JP2020524519A - 全セルフリーｄｎａによる移植合併症リスクの評価 - Google Patents
全セルフリーｄｎａによる移植合併症リスクの評価 Download PDFInfo
- Publication number
- JP2020524519A JP2020524519A JP2019571052A JP2019571052A JP2020524519A JP 2020524519 A JP2020524519 A JP 2020524519A JP 2019571052 A JP2019571052 A JP 2019571052A JP 2019571052 A JP2019571052 A JP 2019571052A JP 2020524519 A JP2020524519 A JP 2020524519A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- amount
- total
- subject
- transplant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/101—Sanger sequencing method, i.e. oligonucleotide sequencing using primer elongation and dideoxynucleotides as chain terminators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522533P | 2017-06-20 | 2017-06-20 | |
| US62/522,533 | 2017-06-20 | ||
| US201762572556P | 2017-10-15 | 2017-10-15 | |
| US62/572,556 | 2017-10-15 | ||
| PCT/US2018/038598 WO2018237075A1 (en) | 2017-06-20 | 2018-06-20 | Assessing transplant complication risk with total cell-free dna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020524519A true JP2020524519A (ja) | 2020-08-20 |
| JP2020524519A5 JP2020524519A5 (enExample) | 2021-07-29 |
Family
ID=64735781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571052A Pending JP2020524519A (ja) | 2017-06-20 | 2018-06-20 | 全セルフリーｄｎａによる移植合併症リスクの評価 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11773434B2 (enExample) |
| EP (2) | EP4488387A3 (enExample) |
| JP (1) | JP2020524519A (enExample) |
| CN (1) | CN110945136A (enExample) |
| AU (2) | AU2018288832B2 (enExample) |
| CA (1) | CA3067637A1 (enExample) |
| IL (1) | IL271460A (enExample) |
| WO (1) | WO2018237075A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| CA3207599A1 (en) | 2010-05-18 | 2011-11-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020206290A1 (en) * | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| CN111667883B (zh) * | 2020-06-03 | 2021-01-22 | 四川大学 | 一种基于复合微单倍型焦磷酸测序图谱解析的法医学混合dna的分析方法 |
| US20230399697A1 (en) * | 2020-11-09 | 2023-12-14 | The Medical College Of Wisconsin, Inc. | Assessing risk with pre-operative total cell-free dna |
| WO2025079958A1 (ko) * | 2023-10-11 | 2025-04-17 | 고려대학교 산학협력단 | 높은 처리량의 돌연변이 특이적 아답터 리게이션 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150086477A1 (en) * | 2012-04-19 | 2015-03-26 | Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| WO2016176662A1 (en) * | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5319071A (en) | 1987-11-25 | 1994-06-07 | Immunex Corporation | Soluble interleukin-1 receptors |
| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| US5645988A (en) | 1991-05-08 | 1997-07-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of identifying drugs with selective effects against cancer cells |
| US5569582A (en) | 1991-07-15 | 1996-10-29 | Institute Of Molecular Biology & Technology | Rapid amplification and detection of nucleic acids |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| NZ505499A (en) | 1998-01-23 | 2002-07-26 | Immunex Corp | Accessory protein-like DNA and polypeptides |
| US20030148301A1 (en) | 1999-12-10 | 2003-08-07 | Toshiya Aono | Method of detecting nucleotide polymorphism |
| DE60123448T2 (de) | 2001-12-24 | 2007-08-23 | Prof. Wolfgang Holzgreve | Verfahren zur nicht-invasiven Diagnose von Transplantationen und Transfusionen |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| JP4116856B2 (ja) | 2002-10-02 | 2008-07-09 | 富士フイルム株式会社 | １塩基多型の検出方法 |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| JP2008501340A (ja) | 2004-06-02 | 2008-01-24 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | ショットガン配列データからの機能推定 |
| WO2006047481A2 (en) | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US8609338B2 (en) | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2007100911A2 (en) | 2006-02-28 | 2007-09-07 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US20100326218A1 (en) | 2007-09-27 | 2010-12-30 | Michael Boeckh | Identifying a subject with an increased risk of invasive mold infection |
| WO2009064789A2 (en) | 2007-11-15 | 2009-05-22 | The Johns Hopkins University | Methods for detecting and monitoring circulating cancer stem cells |
| GB2483810B (en) | 2008-11-07 | 2012-09-05 | Sequenta Inc | Methods for correlating clonotypes with diseases in a population |
| WO2010087985A2 (en) | 2009-01-28 | 2010-08-05 | Yale University | Novel markers for detection of complications resulting from in utero encounters |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
| WO2011094646A1 (en) | 2010-01-28 | 2011-08-04 | Medical College Of Wisconsin, Inc. | Methods and compositions for high yield, specific amplification |
| US20130071844A1 (en) | 2010-03-24 | 2013-03-21 | Toppan Printing Co., Ltd. | Method for detecting target base sequence using competitive primer |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| US9290815B2 (en) | 2011-02-21 | 2016-03-22 | Qiagen Gmbh | Method for quantifying human DNA |
| US20140199781A1 (en) | 2011-03-08 | 2014-07-17 | Beth Israel Deaconess Medical Center, Inc. | Non-invasive methods for diagnosing chronic organ transplant rejection |
| UA115321C2 (uk) | 2011-12-16 | 2017-10-25 | Басф Агрокемікал Продактс Б.В. | Спосіб та комплект для аналізу ahasl генів у рослин |
| US10077474B2 (en) | 2012-05-29 | 2018-09-18 | Abbott Molecular, Inc. | Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits |
| NZ704039A (en) | 2012-08-03 | 2018-04-27 | Ferring Bv | Cell-free dna as a therapeutic target for female infertility and diagnostic marker |
| WO2014143989A1 (en) | 2013-03-15 | 2014-09-18 | Medical College Of Wisconsin, Inc. | Fetal well being surveillance using fetal specific cell free dna |
| GB201304810D0 (en) | 2013-03-15 | 2013-05-01 | Isis Innovation | Assay |
| SI3004388T2 (sl) | 2013-05-29 | 2023-11-30 | Chronix Biomedical | Odkrivanje in kvantifikacija donorjeve brezcelične DNK v cirkulaciji prejemnikov presajenih organov |
| EP3968023B1 (en) | 2013-08-19 | 2025-10-08 | Invitae Corporation | Assays for single molecule detection and use thereof |
| US20160376652A1 (en) | 2013-09-06 | 2016-12-29 | Immucor Gti Diagnostics, Inc. | Compositions and methods for diagnosis and prediction of solid organ graft rejection |
| WO2015069933A1 (en) | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| WO2015178978A2 (en) | 2014-02-14 | 2015-11-26 | The Board Of Regents Of The University Of Texas System | Strand exchange hairpin primers that give high allelic discrimination |
| HUE043288T2 (hu) | 2014-03-14 | 2019-08-28 | Caredx Inc | Eljárások immunszuppresszív terápiák monitorozására transzplantátum recipiensben |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| EP3521454A1 (en) | 2014-05-09 | 2019-08-07 | LifeCodexx AG | Detection of dna that originates from a specific cell-type and related methods |
| US10435750B2 (en) | 2014-07-03 | 2019-10-08 | Multiplicom N.V. | Methods for non-invasive detection of transplant health or rejection |
| DK3194612T3 (da) | 2014-08-22 | 2024-10-14 | Resolution Bioscience Inc | Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna |
| ES2708030T3 (es) | 2014-10-20 | 2019-04-08 | Inst Nat Sante Rech Med | Métodos para explorar a un individuo en busca de un cáncer |
| WO2016109604A2 (en) | 2014-12-29 | 2016-07-07 | InnoGenomics Technologies, LLC | Multiplexed assay for quantitating and assessing integrity of cell-free dna in biological fluids for cancer diagnosis, prognosis, and surveillance |
| WO2016123698A1 (en) | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN108291330A (zh) | 2015-07-10 | 2018-07-17 | 西弗吉尼亚大学 | 卒中和卒中严重性的标志物 |
| CA3001698C (en) | 2015-10-22 | 2025-01-07 | Cytosorbents Corp | Sorbant in the form of porous, blood-compatible polymer beads, multifunctional for the elimination of protein-based toxins and potassium from biological fluids |
| CA3007426A1 (en) | 2015-12-03 | 2017-06-08 | Alfred Health | Monitoring treatment or progression of myeloma |
| AU2017258800A1 (en) | 2016-04-29 | 2018-12-20 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing fetal well being |
| AU2017258799A1 (en) | 2016-04-29 | 2018-12-20 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| EA201892489A1 (ru) * | 2016-04-29 | 2019-05-31 | Дзе Медикал Колледж Оф Висконсин, Инк. | Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma) |
| CA3042722A1 (en) | 2016-11-02 | 2018-05-11 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| EP4488383A3 (en) * | 2016-11-02 | 2025-04-09 | The Medical College of Wisconsin, Inc. | Methods for assessing risk using total and specific cell-free dna |
| WO2018119422A1 (en) | 2016-12-22 | 2018-06-28 | Duke University | Polycationic microfibers and methods of using the same |
| CA3067635A1 (en) | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| CN111094593A (zh) | 2017-06-20 | 2020-05-01 | 威斯康星州立大学医学院 | 使用供体特异性无细胞dna来评估移植对象中的病症 |
| WO2019006561A1 (en) | 2017-07-07 | 2019-01-10 | Mcmaster University | RISK ASSESSMENT TOOL FOR PATIENTS WITH SEPSIS |
| WO2019008408A1 (en) | 2017-07-07 | 2019-01-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM MYELOPROLIFERATIVE NEOPLASM IS AT RISK OF THROMBOSIS |
| AU2018332326B2 (en) | 2017-09-18 | 2025-04-03 | Santersus Ag | Method and device for purification of blood from circulating cell free DNA |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| WO2019217918A1 (en) | 2018-05-10 | 2019-11-14 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets |
| US20200109449A1 (en) | 2018-10-09 | 2020-04-09 | Tai Diagnostics, Inc. | Cell lysis assay for cell-free dna analysis |
| WO2020131955A1 (en) | 2018-12-17 | 2020-06-25 | The Medical College Of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| WO2020206290A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| WO2020206269A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| WO2020206292A2 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
-
2018
- 2018-06-20 CA CA3067637A patent/CA3067637A1/en active Pending
- 2018-06-20 WO PCT/US2018/038598 patent/WO2018237075A1/en not_active Ceased
- 2018-06-20 CN CN201880048495.1A patent/CN110945136A/zh active Pending
- 2018-06-20 JP JP2019571052A patent/JP2020524519A/ja active Pending
- 2018-06-20 US US16/623,707 patent/US11773434B2/en active Active
- 2018-06-20 EP EP24198235.4A patent/EP4488387A3/en active Pending
- 2018-06-20 AU AU2018288832A patent/AU2018288832B2/en active Active
- 2018-06-20 EP EP18820195.8A patent/EP3642353B1/en active Active
-
2019
- 2019-12-16 IL IL271460A patent/IL271460A/en unknown
-
2023
- 2023-06-28 US US18/343,097 patent/US20240026437A1/en active Pending
-
2025
- 2025-06-05 AU AU2025204208A patent/AU2025204208A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150086477A1 (en) * | 2012-04-19 | 2015-03-26 | Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| WO2016176662A1 (en) * | 2015-04-30 | 2016-11-03 | Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
Non-Patent Citations (4)
| Title |
|---|
| "Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation", CLINICAL CHEMISTRY, vol. Volume 55, Issue 11, JPN6022011968, 2009, pages 1958 - 1966, ISSN: 0004889020 * |
| "Quantification of Circulating Cell-Free DNA in Pediatric Heart Transplant Recipients", THE JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. Volume 30, Issue 4, JPN6022011966, 2011, pages 139 - 407, ISSN: 0004889021 * |
| ACTA PAEDIATRICA, vol. 96, JPN6023027208, 2007, pages 644 - 647, ISSN: 0005100406 * |
| 医学図書館, vol. 51, no. 4, JPN6023027207, 2004, pages 387 - 388, ISSN: 0005100405 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3642353B1 (en) | 2025-03-05 |
| CN110945136A (zh) | 2020-03-31 |
| AU2018288832A1 (en) | 2020-01-16 |
| IL271460A (en) | 2020-01-30 |
| CA3067637A1 (en) | 2018-12-27 |
| US20240026437A1 (en) | 2024-01-25 |
| EP3642353A1 (en) | 2020-04-29 |
| WO2018237075A1 (en) | 2018-12-27 |
| EP4488387A2 (en) | 2025-01-08 |
| EP3642353C0 (en) | 2025-03-05 |
| US11773434B2 (en) | 2023-10-03 |
| AU2018288832B2 (en) | 2025-03-06 |
| EP3642353A4 (en) | 2021-02-24 |
| EP4488387A3 (en) | 2025-07-23 |
| AU2025204208A1 (en) | 2025-06-26 |
| US20210139969A1 (en) | 2021-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20240026437A1 (en) | Assessing transplant complication risk with total cell-free dna | |
| JP7323462B2 (ja) | セルフリーｄｎａによる移植患者のモニタリング | |
| US20220267849A1 (en) | Transplant patient monitoring with cell-free dna | |
| US20230167499A1 (en) | Methods for assessing risk using total cell-free dna | |
| US20220356522A1 (en) | Assessing conditions in transplant subjects using donor-specific cell-free dna | |
| US20210139988A1 (en) | Assessing conditions in transplant subjects using donor-specific cell-free dna | |
| EP4488383A2 (en) | Methods for assessing risk using total and specific cell-free dna | |
| WO2020131955A1 (en) | Assessing risk with total cell-free dna | |
| JP2019534017A (ja) | ミスマッチ増幅を使用するリスクを評価するための方法および統計方法 | |
| HK40029115A (en) | Assessing transplant complication risk with total cell-free dna | |
| HK40029115B (en) | Assessing transplant complication risk with total cell-free dna |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210621 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210621 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220328 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220330 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220622 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220829 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20221005 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20221223 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20230301 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230405 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20230705 |