9301446D0 (en) | 1993-01-26 | 1993-03-17 | Scotia Holdings Plc | Internal radiation damage |
| AU683027B2 (en) | 1993-01-27 | 1997-10-30 | Scotia Holdings Plc | Triglycerides |
| US5696166A (en) * | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| SK66198A3 (en) * | 1996-09-20 | 1999-09-10 | Atherogenics Inc | Diagnostics for and mediators of inflammatory disorders |
| GB9715444D0 (en) | 1997-07-22 | 1997-09-24 | Scotia Holdings Plc | Therapeutic and dietary compositions |
| US6359158B1 (en) * | 1998-05-15 | 2002-03-19 | University Of Vermont And State Agricultural College | Methods and products related to 16-HETE analogs |
| JP2000191525A (ja) | 1998-12-25 | 2000-07-11 | Nof Corp | 皮膚外用剤組成物 |
| US6429227B1 (en) * | 1999-11-09 | 2002-08-06 | Alcon Universal Ltd. | Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders |
| AU3846801A (en) | 2000-02-16 | 2001-08-27 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| US20020188024A1 (en) | 2000-08-23 | 2002-12-12 | Chilton Floyd H. | Fatty acid-containing emulsion with increased bioavailability |
| DE10121252A1 (de) | 2001-04-30 | 2002-11-07 | Christos C Zouboulis | Behandlung der Akne |
| WO2004072013A1 (ja) * | 2003-02-14 | 2004-08-26 | Taisho Pharmaceutical Co.,Ltd. | ヒドロキシエイコサジエン酸化合物 |
| JP2005179211A (ja) | 2003-12-17 | 2005-07-07 | Idemitsu Kosan Co Ltd | 皮膚外用剤組成物 |
| WO2005063231A2 (en) | 2003-12-31 | 2005-07-14 | Igennus Limited | Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof |
| WO2005102309A2 (en) | 2004-04-26 | 2005-11-03 | Ltb4 Sweden Ab | In vivo release of endogenous anti-microbial mediators by leukotriene b4 (ltb4) administration |
| US7666447B2 (en) | 2004-10-08 | 2010-02-23 | Pharmanutrients | Compositions including Krill extracts and conjugated linoleic acid and methods of using same |
| US7893106B2 (en) | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| CA2599112C (en) | 2005-02-14 | 2013-10-22 | Suntory Limited | Composition comprising dihomo-.gamma.-linolenic acid (dgla) as the active ingredient |
| TW200711649A (en) | 2005-06-17 | 2007-04-01 | Combinatorx Inc | Combination therapy for the treatment of immunoinflammatory disorders |
| ES2527438T3 (es) | 2006-08-08 | 2015-01-26 | Metabolon, Inc. | Marcadores de la hepatopatía grasa no alcohólica (NAFLD) y de la esteatohepatitis no alcohólica (NASH) y métodos de uso de los mismos |
| JP5101894B2 (ja) | 2007-01-15 | 2012-12-19 | サントリーホールディングス株式会社 | 高度不飽和脂肪酸及びこれを含有する脂質の製造方法 |
| GB0802116D0 (en) | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
| WO2009154230A1 (ja) | 2008-06-17 | 2009-12-23 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防／改善・治療薬 |
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| GB0907601D0 (en) | 2009-05-01 | 2009-06-10 | Equateq Ltd | Novel methods |
| US10154977B2 (en) | 2011-03-25 | 2018-12-18 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory particles |
| US20120264824A1 (en) | 2011-04-15 | 2012-10-18 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| CN104010637A (zh) | 2011-10-19 | 2014-08-27 | 尊贵科学有限公司 | 含有双同-γ-次亚麻油酸及/或15-羟基二十碳三烯酸的药物组合物及其使用方法 |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| BR112014013098A2 (pt) | 2011-11-29 | 2017-06-13 | Dignity Sciences Ltd | composições compreendendo ácidos graxos que têm 20 carbonos e métodos de produção e uso dos mesmos |
| KR102153143B1 (ko) | 2012-01-06 | 2020-09-08 | 옴테라 파마슈티칼스, 인크. | 유리 산 형태의 오메가-3 다중불포화 지방산의 ｄｐａ-농축 조성물 |
| US20120264705A1 (en) | 2012-01-26 | 2012-10-18 | Dignity Sciences Limited | Antimicrobial compositions comprising 15-hetre and methods of use thereof |
| US20130267598A1 (en) | 2012-02-23 | 2013-10-10 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla, 15-ohepa, and/or 15-hetre and methods of reducing sebum production using same |
| EP2833740B1 (en) | 2012-04-04 | 2016-09-14 | Pronova BioPharma Norge AS | Compositions comprising omega-3 fatty acids and vitamin d for acne vulgaris and/or eczema, and methods and uses thereof |
| CN110478342A (zh) | 2012-05-10 | 2019-11-22 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
| WO2014022816A2 (en) | 2012-08-03 | 2014-02-06 | Dignity Sciences Limited | Pharmaceutical compositions comprising 15-hetre and methods of treating or preventing arthritis using same |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| AU2015204531B2 (en) | 2014-01-10 | 2019-11-14 | Afimmune Limited | Pharmaceutical compositions comprising 15-HEPE and methods of treating asthma and lung disorders using same |
| KR102391827B1 (ko) | 2014-06-04 | 2022-04-27 | 디에스 바이오파마 리미티드 | Dgla를 포함하는 약제학적 조성물 및 그의 용도 |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| AU2016370626B2 (en) | 2015-12-18 | 2020-08-20 | Afimmune Limited | Compositions comprising 15-HEPE and methods of using the same |
| WO2017118911A1 (en) | 2016-01-07 | 2017-07-13 | Dignity Sciences Limited | Pharmaceutical compositions comprising dgla and use of same |
-
2014
- 2014-11-17 US US14/543,638 patent/US10017453B2/en active Active
- 2014-11-17 EP EP14843234.7A patent/EP3068757B1/en active Active
- 2014-11-17 JP JP2016530882A patent/JP2016538288A/ja active Pending
- 2014-11-17 EP EP19157319.5A patent/EP3546446A1/en not_active Withdrawn
- 2014-11-17 CN CN201811061377.2A patent/CN109232278A/zh active Pending
- 2014-11-17 WO PCT/IB2014/003027 patent/WO2015071766A1/en active Application Filing
- 2014-11-17 ES ES14843234T patent/ES2727387T3/es active Active
- 2014-11-17 CN CN201480071412.2A patent/CN105899485B/zh not_active Expired - Fee Related
- 2014-11-17 EP EP21159762.0A patent/EP3878835A1/en not_active Withdrawn
-
2017
- 2017-12-01 US US15/828,700 patent/US10544088B2/en not_active Expired - Fee Related
-
2019
- 2019-11-26 JP JP2019212877A patent/JP6818851B2/ja not_active Expired - Fee Related
- 2019-12-05 US US16/704,289 patent/US20200181064A1/en not_active Abandoned
-
2020
- 2020-12-28 JP JP2020218615A patent/JP2021073194A/ja active Pending
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