JP2020535448A5 - - Google Patents
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- JP2020535448A5 JP2020535448A5 JP2020538771A JP2020538771A JP2020535448A5 JP 2020535448 A5 JP2020535448 A5 JP 2020535448A5 JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020538771 A JP2020538771 A JP 2020538771A JP 2020535448 A5 JP2020535448 A5 JP 2020535448A5
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- JP
- Japan
- Prior art keywords
- poly
- biological sample
- subject
- ran
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012472 biological sample Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 102000005912 ran GTP Binding Protein Human genes 0.000 claims 11
- 108010005597 ran GTP Binding Protein Proteins 0.000 claims 11
- 238000003556 assay Methods 0.000 claims 8
- 238000004020 luminiscence type Methods 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 230000036039 immunity Effects 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 2
- 201000003498 spinocerebellar ataxia type 36 Diseases 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108091026821 Artificial microRNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000003285 pharmacodynamic effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023150846A JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563009P | 2017-09-25 | 2017-09-25 | |
| US62/563,009 | 2017-09-25 | ||
| PCT/US2018/052745 WO2019060918A1 (en) | 2017-09-25 | 2018-09-25 | IMMUNOLOGICAL ASSAYS FOR DETECTION OF RAN PROTEINS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150846A Division JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020535448A JP2020535448A (ja) | 2020-12-03 |
| JP2020535448A5 true JP2020535448A5 (enExample) | 2021-11-04 |
Family
ID=65811531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538771A Pending JP2020535448A (ja) | 2017-09-25 | 2018-09-25 | Ｒａｎタンパク質の検出のための免役アッセイ |
| JP2023150846A Pending JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023150846A Pending JP2023174663A (ja) | 2017-09-25 | 2023-09-19 | Ｒａｎタンパク質の検出のための免疫アッセイ |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3688020A4 (enExample) |
| JP (2) | JP2020535448A (enExample) |
| AU (2) | AU2018338451A1 (enExample) |
| CA (1) | CA3075908A1 (enExample) |
| WO (1) | WO2019060918A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2970884A4 (en) | 2013-03-14 | 2016-11-02 | Univ Florida | DI-AMINO ACID-REINFORCED PROTEINS ASSOCIATED WITH ALS |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| US10940161B2 (en) | 2016-04-04 | 2021-03-09 | University Of Florida Research Foundation, Incorporated | Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation |
| JP7526455B2 (ja) | 2017-04-17 | 2024-08-01 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ＰＫＲおよびｅＩＦ２Ａ－Ｐ経路によるＲＡＮタンパク質翻訳の調節 |
| JP7350337B2 (ja) | 2017-09-26 | 2023-09-26 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | 神経障害の処置においてｒａｎタンパク質レベルを低下させるためのメトホルミンおよびそのアナログの使用 |
| US20220267776A1 (en) * | 2019-07-05 | 2022-08-25 | University Of Florida Research Foundation, Incorporated | Methods for treating ran protein-associated neurological diseases |
| JP7620988B2 (ja) * | 2019-09-20 | 2025-01-24 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | 血清および組織ライセートからのｒａｎタンパク質に対する抗体の検出 |
| US20240069039A1 (en) * | 2019-10-10 | 2024-02-29 | University Of Florida Research Foundation, Incorporated | Ran proteins as biomarkers in cag/ctg expansion disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2082225E (pt) * | 2006-09-20 | 2014-04-10 | Univ Belfast | Método para determinar se uma célula tumoral tem potencial invasivo e/ou metastático e agentes moduladores de transformação maligna |
| MX365235B (es) * | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| EP2970884A4 (en) * | 2013-03-14 | 2016-11-02 | Univ Florida | DI-AMINO ACID-REINFORCED PROTEINS ASSOCIATED WITH ALS |
| CA2990161A1 (en) * | 2014-08-13 | 2016-02-18 | The Scripps Research Institute | Treatment of c9ftd/als by targeting rna expanded repeat sequences |
| JP6508996B2 (ja) * | 2015-03-24 | 2019-05-08 | 東ソー株式会社 | β−ＡＮＰによる心不全の検出方法 |
| AU2016333538B2 (en) * | 2015-10-02 | 2022-03-31 | Julius-Maximilians-Universität Würzburg | GDF-15 as a diagnostic marker to predict the clinical outcome of a treatment with immune checkpoint blockers |
-
2018
- 2018-09-25 AU AU2018338451A patent/AU2018338451A1/en not_active Abandoned
- 2018-09-25 JP JP2020538771A patent/JP2020535448A/ja active Pending
- 2018-09-25 CA CA3075908A patent/CA3075908A1/en active Pending
- 2018-09-25 EP EP18859783.5A patent/EP3688020A4/en active Pending
- 2018-09-25 WO PCT/US2018/052745 patent/WO2019060918A1/en not_active Ceased
-
2023
- 2023-09-19 JP JP2023150846A patent/JP2023174663A/ja active Pending
-
2024
- 2024-09-04 AU AU2024219412A patent/AU2024219412A1/en active Pending
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