JP2020533374A - 環状ペプチド抗生物質 - Google Patents
環状ペプチド抗生物質 Download PDFInfo
- Publication number
- JP2020533374A JP2020533374A JP2020515090A JP2020515090A JP2020533374A JP 2020533374 A JP2020533374 A JP 2020533374A JP 2020515090 A JP2020515090 A JP 2020515090A JP 2020515090 A JP2020515090 A JP 2020515090A JP 2020533374 A JP2020533374 A JP 2020533374A
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- substituted
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)CNCCO Chemical compound CC(*)CNCCO 0.000 description 12
- BZSLPKPXTFGZKR-ACCUITESSA-N C/C(/C(C)=O)=C(/C)\[O](C)Cc1ccccc1 Chemical compound C/C(/C(C)=O)=C(/C)\[O](C)Cc1ccccc1 BZSLPKPXTFGZKR-ACCUITESSA-N 0.000 description 1
- QVTTWNXAJRQQHZ-NSCUHMNNSA-N C/C=C/c1c[nH]cn1 Chemical compound C/C=C/c1c[nH]cn1 QVTTWNXAJRQQHZ-NSCUHMNNSA-N 0.000 description 1
- UUNYDCTYXAILRP-XEZPLFJOSA-N CC(C)([C@@H](CC1)C2)[C@@]1(C1)[C@H]2N(C(CCCC=C)=O)S1(=O)=O Chemical compound CC(C)([C@@H](CC1)C2)[C@@]1(C1)[C@H]2N(C(CCCC=C)=O)S1(=O)=O UUNYDCTYXAILRP-XEZPLFJOSA-N 0.000 description 1
- FTXBFXKQCRCTFR-UHFFFAOYSA-N CC(C)CCc1ccc(C(F)(F)F)cc1 Chemical compound CC(C)CCc1ccc(C(F)(F)F)cc1 FTXBFXKQCRCTFR-UHFFFAOYSA-N 0.000 description 1
- JLXUOBFJEACSLR-UHFFFAOYSA-N CC(C)COC(CC1)CCC1N Chemical compound CC(C)COC(CC1)CCC1N JLXUOBFJEACSLR-UHFFFAOYSA-N 0.000 description 1
- ZHKGWDGMUKUETJ-UHFFFAOYSA-N CC(C)COc1ccc(CCN)cc1 Chemical compound CC(C)COc1ccc(CCN)cc1 ZHKGWDGMUKUETJ-UHFFFAOYSA-N 0.000 description 1
- ADWXWIYKDARYIF-UHFFFAOYSA-N CC(CNC(C[n]1cncc1)=O)=C Chemical compound CC(CNC(C[n]1cncc1)=O)=C ADWXWIYKDARYIF-UHFFFAOYSA-N 0.000 description 1
- LDRPULCXZDDSGE-UHFFFAOYSA-N CCCC(F)(F)F Chemical compound CCCC(F)(F)F LDRPULCXZDDSGE-UHFFFAOYSA-N 0.000 description 1
- GENRYAJRHIWOJI-UHFFFAOYSA-N CCCCC(F)(F)F Chemical compound CCCCC(F)(F)F GENRYAJRHIWOJI-UHFFFAOYSA-N 0.000 description 1
- PLWAVCIFCUJNCL-QMMSODDJSA-N CCCCCCCCCC[C@H]([C@@H](C)C(N(C)[C@@H](CC(C)C)C(N[C@@H]([C@H](CC)O)C(N[C@@H](CO)C(N/C(/C(NC1)=O)=C\C)=O)=O)O)=O)OC1=O Chemical compound CCCCCCCCCC[C@H]([C@@H](C)C(N(C)[C@@H](CC(C)C)C(N[C@@H]([C@H](CC)O)C(N[C@@H](CO)C(N/C(/C(NC1)=O)=C\C)=O)=O)O)=O)OC1=O PLWAVCIFCUJNCL-QMMSODDJSA-N 0.000 description 1
- SEHGFQFBSBMNPV-RWZWRJNKSA-N CCCCCC[C@H]([C@@H](C/C=C/c1ccc(C)cc1)C(N([C@@H]1[C@](C)(C2)C(C)(C)[C@@H](C)C1)S2(=O)=O)=O)O Chemical compound CCCCCC[C@H]([C@@H](C/C=C/c1ccc(C)cc1)C(N([C@@H]1[C@](C)(C2)C(C)(C)[C@@H](C)C1)S2(=O)=O)=O)O SEHGFQFBSBMNPV-RWZWRJNKSA-N 0.000 description 1
- WANYSFPMLNKJHN-QLFBSQMISA-N CCCCCC[C@H]([C@@H](CC(F)(F)F)C(N(C)[C@@H](CC(C)C)C(O)=O)=O)O Chemical compound CCCCCC[C@H]([C@@H](CC(F)(F)F)C(N(C)[C@@H](CC(C)C)C(O)=O)=O)O WANYSFPMLNKJHN-QLFBSQMISA-N 0.000 description 1
- DPZOCEQGAYLDIX-ZKCHVHJHSA-N CCCO[C@H]1C[C@H](CN)C1 Chemical compound CCCO[C@H]1C[C@H](CN)C1 DPZOCEQGAYLDIX-ZKCHVHJHSA-N 0.000 description 1
- GYIYOIDRWAKQAR-PZGSVQSZSA-N C[C@@H](C1)C(C)(C)[C@@](C)(C2)[C@H]1N(C(CCc(cc1)ccc1-c1ccccc1)=O)S2(=O)=O Chemical compound C[C@@H](C1)C(C)(C)[C@@](C)(C2)[C@H]1N(C(CCc(cc1)ccc1-c1ccccc1)=O)S2(=O)=O GYIYOIDRWAKQAR-PZGSVQSZSA-N 0.000 description 1
- LUBRSMFTXSITMJ-PKEIRNPWSA-N C[C@H](C1)N1C(OCc1ccccc1)=O Chemical compound C[C@H](C1)N1C(OCc1ccccc1)=O LUBRSMFTXSITMJ-PKEIRNPWSA-N 0.000 description 1
- MIPMFSQSCYTEFI-SUFIHLRJSA-N C[C@H]([C@@H](CCCCC=C)O)C(N([C@@H]1[C@](CC2)(C3)C(C)(C)[C@@H]2C1)S3(=O)=O)=O Chemical compound C[C@H]([C@@H](CCCCC=C)O)C(N([C@@H]1[C@](CC2)(C3)C(C)(C)[C@@H]2C1)S3(=O)=O)=O MIPMFSQSCYTEFI-SUFIHLRJSA-N 0.000 description 1
- CDOFOCUIURQAMM-WWBIDZNWSA-N C[C@H]([C@H]([C@@H](C)C(O)=O)O)[C@H]1C[C@@H](CC2)C[C@@H]2C1 Chemical compound C[C@H]([C@H]([C@@H](C)C(O)=O)O)[C@H]1C[C@@H](CC2)C[C@@H]2C1 CDOFOCUIURQAMM-WWBIDZNWSA-N 0.000 description 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N OCc1ccccc1 Chemical compound OCc1ccccc1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023189200A JP7678057B2 (ja) | 2017-09-15 | 2023-11-06 | 環状ペプチド抗生物質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762559244P | 2017-09-15 | 2017-09-15 | |
| US62/559,244 | 2017-09-15 | ||
| CN2018101004 | 2018-08-17 | ||
| CNPCT/CN2018/101004 | 2018-08-17 | ||
| PCT/CN2018/105821 WO2019052545A1 (en) | 2017-09-15 | 2018-09-14 | CYCLIC PEPTIDE ANTIBIOTICS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189200A Division JP7678057B2 (ja) | 2017-09-15 | 2023-11-06 | 環状ペプチド抗生物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533374A true JP2020533374A (ja) | 2020-11-19 |
| JP2020533374A5 JP2020533374A5 (enExample) | 2021-10-28 |
Family
ID=65723206
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515090A Pending JP2020533374A (ja) | 2017-09-15 | 2018-09-14 | 環状ペプチド抗生物質 |
| JP2023189200A Active JP7678057B2 (ja) | 2017-09-15 | 2023-11-06 | 環状ペプチド抗生物質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023189200A Active JP7678057B2 (ja) | 2017-09-15 | 2023-11-06 | 環状ペプチド抗生物質 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3681875B1 (enExample) |
| JP (2) | JP2020533374A (enExample) |
| CN (1) | CN111148739B (enExample) |
| WO (1) | WO2019052545A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12637411B2 (en) | 2019-01-30 | 2026-05-26 | Mggm Llc | Structurally modified opioids for prevention and treatment of diseases and conditions |
| JP7670618B2 (ja) * | 2019-03-14 | 2025-04-30 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 環状ペプチド抗生物質 |
| WO2026077975A1 (en) * | 2024-10-07 | 2026-04-16 | Univerza V Ljubljani | Polypeptides having nh-triazole functionalizations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS594990B2 (ja) * | 1977-05-13 | 1984-02-02 | 三共株式会社 | 抗生物質グロボマイシン |
| JPS5547644A (en) * | 1978-10-02 | 1980-04-04 | Meiji Seika Kaisha Ltd | New antibiotics sf-1902 a2, a3, a4 and a5 and their preparation |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
-
2018
- 2018-09-14 EP EP18855877.9A patent/EP3681875B1/en active Active
- 2018-09-14 CN CN201880059496.6A patent/CN111148739B/zh active Active
- 2018-09-14 WO PCT/CN2018/105821 patent/WO2019052545A1/en not_active Ceased
- 2018-09-14 JP JP2020515090A patent/JP2020533374A/ja active Pending
-
2023
- 2023-11-06 JP JP2023189200A patent/JP7678057B2/ja active Active
Non-Patent Citations (3)
| Title |
|---|
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, JPN6022044608, 2003, pages 2315 - 2318, ISSN: 0005101789 * |
| SCIENCE, vol. Vol351, Issue6275, JPN6022044610, 19 February 2016 (2016-02-19), pages 876 - 880, ISSN: 0005101791 * |
| 有機合成化学協会誌, vol. 63, no. 1, JPN6022044609, 2005, pages 51 - 62, ISSN: 0005101790 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019052545A1 (en) | 2019-03-21 |
| JP7678057B2 (ja) | 2025-05-15 |
| CN111148739B (zh) | 2025-06-03 |
| EP3681875A1 (en) | 2020-07-22 |
| EP3681875B1 (en) | 2026-01-14 |
| CN111148739A (zh) | 2020-05-12 |
| EP3681875C0 (en) | 2026-01-14 |
| EP3681875A4 (en) | 2021-01-06 |
| JP2024012518A (ja) | 2024-01-30 |
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Legal Events
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