JP2021042159A5 - - Google Patents

Info

Publication number

JP2021042159A5

JP2021042159A5 JP2019165017A JP2019165017A JP2021042159A5 JP 2021042159 A5 JP2021042159 A5 JP 2021042159A5 JP 2019165017 A JP2019165017 A JP 2019165017A JP 2019165017 A JP2019165017 A JP 2019165017A JP 2021042159 A5 JP2021042159 A5 JP 2021042159A5

Authority

JP

Japan

Prior art keywords

cyclodextrin

active compound

pharmaceutically active

derivative

mol

Prior art date

2019-09-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229920000858 Cyclodextrin Polymers 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 12
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 10
• 235000019658 bitter taste Nutrition 0.000 claims 6
• 239000001116 FEMA 4028 Substances 0.000 claims 3
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical group OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 3
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims 3
• 229960004853 betadex Drugs 0.000 claims 3
• 229960002496 duloxetine hydrochloride Drugs 0.000 claims 3
• JFTURWWGPMTABQ-UHFFFAOYSA-N n,n-dimethyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCN(C)C)C1=CC=CS1 JFTURWWGPMTABQ-UHFFFAOYSA-N 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000002904 solvent Substances 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000012669 liquid formulation Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1