JP2020532955A5 - - Google Patents
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- JP2020532955A5 JP2020532955A5 JP2020506983A JP2020506983A JP2020532955A5 JP 2020532955 A5 JP2020532955 A5 JP 2020532955A5 JP 2020506983 A JP2020506983 A JP 2020506983A JP 2020506983 A JP2020506983 A JP 2020506983A JP 2020532955 A5 JP2020532955 A5 JP 2020532955A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- stranded nucleic
- chemically modified
- acid molecule
- modified double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108020004707 nucleic acids Proteins 0.000 claims 35
- 150000007523 nucleic acids Chemical class 0.000 claims 35
- 102000039446 nucleic acids Human genes 0.000 claims 35
- 210000004027 cell Anatomy 0.000 claims 19
- 230000000692 anti-sense effect Effects 0.000 claims 16
- 230000002163 immunogen Effects 0.000 claims 14
- 108091081021 Sense strand Proteins 0.000 claims 13
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 12
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 12
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 8
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- -1 Tet2 Proteins 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 230000004048 modification Effects 0.000 claims 6
- 238000012986 modification Methods 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 claims 4
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 claims 4
- 102100035273 E3 ubiquitin-protein ligase CBL-B Human genes 0.000 claims 4
- 101000737265 Homo sapiens E3 ubiquitin-protein ligase CBL-B Proteins 0.000 claims 4
- 101000617285 Homo sapiens Tyrosine-protein phosphatase non-receptor type 6 Proteins 0.000 claims 4
- 101000687343 Mus musculus PR domain zinc finger protein 1 Proteins 0.000 claims 4
- 108091008611 Protein Kinase B Proteins 0.000 claims 4
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 4
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
- 102100021657 Tyrosine-protein phosphatase non-receptor type 6 Human genes 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 210000004405 cytokine-induced killer cell Anatomy 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 3
- 101000840551 Homo sapiens Hexokinase-2 Proteins 0.000 claims 3
- 101001050577 Homo sapiens Kinesin-like protein KIF2A Proteins 0.000 claims 3
- 101001026214 Homo sapiens Potassium voltage-gated channel subfamily A member 5 Proteins 0.000 claims 3
- 101001048456 Homo sapiens Protein Hook homolog 2 Proteins 0.000 claims 3
- 102100023426 Kinesin-like protein KIF2A Human genes 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108700019146 Transgenes Proteins 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 101100243447 Arabidopsis thaliana PER53 gene Proteins 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 101150080074 TP53 gene Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023146785A JP2024028231A (ja) | 2017-08-07 | 2023-09-11 | 化学修飾されたオリゴヌクレオチド |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762542043P | 2017-08-07 | 2017-08-07 | |
| US62/542,043 | 2017-08-07 | ||
| US201762558183P | 2017-09-13 | 2017-09-13 | |
| US62/558,183 | 2017-09-13 | ||
| PCT/US2018/045671 WO2019032619A1 (en) | 2017-08-07 | 2018-08-07 | CHEMICALLY MODIFIED OLIGONUCLEOTIDES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146785A Division JP2024028231A (ja) | 2017-08-07 | 2023-09-11 | 化学修飾されたオリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020532955A JP2020532955A (ja) | 2020-11-19 |
| JP2020532955A5 true JP2020532955A5 (enExample) | 2021-08-26 |
Family
ID=65271710
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506983A Pending JP2020532955A (ja) | 2017-08-07 | 2018-08-07 | 化学修飾されたオリゴヌクレオチド |
| JP2023146785A Pending JP2024028231A (ja) | 2017-08-07 | 2023-09-11 | 化学修飾されたオリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023146785A Pending JP2024028231A (ja) | 2017-08-07 | 2023-09-11 | 化学修飾されたオリゴヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200215113A1 (enExample) |
| EP (1) | EP3664817A4 (enExample) |
| JP (2) | JP2020532955A (enExample) |
| CN (1) | CN111201024A (enExample) |
| AU (1) | AU2018313149B2 (enExample) |
| CA (1) | CA3070747A1 (enExample) |
| WO (1) | WO2019032619A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108165548B (zh) | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| US9080171B2 (en) | 2010-03-24 | 2015-07-14 | RXi Parmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
| CN103200945B (zh) | 2010-03-24 | 2016-07-06 | 雷克西制药公司 | 眼部症候中的rna干扰 |
| CN113151180A (zh) * | 2013-12-02 | 2021-07-23 | 菲奥医药公司 | 癌症的免疫治疗 |
| CA2947270A1 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic acids targeting mdm2 or mycn |
| KR102689262B1 (ko) | 2014-09-05 | 2024-07-30 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
| EP3862005A1 (en) | 2015-07-06 | 2021-08-11 | Phio Pharmaceuticals Corp. | Nucleic acid molecules targeting superoxide dismutase 1 (sod1) |
| US11021707B2 (en) | 2015-10-19 | 2021-06-01 | Phio Pharmaceuticals Corp. | Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA |
| EP4055167A2 (en) * | 2019-11-08 | 2022-09-14 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides targeting bromodomain containing protein 4 (brd4) for immunotherapy |
| US20210395366A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| CN112266911B (zh) * | 2020-08-27 | 2022-07-22 | 清华大学 | 核酸分子 |
| JP2024527049A (ja) | 2021-07-28 | 2024-07-19 | ジェネンテック， インコーポレイテッド | がんを治療するための方法及び組成物 |
| US20240301430A1 (en) * | 2021-08-04 | 2024-09-12 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides |
| WO2023015264A1 (en) | 2021-08-04 | 2023-02-09 | Phio Pharmaceuticals Corp. | Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗ｔｉｇｉｔ抗體、抗ｃｄ３８抗體及ｐｄ—１軸結合拮抗劑治療血液癌症的方法 |
| WO2023130021A1 (en) * | 2021-12-30 | 2023-07-06 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides with improved delivery properties |
| JP2025523387A (ja) | 2022-06-07 | 2025-07-23 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１アンタゴニストおよび抗ｔｉｇｉｔアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法 |
| WO2024064769A1 (en) * | 2022-09-21 | 2024-03-28 | Phio Pharmaceuticals Corp. | Induction of stem-like activated t cells |
| WO2025101204A1 (en) * | 2023-11-08 | 2025-05-15 | Phio Pharmaceuticals Corp. | Intratumoral targeting of pd-1 |
| WO2025117786A1 (en) * | 2023-11-28 | 2025-06-05 | Phio Pharmaceuticals Corp. | Enhanced combination immune checkpoint inhibition therapy utilizing rnai |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| CN108165548B (zh) * | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| EP2346883B1 (en) * | 2008-09-23 | 2016-03-23 | Scott G. Petersen | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference |
| US9745574B2 (en) * | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| EP3072977B1 (en) * | 2011-04-28 | 2018-09-19 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| CN113151180A (zh) * | 2013-12-02 | 2021-07-23 | 菲奥医药公司 | 癌症的免疫治疗 |
| JP6919118B2 (ja) * | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | ＧＦＲα−４キメラ抗原受容体を用いる癌の治療 |
| US10533173B2 (en) * | 2015-05-05 | 2020-01-14 | Jiangsu Micromedmark Biotech Co., Ltd. | Precursor miRNA and applications in tumor therapy thereof |
| AU2016322934A1 (en) * | 2015-09-14 | 2018-04-12 | Compass Therapeutics Llc | Compositions and methods for treating cancer via antagonism of the CD155/TIGIT pathway and TGF-beta |
-
2018
- 2018-08-07 AU AU2018313149A patent/AU2018313149B2/en active Active
- 2018-08-07 CN CN201880061531.8A patent/CN111201024A/zh active Pending
- 2018-08-07 EP EP18843248.8A patent/EP3664817A4/en active Pending
- 2018-08-07 CA CA3070747A patent/CA3070747A1/en active Pending
- 2018-08-07 JP JP2020506983A patent/JP2020532955A/ja active Pending
- 2018-08-07 US US16/637,514 patent/US20200215113A1/en active Pending
- 2018-08-07 WO PCT/US2018/045671 patent/WO2019032619A1/en not_active Ceased
-
2023
- 2023-09-11 JP JP2023146785A patent/JP2024028231A/ja active Pending
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