JP2020525240A - 乾燥粉末吸入器 - Google Patents
乾燥粉末吸入器 Download PDFInfo
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- JP2020525240A JP2020525240A JP2019572757A JP2019572757A JP2020525240A JP 2020525240 A JP2020525240 A JP 2020525240A JP 2019572757 A JP2019572757 A JP 2019572757A JP 2019572757 A JP2019572757 A JP 2019572757A JP 2020525240 A JP2020525240 A JP 2020525240A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
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- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
図1〜図3に図示されたとおりに、本発明の一実施例に係るKUPD#1およびKUPD#2をそれぞれ製作した。
乾燥粉末薬剤の有効粒子量を測定するため、人工気道および肺モデル非臨床試験用装置(Next Generation Pharmaceutical Impactor、NGI)を使用した。NGIの各ステージは、人体の肺の各部分を模式化した装置で、ステージ1〜7は、それぞれ咽頭(pharynx)、気道(trachea)、気管支(bronchi)および肺胞(alveoli)を示す。
対照薬としてセレタイド250を利用し、前記試験方法に基づいてNGIの各ステージへの伝達量を確認した結果を図9に示した。
KUPD#1を利用し、前記試験方法に基づいてNGIの各ステージへの伝達量を確認した結果を図10に示した。
KUPD#2を利用し、前記試験方法に基づいてNGIの各ステージへの伝達量を確認した結果を図11に示した。
Claims (15)
- 有効成分および伝達体(carrier)を含んだ乾燥粉末薬剤を投与するための吸入器であって、
吸入器ハウジングと、
前記吸入器ハウジング内に備えられ、乾燥粉末薬剤が収容される薬剤収容部と、
前記薬剤収容部の上方に配置され、前記乾燥粉末薬剤が吸入される薬剤吸入口と、
前記薬剤吸入口の経路上に設置され、前記乾燥粉末薬剤との衝突のためのメッシュ部が形成されるメッシュ網と、を含む乾燥粉末吸入器。 - 前記メッシュ網は、前記薬剤吸入口の経路上に少なくとも2つ以上が設置されたものである、請求項1に記載の乾燥粉末吸入器。
- 前記メッシュ部は、前記乾燥粉末薬剤の吸入方向に対して交互に形成されたものである、請求項2に記載の乾燥粉末吸入器。
- 前記吸入器ハウジングは、
外部ハウジング、及び
前記外部ハウジングの内部に収容される内部ハウジングを含み、
前記薬剤吸入口は前記外部ハウジングと内部ハウジングにわたって形成され、前記外部ハウジングと内部ハウジングの間には、空気の流入のための隙間が形成されたものである、請求項2に記載の乾燥粉末吸入器。 - 前記吸入器ハウジングの一側には、外部からの空気流入のための流入穴が形成されたものである、請求項4に記載の乾燥粉末吸入器。
- 前記メッシュ網は、
前記薬剤吸入口の入口に設置される第1メッシュ網、及び
前記薬剤吸入口の出口に設置される第2メッシュ網を含むものである、請求項4に記載の乾燥粉末吸入器。 - 前記メッシュ網中の最下段に設置されたメッシュ網は、前記薬剤吸入口の入口から上方へと離隔された位置に配置されるものである、請求項2に記載の乾燥粉末吸入器。
- 前記メッシュ部は、最下段から最上段へと行くほど緻密に形成されたものである、請求項1に記載の乾燥粉末吸入器。
- 前記メッシュ網は、水溶性材質である、請求項1に記載の乾燥粉末吸入器。
- 前記メッシュ網の表面に、水溶性物質がコーティングされたものである、請求項1に記載の乾燥粉末吸入器。
- 前記有効成分は、フルチカゾン(Fluticasone)、サルメテロール(Salmeterol)、アルフォルモテロール(Arformoterol)、ブデソニド(Budesonide)、フェノテロール(Fenoterol)、プロカテロール(Procaterol)、レバルブテロール(Levalbuterol)、サルブタモール(Salbutamol)、アルブテロール(Albuterol)、テルブタリン(Terbutaline)、ホルモテロ―ル(Formoterol)、インダカテロール(Indacaterol)、オロダテロ―ル(Olodaterol)、ビランテロール(Vilanterol)、インプラトロピウム(Ipratropium)、オキシトロピウム(Oxitropium)、アクリジニウム(Aclidinium)、グリコピロニウム(Glycopyrronium)、チオトロピウム(Tiotropium)、ウメクリジニウム(Umeclidinium)、ベクロメタゾン(Beclomethasone)、シクレソニド(Ciclesonide)、トリアムシノロン(Triamcinolone)、モメタゾン(Mometasone)と、肺癌の標的治療剤であるゲフィチニブ(Gefitinib)、エルロチニブ(Erlotinib)、アファチニブ(Afatinib)、オシメルチニブ(Osimertinib)、オルムチニブ(Olmutinib)、クリゾチニブ(Crizotinib)、セリチニブ(Ceritinib)と、パーキンソン病治療剤であるレボドパ(Levodopa)と、抗生剤であるキノロン系(Quinolones)および製薬学的に許容されるその各塩からなる群から選択される1種以上である、請求項1に記載の乾燥粉末吸入器。
- 前記有効成分は、インスリン(Insulin)、GLP(Glucagon-Like Peptide)、GIP(Glucose-dependent Insulinotropic Polypeptide)、HGH(Human Growth Hormone)、PTH(Parathyroid Hormone)、ESA(Erythropoiesis-Stimulating Agents)およびそのアナログからなる群から選択される1種以上である、請求項1に記載の乾燥粉末吸入器。
- 前記有効成分は、粒子サイズが0.1〜10.0μmである、請求項1に記載の乾燥粉末吸入器。
- 前記伝達体はラクトース、グルコース、プルクトース、スクロース、マルトース、ラフィノース、メレジトース、マンニトール、ラクチトール、マルチトール、キシリトール、デキストリンおよびデンプンからなる群から選択される1種以上である、請求項1に記載の乾燥粉末吸入器。
- 前記伝達体は、粒子サイズが1〜200μmである、請求項1に記載の乾燥粉末吸入器。
Applications Claiming Priority (3)
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KR10-2017-0081320 | 2017-06-27 | ||
KR1020170081320A KR101992171B1 (ko) | 2017-06-27 | 2017-06-27 | 건조분말 흡입기 |
PCT/KR2017/006901 WO2019004501A1 (ko) | 2017-06-27 | 2017-06-29 | 건조분말 흡입기 |
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JP2020525240A true JP2020525240A (ja) | 2020-08-27 |
JP7010978B2 JP7010978B2 (ja) | 2022-01-26 |
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US (1) | US20200139057A1 (ja) |
JP (1) | JP7010978B2 (ja) |
KR (1) | KR101992171B1 (ja) |
CN (1) | CN110799230B (ja) |
WO (1) | WO2019004501A1 (ja) |
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FR3116440A1 (fr) * | 2020-11-20 | 2022-05-27 | Nemera La Verpilliere | Embout pour dispositif de distribution de produit |
US11792714B2 (en) * | 2021-06-16 | 2023-10-17 | Medtronic Minimed, Inc. | Medicine administration in dynamic networks |
WO2023039266A1 (en) * | 2021-09-12 | 2023-03-16 | Niconox Llc | Delivery devices and compositions |
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- 2017-06-27 KR KR1020170081320A patent/KR101992171B1/ko active IP Right Grant
- 2017-06-29 US US16/626,410 patent/US20200139057A1/en active Pending
- 2017-06-29 JP JP2019572757A patent/JP7010978B2/ja active Active
- 2017-06-29 CN CN201780092503.8A patent/CN110799230B/zh active Active
- 2017-06-29 WO PCT/KR2017/006901 patent/WO2019004501A1/ko active Application Filing
Patent Citations (5)
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JP2000503565A (ja) * | 1996-01-03 | 2000-03-28 | グラクソ、グループ、リミテッド | 吸入装置 |
JP2000515787A (ja) * | 1996-07-31 | 2000-11-28 | グラクソ、グループ、リミテッド | 大型凝集薬剤粒子を含む薬剤キャリヤおよびその製法 |
JP2002513649A (ja) * | 1998-05-04 | 2002-05-14 | グラクソ グループ リミテッド | 単位用量吸入装置およびこれを用いた放出法 |
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Publication number | Publication date |
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CN110799230A (zh) | 2020-02-14 |
KR20190001394A (ko) | 2019-01-04 |
CN110799230B (zh) | 2022-04-05 |
WO2019004501A1 (ko) | 2019-01-03 |
US20200139057A1 (en) | 2020-05-07 |
JP7010978B2 (ja) | 2022-01-26 |
KR101992171B1 (ko) | 2019-06-25 |
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