CN111148739B - 环肽抗生素 - Google Patents

环肽抗生素 Download PDF

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Publication number
CN111148739B
CN111148739B CN201880059496.6A CN201880059496A CN111148739B CN 111148739 B CN111148739 B CN 111148739B CN 201880059496 A CN201880059496 A CN 201880059496A CN 111148739 B CN111148739 B CN 111148739B
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CN
China
Prior art keywords
optionally substituted
alkyl
compounds
formula
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201880059496.6A
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English (en)
Chinese (zh)
Other versions
CN111148739A (zh
Inventor
E·J·哈南
G·卡斯塔涅多
M·G·布劳恩
K·加兰
P·A·史密斯
R·帕斯托
P·吉伯恩斯
P-W·源
Y·程
G·吴
Y·付
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN111148739A publication Critical patent/CN111148739A/zh
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Publication of CN111148739B publication Critical patent/CN111148739B/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201880059496.6A 2017-09-15 2018-09-14 环肽抗生素 Active CN111148739B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762559244P 2017-09-15 2017-09-15
US62/559,244 2017-09-15
CN2018101004 2018-08-17
CNPCT/CN2018/101004 2018-08-17
PCT/CN2018/105821 WO2019052545A1 (en) 2017-09-15 2018-09-14 CYCLIC PEPTIDE ANTIBIOTICS

Publications (2)

Publication Number Publication Date
CN111148739A CN111148739A (zh) 2020-05-12
CN111148739B true CN111148739B (zh) 2025-06-03

Family

ID=65723206

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880059496.6A Active CN111148739B (zh) 2017-09-15 2018-09-14 环肽抗生素

Country Status (4)

Country Link
EP (1) EP3681875B1 (enExample)
JP (2) JP2020533374A (enExample)
CN (1) CN111148739B (enExample)
WO (1) WO2019052545A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12637411B2 (en) 2019-01-30 2026-05-26 Mggm Llc Structurally modified opioids for prevention and treatment of diseases and conditions
JP7670618B2 (ja) * 2019-03-14 2025-04-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 環状ペプチド抗生物質
WO2026077975A1 (en) * 2024-10-07 2026-04-16 Univerza V Ljubljani Polypeptides having nh-triazole functionalizations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141202A (en) * 1977-05-13 1978-12-08 Sankyo Co Ltd Antibiotic globomycin
JPS5547644A (en) * 1978-10-02 1980-04-04 Meiji Seika Kaisha Ltd New antibiotics sf-1902 a2, a3, a4 and a5 and their preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141202A (en) * 1977-05-13 1978-12-08 Sankyo Co Ltd Antibiotic globomycin
JPS5547644A (en) * 1978-10-02 1980-04-04 Meiji Seika Kaisha Ltd New antibiotics sf-1902 a2, a3, a4 and a5 and their preparation

Also Published As

Publication number Publication date
WO2019052545A1 (en) 2019-03-21
JP7678057B2 (ja) 2025-05-15
EP3681875A1 (en) 2020-07-22
EP3681875B1 (en) 2026-01-14
CN111148739A (zh) 2020-05-12
JP2020533374A (ja) 2020-11-19
EP3681875C0 (en) 2026-01-14
EP3681875A4 (en) 2021-01-06
JP2024012518A (ja) 2024-01-30

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