KR20200052294A - Setd2의 저해에 의한 암의 치료 방법 - Google Patents

Setd2의 저해에 의한 암의 치료 방법 Download PDF

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KR20200052294A
KR20200052294A KR1020207007131A KR20207007131A KR20200052294A KR 20200052294 A KR20200052294 A KR 20200052294A KR 1020207007131 A KR1020207007131 A KR 1020207007131A KR 20207007131 A KR20207007131 A KR 20207007131A KR 20200052294 A KR20200052294 A KR 20200052294A
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cancer
cell
carcinoma
setd2
tumor
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알렉산드라 로즈 그라씨안
마이클 토메니우스
제니퍼 앤 토트만
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에피자임, 인코포레이티드
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KR1020207007131A 2017-08-14 2018-08-14 Setd2의 저해에 의한 암의 치료 방법 Ceased KR20200052294A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762545353P 2017-08-14 2017-08-14
US62/545,353 2017-08-14
PCT/US2018/046698 WO2019036466A1 (en) 2017-08-14 2018-08-14 METHODS OF TREATING CANCER BY INHIBITING SETD2

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KR20200052294A true KR20200052294A (ko) 2020-05-14

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KR1020207007131A Ceased KR20200052294A (ko) 2017-08-14 2018-08-14 Setd2의 저해에 의한 암의 치료 방법

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US (1) US11952572B2 (https=)
EP (1) EP3669279A4 (https=)
JP (3) JP2020530844A (https=)
KR (1) KR20200052294A (https=)
CN (2) CN119405809A (https=)
AU (2) AU2018318988A1 (https=)
CA (1) CA3072746A1 (https=)
EA (1) EA202090485A1 (https=)
IL (1) IL272379B2 (https=)
MX (1) MX2020001759A (https=)
SG (1) SG11202000839TA (https=)
WO (1) WO2019036466A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020530844A (ja) 2017-08-14 2020-10-29 エピザイム，インコーポレイティド Ｓｅｔｄ２を阻害することにより癌を処置する方法
CN112585119A (zh) 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63907A0 (en) 1980-09-24 1981-12-31 Cetus Corp Diagnostic method and antibody probe for use therein
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
ATE53862T1 (de) 1982-01-22 1990-06-15 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4595766A (en) 1984-10-26 1986-06-17 Ciba-Geigy Corporation Process for the preparation of an indoline carboxylic acid
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
US20040265929A1 (en) * 2001-11-15 2004-12-30 The Regents Of The University Of Michigan Humoral response to HIP1 in cancer
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
AU2003265382A1 (en) 2002-08-23 2004-03-11 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
KR20080007649A (ko) 2005-05-11 2008-01-22 에자이 알앤드디 매니지먼트 가부시키가이샤 피페리딘환을 가지는 인돌 유도체의 결정 및 그의 제조방법
RU2416603C9 (ru) 2005-10-25 2012-06-20 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина
US7838542B2 (en) 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
US20100035862A1 (en) 2008-06-25 2010-02-11 Abbott Laboratories Novel aza-cyclic indole-2-carboxamides and methods of use thereof
EP2330894B8 (en) 2008-09-03 2017-04-19 BioMarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
US20110021362A1 (en) 2009-07-20 2011-01-27 Constellation Pharmaceuticals Agents for stimulating activity of methyl modifying enzymes and methods of use thereof
CA2784894A1 (en) 2009-12-23 2011-06-30 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
US20130137748A1 (en) 2010-02-03 2013-05-30 Oncotherapy Science, Inc. Whsc1 and whsc1l1 for target genes of cancer therapy and diagnosis
JP2012107001A (ja) 2010-10-22 2012-06-07 Shionogi & Co Ltd インドールアミド化合物を含有する医薬
WO2013063417A1 (en) * 2011-10-27 2013-05-02 Memorial Sloan-Kettering Cancer Center Methyltransferase inhibitors for treating cancer
EP3119390A4 (en) 2014-03-21 2017-09-20 Glaxosmithkline Intellectual Property (No. 2) Limited Methods of treating cancer
NZ725860A (en) 2014-04-04 2019-08-30 Iomet Pharma Ltd Indole derivatives for use in medicine
WO2015164482A1 (en) 2014-04-22 2015-10-29 The Johns Hopkins University Inhibitors of drug-resistant mycobacterium tuberculosis
US9902702B2 (en) 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
WO2016040505A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Smyd inhibitors
WO2016079321A1 (en) * 2014-11-20 2016-05-26 Cemm Forschungszentrum Für Molekulare Medizin Gmbh Antagonists of setdb2 for use in the therapy of infectious diseases
WO2017106259A1 (en) * 2015-12-17 2017-06-22 Albert Einstein College Of Medicine, Inc. Nuclear receptor set domain containing protein 2 transition state and uses thereof
CN106317043B (zh) 2016-08-19 2018-11-02 成都理工大学 一种大麻素受体2激动剂
JP2020530844A (ja) 2017-08-14 2020-10-29 エピザイム，インコーポレイティド Ｓｅｔｄ２を阻害することにより癌を処置する方法
CN112585119A (zh) 2018-08-14 2021-03-30 Epizyme股份有限公司 经取代的吲哚及其使用方法
SG11202105325QA (en) 2018-11-30 2021-06-29 Epizyme Inc Methods of treating whsc1-overexpressing cancers by inhibiting setd2
WO2021168313A1 (en) 2020-02-19 2021-08-26 Epizyme, Inc. Setd2 inhibitors and related methods and uses, including combination therapies
US20240299352A1 (en) 2021-06-09 2024-09-12 Epizyme, Inc. Combination therapies with setd2 inhibitors
JP2024539726A (ja) 2021-11-01 2024-10-29 エピザイム，インコーポレイティド Ｎ－（（１ｒ，３ｓ）－３－（４－アセチルピペラジン－１－イル）シクロヘキシル）－４－フルオロ－７－メチル－１ｈ－インドール－２－カルボキサミドの結晶形態

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