JP2020532315A - ラクトバチルス・ラムノサスlm1019菌株およびこれを含む肥満または糖尿病の予防および治療用の組成物 - Google Patents
ラクトバチルス・ラムノサスlm1019菌株およびこれを含む肥満または糖尿病の予防および治療用の組成物 Download PDFInfo
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Abstract
Description
3T3−L1脂肪前駆細胞から脂肪細胞への分化抑制および脂肪蓄積の抑制作用
韓国微生物保存センター(Korean Culture Center of Microorganisms;KCCM)に受託番号KCCM12308Pとして寄託されたラクトバチルス・ラムノサスLM1019菌株(Lactobacillus rhamnosus LM1019)の脂肪前駆細胞から脂肪細胞への分化抑制作用および細胞内の脂肪蓄積の抑制作用を確認するために、次のように実験した。
3T3−L1脂肪細胞内の中性脂肪の分解促進および蓄積抑制作用
脂肪細胞への分化過程で蓄積される細胞内の中性脂肪(TG、トリグリセリド)の量を測定するために、LM1019菌株の抽出物1%および10%を各々添加して培養し、対照群として菌株の抽出物の代わりにPBSを用いて培養した。分化9日目の脂肪細胞を収穫して用いた。
表1に示すように、LM1019の1%処理群および10%処理群では、対照群に対比して、中性脂肪減少量が各々14.1および63.4%に確認された。
脂肪分解酵素(リパーゼ)の活性測定
LM1019菌株の脂肪分解酵素(リパーゼ)の活性を確認するために、次のように実験した。
実験動物における抗肥満効果の実験
マウスにおける抗肥満効果を確認するために、5週齢のC57BL6/Jマウスを1週間馴致した後、3群に分けて実験を行った。
0週目の体重を100%にして時間に応じた体重増加率を測定して図2に示す。図2に示すように、第3群(HFDおよびLM1019の投与群)は、第2群(HFD)と比較して、1週後から体重増加率に差を示した。
8週間の体重増加量、週当たりの食餌摂取量、カロリー摂取量、食餌効率を下記表3に示す。
8週間の皮下脂肪、副睾丸脂肪および褐色脂肪組織の量を測定して下記表4に示す。
8週間の肝臓、脾臓および腎臓の重さを測定して下記表5に示す。
肝臓をH&E stainで染色してmacro fat vacuoleの有無(X20倍率およびX40倍率)を観察して図6に示す。
8週間の血中グルコース、中性脂肪およびコレステロール数値を測定して下記表6に示す。
8週間のインスリンおよびレプチンの数値を測定して下記表7に示す。
8週間LM1019菌株を投与したマウスの肝臓および副睾丸脂肪を摘出してTrizol(Thermo scientific、USA)を用いてRNAを抽出した。その後、PrimeScriptTM 1st strand cDNA Synthesis kit(TAKARA、Japan)を用いてRNAに相補的なDNAを得た後、SYBR green(TAKARA、Japan)を用いて脂肪酸化と関連した遺伝子であるCPT2の発現をリアルタイムPCRにより確認した。
CTP遺伝子の発現実験時に製作したRNAに相補的のDNAを用いて肝臓内の肥満関連遺伝子であるSCD1、FASおよびSREBP1の発現をリアルタイムPCRにより確認した。
Claims (9)
- ラクトバチルス・ラムノサスLM1019(Lactobacillus rhamnosus LM1019)菌株(KCCM12308P)。
- 肥満および糖尿病を同時に予防または治療する効能があるラクトバチルス・ラムノサスLM1019(Lactobacillus rhamnosus LM1019)菌株(KCCM12308P)。
- ラクトバチルス・ラムノサスLM1019菌株(KCCM12308P)を含み、前記ラクトバチルス・ラムノサスLM1019菌株が小腸細胞または消化管において脂肪分解阻害効果および食欲調節効果を同時に示すことを特徴とする、肥満または糖尿病の予防または治療用の薬学組成物。
- 脂肪分解阻害は、リパーゼの活性を抑制することによって達成されることを特徴とする、請求項3に記載の肥満または糖尿病の予防または治療用の薬学組成物。
- 食欲調節は、レプチンホルモンの分泌を減少させることによって達成されることを特徴とする、請求項3に記載の肥満または糖尿病の予防または治療用の薬学組成物。
- 前記ラクトバチルス・ラムノサスLM1019菌株がインスリン抵抗性を減少させることを特徴とする、請求項3に記載の肥満または糖尿病の予防または治療用の薬学組成物。
- ラクトバチルス・ラムノサスLM1019菌株(KCCM12308P)を含み、前記ラクトバチルス・ラムノサスLM1019菌株が小腸細胞または消化管において脂肪分解阻害効果および食欲調節効果を同時に示すことを特徴とする、肥満または糖尿病の予防または改善用の食品組成物。
- 前記食品組成物は、健康機能食品、乳製品、発酵製品または食品添加物であることを特徴とする、請求項7に記載の肥満または糖尿病の予防または改善用の食品組成物。
- ラクトバチルス・ラムノサスLM1019菌株(KCCM12308P)を含み、前記ラクトバチルス・ラムノサスLM1019菌株が小腸細胞または消化管において脂肪分解阻害効果および食欲調節効果を同時に示すことを特徴とする、肥満または糖尿病の予防または改善のための動物用飼料組成物。
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CN111801413A (zh) | 2020-10-20 |
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JP6864784B2 (ja) | 2021-04-28 |
US20210106630A1 (en) | 2021-04-15 |
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