JP2020524152A5 - - Google Patents

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JP2020524152A5
JP2020524152A5 JP2019570000A JP2019570000A JP2020524152A5 JP 2020524152 A5 JP2020524152 A5 JP 2020524152A5 JP 2019570000 A JP2019570000 A JP 2019570000A JP 2019570000 A JP2019570000 A JP 2019570000A JP 2020524152 A5 JP2020524152 A5 JP 2020524152A5
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JP2019570000A
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Japanese (ja)
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JP2020524152A (ja
JP7670462B2 (ja
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Priority claimed from PCT/US2018/038075 external-priority patent/WO2018236749A2/en
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Priority to JP2022136739A priority Critical patent/JP2022164775A/ja
Priority to JP2025026258A priority patent/JP2025071259A/ja
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JP2019570000A 2017-06-20 2018-06-18 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法 Active JP7670462B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022136739A JP2022164775A (ja) 2017-06-20 2022-08-30 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
JP2025026258A JP2025071259A (ja) 2017-06-20 2025-02-20 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762522489P 2017-06-20 2017-06-20
US62/522,489 2017-06-20
PCT/US2018/038075 WO2018236749A2 (en) 2017-06-20 2018-06-18 Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022136739A Division JP2022164775A (ja) 2017-06-20 2022-08-30 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
JP2025026258A Division JP2025071259A (ja) 2017-06-20 2025-02-20 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法

Publications (3)

Publication Number Publication Date
JP2020524152A JP2020524152A (ja) 2020-08-13
JP2020524152A5 true JP2020524152A5 (https=) 2021-07-26
JP7670462B2 JP7670462B2 (ja) 2025-04-30

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ID=64737393

Family Applications (3)

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JP2019570000A Active JP7670462B2 (ja) 2017-06-20 2018-06-18 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
JP2022136739A Pending JP2022164775A (ja) 2017-06-20 2022-08-30 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
JP2025026258A Pending JP2025071259A (ja) 2017-06-20 2025-02-20 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法

Family Applications After (2)

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JP2022136739A Pending JP2022164775A (ja) 2017-06-20 2022-08-30 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法
JP2025026258A Pending JP2025071259A (ja) 2017-06-20 2025-02-20 選択的グルココルチコイドレセプターモジュレーターを使用して神経上皮腫瘍を処置する方法

Country Status (8)

Country Link
US (3) US11213526B2 (https=)
EP (1) EP3641780B1 (https=)
JP (3) JP7670462B2 (https=)
AU (1) AU2018289307B2 (https=)
CA (1) CA3065555A1 (https=)
ES (1) ES3043682T3 (https=)
MX (1) MX393313B (https=)
WO (1) WO2018236749A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018236749A2 (en) 2017-06-20 2018-12-27 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
JP7196201B2 (ja) 2018-06-04 2022-12-26 コーセプト セラピューティクス, インコーポレイテッド ピリミジンシクロヘキセニル糖質コルチコイドレセプター調節因子
ES2980934T3 (es) 2019-01-22 2024-10-03 Akribes Biomedical Gmbh Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel
KR102911885B1 (ko) 2020-05-06 2026-01-12 코어셉트 쎄라퓨틱스 인코포레이티드 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제의 다형체
JP7474869B2 (ja) 2020-05-06 2024-04-25 コーセプト セラピューティクス, インコーポレイテッド ピリミジンシクロヘキシルグルココルチコイド受容体モジュレーターの製剤
AU2021409656B2 (en) 2020-12-21 2025-04-10 Corcept Therapeutics Incorporated Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators
CN114907349A (zh) * 2021-02-10 2022-08-16 江苏恒瑞医药股份有限公司 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用
WO2024050500A1 (en) * 2022-09-02 2024-03-07 Corcept Therapeutics Incorporated Methods of assessing selective glucocorticoid receptor modulation and of identifying and treating patients likely to benefit from glucocorticoid receptor modulation
WO2025255357A1 (en) * 2024-06-06 2025-12-11 Corcept Therapeutics Incorporated Methods for preparing and maintaining livers and portions thereof for liver transplantation

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4296206A (en) 1980-04-30 1981-10-20 United States Of America Irreversible anti-glucocorticoids
FR2528434B1 (fr) 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US4978657A (en) 1981-01-09 1990-12-18 Roussel Uclaf Novel 11β-substituted-19-nor-steroids
ZA8231B (en) 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2639045B2 (fr) 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
FR2522328B1 (fr) 1982-03-01 1986-02-14 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
DE3438994A1 (de) 1984-10-22 1986-04-24 Schering AG, Berlin und Bergkamen, 1000 Berlin Antigestagene, glukokortikoide und prostaglandine zur geburtseinleitung oder fuer den schwangerschaftsabbruch
FR2576025B1 (fr) 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
AU580843B2 (en) 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
DE3506785A1 (de) 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US5380840A (en) 1985-09-12 1995-01-10 The Upjohn Company Triazinylpiperazinyl steroids
FR2598421B1 (fr) 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3761308D1 (de) 1986-07-23 1990-02-08 Akzo Nv 18-phenylestrane-derivate.
DE3625315A1 (de) 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4774236A (en) 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
US4861763A (en) 1986-09-17 1989-08-29 Research Triangle Institute 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US4921638A (en) 1986-11-05 1990-05-01 The Upjohn Company 17β-cyano-9α,17α-dihydroxyandrost-4-en-3-one
DE3708942A1 (de) 1987-03-18 1988-09-29 Schering Ag 19,11ss-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3723788A1 (de) 1987-07-16 1989-01-26 Schering Ag 11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2618783B1 (fr) 1987-07-30 1991-02-01 Roussel Uclaf Nouveaux 17-aryle steroides, leurs procedes et des intermediaires de preparation comme medicaments et les compositions pharmaceutiques les renfermant
JP2785023B2 (ja) 1987-12-30 1998-08-13 ルセル―ユクラフ 17α位置を置換された17β―OH―19―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物
DE3820948A1 (de) 1988-06-16 1989-12-21 Schering Ag 10ss, 11ss-ueberbrueckte steroide
US4954490A (en) 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
US5348729A (en) 1988-11-30 1994-09-20 The United States Of America As Represented By The Department Of Health And Human Services Evaluative means for detecting inflammatory reactivity
DD289541A5 (de) 1989-08-04 1991-05-02 ��@�K@�������������@�K@��������������@��������k�� Verfahren zur herstellung von 11beta-aryl-16 alpha, 17 alph-cyclohexanoestra-4,9-dienen
US5276023A (en) 1989-08-08 1994-01-04 Roussel Uclaf 19-nor-steroid esters
FR2651233B1 (fr) 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
US5173405A (en) 1990-01-23 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Use of arsenite to reversibly block steroid binding to glucocorticoid receptors in the presence of other steroid receptors
US5616458A (en) 1990-03-14 1997-04-01 Board Of Regents, University Of Tx System Tripterygium wilfordii hook F extracts and components, and uses thereof
DE4042004A1 (de) 1990-12-22 1992-06-25 Schering Ag 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
US5215916A (en) 1991-06-19 1993-06-01 The United States Of America As Represented By The Department Of Health & Human Services Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
EP0683172B1 (en) 1994-05-19 1997-08-13 Akzo Nobel N.V. 11,21-Bisphenyl-19-norpregnane derivatives
US6051573A (en) 1994-06-28 2000-04-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
US5696127A (en) 1994-12-22 1997-12-09 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
EP1043325B1 (en) 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
IL118974A (en) 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
AU5729098A (en) 1996-12-24 1998-07-17 Zymogenetics Inc. Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes
EP0903146A1 (en) 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
DE10038639A1 (de) 2000-07-28 2002-02-21 Schering Ag Nichtsteroidale Entzündungshemmer
IL180679A0 (en) 2000-10-27 2009-02-11 Pfizer Prod Inc Process for the preparation of non-steroidal glucocorticoid receptor modulators
AU2002366217A1 (en) 2001-11-23 2003-06-10 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists
CA2558899C (en) 2004-03-09 2013-02-05 Corcept Therapeutics, Inc. Fused ring azadecalin glucocorticoid receptor modulators
US20060205700A1 (en) * 2005-03-09 2006-09-14 May Flavia S Non invasive method for prevention and treatment of cancer
JP5637568B2 (ja) 2009-05-12 2014-12-10 コーセプト セラピューティクス, インコーポレイテッド 固体形態および調製のためのプロセス
EP2440577A4 (en) 2009-06-12 2013-01-23 Acceleron Pharma Inc SHORTEN ACTRIIB FC FUSION PROTEINS
US8710035B2 (en) 2010-03-24 2014-04-29 The University Of Chicago Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
MY161170A (en) * 2011-03-18 2017-04-14 Corcept Therapeutics Inc Pyrimidine cyclohexyl glucocorticoid receptor modulators
US9289436B2 (en) 2012-02-24 2016-03-22 The University Of Chicago Method of treatment of prostate cancer with androgen receptor and glucocorticoid receptor antagonists
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CA2872260C (en) 2012-05-25 2020-12-22 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8986677B2 (en) * 2012-07-30 2015-03-24 Pop Test Cortisol Llc Therapeutic compositions and methods
PL3848027T3 (pl) 2013-11-25 2023-07-24 Corcept Therapeutics Incorporated Skondensowane oktahydrozwiązki azadekaliny jako modulatory receptora glukokortykoidowego
AU2016226451B2 (en) * 2015-03-02 2019-12-19 Corcept Therapeutics, Inc. Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors
WO2017151613A1 (en) * 2016-03-01 2017-09-08 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
WO2018209142A2 (en) * 2017-05-10 2018-11-15 Corcept Therapeutics, Inc. Octahydro azadecalin formulations
WO2018236749A2 (en) * 2017-06-20 2018-12-27 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators

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