JP2020531529A5 - - Google Patents
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- Publication number
- JP2020531529A5 JP2020531529A5 JP2020511359A JP2020511359A JP2020531529A5 JP 2020531529 A5 JP2020531529 A5 JP 2020531529A5 JP 2020511359 A JP2020511359 A JP 2020511359A JP 2020511359 A JP2020511359 A JP 2020511359A JP 2020531529 A5 JP2020531529 A5 JP 2020531529A5
- Authority
- JP
- Japan
- Prior art keywords
- organ
- perfusion system
- organ perfusion
- ppm
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000000056 organ Anatomy 0.000 claims description 112
- 230000010412 perfusion Effects 0.000 claims description 64
- 239000007789 gas Substances 0.000 claims description 23
- 238000002054 transplantation Methods 0.000 claims description 9
- 208000007204 Brain death Diseases 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 210000004087 cornea Anatomy 0.000 claims description 6
- 210000002216 heart Anatomy 0.000 claims description 6
- 210000000936 intestine Anatomy 0.000 claims description 6
- 210000003734 kidney Anatomy 0.000 claims description 6
- 210000004185 liver Anatomy 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 6
- 230000002438 mitochondrial effect Effects 0.000 claims description 6
- 230000004898 mitochondrial function Effects 0.000 claims description 6
- 210000000496 pancreas Anatomy 0.000 claims description 6
- 239000003642 reactive oxygen metabolite Substances 0.000 claims description 6
- 210000001541 thymus gland Anatomy 0.000 claims description 6
- 230000035899 viability Effects 0.000 claims description 3
- 208000028867 ischemia Diseases 0.000 claims description 2
- 238000000034 method Methods 0.000 description 52
- 230000004083 survival effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022123251A JP2022140622A (ja) | 2017-08-25 | 2022-08-02 | 器官の生存率を改善する方法 |
| JP2024137625A JP2024159817A (ja) | 2017-08-25 | 2024-08-19 | 器官の生存率を改善する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762550463P | 2017-08-25 | 2017-08-25 | |
| US62/550,463 | 2017-08-25 | ||
| PCT/US2018/048028 WO2019040921A1 (en) | 2017-08-25 | 2018-08-24 | METHODS OF ENHANCING VIABILITY OF AN ORGAN |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022123251A Division JP2022140622A (ja) | 2017-08-25 | 2022-08-02 | 器官の生存率を改善する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531529A JP2020531529A (ja) | 2020-11-05 |
| JP2020531529A5 true JP2020531529A5 (enExample) | 2021-08-05 |
| JP7249331B2 JP7249331B2 (ja) | 2023-03-30 |
Family
ID=65434015
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511359A Active JP7249331B2 (ja) | 2017-08-25 | 2018-08-24 | 器官の生存率を改善する方法 |
| JP2022123251A Pending JP2022140622A (ja) | 2017-08-25 | 2022-08-02 | 器官の生存率を改善する方法 |
| JP2024137625A Pending JP2024159817A (ja) | 2017-08-25 | 2024-08-19 | 器官の生存率を改善する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022123251A Pending JP2022140622A (ja) | 2017-08-25 | 2022-08-02 | 器官の生存率を改善する方法 |
| JP2024137625A Pending JP2024159817A (ja) | 2017-08-25 | 2024-08-19 | 器官の生存率を改善する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US11044904B2 (enExample) |
| EP (1) | EP3672403A4 (enExample) |
| JP (3) | JP7249331B2 (enExample) |
| KR (2) | KR102708577B1 (enExample) |
| CN (1) | CN111107742A (enExample) |
| AU (2) | AU2018322317B2 (enExample) |
| CA (1) | CA3073399A1 (enExample) |
| MX (1) | MX2020001853A (enExample) |
| WO (1) | WO2019040921A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3030789A1 (en) | 2016-07-13 | 2018-01-18 | The Trustees Of Columbia University In The City Of New York | Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs |
| AU2018322317B2 (en) * | 2017-08-25 | 2023-11-23 | Mallinckrodt Pharmaceuticals Ireland Limited | Methods to improve organ viability |
| CN110583620A (zh) * | 2019-08-26 | 2019-12-20 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 离体肺脏机械灌注的调温设备及方法、装置 |
| CN112106766B (zh) * | 2020-11-18 | 2021-03-12 | 中山大学附属第一医院 | 一种离体心肺联合灌注系统及灌注方法 |
| CN118142012B (zh) * | 2024-03-20 | 2025-05-13 | 中国人民解放军总医院第四医学中心 | 离断肢体血液交叉循环系统 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338662A (en) * | 1992-09-21 | 1994-08-16 | Bio-Preserve Medical Corporation | Organ perfusion device |
| GB9908335D0 (en) * | 1999-04-12 | 1999-06-09 | Univ Cambridge Tech | Methods and means for extracorporeal organ perfusion |
| AU2001241908A1 (en) * | 2000-03-08 | 2001-09-17 | Frederick A. Gage | Kidney perfusion solution containing nitric oxide donor |
| MXPA03012031A (es) | 2001-06-21 | 2005-07-01 | Univ Yale | El monoxido de carbono mejoraresultados en transplantes de tejido y organo y suprime apoptosis. |
| US7504201B2 (en) * | 2004-04-05 | 2009-03-17 | Organ Recovery Systems | Method for perfusing an organ and for isolating cells from the organ |
| US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| JP4935242B2 (ja) * | 2006-08-24 | 2012-05-23 | ニプロ株式会社 | 脂肪酸を含有するs−ニトロソタンパク質とその製法 |
| WO2008063868A2 (en) | 2006-11-07 | 2008-05-29 | The General Hospital Corporation | Attenuation of vasoactive oxygen carrier-induced vasoconstriction |
| JP2010530001A (ja) | 2007-06-15 | 2010-09-02 | イカリア, インコーポレイテッド | 硫化物単独または一酸化窒素との組み合わせを含む組成物およびその使用 |
| AU2011336358B2 (en) | 2010-12-03 | 2016-09-29 | VERO Biotech LLC. | Nitric oxide treatments |
| US9629358B2 (en) * | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
| JP2019505569A (ja) | 2015-12-10 | 2019-02-28 | ベロ バイオテック エルエルシー | 血漿遊離ヘモグロビンを除去するための方法及び装置 |
| DE102017204681A1 (de) | 2017-03-21 | 2018-09-27 | Robert Bosch Gmbh | Vorrichtung zum Auslösen einer externen Schutzfunktion |
| AU2018322317B2 (en) * | 2017-08-25 | 2023-11-23 | Mallinckrodt Pharmaceuticals Ireland Limited | Methods to improve organ viability |
-
2018
- 2018-08-24 AU AU2018322317A patent/AU2018322317B2/en active Active
- 2018-08-24 WO PCT/US2018/048028 patent/WO2019040921A1/en not_active Ceased
- 2018-08-24 EP EP18848433.1A patent/EP3672403A4/en active Pending
- 2018-08-24 CA CA3073399A patent/CA3073399A1/en active Pending
- 2018-08-24 KR KR1020207007478A patent/KR102708577B1/ko active Active
- 2018-08-24 US US16/112,297 patent/US11044904B2/en active Active
- 2018-08-24 CN CN201880059363.9A patent/CN111107742A/zh active Pending
- 2018-08-24 JP JP2020511359A patent/JP7249331B2/ja active Active
- 2018-08-24 MX MX2020001853A patent/MX2020001853A/es unknown
- 2018-08-24 KR KR1020247031003A patent/KR20240142604A/ko active Pending
-
2021
- 2021-06-28 US US17/360,916 patent/US11950590B2/en active Active
-
2022
- 2022-08-02 JP JP2022123251A patent/JP2022140622A/ja active Pending
-
2024
- 2024-01-10 US US18/409,181 patent/US12285008B2/en active Active
- 2024-01-25 AU AU2024200468A patent/AU2024200468A1/en active Pending
- 2024-08-19 JP JP2024137625A patent/JP2024159817A/ja active Pending
-
2025
- 2025-04-02 US US19/098,522 patent/US20250228235A1/en active Pending
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