JP2020533373A - アレルギー性気道疾患(aad)/喘息の処置方法 - Google Patents

アレルギー性気道疾患(aad)/喘息の処置方法 Download PDF

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JP2020533373A
JP2020533373A JP2020515070A JP2020515070A JP2020533373A JP 2020533373 A JP2020533373 A JP 2020533373A JP 2020515070 A JP2020515070 A JP 2020515070A JP 2020515070 A JP2020515070 A JP 2020515070A JP 2020533373 A JP2020533373 A JP 2020533373A
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mca
msc
asthma
cells
mir
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JP2020533373A5 (enExample
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サムエル、クリシャン
ロイス、シモン
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サイナータ セラピューティクス リミテッド
サイナータ セラピューティクス リミテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/069Vascular Endothelial cells
    • C12N5/0692Stem cells; Progenitor cells; Precursor cells
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/12Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Pulmonology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2020515070A 2017-09-15 2018-08-31 アレルギー性気道疾患(aad)/喘息の処置方法 Pending JP2020533373A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2017903758A AU2017903758A0 (en) 2017-09-15 Method
AU2017903758 2017-09-15
PCT/AU2018/050937 WO2019051536A1 (en) 2017-09-15 2018-08-31 METHOD OF TREATING ALLERGIC RESPIRATORY TRACT DISEASE (DAA) / ASTHMA

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JP2020533373A true JP2020533373A (ja) 2020-11-19
JP2020533373A5 JP2020533373A5 (enExample) 2021-10-14

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US (1) US11471493B2 (enExample)
EP (1) EP3681519B1 (enExample)
JP (1) JP2020533373A (enExample)
KR (1) KR20200053501A (enExample)
CN (1) CN111093680A (enExample)
AR (1) AR112802A1 (enExample)
AU (1) AU2018333272B2 (enExample)
BR (1) BR112020004856A2 (enExample)
CA (1) CA3074470C (enExample)
ES (1) ES2996339T3 (enExample)
MX (1) MX2020002760A (enExample)
SG (1) SG11202001909TA (enExample)
TW (1) TWI806896B (enExample)
WO (1) WO2019051536A1 (enExample)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785969B1 (ko) * 2004-05-12 2007-12-14 동아제약주식회사 Fgf2를 유효성분으로 포함하는 천식 및 만성폐쇄성폐질환 예방 또는 치료제
AU2011343736A1 (en) * 2010-12-17 2013-05-02 Anthrogenesis Corporation Treatment of immune-related diseases and disorders using amnion derived adherent cells
RU2018128383A (ru) * 2012-03-07 2019-03-14 Янссен Байотек, Инк. Среда определенного состава для размножения и обновления плюрипотентных стволовых клеток
US20150064141A1 (en) * 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
WO2013159091A2 (en) * 2012-04-20 2013-10-24 Aptamir Therapeutics, Inc. Mirna modulators of thermogenesis
CN104471059B (zh) * 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
ES2813407T3 (es) * 2012-08-06 2021-03-23 Brainstorm Cell Therapeutics Ltd Métodos para generar células madre mesenquimales que secretan factores neurotróficos
EP2931373B1 (en) * 2012-12-12 2019-08-21 Mesoblast, Inc. Methods of treating or preventing respiratory conditions
CA3141731A1 (en) 2013-03-13 2014-10-09 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
EP3233097A4 (en) * 2014-12-19 2018-08-08 Cell Ideas Pty Ltd. Improved cell therapies
CA3017772C (en) 2016-03-16 2023-02-21 Cynata Therapeutics Limited Colony forming medium and use thereof
WO2018023170A1 (en) * 2016-08-04 2018-02-08 Hudson Institute of Medical Research A method of treatment
AU2018285953A1 (en) 2017-06-16 2020-01-16 Cynata Therapeutics Limited Method for treating a side effect of immunotherapy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROYCE SG: "Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fi", FASEB J, JPN6022026871, 16 June 2017 (2017-06-16), pages 4168 - 4178, ISSN: 0004955649 *

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Publication number Publication date
RU2020111190A3 (enExample) 2022-03-30
KR20200053501A (ko) 2020-05-18
CN111093680A (zh) 2020-05-01
TWI806896B (zh) 2023-07-01
AU2018333272A1 (en) 2020-03-05
AU2018333272B2 (en) 2022-12-08
EP3681519C0 (en) 2024-10-30
SG11202001909TA (en) 2020-04-29
EP3681519B1 (en) 2024-10-30
ES2996339T3 (en) 2025-02-12
US11471493B2 (en) 2022-10-18
RU2020111190A (ru) 2021-10-15
MX2020002760A (es) 2020-07-20
CA3074470A1 (en) 2019-03-21
US20200276243A1 (en) 2020-09-03
EP3681519A4 (en) 2021-04-28
WO2019051536A1 (en) 2019-03-21
AR112802A1 (es) 2019-12-11
TW201919666A (zh) 2019-06-01
BR112020004856A2 (pt) 2020-09-15
EP3681519A1 (en) 2020-07-22
CA3074470C (en) 2024-01-16

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