JP2020530844A5 - - Google Patents

Download PDF

Info

Publication number
JP2020530844A5
JP2020530844A5 JP2020508022A JP2020508022A JP2020530844A5 JP 2020530844 A5 JP2020530844 A5 JP 2020530844A5 JP 2020508022 A JP2020508022 A JP 2020508022A JP 2020508022 A JP2020508022 A JP 2020508022A JP 2020530844 A5 JP2020530844 A5 JP 2020530844A5
Authority
JP
Japan
Prior art keywords
cancer
cell
tumor
pharmaceutical composition
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020508022A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020530844A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/046698 external-priority patent/WO2019036466A1/en
Publication of JP2020530844A publication Critical patent/JP2020530844A/ja
Publication of JP2020530844A5 publication Critical patent/JP2020530844A5/ja
Priority to JP2023042770A priority Critical patent/JP2023082028A/ja
Priority to JP2025050879A priority patent/JP2025094223A/ja
Pending legal-status Critical Current

Links

JP2020508022A 2017-08-14 2018-08-14 Setd2を阻害することにより癌を処置する方法 Pending JP2020530844A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023042770A JP2023082028A (ja) 2017-08-14 2023-03-17 Setd2を阻害することにより癌を処置する方法
JP2025050879A JP2025094223A (ja) 2017-08-14 2025-03-26 Setd2を阻害することにより癌を処置する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762545353P 2017-08-14 2017-08-14
US62/545,353 2017-08-14
PCT/US2018/046698 WO2019036466A1 (en) 2017-08-14 2018-08-14 METHODS OF TREATING CANCER BY INHIBITING SETD2

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023042770A Division JP2023082028A (ja) 2017-08-14 2023-03-17 Setd2を阻害することにより癌を処置する方法

Publications (2)

Publication Number Publication Date
JP2020530844A JP2020530844A (ja) 2020-10-29
JP2020530844A5 true JP2020530844A5 (https=) 2021-09-16

Family

ID=65362451

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020508022A Pending JP2020530844A (ja) 2017-08-14 2018-08-14 Setd2を阻害することにより癌を処置する方法
JP2023042770A Pending JP2023082028A (ja) 2017-08-14 2023-03-17 Setd2を阻害することにより癌を処置する方法
JP2025050879A Pending JP2025094223A (ja) 2017-08-14 2025-03-26 Setd2を阻害することにより癌を処置する方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023042770A Pending JP2023082028A (ja) 2017-08-14 2023-03-17 Setd2を阻害することにより癌を処置する方法
JP2025050879A Pending JP2025094223A (ja) 2017-08-14 2025-03-26 Setd2を阻害することにより癌を処置する方法

Country Status (12)

Country Link
US (1) US11952572B2 (https=)
EP (1) EP3669279A4 (https=)
JP (3) JP2020530844A (https=)
KR (1) KR20200052294A (https=)
CN (2) CN119405809A (https=)
AU (2) AU2018318988A1 (https=)
CA (1) CA3072746A1 (https=)
EA (1) EA202090485A1 (https=)
IL (1) IL272379B2 (https=)
MX (1) MX2020001759A (https=)
SG (1) SG11202000839TA (https=)
WO (1) WO2019036466A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119405809A (zh) 2017-08-14 2025-02-11 Epizyme股份有限公司 通过抑制setd2治疗癌症的方法
CN112585119A (zh) 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63907A0 (en) 1980-09-24 1981-12-31 Cetus Corp Diagnostic method and antibody probe for use therein
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
ATE53862T1 (de) 1982-01-22 1990-06-15 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4595766A (en) 1984-10-26 1986-06-17 Ciba-Geigy Corporation Process for the preparation of an indoline carboxylic acid
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
US20040265929A1 (en) * 2001-11-15 2004-12-30 The Regents Of The University Of Michigan Humoral response to HIP1 in cancer
AU2003265382A1 (en) 2002-08-23 2004-03-11 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
EP1880994A4 (en) 2005-05-11 2010-04-14 Eisai R&D Man Co Ltd INDOLE DERIVED CRYSTAL COMPRISING A PIPERIDINE CYCLE AND PROCESS FOR SYNTHESIZING SAID CRYSTAL
CA2628074C (en) 2005-10-25 2014-01-14 Shionogi & Co., Ltd. Aminodihydrothiazine derivative
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
WO2009158375A1 (en) 2008-06-25 2009-12-30 Abbott Laboratories Aza-cylic indole- 2 -carboxamides and methods of use thereof
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
WO2011011366A2 (en) 2009-07-20 2011-01-27 Constellation Pharmaceuticals Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
AU2010333779A1 (en) 2009-12-23 2012-07-12 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
JP2013518560A (ja) 2010-02-03 2013-05-23 オンコセラピー・サイエンス株式会社 がんの治療および診断の標的遺伝子としてのwhsc1およびwhsc1l1
JP2012107001A (ja) 2010-10-22 2012-06-07 Shionogi & Co Ltd インドールアミド化合物を含有する医薬
CA2853501A1 (en) * 2011-10-27 2013-05-02 Memorial Sloan-Kettering Cancer Center Methyltransferase inhibitors for treating cancer
WO2015143424A2 (en) 2014-03-21 2015-09-24 Glaxosmithkline Intellectual Property (No. 2) Limited Methods of treating cancer
US10167257B2 (en) 2014-04-04 2019-01-01 Iomet Pharma Ltd. Indole derivatives for use in medicine
WO2015164482A1 (en) 2014-04-22 2015-10-29 The Johns Hopkins University Inhibitors of drug-resistant mycobacterium tuberculosis
US9902702B2 (en) 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
BR112017004612A2 (pt) 2014-09-10 2018-01-30 Epizyme, Inc. compostos, composição farmacêutica, usos de um composto, e kit
WO2016079321A1 (en) * 2014-11-20 2016-05-26 Cemm Forschungszentrum Für Molekulare Medizin Gmbh Antagonists of setdb2 for use in the therapy of infectious diseases
US20190026440A1 (en) * 2015-12-17 2019-01-24 Albert Einstein College Of Medicine, Inc. Nuclear receptor set domain containing protein 2 transition state and uses thereof
CN106317043B (zh) 2016-08-19 2018-11-02 成都理工大学 一种大麻素受体2激动剂
CN119405809A (zh) 2017-08-14 2025-02-11 Epizyme股份有限公司 通过抑制setd2治疗癌症的方法
CN112585119A (zh) 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法
MX2021006347A (es) 2018-11-30 2021-10-13 Epizyme Inc Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2.
IL295654A (en) 2020-02-19 2022-10-01 Epizyme Inc Setd2 inhibitors and related methods and uses, including combination therapies
IL308868A (en) 2021-06-09 2024-01-01 Epizyme Inc Combined treatments with SETD2 inhibitors
WO2023077117A1 (en) 2021-11-01 2023-05-04 Epizyme, Inc. Crystalline forms of n-((1r,3s)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1h-indole-2-carboxamide

Similar Documents

Publication Publication Date Title
Yadav et al. Cancer stem cells: acquisition, characteristics, therapeutic implications, targeting strategies and future prospects
Zhang et al. Expressions of nuclear factor κB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome
Selvakumaran et al. Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy
US20200332300A1 (en) Multi-target modulation for treating fibrosis and inflammatory conditions
CN105378083B (zh) 修饰的TGF-β寡核苷酸
JP6340162B2 (ja) アポトーシス誘導剤
CN112007161B (zh) Cdca8在制备治疗卵巢癌药物中的应用
JP2011506343A (ja) トポイソメラーゼ阻害剤とparp阻害剤との組み合わせによるがんの治療
JP6667967B2 (ja) Met阻害剤に対する感受性予測用の新規なバイオマーカー及びその用途
Sheng et al. MicroRNA-429 decreases the invasion ability of gastric cancer cell line BGC-823 by downregulating the expression of heparanase
JP2020530844A5 (https=)
RU2014142057A (ru) Комплексная терапия
Yang et al. Clinical and biological significance of hepatoma‐derived growth factor in Ewing's sarcoma
CN104623663B (zh) 评估癌症于治疗后情况的方法及其相关应用
US11110182B2 (en) Multifunctional RNA nanoparticles and methods for treating cancer and therapeutic resistant cancer
Qin et al. piRNA28846 has the potential to be a novel RNA nucleic acid drug for ovarian cancer
WO2015194522A1 (ja) アポトーシス誘導剤
Chen et al. DJ‐1/FGFR‐1 signaling pathway contributes to sorafenib resistance in hepatocellular carcinoma
Chen et al. Inhibiting lncRNA NEAT1 facilitates the sensitization of melanoma cells to cisplatin through modulating the miR-519c-3p-MeCP2 axis
CN117018204A (zh) 一种治疗癌症的组合物及其应用和药物
Qi et al. The METTL3/TGF-β1 signaling axis promotes osteosarcoma progression by inducing MSC differentiation into CAFs via m6A modification
CN114099684B (zh) miR-32-5p在制备提高肿瘤细胞对双氢青蒿素敏感性的药物中的应用
JP2020530844A (ja) Setd2を阻害することにより癌を処置する方法
JP2013203673A (ja) 単鎖切断誘導剤の増感剤及びその製造方法
Zheng et al. IGHG1 functions as an oncogene in tongue squamous cell carcinoma via JAK1/STAT5 signaling.