JP2012508575A5 - - Google Patents

Info

Publication number

JP2012508575A5

JP2012508575A5 JP2011536276A JP2011536276A JP2012508575A5 JP 2012508575 A5 JP2012508575 A5 JP 2012508575A5 JP 2011536276 A JP2011536276 A JP 2011536276A JP 2011536276 A JP2011536276 A JP 2011536276A JP 2012508575 A5 JP2012508575 A5 JP 2012508575A5

Authority

JP

Japan

Prior art keywords

cells

natural killer

cell population

pharmaceutical composition

foxp3

Prior art date

2009-11-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 210000000581 natural killer T-cell Anatomy 0.000 claims 25
• 210000004027 cell Anatomy 0.000 claims 24
• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 238000000034 method Methods 0.000 claims 10
• 210000000056 organ Anatomy 0.000 claims 10
• 230000028993 immune response Effects 0.000 claims 7
• 210000004185 liver Anatomy 0.000 claims 7
• 210000001744 T-lymphocyte Anatomy 0.000 claims 6
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 6
• 235000012012 Paullinia yoco Nutrition 0.000 claims 4
• 238000002054 transplantation Methods 0.000 claims 4
• 108010002350 Interleukin-2 Proteins 0.000 claims 3
• 210000000601 blood cell Anatomy 0.000 claims 3
• 238000006243 chemical reaction Methods 0.000 claims 3
• 210000000265 leukocyte Anatomy 0.000 claims 3
• 230000003472 neutralizing effect Effects 0.000 claims 3
• 239000000021 stimulant Substances 0.000 claims 3
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 108090000172 Interleukin-15 Proteins 0.000 claims 2
• 108010002586 Interleukin-7 Proteins 0.000 claims 2
• 210000005260 human cell Anatomy 0.000 claims 2
• 230000008105 immune reaction Effects 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000001965 increasing effect Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 206010025482 malaise Diseases 0.000 claims 2
• 210000004400 mucous membrane Anatomy 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 230000035755 proliferation Effects 0.000 claims 2
• 230000001629 suppression Effects 0.000 claims 2
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 230000003796 beauty Effects 0.000 claims 1
• 230000001079 digestive effect Effects 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 210000005228 liver tissue Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1