JP2020532981A5 - - Google Patents
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- Publication number
- JP2020532981A5 JP2020532981A5 JP2020512843A JP2020512843A JP2020532981A5 JP 2020532981 A5 JP2020532981 A5 JP 2020532981A5 JP 2020512843 A JP2020512843 A JP 2020512843A JP 2020512843 A JP2020512843 A JP 2020512843A JP 2020532981 A5 JP2020532981 A5 JP 2020532981A5
- Authority
- JP
- Japan
- Prior art keywords
- cedna vector
- cedna
- vector according
- stem
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022176371A JP2022190081A (ja) | 2017-09-08 | 2022-11-02 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
| JP2024189111A JP2025010253A (ja) | 2017-09-08 | 2024-10-28 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762556319P | 2017-09-08 | 2017-09-08 | |
| US201762556329P | 2017-09-08 | 2017-09-08 | |
| US201762556335P | 2017-09-08 | 2017-09-08 | |
| US201762556331P | 2017-09-08 | 2017-09-08 | |
| US201762556324P | 2017-09-08 | 2017-09-08 | |
| US201762556281P | 2017-09-08 | 2017-09-08 | |
| US62/556,331 | 2017-09-08 | ||
| US62/556,329 | 2017-09-08 | ||
| US62/556,335 | 2017-09-08 | ||
| US62/556,281 | 2017-09-08 | ||
| US62/556,319 | 2017-09-08 | ||
| US62/556,324 | 2017-09-08 | ||
| PCT/US2018/049996 WO2019051255A1 (en) | 2017-09-08 | 2018-09-07 | CLOSED-ENDED DNA (CEDNA) MODIFIED |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176371A Division JP2022190081A (ja) | 2017-09-08 | 2022-11-02 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532981A JP2020532981A (ja) | 2020-11-19 |
| JP2020532981A5 true JP2020532981A5 (enExample) | 2021-10-21 |
Family
ID=65635235
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512843A Pending JP2020532981A (ja) | 2017-09-08 | 2018-09-07 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
| JP2022176371A Pending JP2022190081A (ja) | 2017-09-08 | 2022-11-02 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
| JP2024189111A Pending JP2025010253A (ja) | 2017-09-08 | 2024-10-28 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176371A Pending JP2022190081A (ja) | 2017-09-08 | 2022-11-02 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
| JP2024189111A Pending JP2025010253A (ja) | 2017-09-08 | 2024-10-28 | 修飾型閉端ｄｎａ（ｃｅｄｎａ） |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20200283794A1 (enExample) |
| EP (1) | EP3678710A4 (enExample) |
| JP (3) | JP2020532981A (enExample) |
| KR (1) | KR20200051011A (enExample) |
| CN (1) | CN111132699A (enExample) |
| AU (1) | AU2018327348A1 (enExample) |
| BR (1) | BR112020004151A2 (enExample) |
| CA (1) | CA3075168A1 (enExample) |
| IL (1) | IL272797A (enExample) |
| MA (1) | MA50100A (enExample) |
| MX (1) | MX2020002500A (enExample) |
| PH (1) | PH12020500465A1 (enExample) |
| SG (1) | SG11202000698SA (enExample) |
| UA (1) | UA129010C2 (enExample) |
| WO (1) | WO2019051255A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| TWI904068B (zh) | 2017-08-09 | 2025-11-11 | 美商生物化學醫療公司 | 核酸分子及其用途 |
| US20220290186A1 (en) * | 2017-12-06 | 2022-09-15 | Generation Bio Co. | Gene editing using a modified closed-ended dna (cedna) |
| JP2021507561A (ja) | 2017-12-14 | 2021-02-22 | フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． | 音響トランスデューサドライバ及びコントローラ |
| AU2019221642A1 (en) * | 2018-02-14 | 2020-07-09 | Generation Bio Co. | Non-viral DNA vectors and uses thereof for antibody and fusion protein production |
| WO2020033863A1 (en) | 2018-08-09 | 2020-02-13 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
| EP3877528A4 (en) * | 2018-11-09 | 2022-11-30 | Generation Bio Co. | Modified closed-ended dna (cedna) comprising symmetrical modified inverted terminal repeats |
| GB201905651D0 (en) * | 2019-04-24 | 2019-06-05 | Lightbio Ltd | Nucleic acid constructs and methods for their manufacture |
| AU2020314865A1 (en) * | 2019-07-17 | 2021-12-23 | Generation Bio Co. | Compositions and production of nicked closed-ended DNA vectors |
| EP3999122A4 (en) * | 2019-07-17 | 2023-08-30 | Generation Bio Co. | SYNTHETIC PRODUCTION OF SINGLE-STRANDED ADENO-ASSOCIATED VIRAL DNA-LIKE VECTORS |
| CN114555084A (zh) * | 2019-08-15 | 2022-05-27 | 费城儿童医院 | 用于治疗SCA1的转基因和内含子衍生miRNA联合疗法 |
| JP7700101B2 (ja) * | 2019-09-06 | 2025-06-30 | ジェネレーション バイオ カンパニー | 閉端ｄｎａおよび切断可能脂質を含む脂質ナノ粒子組成物ならびにそれらの使用方法 |
| GB2700048B (en) * | 2019-09-18 | 2026-03-04 | Aldevron Llc | synthetic dna vectors and method of use |
| WO2021072031A1 (en) * | 2019-10-11 | 2021-04-15 | Insideoutbio, Inc. | Methods and compositions for the manufacture and use of circular dna encoded therapeutics for genetic disorders and other diseases |
| WO2021169167A1 (en) * | 2020-02-29 | 2021-09-02 | Nanjing GenScript Biotech Co., Ltd. | Method for treating coronavirus infections |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| CA3172591A1 (en) * | 2020-03-24 | 2021-09-30 | Douglas Anthony KERR | Non-viral dna vectors and uses thereof for expressing gaucher therapeutics |
| IL296660A (en) * | 2020-03-24 | 2022-11-01 | Generation Bio Co | Non-viral dna vectors and uses thereof for expressing factor ix therapeutics |
| AU2021274481A1 (en) * | 2020-05-18 | 2022-11-03 | Generation Bio Co. | Novel lipids and nanoparticle compositions thereof |
| EP4189098A1 (en) | 2020-07-27 | 2023-06-07 | Anjarium Biosciences AG | Compositions of dna molecules, methods of making therefor, and methods of use thereof |
| BR112023002395A2 (pt) | 2020-08-23 | 2023-03-21 | Bioverativ Therapeutics Inc | Sistema de baculovírus modificado para produção aprimorada de dna com extremidades fechadas (cedna) |
| US20220243201A1 (en) * | 2020-08-23 | 2022-08-04 | Bioverativ Therapeutics Inc. | Engineered itr sequences and methods of use |
| CA3191743A1 (en) * | 2020-09-16 | 2022-03-24 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing fviii therapeutics |
| IL301196A (en) * | 2020-09-16 | 2023-05-01 | Generation Bio Co | Closed-end DNA vectors and their uses for phenylalanine hydroxylase (pah) expression |
| GB202014751D0 (en) * | 2020-09-18 | 2020-11-04 | Lightbio Ltd | Targeting vector |
| US20240181085A1 (en) * | 2021-03-19 | 2024-06-06 | Generation Bio Co. | Non-viral dna vectors and uses thereof for expressing pfic therapeutics |
| WO2022232029A2 (en) * | 2021-04-26 | 2022-11-03 | University Of Florida Research Foundation, Incorporated | Synthetic aav vectors for repeated delivery of therapeutic genes |
| EP4329884A1 (en) * | 2021-04-27 | 2024-03-06 | Generation Bio Co. | Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof |
| AU2022264509A1 (en) * | 2021-04-27 | 2023-12-14 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
| EP4333886A4 (en) * | 2021-05-07 | 2025-11-12 | Generation Bio Co | NON-VIRAL DNA VECTORS FOR VACCINE ADMINISTRATION |
| US20240261395A1 (en) * | 2021-05-07 | 2024-08-08 | Generation Bio Co. | Lyophilized non-viral dna vector compositions and uses thereof |
| WO2023069948A1 (en) * | 2021-10-18 | 2023-04-27 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| CN119072330A (zh) | 2022-03-14 | 2024-12-03 | 世代生物公司 | 异源初免加强疫苗组合物和使用方法 |
| CN117802161A (zh) * | 2022-06-30 | 2024-04-02 | 苏州吉恒基因科技有限公司 | 精准重组腺相关病毒载体及其用途 |
| WO2024040222A1 (en) * | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Cleavable closed-ended dna (cedna) and methods of use thereof |
| AU2024229184A1 (en) | 2023-03-02 | 2025-08-28 | Krystal Biotech, Inc. | Interleukin-2 and interleukin-12 for cancer therapy |
| US11891617B1 (en) * | 2023-03-27 | 2024-02-06 | Genecraft Inc. | Modified complex platform of adeno-associated virus with improved rate of expression of loaded genes and reduced genotoxicity |
| US11993783B1 (en) * | 2023-03-27 | 2024-05-28 | Genecraft Inc. | Nucleic acid molecule comprising asymmetrically modified ITR for improving expression rate of inserted gene, and use thereof |
| US11767541B1 (en) * | 2023-03-27 | 2023-09-26 | Genecraft, Inc. | Adeno-associated virus complex with improved expression of RUNX3 gene and uses for preventing or treating KRAS mutated lung cancer |
| WO2024220969A2 (en) * | 2023-04-21 | 2024-10-24 | Arizona Board Of Regents On Behalf Of Arizona State University | Novel transmembrane sensors and method of characterization for lysis-free detection of intracellular targets |
| WO2025114932A1 (en) * | 2023-11-30 | 2025-06-05 | Sanofi | Purification of closed-ended dna molecules |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050019824A1 (en) * | 1994-03-08 | 2005-01-27 | Human Genome Sciences, Inc. | Fibroblast Growth Factor-10 |
| US20050026838A1 (en) * | 1995-06-05 | 2005-02-03 | Human Genome Sciences, Inc. | Fibroblast Growth Factor-13 |
| DE10066104A1 (de) * | 2000-09-08 | 2003-01-09 | Medigene Ag | Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung |
| WO2005072364A2 (en) * | 2004-01-27 | 2005-08-11 | University Of Florida | A modified baculovirus expression system for production of pseudotyped raav vector |
| WO2008016391A2 (en) * | 2006-01-31 | 2008-02-07 | The Board Of Trustees Of The Leland Stanford Junior University | Self-complementary parvoviral vectors, and methods for making and using the same |
| EP2500434A1 (en) * | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
| US9943574B2 (en) * | 2012-06-27 | 2018-04-17 | Arthrogen B.V. | Combination for treating an inflammatory disorder |
| CN104087613B (zh) * | 2014-06-30 | 2017-08-29 | 中国科学院苏州生物医学工程技术研究所 | 基于aav‑itr的基因表达微载体及其构建方法和应用 |
| IL310925A (en) * | 2016-01-15 | 2024-04-01 | American Gene Tech Int Inc | Methods and compositons for the activation of gamma-delta t-cells |
| EP3423110B1 (en) * | 2016-03-03 | 2021-08-11 | University of Massachusetts | Closed-ended linear duplex dna for non-viral gene transfer |
-
2018
- 2018-09-07 WO PCT/US2018/049996 patent/WO2019051255A1/en not_active Ceased
- 2018-09-07 EP EP18854941.4A patent/EP3678710A4/en active Pending
- 2018-09-07 SG SG11202000698SA patent/SG11202000698SA/en unknown
- 2018-09-07 CA CA3075168A patent/CA3075168A1/en active Pending
- 2018-09-07 KR KR1020207009737A patent/KR20200051011A/ko not_active Ceased
- 2018-09-07 AU AU2018327348A patent/AU2018327348A1/en not_active Abandoned
- 2018-09-07 BR BR112020004151-3A patent/BR112020004151A2/pt not_active Application Discontinuation
- 2018-09-07 MX MX2020002500A patent/MX2020002500A/es unknown
- 2018-09-07 UA UAA202000594A patent/UA129010C2/uk unknown
- 2018-09-07 CN CN201880058155.7A patent/CN111132699A/zh active Pending
- 2018-09-07 MA MA050100A patent/MA50100A/fr unknown
- 2018-09-07 US US16/644,568 patent/US20200283794A1/en not_active Abandoned
- 2018-09-07 JP JP2020512843A patent/JP2020532981A/ja active Pending
-
2020
- 2020-02-20 IL IL272797A patent/IL272797A/en unknown
- 2020-03-06 PH PH12020500465A patent/PH12020500465A1/en unknown
-
2022
- 2022-11-02 JP JP2022176371A patent/JP2022190081A/ja active Pending
-
2024
- 2024-10-28 JP JP2024189111A patent/JP2025010253A/ja active Pending
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