TW201925224A - 高濃縮低黏度masp-2抑制性抗體製劑、試劑盒和治療患有非典型溶血綜合症的受試者的方法 - Google Patents

高濃縮低黏度masp-2抑制性抗體製劑、試劑盒和治療患有非典型溶血綜合症的受試者的方法 Download PDF

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Publication number
TW201925224A
TW201925224A TW107129307A TW107129307A TW201925224A TW 201925224 A TW201925224 A TW 201925224A TW 107129307 A TW107129307 A TW 107129307A TW 107129307 A TW107129307 A TW 107129307A TW 201925224 A TW201925224 A TW 201925224A
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Taiwan
Prior art keywords
masp
formulation
antibody
oms646
viscosity
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TW107129307A
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English (en)
Chinese (zh)
Inventor
格雷戈里 戴莫普勒
肯尼斯 佛格森
威廉 藍伯特
約翰 懷塔克
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美商歐米諾斯公司
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Publication of TW201925224A publication Critical patent/TW201925224A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
TW107129307A 2017-08-25 2018-08-22 高濃縮低黏度masp-2抑制性抗體製劑、試劑盒和治療患有非典型溶血綜合症的受試者的方法 TW201925224A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762550328P 2017-08-25 2017-08-25
US62/550,328 2017-08-25

Publications (1)

Publication Number Publication Date
TW201925224A true TW201925224A (zh) 2019-07-01

Family

ID=65436837

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107129307A TW201925224A (zh) 2017-08-25 2018-08-22 高濃縮低黏度masp-2抑制性抗體製劑、試劑盒和治療患有非典型溶血綜合症的受試者的方法

Country Status (15)

Country Link
US (2) US20190062455A1 (cg-RX-API-DMAC7.html)
EP (1) EP3672994A4 (cg-RX-API-DMAC7.html)
JP (1) JP2020531523A (cg-RX-API-DMAC7.html)
KR (1) KR20200037863A (cg-RX-API-DMAC7.html)
CN (1) CN111278863A (cg-RX-API-DMAC7.html)
AU (1) AU2018322032B2 (cg-RX-API-DMAC7.html)
BR (1) BR112020003632A2 (cg-RX-API-DMAC7.html)
CA (1) CA3072913A1 (cg-RX-API-DMAC7.html)
CL (1) CL2020000397A1 (cg-RX-API-DMAC7.html)
IL (1) IL272673B2 (cg-RX-API-DMAC7.html)
MA (1) MA49960A (cg-RX-API-DMAC7.html)
MX (1) MX2020002077A (cg-RX-API-DMAC7.html)
RU (1) RU2020111574A (cg-RX-API-DMAC7.html)
TW (1) TW201925224A (cg-RX-API-DMAC7.html)
WO (1) WO2019040453A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL292899A (en) * 2019-11-15 2022-07-01 Hoffmann La Roche Prevention of visible particle formation in aqueous protein solutions
TW202135860A (zh) * 2019-12-10 2021-10-01 美商再生元醫藥公司 含有抗cd20x抗cd3雙特異性抗體之穩定調配物
JP2023537316A (ja) * 2020-07-31 2023-08-31 アラマブ セラピューティクス, インコーポレイテッド 抗コネキシン抗体製剤
WO2023173036A2 (en) * 2022-03-10 2023-09-14 Omeros Corporation Masp-2 and masp-3 inhibitors, and related compositions and methods, for treatment of sickle cell disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2646717T3 (es) * 2011-05-02 2017-12-15 Millennium Pharmaceuticals, Inc. Formulación para anticuerpo anti- 4 7
WO2012151481A1 (en) * 2011-05-04 2012-11-08 Omeros Corporation Compositions for inhibiting masp-2 dependent complement acitivation
MX381048B (es) * 2012-06-18 2025-04-01 Omeros Corp Composiciones y métodos para inhibir masp-1 y/o masp-2 y/o masp-3 para el tratamiento de varias enfermedades y trastornos.
KR102744762B1 (ko) * 2013-10-17 2024-12-20 오메로스 코포레이션 Masp-2 의존성 보체 활성화와 관련된 상태의 치료 방법
US20160168237A1 (en) * 2014-12-12 2016-06-16 Alexion Pharmaceuticals, Inc. Method for treating a complement mediated disorder caused by an infectious agent in a patient
GEP20247583B (en) * 2015-11-09 2024-01-10 Univ Leicester Methods for treating condi tions associated with masp-2 dependent complement activation
JOP20170170B1 (ar) * 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق

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Publication number Publication date
US20240247078A1 (en) 2024-07-25
CN111278863A (zh) 2020-06-12
MX2020002077A (es) 2020-03-24
RU2020111574A3 (cg-RX-API-DMAC7.html) 2021-11-17
EP3672994A1 (en) 2020-07-01
WO2019040453A1 (en) 2019-02-28
US20190062455A1 (en) 2019-02-28
JP2020531523A (ja) 2020-11-05
BR112020003632A2 (pt) 2020-10-27
CA3072913A1 (en) 2019-02-28
EP3672994A4 (en) 2021-06-02
AU2018322032B2 (en) 2025-04-17
CL2020000397A1 (es) 2020-07-10
IL272673B1 (en) 2024-06-01
AU2018322032A1 (en) 2020-03-12
IL272673A (en) 2020-03-31
IL272673B2 (en) 2024-10-01
KR20200037863A (ko) 2020-04-09
RU2020111574A (ru) 2021-09-27
MA49960A (fr) 2021-06-02

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