JP2020532300A5 - - Google Patents
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- JP2020532300A5 JP2020532300A5 JP2020512512A JP2020512512A JP2020532300A5 JP 2020532300 A5 JP2020532300 A5 JP 2020532300A5 JP 2020512512 A JP2020512512 A JP 2020512512A JP 2020512512 A JP2020512512 A JP 2020512512A JP 2020532300 A5 JP2020532300 A5 JP 2020532300A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 80
- 238000000034 method Methods 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 45
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 43
- 206010028980 Neoplasm Diseases 0.000 claims description 39
- 201000011510 cancer Diseases 0.000 claims description 39
- 210000004027 cell Anatomy 0.000 claims description 38
- 101000795167 Homo sapiens Tumor necrosis factor receptor superfamily member 13B Proteins 0.000 claims description 30
- 102100029675 Tumor necrosis factor receptor superfamily member 13B Human genes 0.000 claims description 30
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 29
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 29
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 28
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 21
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 239000002105 nanoparticle Substances 0.000 claims description 15
- 239000002671 adjuvant Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 210000004443 dendritic cell Anatomy 0.000 claims description 10
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000009016 Cholera Toxin Human genes 0.000 claims description 6
- 108010049048 Cholera Toxin Proteins 0.000 claims description 6
- 208000034578 Multiple myelomas Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 210000004748 cultured cell Anatomy 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 5
- 210000004180 plasmocyte Anatomy 0.000 claims description 5
- 230000002062 proliferating effect Effects 0.000 claims description 5
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 4
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 4
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 201000005787 hematologic cancer Diseases 0.000 claims description 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 4
- 239000003446 ligand Substances 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims description 3
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims description 3
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 3
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims description 3
- 229960004942 lenalidomide Drugs 0.000 claims description 3
- 241000702421 Dependoparvovirus Species 0.000 claims description 2
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 2
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims description 2
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims description 2
- 206010020631 Hypergammaglobulinaemia benign monoclonal Diseases 0.000 claims description 2
- 102000006992 Interferon-alpha Human genes 0.000 claims description 2
- 108010047761 Interferon-alpha Proteins 0.000 claims description 2
- 102000008070 Interferon-gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 241000713666 Lentivirus Species 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 102000043129 MHC class I family Human genes 0.000 claims description 2
- 108091054437 MHC class I family Proteins 0.000 claims description 2
- 206010060880 Monoclonal gammopathy Diseases 0.000 claims description 2
- 239000012648 POLY-ICLC Substances 0.000 claims description 2
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 claims description 2
- 108091008874 T cell receptors Proteins 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 102000002689 Toll-like receptor Human genes 0.000 claims description 2
- 108020000411 Toll-like receptor Proteins 0.000 claims description 2
- 102000008230 Toll-like receptor 3 Human genes 0.000 claims description 2
- 108010060885 Toll-like receptor 3 Proteins 0.000 claims description 2
- 229940037003 alum Drugs 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 229920002988 biodegradable polymer Polymers 0.000 claims description 2
- 239000004621 biodegradable polymer Substances 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 229960001438 immunostimulant agent Drugs 0.000 claims description 2
- 239000003022 immunostimulating agent Substances 0.000 claims description 2
- 230000003308 immunostimulating effect Effects 0.000 claims description 2
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- 229960003130 interferon gamma Drugs 0.000 claims description 2
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- 239000002502 liposome Substances 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
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- 201000005328 monoclonal gammopathy of uncertain significance Diseases 0.000 claims description 2
- 108700002563 poly ICLC Proteins 0.000 claims description 2
- 229940115270 poly iclc Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
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- 208000010721 smoldering plasma cell myeloma Diseases 0.000 claims description 2
- 229960000814 tetanus toxoid Drugs 0.000 claims description 2
- 239000003970 toll like receptor agonist Substances 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 102100033726 Tumor necrosis factor receptor superfamily member 17 Human genes 0.000 claims 9
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- -1 immunoagonists Substances 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 21
- 239000000556 agonist Substances 0.000 description 6
- 210000005087 mononuclear cell Anatomy 0.000 description 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 4
- 108010092262 T-Cell Antigen Receptors Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 2
- 108010075704 HLA-A Antigens Proteins 0.000 description 2
- 102000011786 HLA-A Antigens Human genes 0.000 description 2
- 102000004388 Interleukin-4 Human genes 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
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- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 229940028885 interleukin-4 Drugs 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 229940046168 CpG oligodeoxynucleotide Drugs 0.000 description 1
- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 description 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023192306A JP7644200B2 (ja) | 2017-09-01 | 2023-11-10 | Ｂｃｍａ抗原に特異的な免疫原性ペプチドおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553669P | 2017-09-01 | 2017-09-01 | |
| US62/553,669 | 2017-09-01 | ||
| PCT/US2018/049260 WO2019046818A1 (en) | 2017-09-01 | 2018-08-31 | SPECIFIC IMMUNOGENIC PEPTIDES OF BCMA AND TACI ANTIGENS FOR THE TREATMENT OF CANCER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023192306A Division JP7644200B2 (ja) | 2017-09-01 | 2023-11-10 | Ｂｃｍａ抗原に特異的な免疫原性ペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532300A JP2020532300A (ja) | 2020-11-12 |
| JP2020532300A5 true JP2020532300A5 (https=) | 2021-10-07 |
| JP7385556B2 JP7385556B2 (ja) | 2023-11-22 |
Family
ID=63678690
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512512A Active JP7385556B2 (ja) | 2017-09-01 | 2018-08-31 | Ｂｃｍａ抗原に特異的な免疫原性ペプチドおよびその使用 |
| JP2023192306A Active JP7644200B2 (ja) | 2017-09-01 | 2023-11-10 | Ｂｃｍａ抗原に特異的な免疫原性ペプチドおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023192306A Active JP7644200B2 (ja) | 2017-09-01 | 2023-11-10 | Ｂｃｍａ抗原に特異的な免疫原性ペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11517591B2 (https=) |
| EP (1) | EP3675897A1 (https=) |
| JP (2) | JP7385556B2 (https=) |
| KR (1) | KR102794702B1 (https=) |
| CN (1) | CN111655280B (https=) |
| AU (2) | AU2018326805B2 (https=) |
| CA (1) | CA3070468A1 (https=) |
| WO (1) | WO2019046818A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018111981A1 (en) * | 2016-12-13 | 2018-06-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of preparing an isolated or purified population of thymic emigrant cells and methods of treatment using same |
| US12448429B2 (en) | 2019-03-06 | 2025-10-21 | Dana-Farber Cancer Institute, Inc. | T cell receptors specific to b-cell maturation antigen for treatment of cancer |
| JP7748393B2 (ja) | 2020-05-08 | 2025-10-02 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ａｐｒｉｌおよびｂａｆｆ阻害免疫調節タンパク質、ならびにその使用方法 |
| US20240285740A1 (en) | 2021-05-12 | 2024-08-29 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating cancer |
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2018
- 2018-08-31 CN CN201880067594.4A patent/CN111655280B/zh active Active
- 2018-08-31 AU AU2018326805A patent/AU2018326805B2/en active Active
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