JP2012515213A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012515213A5 JP2012515213A5 JP2011546329A JP2011546329A JP2012515213A5 JP 2012515213 A5 JP2012515213 A5 JP 2012515213A5 JP 2011546329 A JP2011546329 A JP 2011546329A JP 2011546329 A JP2011546329 A JP 2011546329A JP 2012515213 A5 JP2012515213 A5 JP 2012515213A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- individual
- combination
- antigen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14453709P | 2009-01-14 | 2009-01-14 | |
| US61/144,537 | 2009-01-14 | ||
| US29309610P | 2010-01-07 | 2010-01-07 | |
| US61/293,096 | 2010-01-07 | ||
| PCT/US2010/021029 WO2010083298A1 (en) | 2009-01-14 | 2010-01-14 | Methods and compositions containing mtor inhibitors for enhancing immune responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515213A JP2012515213A (ja) | 2012-07-05 |
| JP2012515213A5 true JP2012515213A5 (cg-RX-API-DMAC7.html) | 2012-12-27 |
Family
ID=42340082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546329A Pending JP2012515213A (ja) | 2009-01-14 | 2010-01-14 | 免疫応答を増強するための、mTOR阻害剤を含有する方法及び組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20100196311A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2375897A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012515213A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102281761A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2748931A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010083298A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011133636A1 (en) | 2010-04-20 | 2011-10-27 | Cedars-Sinai Medical Center | COMBINATION THERAPY WITH CD4 LYMPHOCYTE DEPLETION AND mTOR INHIBITORS |
| CN104338129B (zh) * | 2013-07-26 | 2017-05-24 | 中国科学院上海巴斯德研究所 | 雷帕霉素作为疫苗佐剂的用途及制备方法 |
| US20150140036A1 (en) * | 2013-11-13 | 2015-05-21 | Novartis Institutes For Biomedical Research, Inc. | Low, immune enhancing, dose mtor inhibitors and uses thereof |
| WO2015120198A1 (en) | 2014-02-05 | 2015-08-13 | Cedars-Sinai Medical Center | Methods and compositions for treating cancer and infectious diseases |
| EP3171882A1 (en) | 2014-07-21 | 2017-05-31 | Novartis AG | Treatment of cancer using a cll-1 chimeric antigen receptor |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| HK1245095A1 (zh) | 2015-05-20 | 2018-08-24 | Novartis Ag | 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合 |
| EA201890159A1 (ru) * | 2015-06-29 | 2018-11-30 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | СПОСОБЫ ЛЕЧЕНИЯ ГЕМАТОЛОГИЧЕСКОГО ЗЛОКАЧЕСТВЕННОГО НОВООБРАЗОВАНИЯ С ПОМОЩЬЮ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ |
| AU2016285720C1 (en) | 2015-06-29 | 2022-02-03 | Abraxis Bioscience, Llc | Methods of treating epithelioid cell tumors |
| EP3324983A4 (en) | 2015-07-20 | 2019-04-10 | Mayo Foundation for Medical Education and Research | METHOD AND MATERIALS FOR PRODUCING T-CELLS |
| EP3405568A4 (en) * | 2016-01-20 | 2019-12-04 | Fate Therapeutics, Inc. | COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES |
| CN108473959B (zh) | 2016-01-20 | 2023-04-21 | 菲特治疗公司 | 用来在过继性免疫疗法中进行免疫细胞调节的组合物和方法 |
| WO2018096402A1 (en) | 2016-11-23 | 2018-05-31 | Novartis Ag | Methods of enhancing immune response with everolimus, dactolisib or both |
| EP3548049A4 (en) * | 2016-12-05 | 2020-07-22 | Fate Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE CELLS IN ADOPTIVE IMMUNOTHERAPIES |
| WO2019157516A1 (en) | 2018-02-12 | 2019-08-15 | resTORbio, Inc. | Combination therapies |
| MY208825A (en) | 2018-06-13 | 2025-05-30 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
| CN110412289B (zh) * | 2019-07-25 | 2022-08-02 | 北京美迪阿姆科技发展有限公司 | 抑制性t细胞及筛选方法和抑制自身免疫反应中的应用 |
| CN114426952A (zh) * | 2020-10-29 | 2022-05-03 | 中国科学技术大学 | 用于白血病的car t细胞疗法的t细胞增效剂及获得增效t细胞的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3066599A (en) * | 1998-03-03 | 1999-10-18 | University Of Southern California | Use of cytokines and mitogens to inhibit graft versus host disease |
| US7198789B2 (en) * | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| WO2005003335A2 (en) * | 2003-06-12 | 2005-01-13 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Rapamycin resistant t cells and therapeutic uses thereof |
| WO2003038062A2 (en) * | 2001-10-31 | 2003-05-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Generation of use of tc1 and tc2 cells |
| US7718196B2 (en) * | 2001-07-02 | 2010-05-18 | The United States Of America, As Represented By The Department Of Health And Human Services | Rapamycin-resistant T cells and therapeutic uses thereof |
| US20060094674A1 (en) * | 2002-07-05 | 2006-05-04 | Neel Benjamin G | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
| PT1408106E (pt) * | 2002-10-11 | 2007-04-30 | Sentoclone Ab | Imunoterapia de cancro |
| KR20140019032A (ko) * | 2006-04-05 | 2014-02-13 | 노파르티스 아게 | 암을 치료하기 위한 치료제의 조합물 |
| WO2008042814A2 (en) * | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| US8765462B2 (en) * | 2007-05-04 | 2014-07-01 | University Health Network | IL-12 immunotherapy for cancer |
| CA2733203A1 (en) * | 2008-08-05 | 2010-02-11 | Emory University | Use of mtor inhibitors to enhance t cell immune responses |
-
2010
- 2010-01-14 CN CN2010800048759A patent/CN102281761A/zh active Pending
- 2010-01-14 JP JP2011546329A patent/JP2012515213A/ja active Pending
- 2010-01-14 US US12/687,650 patent/US20100196311A1/en not_active Abandoned
- 2010-01-14 CA CA2748931A patent/CA2748931A1/en not_active Abandoned
- 2010-01-14 EP EP10732083.0A patent/EP2375897A4/en not_active Withdrawn
- 2010-01-14 WO PCT/US2010/021029 patent/WO2010083298A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012515213A5 (cg-RX-API-DMAC7.html) | ||
| Khosravi et al. | Immunologic tumor microenvironment modulators for turning cold tumors hot | |
| Dzutsev et al. | Microbes and cancer | |
| Yang et al. | Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment | |
| Dallenga et al. | Neutrophils in tuberculosisâ   first line of defence or booster of disease and targets for host-directed therapy? | |
| Wang et al. | Modulation of gut microbiota: a novel paradigm of enhancing the efficacy of programmed death-1 and programmed death ligand-1 blockade therapy | |
| US9730967B2 (en) | Method and system for treating cancer cachexia | |
| JP2019512020A5 (cg-RX-API-DMAC7.html) | ||
| Hu et al. | Inhibition of the PD-1/PD-L1 signaling pathway enhances innate immune response of alveolar macrophages to mycobacterium tuberculosis in mice | |
| Li et al. | Characteristics of CD8+ and CD4+ tissue‐resident memory lymphocytes in the gastrointestinal tract | |
| Lu et al. | Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy | |
| Chen et al. | Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients | |
| Wu et al. | Matrine ameliorates spontaneously developed colitis in interleukin-10-deficient mice | |
| Xie et al. | Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth | |
| Viudez-Pareja et al. | Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment | |
| Guo et al. | Cooperative effect of Bifidobacteria lipoteichoic acid combined with 5-fluorouracil on hepatoma-22 cells growth and apoptosis | |
| Yue et al. | Harnessing CD8+ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directions | |
| Nobel et al. | STAT signaling in the intestine | |
| Madan et al. | Cenicriviroc, a CCR2/CCR5 antagonist, promotes the generation of type 1 regulatory T cells | |
| Zhang et al. | IL-35 inhibits acute graft-versus-host disease in a mouse model | |
| Huart et al. | Could protons and carbon ions be the silver bullets against pancreatic cancer? | |
| Xiong et al. | Tissue‐resident memory T cells in immunotherapy and immune‐related adverse events by immune checkpoint inhibitor | |
| Chen et al. | Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells | |
| Wu et al. | Tumor cell repopulation between cycles of chemotherapy is inhibited by regulatory T-cell depletion in a murine mesothelioma model | |
| Wang et al. | Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor |