CN111093680A - 治疗变应性气道疾病(aad)/哮喘的方法 - Google Patents

治疗变应性气道疾病(aad)/哮喘的方法 Download PDF

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CN111093680A
CN111093680A CN201880059290.3A CN201880059290A CN111093680A CN 111093680 A CN111093680 A CN 111093680A CN 201880059290 A CN201880059290 A CN 201880059290A CN 111093680 A CN111093680 A CN 111093680A
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msc
asthma
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C·塞缪尔
S·罗伊斯
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Cynata Therapeutics Ltd
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CN201880059290.3A 2017-09-15 2018-08-31 治疗变应性气道疾病(aad)/哮喘的方法 Pending CN111093680A (zh)

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AU2017903758 2017-09-15
AU2017903758A AU2017903758A0 (en) 2017-09-15 Method
PCT/AU2018/050937 WO2019051536A1 (en) 2017-09-15 2018-08-31 METHOD OF TREATING ALLERGIC RESPIRATORY TRACT DISEASE (DAA) / ASTHMA

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US (1) US11471493B2 (enExample)
EP (1) EP3681519B1 (enExample)
JP (1) JP2020533373A (enExample)
KR (1) KR20200053501A (enExample)
CN (1) CN111093680A (enExample)
AR (1) AR112802A1 (enExample)
AU (1) AU2018333272B2 (enExample)
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CA (1) CA3074470C (enExample)
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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1953765A (zh) * 2004-05-12 2007-04-25 东亚制药株式会社 含有fgf2作为有效成分的治疗或预防哮喘和慢性阻塞性肺病的药剂
WO2013134378A1 (en) * 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
WO2013151725A1 (en) * 2012-04-05 2013-10-10 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
CN103403150A (zh) * 2010-12-17 2013-11-20 人类起源公司 利用羊膜来源贴壁细胞治疗与免疫相关的疾病和紊乱
CA2877223A1 (en) * 2012-08-06 2014-02-13 Brainstorm Cell Therapeutics Ltd. Methods of generating mesenchymal stem cells which secrete neurotrophic factors
CN104471059A (zh) * 2012-07-12 2015-03-25 爱姆斯坦生物技术公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
CN104704122A (zh) * 2012-04-20 2015-06-10 艾珀特玛治疗公司 产热的miRNA调节剂
CN105377274A (zh) * 2012-12-12 2016-03-02 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
WO2017156580A1 (en) * 2016-03-16 2017-09-21 Cynata Therapeutics Limited Colony forming medium and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX366900B (es) 2013-03-13 2019-07-30 Wisconsin Alumni Res Found Métodos y materiales para diferenciación hematoendotelial de células germinales pluripotentes humanas bajo condiciones definidas.
JP2018501241A (ja) * 2014-12-19 2018-01-18 セル・アイディアズ・ピーティーワイ・リミテッド 改良された細胞療法
JP2019523293A (ja) * 2016-08-04 2019-08-22 ハドソン インスティテュート オブ メディカル リサーチ 処置の方法
JP2020523400A (ja) 2017-06-16 2020-08-06 サイナータ セラピューティクス リミテッド 免疫療法の副作用を治療するための方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1953765A (zh) * 2004-05-12 2007-04-25 东亚制药株式会社 含有fgf2作为有效成分的治疗或预防哮喘和慢性阻塞性肺病的药剂
CN103403150A (zh) * 2010-12-17 2013-11-20 人类起源公司 利用羊膜来源贴壁细胞治疗与免疫相关的疾病和紊乱
WO2013134378A1 (en) * 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
WO2013151725A1 (en) * 2012-04-05 2013-10-10 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
CN104704122A (zh) * 2012-04-20 2015-06-10 艾珀特玛治疗公司 产热的miRNA调节剂
CN104471059A (zh) * 2012-07-12 2015-03-25 爱姆斯坦生物技术公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
CA2877223A1 (en) * 2012-08-06 2014-02-13 Brainstorm Cell Therapeutics Ltd. Methods of generating mesenchymal stem cells which secrete neurotrophic factors
CN105377274A (zh) * 2012-12-12 2016-03-02 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
WO2017156580A1 (en) * 2016-03-16 2017-09-21 Cynata Therapeutics Limited Colony forming medium and use thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
KOCH JM等: "Mesenchymoangioblast-derived mesenchymal stromal cells inhibit cell damage, tissue damage and improve peripheral blood flow following hindlimb ischemic injury in mice", 《CYTOTHERAPY》 *
QU YING等: "Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation", 《J CELL MOL MED》 *
ROYCE SG等: "Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease", 《FASEB J》 *
ROYCE SG等: "iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid", 《FASEB J》 *
ROYCE SG等: "Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease", 《STEM CELL RES》 *
TANG GN等: "MicroRNAs Involved in Asthma After Mesenchymal Stem Cells Treatment", 《STEM CELLS DEV》 *
VODYANIK MA 等: "A mesoderm-derived precursor for mesenchymal stem and endothelial cells", 《CELL STEM CELL》 *
任妮娜 等: "人脐带间充质干细胞移植对支气管哮喘小鼠气道炎症的作用及其机制", 《中华医学杂志》 *
王敏: "MicroRNAs调控人脂肪源性干细胞成骨分化及ODN影响其调控的研究", 《中国博士学位论文全文数据库》 *
颛孙永勋 等: "间充质干细胞对去除CD4~+CD25~+调节性T细胞哮喘小鼠气道炎症的影响", 《中国组织工程研究》 *

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KR20200053501A (ko) 2020-05-18
RU2020111190A (ru) 2021-10-15
JP2020533373A (ja) 2020-11-19
AU2018333272B2 (en) 2022-12-08
CA3074470C (en) 2024-01-16
RU2020111190A3 (enExample) 2022-03-30
EP3681519B1 (en) 2024-10-30
BR112020004856A2 (pt) 2020-09-15
CA3074470A1 (en) 2019-03-21
TW201919666A (zh) 2019-06-01
MX2020002760A (es) 2020-07-20
TWI806896B (zh) 2023-07-01
US11471493B2 (en) 2022-10-18
AR112802A1 (es) 2019-12-11
AU2018333272A1 (en) 2020-03-05
EP3681519C0 (en) 2024-10-30
ES2996339T3 (en) 2025-02-12
EP3681519A4 (en) 2021-04-28
EP3681519A1 (en) 2020-07-22
SG11202001909TA (en) 2020-04-29
WO2019051536A1 (en) 2019-03-21
US20200276243A1 (en) 2020-09-03

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