JP2021006028A5 - - Google Patents
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- JP2021006028A5 JP2021006028A5 JP2020135592A JP2020135592A JP2021006028A5 JP 2021006028 A5 JP2021006028 A5 JP 2021006028A5 JP 2020135592 A JP2020135592 A JP 2020135592A JP 2020135592 A JP2020135592 A JP 2020135592A JP 2021006028 A5 JP2021006028 A5 JP 2021006028A5
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- rca
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- rca products
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- 239000000758 substrate Substances 0.000 claims 10
- 210000000349 Chromosomes Anatomy 0.000 claims 5
- 230000000875 corresponding Effects 0.000 claims 4
- 210000003917 Chromosomes, Human Anatomy 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- 229920000272 Oligonucleotide Polymers 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1321196.6 | 2013-12-02 | ||
| GB1321196.6A GB2520765A (en) | 2013-12-02 | 2013-12-02 | Multiplex detection of nucleic acids |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535001A Division JP6749236B2 (ja) | 2013-12-02 | 2014-11-26 | 核酸の多重検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021006028A JP2021006028A (ja) | 2021-01-21 |
| JP2021006028A5 true JP2021006028A5 (da) | 2021-04-22 |
| JP7091400B2 JP7091400B2 (ja) | 2022-06-27 |
Family
ID=49979622
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535001A Active JP6749236B2 (ja) | 2013-12-02 | 2014-11-26 | 核酸の多重検出 |
| JP2020135592A Active JP7091400B2 (ja) | 2013-12-02 | 2020-08-11 | 核酸の多重検出 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535001A Active JP6749236B2 (ja) | 2013-12-02 | 2014-11-26 | 核酸の多重検出 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10526643B2 (da) |
| EP (2) | EP3077541B1 (da) |
| JP (2) | JP6749236B2 (da) |
| KR (2) | KR102307230B1 (da) |
| CN (1) | CN105934523B (da) |
| AU (1) | AU2014358862B2 (da) |
| BR (1) | BR112016012319B1 (da) |
| CA (1) | CA2931015C (da) |
| ES (1) | ES2807614T3 (da) |
| GB (1) | GB2520765A (da) |
| RU (1) | RU2733887C2 (da) |
| WO (1) | WO2015083002A2 (da) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3013984T3 (da) | 2013-06-25 | 2023-06-06 | Prognosys Biosciences Inc | Metode til bestemmelse af spatiale mønstre i biologiske targets i en prøve |
| GB2520765A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
| GB2520763A (en) * | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| AU2015273443B2 (en) | 2014-06-13 | 2021-03-04 | Q-Linea Ab | Method for detecting and characterising a microorganism |
| FI3901281T3 (fi) | 2015-04-10 | 2023-01-31 | Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi | |
| GB201507026D0 (en) | 2015-04-24 | 2015-06-10 | Linea Ab Q | Medical sample transportation container |
| GB201507376D0 (en) | 2015-04-30 | 2015-06-17 | Vanadis Diagnostics Ab | Use of a porous transparent capillary membrane for counting rolling circle amplification products |
| EP3350342B1 (en) | 2015-09-18 | 2020-02-19 | Vanadis Diagnostics | Probe set for analyzing a dna sample and method for using the same |
| GB2554767A (en) | 2016-04-21 | 2018-04-11 | Q Linea Ab | Detecting and characterising a microorganism |
| RU2755151C2 (ru) * | 2016-10-27 | 2021-09-13 | Ванадис Дайэгностикс | Способ получения продуктов с помощью амплификации по типу катящегося кольца |
| GB201621514D0 (en) | 2016-12-16 | 2017-02-01 | Q-Linea Ab | Padlock probe detection method |
| CN106929593B (zh) * | 2017-04-27 | 2021-04-30 | 华侨大学 | 一种原位核酸检测方法 |
| CN109252224A (zh) * | 2017-07-14 | 2019-01-22 | 深圳华大基因股份有限公司 | 一种环状探针和基于环状探针捕获的测序文库构建方法 |
| US11117128B2 (en) | 2017-08-25 | 2021-09-14 | Vanadis Diagnostics Ab | Filtration device |
| AU2019247652A1 (en) | 2018-04-02 | 2020-10-15 | Enumera Molecular, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| JP7393429B2 (ja) * | 2018-12-05 | 2023-12-06 | 深▲せん▼華大智造極創科技有限公司 | ローリングサークル増幅方法、シーケンシングライブラリの調製方法及び調製されたｄｎａナノスフィア |
| EP3894587A1 (en) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Resolving spatial arrays by proximity-based deconvolution |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020206170A1 (en) | 2019-04-02 | 2020-10-08 | Progenity, Inc. | Methods, systems, and compositions for counting nucleic acid molecules |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| CN112029841B (zh) * | 2019-06-03 | 2024-02-09 | 香港中文大学 | 定量端粒长度和基因组基序的方法 |
| EP4025711A2 (en) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| EP4424843A3 (en) | 2019-12-23 | 2024-09-25 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
| WO2021133842A1 (en) | 2019-12-23 | 2021-07-01 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| CN115916999A (zh) | 2020-04-22 | 2023-04-04 | 10X基因组学有限公司 | 用于使用靶向rna耗竭进行空间分析的方法 |
| AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| EP4414459A3 (en) | 2020-05-22 | 2024-09-18 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| WO2021252733A2 (en) * | 2020-06-10 | 2021-12-16 | Bonadea Diagnostics, Llc | Sequence conversion reaction |
| EP4450639A2 (en) | 2020-06-25 | 2024-10-23 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| CA3195721A1 (en) | 2020-09-21 | 2022-03-24 | Progenity, Inc. | Compositions and methods for isolation of cell-free dna |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4347879A1 (en) | 2021-06-03 | 2024-04-10 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| EP4352252A1 (en) * | 2021-07-13 | 2024-04-17 | 10X Genomics, Inc. | Methods for spatial analysis using targeted probe silencing |
| EP4196605A1 (en) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
| CN113801923A (zh) * | 2021-10-20 | 2021-12-17 | 南京鼓楼医院 | 一种可直接用于血清标志物检测的数字滚环扩增检测方法 |
| CN116625999B (zh) * | 2023-05-17 | 2023-11-28 | 中国科学院苏州生物医学工程技术研究所 | 一种评估零模波导孔有效载样的方法及其应用 |
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| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| EP1997909B1 (en) | 1998-03-25 | 2012-02-01 | Olink AB | Rolling circle replication of circularised target nucleic acid fragments |
| WO2000004193A1 (en) * | 1998-07-20 | 2000-01-27 | Yale University | Method for detecting nucleic acids using target-mediated ligation of bipartite primers |
| JP2003535599A (ja) | 2000-06-06 | 2003-12-02 | ティーエム バイオサイエンス コーポレイション | 核酸の捕捉部とその使用 |
| AU2002246612B2 (en) | 2000-10-24 | 2007-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic DNA |
| GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
| ATE425263T1 (de) | 2001-11-19 | 2009-03-15 | Parallele Bioscience Inc | Multiplex-oligonukleotidaddition und zielamplifikation |
| US20060003333A1 (en) * | 2002-11-19 | 2006-01-05 | Singulex, Inc. | Preparation of defined highly labeled probes |
| ATE462801T1 (de) | 2003-11-04 | 2010-04-15 | Applied Biosystems Llc | Konkatamere ligationsprodukte: zusammensetzungen, verfahren und kits dafür |
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| US20070087355A1 (en) * | 2005-10-14 | 2007-04-19 | Barrett Michael T | Comparative genomic hybridization assays and compositions for practicing the same |
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| US20100291636A1 (en) | 2007-06-11 | 2010-11-18 | Olink Genomics Ab | Method for introducing common and/or individual sequence elements in a target nucleic acid molecule |
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| GB0912909D0 (en) | 2009-07-23 | 2009-08-26 | Olink Genomics Ab | Probes for specific analysis of nucleic acids |
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| EP2569447A4 (en) * | 2010-05-14 | 2013-11-27 | Fluidigm Corp | ANALYZES FOR DETECTION OF GENOTYPE, MUTATIONS, AND / OR ANEUPLOIDIE |
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| US9892230B2 (en) * | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CN107841543B (zh) | 2012-04-06 | 2021-12-31 | 香港中文大学 | 通过使用靶向大规模并行测序的等位基因比率分析进行的胎儿三体性的非侵入性产前诊断 |
| US9193994B2 (en) | 2012-04-20 | 2015-11-24 | Samsung Electronics Co., Ltd. | Polynucleotide and use thereof |
| CN105074007A (zh) * | 2013-03-12 | 2015-11-18 | 考希尔股份有限公司 | 用于产前遗传分析的系统和方法 |
| GB2520765A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
| GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
| US10174383B2 (en) * | 2014-08-13 | 2019-01-08 | Vanadis Diagnostics | Method of estimating the amount of a methylated locus in a sample |
-
2013
- 2013-12-02 GB GB1321196.6A patent/GB2520765A/en not_active Withdrawn
-
2014
- 2014-11-26 RU RU2016126375A patent/RU2733887C2/ru active
- 2014-11-26 EP EP14863081.7A patent/EP3077541B1/en active Active
- 2014-11-26 AU AU2014358862A patent/AU2014358862B2/en active Active
- 2014-11-26 US US15/036,778 patent/US10526643B2/en active Active
- 2014-11-26 CN CN201480070068.5A patent/CN105934523B/zh active Active
- 2014-11-26 WO PCT/IB2014/003062 patent/WO2015083002A2/en active Application Filing
- 2014-11-26 BR BR112016012319-0A patent/BR112016012319B1/pt active IP Right Grant
- 2014-11-26 CA CA2931015A patent/CA2931015C/en active Active
- 2014-11-26 JP JP2016535001A patent/JP6749236B2/ja active Active
- 2014-11-26 KR KR1020167017427A patent/KR102307230B1/ko active IP Right Grant
- 2014-11-26 EP EP20176773.8A patent/EP3757228B1/en active Active
- 2014-11-26 ES ES14863081T patent/ES2807614T3/es active Active
- 2014-11-26 KR KR1020217030684A patent/KR102451174B1/ko active IP Right Grant
-
2019
- 2019-11-14 US US16/683,763 patent/US20200140922A1/en active Pending
-
2020
- 2020-08-11 JP JP2020135592A patent/JP7091400B2/ja active Active
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