JP2020536082A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020536082A5 JP2020536082A5 JP2020518661A JP2020518661A JP2020536082A5 JP 2020536082 A5 JP2020536082 A5 JP 2020536082A5 JP 2020518661 A JP2020518661 A JP 2020518661A JP 2020518661 A JP2020518661 A JP 2020518661A JP 2020536082 A5 JP2020536082 A5 JP 2020536082A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- alkylene
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 241000588914 Enterobacter Species 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 4
- 241000607720 Serratia Species 0.000 claims 4
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 4
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 4
- 208000035143 Bacterial infection Diseases 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000006413 ring segment Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 241000894007 species Species 0.000 claims 3
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims 2
- 241000588722 Escherichia Species 0.000 claims 2
- 241000588748 Klebsiella Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical compound OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims 2
- 229960003324 clavulanic acid Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229960005256 sulbactam Drugs 0.000 claims 2
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 claims 2
- 229960003865 tazobactam Drugs 0.000 claims 2
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- NDCUAPJVLWFHHB-UHNVWZDZSA-N avibactam Chemical compound C1N2[C@H](C(N)=O)CC[C@@]1([H])N(OS(O)(=O)=O)C2=O NDCUAPJVLWFHHB-UHNVWZDZSA-N 0.000 claims 1
- 229960002379 avibactam Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566779P | 2017-10-02 | 2017-10-02 | |
| US62/566,779 | 2017-10-02 | ||
| PCT/US2018/053039 WO2019070492A1 (en) | 2017-10-02 | 2018-09-27 | CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536082A JP2020536082A (ja) | 2020-12-10 |
| JP2020536082A5 true JP2020536082A5 (enExample) | 2021-05-13 |
| JP7252948B2 JP7252948B2 (ja) | 2023-04-05 |
Family
ID=65994576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020518661A Active JP7252948B2 (ja) | 2017-10-02 | 2018-09-27 | 細菌感染症を治療するためのクロマンモノバクタム化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11433055B2 (enExample) |
| EP (1) | EP3691639B1 (enExample) |
| JP (1) | JP7252948B2 (enExample) |
| KR (1) | KR102425959B1 (enExample) |
| CN (2) | CN118496221A (enExample) |
| AU (1) | AU2018345523B2 (enExample) |
| CA (1) | CA3076022C (enExample) |
| CL (1) | CL2020000860A1 (enExample) |
| CO (1) | CO2020004087A2 (enExample) |
| CR (1) | CR20200148A (enExample) |
| DO (1) | DOP2020000058A (enExample) |
| EA (1) | EA202090604A1 (enExample) |
| ES (1) | ES2968467T3 (enExample) |
| GE (1) | GEP20227406B (enExample) |
| IL (1) | IL273306B (enExample) |
| JO (1) | JOP20200130A1 (enExample) |
| MA (1) | MA50629A (enExample) |
| MX (1) | MX2020003581A (enExample) |
| NI (1) | NI202000023A (enExample) |
| PE (1) | PE20201256A1 (enExample) |
| PH (1) | PH12020550107A1 (enExample) |
| SA (1) | SA520411571B1 (enExample) |
| SG (1) | SG11202002575UA (enExample) |
| UA (1) | UA126000C2 (enExample) |
| WO (1) | WO2019070492A1 (enExample) |
| ZA (1) | ZA202001721B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156697B (zh) * | 2019-05-30 | 2022-05-06 | 常州沃腾化工科技有限公司 | 一种1,2-二甲基-1,4,5,6-四氢嘧啶的合成方法 |
| US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
| RS66978B1 (sr) | 2020-07-02 | 2025-07-31 | Incyte Corp | Triciklična jedinjenja uree kao inhibitori jak2 v617f |
| US11661422B2 (en) | 2020-08-27 | 2023-05-30 | Incyte Corporation | Tricyclic urea compounds as JAK2 V617F inhibitors |
| US20240051931A1 (en) * | 2020-12-03 | 2024-02-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Hdac inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| WO2023082055A1 (zh) * | 2021-11-09 | 2023-05-19 | 中国医学科学院医药生物技术研究所 | 包含β-内酰胺类化合物的药物组合物及其用途 |
| KR20240105442A (ko) | 2021-11-18 | 2024-07-05 | 머크 샤프 앤드 돔 엘엘씨 | 크로만 아미딘 모노박탐 항생제 |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| KR20240163688A (ko) | 2022-03-17 | 2024-11-19 | 인사이트 코포레이션 | Jak2 v617f 억제제로서의 삼환계 우레아 화합물 |
| EP4558137A2 (en) * | 2022-07-18 | 2025-05-28 | Merck Sharp & Dohme LLC | Chromane amidine monobactam compounds for the treatment of bacterial infections |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684722A (en) | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
| US5250691A (en) * | 1991-09-09 | 1993-10-05 | E. R. Squibb & Sons, Inc. | Heteroaryl derivatives of monocyclic beta-lactam antibiotics |
| ES2373461T3 (es) | 2005-12-07 | 2012-02-03 | Basilea Pharmaceutica Ag | Antibióticos útiles de monobactama. |
| EP1938822A1 (en) | 2006-12-21 | 2008-07-02 | Novartis AG | Combination therapy for the treatment of airways disease |
| CN103339146B (zh) | 2010-10-11 | 2017-09-01 | 比奥根国际神经科学公司 | 人抗tau抗体 |
| DK2646436T3 (en) | 2010-11-29 | 2015-06-29 | Pfizer | monobactams |
| UY34585A (es) | 2012-01-24 | 2013-09-02 | Aicuris Gmbh & Co Kg | Compuestos b-lactámicos sustituidos con amidina, su preparación y uso |
| HRP20192267T1 (hr) | 2012-05-31 | 2020-03-20 | Osaka City University | Terapeutski agens ili profilaktički agens za demenciju |
| US20140275007A1 (en) | 2013-03-14 | 2014-09-18 | Rempex Pharmaceuticals, Inc. | Oxamazin antibiotics |
| US20160326157A1 (en) | 2014-01-06 | 2016-11-10 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| WO2015148379A1 (en) | 2014-03-24 | 2015-10-01 | Novartis Ag | Monobactam organic compounds for the treatment of bacterial infections |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| HRP20201666T1 (hr) | 2014-10-31 | 2020-12-25 | AbbVie Overseas S.à r.l. | Supstituirani kromani i postupak njihove upotrebe |
| FR3031423B1 (fr) * | 2015-01-06 | 2018-11-30 | Centre National De La Recherche Scientifique | Procede et dispositif de conversion de courant et vehicule comportant un tel dispositif |
| CA3008006C (en) * | 2015-12-15 | 2024-04-09 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections |
| KR102408800B1 (ko) | 2016-03-07 | 2022-06-13 | 머크 샤프 앤드 돔 코포레이션 | 비시클릭 아릴 모노박탐 화합물 및 박테리아 감염의 치료를 위한 그의 사용 방법 |
-
2018
- 2018-09-27 SG SG11202002575UA patent/SG11202002575UA/en unknown
- 2018-09-27 CA CA3076022A patent/CA3076022C/en active Active
- 2018-09-27 AU AU2018345523A patent/AU2018345523B2/en active Active
- 2018-09-27 GE GEAP201815303A patent/GEP20227406B/en unknown
- 2018-09-27 ES ES18864229T patent/ES2968467T3/es active Active
- 2018-09-27 UA UAA202002037A patent/UA126000C2/uk unknown
- 2018-09-27 US US16/651,456 patent/US11433055B2/en active Active
- 2018-09-27 WO PCT/US2018/053039 patent/WO2019070492A1/en not_active Ceased
- 2018-09-27 PE PE2020000692A patent/PE20201256A1/es unknown
- 2018-09-27 CR CR20200148A patent/CR20200148A/es unknown
- 2018-09-27 CN CN202410563311.2A patent/CN118496221A/zh active Pending
- 2018-09-27 JO JOP/2020/0130A patent/JOP20200130A1/ar unknown
- 2018-09-27 CN CN201880064269.2A patent/CN111201021B/zh active Active
- 2018-09-27 MA MA050629A patent/MA50629A/fr unknown
- 2018-09-27 MX MX2020003581A patent/MX2020003581A/es unknown
- 2018-09-27 KR KR1020207012234A patent/KR102425959B1/ko active Active
- 2018-09-27 JP JP2020518661A patent/JP7252948B2/ja active Active
- 2018-09-27 EA EA202090604A patent/EA202090604A1/ru unknown
- 2018-09-27 EP EP18864229.2A patent/EP3691639B1/en active Active
-
2020
- 2020-03-15 IL IL273306A patent/IL273306B/en unknown
- 2020-03-16 DO DO2020000058A patent/DOP2020000058A/es unknown
- 2020-03-18 ZA ZA2020/01721A patent/ZA202001721B/en unknown
- 2020-03-19 SA SA520411571A patent/SA520411571B1/ar unknown
- 2020-03-20 PH PH12020550107A patent/PH12020550107A1/en unknown
- 2020-03-24 NI NI202000023A patent/NI202000023A/es unknown
- 2020-03-31 CO CONC2020/0004087A patent/CO2020004087A2/es unknown
- 2020-03-31 CL CL2020000860A patent/CL2020000860A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020536082A5 (enExample) | ||
| JP2018537483A5 (enExample) | ||
| IL273306A (en) | Chromane monobactam compounds for the treatment of bacterial infections | |
| EA201991693A1 (ru) | Производное пиридина в качестве ингибитора ask1 и способ его получения и применения | |
| JP2017523169A5 (enExample) | ||
| JP2019519598A5 (enExample) | ||
| JP2018507890A5 (enExample) | ||
| CN112955454A (zh) | 作为Wee1抑制剂的嘧啶并吡唑酮类衍生物及其应用 | |
| RU2018134948A (ru) | Бициклические арильные монобактамовые соединения и способы их применения для лечения бактериальных инфекций | |
| RU2018105549A (ru) | Производные бензодиазепина как ингибиторы rsv | |
| NO20050841L (no) | Pyrazolo [3,4-B] pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer | |
| JO3588B1 (ar) | مشتقات 3-تترازوليل -بنزين- 1، 2-ثنائي سلفوناميد كمثبطات ميتالو -بيتا- لاكتاماز | |
| MX2022006608A (es) | Nuevos inhibidores de aurora cinasa y uso de los mismos. | |
| MX2020011317A (es) | Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa de vih. | |
| MX2022012812A (es) | Métodos para tratar el síndrome de liberación de citocinas. | |
| JP2017525699A5 (enExample) | ||
| AU2020288567A8 (en) | Pyrrolopyrimidine compound and use thereof | |
| EA201791667A1 (ru) | Соединения бензоксаборола и их применение | |
| WO2020132471A8 (en) | Crystalline and salt forms of an organic compound and pharmaceutical compositions thereof | |
| JP2020504184A5 (enExample) | ||
| JOP20210353A1 (ar) | مركبات وطرق استخدامها كعوامل مضادة للجراثيم | |
| WO2023154905A8 (en) | Antiviral naphthyridinone compounds | |
| MX2024006176A (es) | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno. | |
| MX2021014850A (es) | Procedimiento alternativo para la preparacion de acido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il] metil]-3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5-a]pirazin-2-il]-c arboxilico. | |
| MX2022014523A (es) | Derivado de piridina y aplicacion del mismo. |