RU2723178C2 - Слитые молекулы, происходящие от Cholix-токсина, для пероральной доставки биологически активных нагрузок - Google Patents
Слитые молекулы, происходящие от Cholix-токсина, для пероральной доставки биологически активных нагрузок Download PDFInfo
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/241—Tumor Necrosis Factors
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- C12Y—ENZYMES
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- C12Y204/02036—NAD(+)--diphthamide ADP-ribosyltransferase (2.4.2.36)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
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- C12Y304/21—Serine endopeptidases (3.4.21)
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- C12Y305/04004—Adenosine deaminase (3.5.4.4)
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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| CA2848656C (en) | 2010-09-15 | 2017-10-10 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| DK3139965T3 (da) * | 2014-05-07 | 2021-11-22 | Applied Molecular Transport Inc | Fusionsmolekyler afledt af cholix-toksin til oral indgivelse af biologisk aktive stoffer |
| US10676723B2 (en) * | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2018075357A1 (en) | 2016-10-17 | 2018-04-26 | Duke University | PRODUCTION OF IMMUNOTOXIN D2C7-(scdsFv)-PE38KDEL |
| AU2019230230B2 (en) * | 2018-03-08 | 2025-04-10 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| EP4082558B1 (en) | 2018-03-08 | 2023-08-23 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| SG11202104734YA (en) * | 2018-11-07 | 2021-06-29 | Applied Molecular Transport Inc | Cholix-derived carriers for oral delivery of heterologous payload |
| KR20210110294A (ko) * | 2018-11-07 | 2021-09-07 | 어플라이드 몰레큘라 트랜스포트 인크. | 통과세포외배출용 전달 구조체 및 관련 방법 |
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| CN114555058A (zh) * | 2019-08-16 | 2022-05-27 | 应用分子转运公司 | 用于有效载荷递送的组合物和颗粒 |
| US12122817B2 (en) * | 2020-09-22 | 2024-10-22 | Serpentide Inc. | Long-lasting GLP1 analogue drug for type-2 diabetes |
| IT202000028418A1 (it) * | 2020-11-25 | 2022-05-25 | Raicam Driveline S R L | Unità valvolare per un sistema di frenatura antibloccaggio |
| WO2023196532A1 (en) * | 2022-04-08 | 2023-10-12 | Applied Molecular Transport Inc. | Chimeric il-10/carrier constructs for treatment of pouchitis and methods of use |
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