JP2020533971A5 - - Google Patents
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- Publication number
- JP2020533971A5 JP2020533971A5 JP2020511477A JP2020511477A JP2020533971A5 JP 2020533971 A5 JP2020533971 A5 JP 2020533971A5 JP 2020511477 A JP2020511477 A JP 2020511477A JP 2020511477 A JP2020511477 A JP 2020511477A JP 2020533971 A5 JP2020533971 A5 JP 2020533971A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cells
- soluble
- protein complex
- soluble fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762551218P | 2017-08-28 | 2017-08-28 | |
| US62/551,218 | 2017-08-28 | ||
| PCT/US2018/048365 WO2019046313A1 (en) | 2017-08-28 | 2018-08-28 | IL-15 BASED FUSIONS WITH IL-7 AND IL-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533971A JP2020533971A (ja) | 2020-11-26 |
| JP2020533971A5 true JP2020533971A5 (ja�@�@) | 2021-10-07 |
Family
ID=65526059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511477A Withdrawn JP2020533971A (ja) | 2017-08-28 | 2018-08-28 | Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11161890B2 (ja�@�@) |
| EP (1) | EP3676289B1 (ja�@�@) |
| JP (1) | JP2020533971A (ja�@�@) |
| KR (1) | KR20200090742A (ja�@�@) |
| CN (1) | CN111655716B (ja�@�@) |
| AU (1) | AU2018323455B2 (ja�@�@) |
| CA (1) | CA3074635A1 (ja�@�@) |
| WO (1) | WO2019046313A1 (ja�@�@) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101743249B (zh) * | 2007-05-11 | 2017-08-08 | 阿尔托生物科学有限公司 | 融合分子与il‑15变异体 |
| CN110199017A (zh) * | 2017-01-20 | 2019-09-03 | 国立大学法人京都大学 | CD8α+β+细胞毒性T细胞的制备方法 |
| KR102867975B1 (ko) | 2017-03-06 | 2025-10-14 | 알토 바이오사이언스 엘엘씨 | Il-12 및 il-18로의 il-15-기반 융합 |
| JP2020533971A (ja) | 2017-08-28 | 2020-11-26 | アルター・バイオサイエンス・コーポレーション | Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物 |
| WO2020037120A1 (en) * | 2018-08-16 | 2020-02-20 | Nantbio, Inc. | Il7-il15 txm compositions and methods |
| CN120365435A (zh) | 2018-08-30 | 2025-07-25 | 免疫生物公司 | 单链嵌合多肽和多链嵌合多肽以及其用途 |
| EP3843788A1 (en) | 2018-08-30 | 2021-07-07 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| CN112996805A (zh) | 2018-08-30 | 2021-06-18 | Hcw生物科技公司 | 多链嵌合多肽和其用途 |
| GB201818816D0 (en) * | 2018-11-19 | 2019-01-02 | Synpromics Ltd | Regulatory nucleic acid sequences |
| CN111825770B (zh) * | 2019-04-16 | 2023-06-09 | 成都医学院 | 长效白介素21-Fc融合蛋白及其用途 |
| JP7713393B2 (ja) * | 2019-06-21 | 2025-07-25 | イミュニティーバイオ インコーポレイテッド | 多鎖キメラポリペプチドおよびその使用 |
| GB201909144D0 (en) | 2019-06-25 | 2019-08-07 | Autolus Ltd | Culture medium |
| AU2019456283B2 (en) * | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US20210061871A1 (en) * | 2019-08-29 | 2021-03-04 | Nantbio, Inc. | Modified N-810 and Methods Therefor |
| WO2021122866A1 (en) | 2019-12-17 | 2021-06-24 | Ose Immunotherapeutics | Bifunctional molecules comprising an il-7 variant |
| KR20220140535A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 크로마토그래피 수지 및 이의 용도 |
| US12115191B2 (en) | 2020-02-11 | 2024-10-15 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| EP4103599A1 (en) | 2020-02-11 | 2022-12-21 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| EP4143231A1 (en) | 2020-04-29 | 2023-03-08 | HCW Biologics, Inc. | Anti-cd26 proteins and uses thereof |
| WO2021247003A1 (en) * | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| EP4157460A1 (en) * | 2020-06-01 | 2023-04-05 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| GB202008957D0 (en) | 2020-06-12 | 2020-07-29 | Autolus Ltd | Culture medium |
| KR20230112632A (ko) | 2020-10-23 | 2023-07-27 | 애셔 바이오테라퓨틱스, 인크. | 면역 세포 기능을 조절하기 위한 cd8 항원 결합 분자와의 융합 |
| IL308609A (en) | 2021-05-19 | 2024-01-01 | Asher Biotherapeutics Inc | IL-21 polypeptides and target constructs |
| WO2022260849A1 (en) | 2021-06-09 | 2022-12-15 | Nant Holdings Ip, Llc | Methods and systems for producing a protein of interest in a plant |
| US20250051414A1 (en) * | 2021-06-30 | 2025-02-13 | The Regents Of The University Of California | Altering cytokine specificity through binding valency |
| CN113549158B (zh) * | 2021-07-19 | 2022-10-21 | 广州百暨基因科技有限公司 | 包含突变型il15以及嵌合抗原受体的融合蛋白 |
| EP4507711A1 (en) | 2022-04-13 | 2025-02-19 | ImmunityBio, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| CN119546343A (zh) * | 2022-04-27 | 2025-02-28 | 亚设生物治疗公司 | 细胞因子融合蛋白与cd8抗原结合分子的组合 |
| US20260048099A1 (en) * | 2022-08-16 | 2026-02-19 | The United States Of America, As Represented By The Secretary, Deparment Of Health And Human Service | Synergistic interactions for improved cancer treatment |
| KR20250160456A (ko) * | 2023-03-23 | 2025-11-13 | 길리애드 사이언시즈, 인코포레이티드 | Tnf 슈퍼패밀리 멤버 면역사이토카인 및 이의 용도 |
| CN117186243B (zh) * | 2023-07-26 | 2025-08-19 | 四川三优康生物技术有限公司 | 猪白细胞介素15，21和23共表达生物制剂材料及应用 |
| WO2025064822A2 (en) * | 2023-09-20 | 2025-03-27 | Factor Bioscience Inc. | Cells and methods for engineering cells with persistent transgene expression |
| CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8507A (en) | 1851-11-11 | petess | ||
| US222A (en) | 1837-06-10 | Truss for the retention and radical cure qe hernia | ||
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| AU5098393A (en) | 1992-08-14 | 1994-03-15 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Recombinant toxin with increased half-life |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5534592A (en) | 1995-09-22 | 1996-07-09 | The Goodyear Tire & Rubber Company | High performance blend for tire treads |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| KR101131297B1 (ko) | 2003-11-10 | 2012-03-30 | 알토 바이오사이언스 코포레이션 | 가용성 티씨알 분자 및 이용 방법 |
| CN101743249B (zh) | 2007-05-11 | 2017-08-08 | 阿尔托生物科学有限公司 | 融合分子与il‑15变异体 |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| US8507222B2 (en) * | 2010-09-21 | 2013-08-13 | Altor Bioscience Corporation | Multimeric IL-15 soluble fusion molecules and methods of making and using same |
| EP3359157A4 (en) * | 2015-10-06 | 2019-05-15 | The Wistar Institute Of Anatomy And Biology | METHOD AND COMPOSITIONS FOR THE TREATMENT OF METASTASIVE AND REFRACTORY CANCER DISEASES AND TUMORS |
| EP4613776A3 (en) | 2016-10-21 | 2025-11-26 | Altor BioScience Corporation | Multimeric il-15-based molecules |
| JP2020533971A (ja) | 2017-08-28 | 2020-11-26 | アルター・バイオサイエンス・コーポレーション | Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物 |
-
2018
- 2018-08-28 JP JP2020511477A patent/JP2020533971A/ja not_active Withdrawn
- 2018-08-28 US US16/114,870 patent/US11161890B2/en active Active
- 2018-08-28 KR KR1020207009046A patent/KR20200090742A/ko not_active Ceased
- 2018-08-28 CA CA3074635A patent/CA3074635A1/en not_active Abandoned
- 2018-08-28 CN CN201880070462.7A patent/CN111655716B/zh active Active
- 2018-08-28 WO PCT/US2018/048365 patent/WO2019046313A1/en not_active Ceased
- 2018-08-28 AU AU2018323455A patent/AU2018323455B2/en active Active
- 2018-08-28 EP EP18851494.7A patent/EP3676289B1/en active Active
-
2021
- 2021-10-18 US US17/504,100 patent/US11965007B2/en active Active
-
2023
- 2023-09-21 US US18/472,053 patent/US12410224B2/en active Active
-
2024
- 2024-07-17 US US18/775,868 patent/US20240368237A1/en active Pending
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