JP2020531523A5 - - Google Patents

Info

Publication number

JP2020531523A5

JP2020531523A5 JP2020511307A JP2020511307A JP2020531523A5 JP 2020531523 A5 JP2020531523 A5 JP 2020531523A5 JP 2020511307 A JP2020511307 A JP 2020511307A JP 2020511307 A JP2020511307 A JP 2020511307A JP 2020531523 A5 JP2020531523 A5 JP 2020531523A5

Authority

JP

Japan

Prior art keywords

pharmaceutical preparation

preparation according

period

weeks

administered

Prior art date

2018-08-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000825 pharmaceutical preparation Substances 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
• 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 238000012423 maintenance Methods 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 4
• 102000036639 antigens Human genes 0.000 claims 4
• 108091007433 antigens Proteins 0.000 claims 4
• 239000004475 Arginine Substances 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 229960003121 arginine Drugs 0.000 claims 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
• 235000009697 arginine Nutrition 0.000 claims 2
• 230000006698 induction Effects 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
• 229920000053 polysorbate 80 Polymers 0.000 claims 2
• 229940068968 polysorbate 80 Drugs 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• KWTQSFXGGICVPE-WCCKRBBISA-N Arginine hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCCN=C(N)N KWTQSFXGGICVPE-WCCKRBBISA-N 0.000 claims 1
• 101001056015 Homo sapiens Mannan-binding lectin serine protease 2 Proteins 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 102000054960 human MASP2 Human genes 0.000 claims 1
• 230000002045 lasting effect Effects 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 239000001509 sodium citrate Substances 0.000 claims 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1