JP2020536500A5 - - Google Patents

Info

Publication number

JP2020536500A5

JP2020536500A5 JP2020513750A JP2020513750A JP2020536500A5 JP 2020536500 A5 JP2020536500 A5 JP 2020536500A5 JP 2020513750 A JP2020513750 A JP 2020513750A JP 2020513750 A JP2020513750 A JP 2020513750A JP 2020536500 A5 JP2020536500 A5 JP 2020536500A5

Authority

JP

Japan

Prior art keywords

nucleic acid

seq

acid sequence

slc14a1

isoleucine

Prior art date

2018-09-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000007523 nucleic acids Chemical class 0.000 claims 87
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 50
• 101710178528 Urea transporter 1 Proteins 0.000 claims 40
• 102100040076 Urea transporter 1 Human genes 0.000 claims 40
• 108020004707 nucleic acids Proteins 0.000 claims 37
• 102000039446 nucleic acids Human genes 0.000 claims 37
• 229960000310 isoleucine Drugs 0.000 claims 23
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 23
• 239000000523 sample Substances 0.000 claims 22
• 239000002299 complementary DNA Substances 0.000 claims 18
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 14
• 108020004999 messenger RNA Proteins 0.000 claims 10
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• 208000029078 coronary artery disease Diseases 0.000 claims 8
• 208000007536 Thrombosis Diseases 0.000 claims 7
• 230000000295 complement effect Effects 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• 150000001413 amino acids Chemical group 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 238000012163 sequencing technique Methods 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 208000024891 symptom Diseases 0.000 claims 4
• 238000003556 assay Methods 0.000 claims 3
• 238000002955 isolation Methods 0.000 claims 3
• 108020004705 Codon Proteins 0.000 claims 2
• 206010051055 Deep vein thrombosis Diseases 0.000 claims 2
• 206010014522 Embolism venous Diseases 0.000 claims 2
• 101000671665 Homo sapiens Urea transporter 1 Proteins 0.000 claims 2
• 206010047249 Venous thrombosis Diseases 0.000 claims 2
• 208000010125 myocardial infarction Diseases 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 208000004043 venous thromboembolism Diseases 0.000 claims 2
• 201000008450 Intracranial aneurysm Diseases 0.000 claims 1
• 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 230000023555 blood coagulation Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1