|
US1014372A
(en)
|
1910-12-01 |
1912-01-09 |
Bush Mfg Company |
Hinge.
|
|
US1013068A
(en)
|
1911-09-09 |
1911-12-26 |
Frederick F Mcintosh |
Single-trigger gun mechanism.
|
|
US2643653A
(en)
|
1951-07-19 |
1953-06-30 |
Heidrich John |
Pill injector
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
EP0092227B1
(en)
|
1982-04-19 |
1988-07-27 |
Nissan Motor Co., Ltd. |
Method for controlling reduction ratio of continuously variable transmission with acceleration compensation
|
|
US5272065A
(en)
|
1983-10-20 |
1993-12-21 |
Research Foundation Of State University Of New York |
Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
|
|
US6022950A
(en)
|
1984-06-07 |
2000-02-08 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
US5668255A
(en)
|
1984-06-07 |
1997-09-16 |
Seragen, Inc. |
Hybrid molecules having translocation region and cell-binding region
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
ATE66469T1
(de)
|
1985-01-14 |
1991-09-15 |
Neorx Corp |
Metall-radionuklid markiertes protein fuer diagnose und therapie.
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
US6051405A
(en)
|
1986-09-24 |
2000-04-18 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Constructs encoding recombinant antibody-toxin fusion proteins
|
|
US4892827A
(en)
|
1986-09-24 |
1990-01-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
|
|
US5807832A
(en)
|
1987-06-09 |
1998-09-15 |
Biotech Australia Pty Limited |
Oral delivery of biologically active substances bound to vitamin B12
|
|
US5997856A
(en)
|
1988-10-05 |
1999-12-07 |
Chiron Corporation |
Method and compositions for solubilization and stabilization of polypeptides, especially proteins
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
DE69131449T2
(de)
|
1990-05-11 |
1999-11-25 |
The United States Of America, Represented By The Secretary |
Verbesserte exotoxine aus pseudomonas mit geringer toxität bei tieren und hoher zelltötender aktivität
|
|
GB9112553D0
(en)
|
1991-06-11 |
1991-07-31 |
Wellcome Found |
Fusion proteins
|
|
ES2109362T3
(es)
|
1991-06-21 |
1998-01-16 |
Univ Cincinnati |
Unas proteinas administrables oralmente y metodo para hacerlas.
|
|
US6613332B1
(en)
|
1991-06-21 |
2003-09-02 |
The University Of Cincinnati |
Oral administration of therapeutic proteins
|
|
US5487994A
(en)
*
|
1992-04-03 |
1996-01-30 |
The Johns Hopkins University |
Insertion and deletion mutants of FokI restriction endonuclease
|
|
DE69333951D1
(de)
|
1992-06-18 |
2006-02-02 |
Us Gov Health & Human Serv |
Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
|
|
ES2164098T3
(es)
|
1993-02-02 |
2002-02-16 |
Xoma Technology Ltd |
Composiciones farmaceuticas que contienen una proteina bactericida aumentadora de la permeabilidad y un tensioactivo.
|
|
GB9401787D0
(en)
|
1994-01-31 |
1994-03-23 |
Medeva Holdings Bv |
Vaccine compositions
|
|
GB9320782D0
(en)
|
1993-10-08 |
1993-12-01 |
Univ Leeds Innovations Ltd |
Stabilising of proteins on solution
|
|
GB9420355D0
(en)
|
1994-10-10 |
1994-11-23 |
Univ Nottingham |
Preparation of protein microspheres, films and coatings
|
|
US5656730A
(en)
|
1995-04-07 |
1997-08-12 |
Enzon, Inc. |
Stabilized monomeric protein compositions
|
|
US5912014A
(en)
|
1996-03-15 |
1999-06-15 |
Unigene Laboratories, Inc. |
Oral salmon calcitonin pharmaceutical products
|
|
US5922680A
(en)
|
1996-10-23 |
1999-07-13 |
Ferring, B.V. |
Stabilized composition for oral administration of peptides
|
|
US6391296B1
(en)
|
1997-08-01 |
2002-05-21 |
Toray Industries, Inc. |
Method of stabilizing useful protein and useful protein compositions
|
|
US6342611B1
(en)
|
1997-10-10 |
2002-01-29 |
Cytovia, Inc. |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
|
|
US6251392B1
(en)
|
1997-10-20 |
2001-06-26 |
Epicyte Pharmaceuticals, Inc. |
Epithelial cell targeting agent
|
|
US6592847B1
(en)
|
1998-05-14 |
2003-07-15 |
The General Hospital Corporation |
Intramolecularly-quenched near infrared flourescent probes
|
|
US7053200B1
(en)
|
1999-06-01 |
2006-05-30 |
Baylor College Of Medicine |
Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
|
|
ATE464062T1
(de)
|
1999-10-04 |
2010-04-15 |
Novartis Vaccines & Diagnostic |
Stabilisierte flüssige pharmazeutische zusammensetzung enthaltend tfpi
|
|
US20030186386A1
(en)
*
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
DK1379273T3
(da)
|
2000-11-27 |
2009-11-09 |
Powderject Vaccines Inc |
Nukleinsyreadjuvanser
|
|
US6673574B2
(en)
|
2000-11-30 |
2004-01-06 |
Unigene Laboratories Inc. |
Oral delivery of peptides using enzyme-cleavable membrane translocators
|
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
|
ATE440617T1
(de)
|
2001-05-23 |
2009-09-15 |
Duotol Ab |
Unterdrückung von allergischen reaktionen durch transkutane verabreichung von allergenen zusammen mit oder fusioniert mit toxinuntereinheiten oder deren fragmenten
|
|
JP4623625B2
(ja)
|
2003-07-24 |
2011-02-02 |
株式会社AMBiS |
ヘテロ型5量体組換えワクチン
|
|
EP1522585A1
(en)
|
2003-10-09 |
2005-04-13 |
Plant Research International B.V. |
Chimeric carrier molecules for the production of mucosal vaccines
|
|
AR046960A1
(es)
*
|
2003-12-17 |
2006-01-04 |
Wyeth Corp |
Metodos para producir los conjugados portadores de peptidos inmunogenicos
|
|
US20080317761A1
(en)
*
|
2004-04-28 |
2008-12-25 |
The Trustees Of The University Of Pennsylvania |
Peptide-Mediated Protein Transduction Into Cells of the Hematopoietic Lineage
|
|
US20050281885A1
(en)
*
|
2004-06-21 |
2005-12-22 |
Egilmez Nejat K |
Method for treating inflammatory bowel disease by oral administration of IL-10
|
|
WO2006135428A2
(en)
|
2004-10-04 |
2006-12-21 |
Trinity Biosystems, Inc. |
Methods and compositions for inducing an immune response against multiple antigens
|
|
US7713737B2
(en)
|
2004-10-04 |
2010-05-11 |
Trinity Biosystems, Inc. |
Methods and compositions for needleless delivery of macromolecules
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
EP1910407B1
(en)
|
2005-07-29 |
2011-09-14 |
The Government of the United States of America, as represented by the Secretary of Health and Human Services |
Mutated pseudomonas exotoxins with reduced antigenicity
|
|
WO2007067597A2
(en)
|
2005-12-05 |
2007-06-14 |
Trinity Biosystems, Inc. |
Methods and compositions for needleless delivery of binding partners
|
|
CA2647168A1
(en)
|
2006-03-16 |
2007-09-27 |
Trinity Biosystems, Inc. |
Methods for increasing the size of animals using needleless delivery constructs
|
|
JP2010500967A
(ja)
|
2006-07-20 |
2010-01-14 |
ザ ジェネラル ホスピタル コーポレイション |
コンビナトリアルターゲティングを通じたプロトキシンの選択的活性化のための方法、組成物、およびキット
|
|
US20090092660A1
(en)
|
2006-08-09 |
2009-04-09 |
Trinity Biosystems, Inc. |
Methods and compositions for needleless delivery of particles
|
|
WO2008045486A2
(en)
|
2006-10-09 |
2008-04-17 |
The University Of North Carolina At Chapel Hill |
Nanoparticle compositions for controlled delivery of nucleic acids
|
|
AU2008257419B2
(en)
|
2007-05-23 |
2013-10-24 |
The Trustees Of The University Of Pennsylvania |
Targeted carriers for intracellular drug delivery
|
|
WO2009014650A2
(en)
*
|
2007-07-20 |
2009-01-29 |
The General Hospital Corporation |
Recombinant vibrio cholerae exotoxins
|
|
CN101361968B
(zh)
|
2007-08-06 |
2011-08-03 |
健能隆医药技术(上海)有限公司 |
白介素-22在治疗脂肪肝中的应用
|
|
US20110177155A1
(en)
|
2007-08-21 |
2011-07-21 |
Immune Disease Institute, Inc. |
Methods of delivery of agents to leukocytes and endothelial cells
|
|
AU2009226972B2
(en)
|
2008-03-17 |
2014-05-29 |
Gerhard Heusipp |
YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
|
|
WO2009149281A1
(en)
|
2008-06-04 |
2009-12-10 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Immunotoxins and uses thereof
|
|
NO2344540T3
(enExample)
|
2008-10-02 |
2018-04-28 |
|
|
|
CA2768598A1
(en)
|
2009-07-22 |
2011-01-27 |
Cenix Bioscience Gmbh |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2011031441A1
(en)
|
2009-08-28 |
2011-03-17 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Therapy with a chimeric molecule and a pro-apoptotic agent
|
|
US11246915B2
(en)
*
|
2010-09-15 |
2022-02-15 |
Applied Molecular Transport Inc. |
Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
|
|
AU2011302645B2
(en)
|
2010-09-15 |
2015-02-26 |
Applied Molecular Transport, Llc |
Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
|
|
JP2014505064A
(ja)
*
|
2011-01-26 |
2014-02-27 |
セニックス バイオサイエンス ゲーエムベーハー |
自然に存在する細胞内輸送経路を介して化合物を送達するための送達システム及びコンジュゲート
|
|
WO2012110596A1
(en)
*
|
2011-02-16 |
2012-08-23 |
Friedrich-Alexander-Universität Erlangen-Nürnberg |
Fusion protein for the treatment of immunologic or allergic reactions
|
|
EP3653224A1
(en)
|
2011-06-29 |
2020-05-20 |
Rani Therapeutics, LLC |
Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
|
|
AU2014257123A1
(en)
|
2013-04-24 |
2015-10-15 |
Armo Biosciences, Inc. |
Interleukin-10 compositions and uses thereof
|
|
CN104623637A
(zh)
|
2013-11-07 |
2015-05-20 |
健能隆医药技术(上海)有限公司 |
Il-22二聚体在制备静脉注射药物中的应用
|
|
US20160287670A1
(en)
|
2013-11-07 |
2016-10-06 |
Memorial Sloan-Kettering Cancer Center |
Methods of use for il-22 in the treatment of gastrointestinal graft vs. host disease
|
|
JP6655017B2
(ja)
|
2014-01-27 |
2020-02-26 |
モレキュラー テンプレーツ, インク.Molecular Templates, Inc. |
Mhcクラスiエピトープ送達ポリペプチド
|
|
KR20230154480A
(ko)
|
2014-05-07 |
2023-11-08 |
어플라이드 몰레큘라 트랜스포트 인크. |
생물학적 활성 화물의 경구 전달용 콜릭스 독소-유래 융합 분자
|
|
CN107106655A
(zh)
|
2014-10-22 |
2017-08-29 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素‑10治疗疾病和病症的方法
|
|
WO2016146833A1
(en)
|
2015-03-19 |
2016-09-22 |
F. Hoffmann-La Roche Ag |
Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US10828318B2
(en)
|
2016-01-06 |
2020-11-10 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for treating malignant, autoimmune and inflammatory diseases
|
|
EP3192805A1
(en)
|
2016-01-15 |
2017-07-19 |
Humanitas Mirasole S.p.A. |
Inhibitors of t cell activation or stimulation and uses thereof
|
|
WO2017210684A1
(en)
|
2016-06-03 |
2017-12-07 |
New York University |
Methods and reagents for modulating macrophage phenotype
|
|
WO2018005226A2
(en)
|
2016-06-22 |
2018-01-04 |
Alkermes, Inc. |
Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
|
|
CA3046023A1
(en)
|
2016-12-14 |
2018-06-21 |
Progenity, Inc. |
Treatment of a disease of the gastrointestinal tract with an immunosuppressant
|
|
WO2018112264A1
(en)
|
2016-12-14 |
2018-06-21 |
Progenity Inc. |
Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
|
|
CA3054156A1
(en)
|
2017-03-30 |
2018-10-04 |
Progenity Inc. |
Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
|
|
CA3093386A1
(en)
|
2018-03-08 |
2019-09-12 |
Applied Molecular Transport Inc. |
Toxin-derived delivery constructs for oral delivery
|
|
BR112021009001A8
(pt)
|
2018-11-07 |
2021-10-26 |
Applied Molecular Transport Inc |
Veículos derivados de cholix para administração oral de carga útil heteróloga
|