CN111107742A - 提高器官生存能力的方法 - Google Patents

提高器官生存能力的方法 Download PDF

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Publication number
CN111107742A
CN111107742A CN201880059363.9A CN201880059363A CN111107742A CN 111107742 A CN111107742 A CN 111107742A CN 201880059363 A CN201880059363 A CN 201880059363A CN 111107742 A CN111107742 A CN 111107742A
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CN
China
Prior art keywords
organ
composition
gas
20ppm
perfusion solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880059363.9A
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English (en)
Chinese (zh)
Inventor
J·普朗西亚诺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Hospital Products IP Unlimited Co
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Mallinckrodt Hospital Products IP Unlimited Co
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Filing date
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Application filed by Mallinckrodt Hospital Products IP Unlimited Co filed Critical Mallinckrodt Hospital Products IP Unlimited Co
Publication of CN111107742A publication Critical patent/CN111107742A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00969—Surgical instruments, devices or methods used for transplantation

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
CN201880059363.9A 2017-08-25 2018-08-24 提高器官生存能力的方法 Pending CN111107742A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762550463P 2017-08-25 2017-08-25
US62/550,463 2017-08-25
PCT/US2018/048028 WO2019040921A1 (en) 2017-08-25 2018-08-24 METHODS OF ENHANCING VIABILITY OF AN ORGAN

Publications (1)

Publication Number Publication Date
CN111107742A true CN111107742A (zh) 2020-05-05

Family

ID=65434015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880059363.9A Pending CN111107742A (zh) 2017-08-25 2018-08-24 提高器官生存能力的方法

Country Status (9)

Country Link
US (4) US11044904B2 (enExample)
EP (1) EP3672403A4 (enExample)
JP (3) JP7249331B2 (enExample)
KR (2) KR102708577B1 (enExample)
CN (1) CN111107742A (enExample)
AU (2) AU2018322317B2 (enExample)
CA (1) CA3073399A1 (enExample)
MX (1) MX2020001853A (enExample)
WO (1) WO2019040921A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118142012A (zh) * 2024-03-20 2024-06-07 中国人民解放军总医院第四医学中心 离断肢体血液交叉循环系统

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3030789A1 (en) 2016-07-13 2018-01-18 The Trustees Of Columbia University In The City Of New York Cross-circulation platform for recovery, regeneration, and maintenance of extracorporeal organs
AU2018322317B2 (en) * 2017-08-25 2023-11-23 Mallinckrodt Pharmaceuticals Ireland Limited Methods to improve organ viability
CN110583620A (zh) * 2019-08-26 2019-12-20 广东顺德工业设计研究院(广东顺德创新设计研究院) 离体肺脏机械灌注的调温设备及方法、装置
CN112106766B (zh) * 2020-11-18 2021-03-12 中山大学附属第一医院 一种离体心肺联合灌注系统及灌注方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494822A (en) * 1992-09-21 1996-02-27 Bio-Preserve Medical Corporation Organ perfusion device
US20050221269A1 (en) * 2004-04-05 2005-10-06 Organ Recovery Systems Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue
US7238469B2 (en) * 2001-06-21 2007-07-03 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
US7410474B1 (en) * 1999-04-12 2008-08-12 Isis Innovation Limited Methods and means for extracorporeal organ perfusion
US8084195B2 (en) * 2005-01-14 2011-12-27 Philadelphia College Of Osteopathic Medicine Method of perfusing an organ with a solution comprising a peptide which inhibits protein kinase C βII
US20170215411A1 (en) * 2013-03-15 2017-08-03 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001241908A1 (en) * 2000-03-08 2001-09-17 Frederick A. Gage Kidney perfusion solution containing nitric oxide donor
JP4935242B2 (ja) * 2006-08-24 2012-05-23 ニプロ株式会社 脂肪酸を含有するｓ−ニトロソタンパク質とその製法
WO2008063868A2 (en) 2006-11-07 2008-05-29 The General Hospital Corporation Attenuation of vasoactive oxygen carrier-induced vasoconstriction
JP2010530001A (ja) 2007-06-15 2010-09-02 イカリア， インコーポレイテッド 硫化物単独または一酸化窒素との組み合わせを含む組成物およびその使用
AU2011336358B2 (en) 2010-12-03 2016-09-29 VERO Biotech LLC. Nitric oxide treatments
JP2019505569A (ja) 2015-12-10 2019-02-28 ベロ バイオテック エルエルシー 血漿遊離ヘモグロビンを除去するための方法及び装置
DE102017204681A1 (de) 2017-03-21 2018-09-27 Robert Bosch Gmbh Vorrichtung zum Auslösen einer externen Schutzfunktion
AU2018322317B2 (en) * 2017-08-25 2023-11-23 Mallinckrodt Pharmaceuticals Ireland Limited Methods to improve organ viability

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494822A (en) * 1992-09-21 1996-02-27 Bio-Preserve Medical Corporation Organ perfusion device
US7410474B1 (en) * 1999-04-12 2008-08-12 Isis Innovation Limited Methods and means for extracorporeal organ perfusion
US7238469B2 (en) * 2001-06-21 2007-07-03 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
US20050221269A1 (en) * 2004-04-05 2005-10-06 Organ Recovery Systems Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue
US8084195B2 (en) * 2005-01-14 2011-12-27 Philadelphia College Of Osteopathic Medicine Method of perfusing an organ with a solution comprising a peptide which inhibits protein kinase C βII
US20170215411A1 (en) * 2013-03-15 2017-08-03 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118142012A (zh) * 2024-03-20 2024-06-07 中国人民解放军总医院第四医学中心 离断肢体血液交叉循环系统

Also Published As

Publication number Publication date
EP3672403A4 (en) 2021-05-19
JP7249331B2 (ja) 2023-03-30
KR20240142604A (ko) 2024-09-30
JP2020531529A (ja) 2020-11-05
AU2018322317A1 (en) 2020-03-12
KR102708577B1 (ko) 2024-09-24
AU2024200468A1 (en) 2024-02-15
US12285008B2 (en) 2025-04-29
CA3073399A1 (en) 2019-02-28
US20190059359A1 (en) 2019-02-28
US11950590B2 (en) 2024-04-09
US20240138399A1 (en) 2024-05-02
US20250228235A1 (en) 2025-07-17
US20210321605A1 (en) 2021-10-21
JP2022140622A (ja) 2022-09-26
MX2020001853A (es) 2020-08-03
US11044904B2 (en) 2021-06-29
EP3672403A1 (en) 2020-07-01
AU2018322317B2 (en) 2023-11-23
KR20200041359A (ko) 2020-04-21
WO2019040921A1 (en) 2019-02-28
JP2024159817A (ja) 2024-11-08

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