JP2020535832A5 - - Google Patents
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- Publication number
- JP2020535832A5 JP2020535832A5 JP2020519092A JP2020519092A JP2020535832A5 JP 2020535832 A5 JP2020535832 A5 JP 2020535832A5 JP 2020519092 A JP2020519092 A JP 2020519092A JP 2020519092 A JP2020519092 A JP 2020519092A JP 2020535832 A5 JP2020535832 A5 JP 2020535832A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- tcr
- human
- antigen
- constant region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 22
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 108091081548 Palindromic sequence Proteins 0.000 claims 1
- 239000004234 Yellow 2G Substances 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002151 riboflavin Substances 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023220106A JP7747724B2 (ja) | 2017-10-05 | 2023-12-26 | マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762568339P | 2017-10-05 | 2017-10-05 | |
| US62/568,339 | 2017-10-05 | ||
| PCT/US2018/052432 WO2019070435A1 (en) | 2017-10-05 | 2018-09-24 | METHODS FOR SELECTIVE EXPANSION OF CELLS EXPRESSING A TCR WITH A CONSTANT MURINE REGION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023220106A Division JP7747724B2 (ja) | 2017-10-05 | 2023-12-26 | マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020535832A JP2020535832A (ja) | 2020-12-10 |
| JP2020535832A5 true JP2020535832A5 (cg-RX-API-DMAC7.html) | 2021-11-04 |
Family
ID=63841049
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519092A Pending JP2020535832A (ja) | 2017-10-05 | 2018-09-24 | マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法 |
| JP2023220106A Active JP7747724B2 (ja) | 2017-10-05 | 2023-12-26 | マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023220106A Active JP7747724B2 (ja) | 2017-10-05 | 2023-12-26 | マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12227554B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3692140B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2020535832A (cg-RX-API-DMAC7.html) |
| KR (1) | KR102757789B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN111417720B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2018345400B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3077595A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2960313T3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI3692140T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL273698B2 (cg-RX-API-DMAC7.html) |
| MA (1) | MA50748A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11202003112QA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019070435A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230124983A (ko) * | 2020-12-22 | 2023-08-28 | 네오진 테라퓨틱스 비.브이. | 유전적으로 조작된 세포를 추적하기 위한 펩타이드마커 |
| JP2024507929A (ja) | 2021-02-25 | 2024-02-21 | アラウノス セラピューティクス インコーポレイテッド | 多シストロン性発現カセットを含む組換えベクター及びそれらの使用方法 |
| US20250145950A1 (en) * | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2103887C (en) | 1991-12-13 | 2005-08-30 | Gary M. Studnicka | Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof |
| AU6969096A (en) * | 1995-09-05 | 1997-03-27 | General Hospital Corporation, The | Monoclonal lymphocytes and methods of use |
| DE19905048A1 (de) | 1999-02-08 | 2000-08-10 | Gsf Forschungszentrum Umwelt | Verwendung depletorisch oder mitogen wirkender Antikörper in der Immuntherapie |
| JP2003274960A (ja) * | 2000-02-03 | 2003-09-30 | Japan Science & Technology Corp | 可溶性ｔ細胞受容体タンパク質およびその作成方法 |
| JP2003276960A (ja) * | 2002-03-26 | 2003-10-02 | Mitsubishi Electric Corp | エレベーター制御システム |
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| AU2004289316B2 (en) * | 2003-11-10 | 2011-03-31 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
| AU2007248019B2 (en) * | 2006-05-03 | 2012-10-11 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Chimeric T cell receptors and related materials and methods of use |
| US8216565B2 (en) | 2007-01-12 | 2012-07-10 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | GP100-specific T cell receptors and related materials and methods of use |
| US8785601B2 (en) | 2009-01-28 | 2014-07-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| ES2876176T3 (es) | 2010-09-21 | 2021-11-12 | The Us Secretary Department Of Health And Human Services Office Of Technology Transfer National Inst | Receptores de células T anti-SSX-2 y materiales relacionados y métodos de uso |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| EP3828197B1 (en) | 2012-05-22 | 2024-10-02 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Pharmaceutical composition comprising host cells encoding anti-ny-eso-1 t cell receptors |
| PT2895509T (pt) * | 2012-09-14 | 2020-03-13 | Us Health | Recetores de células t que reconhecem mage-3 restrito a mhc de classe ii |
| ES2745472T3 (es) * | 2013-07-15 | 2020-03-02 | The U S A As Represented By The Secretary Department Of Health And Human Services Office Of Tech Tra | Receptores de células T anti-virus del papiloma humano 16 E6 |
| US10174098B2 (en) * | 2014-05-29 | 2019-01-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human papillomavirus 16 E7 T cell receptors |
| EP3848456A1 (en) * | 2014-10-02 | 2021-07-14 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods of isolating t cells having antigenic specificity for a cancer-specific mutation |
| KR20170100517A (ko) * | 2014-11-20 | 2017-09-04 | 유엠씨 우트레크트 홀딩 비.브이. | 외래 면역 수용체를 갖는 조작된 T 세포의 농축(enriched)을 위한 항체 및 조작된 T 세포의 디플리션에 사용하기 위한 항체의 용도 |
| US11207394B2 (en) | 2014-11-26 | 2021-12-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mutated KRAS T cell receptors |
| EP3350213B1 (en) | 2015-09-15 | 2021-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing hla-cw8 restricted mutated kras |
| ES2906795T3 (es) | 2016-04-26 | 2022-04-20 | Us Health | Receptores de células T anti-KK-LC-1 |
| HUE060121T2 (hu) | 2016-08-02 | 2023-01-28 | The U S A As Represented By The Secretary | Anti-KRAS-G12D T-sejt receptorok |
-
2018
- 2018-09-24 CA CA3077595A patent/CA3077595A1/en active Pending
- 2018-09-24 EP EP18786145.5A patent/EP3692140B1/en active Active
- 2018-09-24 WO PCT/US2018/052432 patent/WO2019070435A1/en not_active Ceased
- 2018-09-24 KR KR1020207012314A patent/KR102757789B1/ko active Active
- 2018-09-24 IL IL273698A patent/IL273698B2/en unknown
- 2018-09-24 ES ES18786145T patent/ES2960313T3/es active Active
- 2018-09-24 FI FIEP18786145.5T patent/FI3692140T3/fi active
- 2018-09-24 MA MA050748A patent/MA50748A/fr unknown
- 2018-09-24 EP EP23185846.5A patent/EP4269595A3/en active Pending
- 2018-09-24 US US16/652,948 patent/US12227554B2/en active Active
- 2018-09-24 CN CN201880076862.9A patent/CN111417720B/zh active Active
- 2018-09-24 AU AU2018345400A patent/AU2018345400B2/en active Active
- 2018-09-24 JP JP2020519092A patent/JP2020535832A/ja active Pending
- 2018-09-24 SG SG11202003112QA patent/SG11202003112QA/en unknown
-
2023
- 2023-12-26 JP JP2023220106A patent/JP7747724B2/ja active Active
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