KR102708577B1 - 기관 생존력을 개선시키는 방법 - Google Patents

기관 생존력을 개선시키는 방법 Download PDF

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Publication number
KR102708577B1
KR102708577B1 KR1020207007478A KR20207007478A KR102708577B1 KR 102708577 B1 KR102708577 B1 KR 102708577B1 KR 1020207007478 A KR1020207007478 A KR 1020207007478A KR 20207007478 A KR20207007478 A KR 20207007478A KR 102708577 B1 KR102708577 B1 KR 102708577B1
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South Korea
Prior art keywords
organ
ppm
composition
perfusion system
gas
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Korean (ko)
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KR20200041359A (ko
Inventor
짐 포텐지아노
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말린크로트 파마슈티칼스 아일랜드 리미티드
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Priority to KR1020247031003A priority Critical patent/KR20240142604A/ko
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    • A01N1/0247—
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A01N1/0226—
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00969—Surgical instruments, devices or methods used for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
KR1020207007478A 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법 Active KR102708577B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247031003A KR20240142604A (ko) 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550463P 2017-08-25 2017-08-25
US62/550,463 2017-08-25
PCT/US2018/048028 WO2019040921A1 (en) 2017-08-25 2018-08-24 METHODS OF ENHANCING VIABILITY OF AN ORGAN

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247031003A Division KR20240142604A (ko) 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법

Publications (2)

Publication Number Publication Date
KR20200041359A KR20200041359A (ko) 2020-04-21
KR102708577B1 true KR102708577B1 (ko) 2024-09-24

Family

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KR1020207007478A Active KR102708577B1 (ko) 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법
KR1020247031003A Pending KR20240142604A (ko) 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020247031003A Pending KR20240142604A (ko) 2017-08-25 2018-08-24 기관 생존력을 개선시키는 방법

Country Status (9)

Country Link
US (4) US11044904B2 (enExample)
EP (1) EP3672403A4 (enExample)
JP (3) JP7249331B2 (enExample)
KR (2) KR102708577B1 (enExample)
CN (1) CN111107742A (enExample)
AU (2) AU2018322317B2 (enExample)
CA (1) CA3073399A1 (enExample)
MX (1) MX2020001853A (enExample)
WO (1) WO2019040921A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3030789A1 (en) 2016-07-13 2018-01-18 The Trustees Of Columbia University In The City Of New York Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
AU2018322317B2 (en) * 2017-08-25 2023-11-23 Mallinckrodt Pharmaceuticals Ireland Limited Methods to improve organ viability
CN110583620A (zh) * 2019-08-26 2019-12-20 广东顺德工业设计研究院(广东顺德创新设计研究院) 离体肺脏机械灌注的调温设备及方法、装置
CN112106766B (zh) * 2020-11-18 2021-03-12 中山大学附属第一医院 一种离体心肺联合灌注系统及灌注方法
CN118142012B (zh) * 2024-03-20 2025-05-13 中国人民解放军总医院第四医学中心 离断肢体血液交叉循环系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170215411A1 (en) * 2013-03-15 2017-08-03 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids

Family Cites Families (13)

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US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
GB9908335D0 (en) * 1999-04-12 1999-06-09 Univ Cambridge Tech Methods and means for extracorporeal organ perfusion
AU2001241908A1 (en) * 2000-03-08 2001-09-17 Frederick A. Gage Kidney perfusion solution containing nitric oxide donor
MXPA03012031A (es) 2001-06-21 2005-07-01 Univ Yale El monoxido de carbono mejoraresultados en transplantes de tejido y organo y suprime apoptosis.
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US20060160062A1 (en) * 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
JP4935242B2 (ja) * 2006-08-24 2012-05-23 ニプロ株式会社 脂肪酸を含有するｓ−ニトロソタンパク質とその製法
WO2008063868A2 (en) 2006-11-07 2008-05-29 The General Hospital Corporation Attenuation of vasoactive oxygen carrier-induced vasoconstriction
JP2010530001A (ja) 2007-06-15 2010-09-02 イカリア， インコーポレイテッド 硫化物単独または一酸化窒素との組み合わせを含む組成物およびその使用
AU2011336358B2 (en) 2010-12-03 2016-09-29 VERO Biotech LLC. Nitric oxide treatments
JP2019505569A (ja) 2015-12-10 2019-02-28 ベロ バイオテック エルエルシー 血漿遊離ヘモグロビンを除去するための方法及び装置
DE102017204681A1 (de) 2017-03-21 2018-09-27 Robert Bosch Gmbh Vorrichtung zum Auslösen einer externen Schutzfunktion
AU2018322317B2 (en) * 2017-08-25 2023-11-23 Mallinckrodt Pharmaceuticals Ireland Limited Methods to improve organ viability

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170215411A1 (en) * 2013-03-15 2017-08-03 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids

Also Published As

Publication number Publication date
EP3672403A4 (en) 2021-05-19
JP7249331B2 (ja) 2023-03-30
KR20240142604A (ko) 2024-09-30
JP2020531529A (ja) 2020-11-05
AU2018322317A1 (en) 2020-03-12
AU2024200468A1 (en) 2024-02-15
US12285008B2 (en) 2025-04-29
CA3073399A1 (en) 2019-02-28
US20190059359A1 (en) 2019-02-28
US11950590B2 (en) 2024-04-09
US20240138399A1 (en) 2024-05-02
US20250228235A1 (en) 2025-07-17
US20210321605A1 (en) 2021-10-21
JP2022140622A (ja) 2022-09-26
MX2020001853A (es) 2020-08-03
US11044904B2 (en) 2021-06-29
EP3672403A1 (en) 2020-07-01
CN111107742A (zh) 2020-05-05
AU2018322317B2 (en) 2023-11-23
KR20200041359A (ko) 2020-04-21
WO2019040921A1 (en) 2019-02-28
JP2024159817A (ja) 2024-11-08

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