JP2020523322A5 - - Google Patents
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- Publication number
- JP2020523322A5 JP2020523322A5 JP2019567981A JP2019567981A JP2020523322A5 JP 2020523322 A5 JP2020523322 A5 JP 2020523322A5 JP 2019567981 A JP2019567981 A JP 2019567981A JP 2019567981 A JP2019567981 A JP 2019567981A JP 2020523322 A5 JP2020523322 A5 JP 2020523322A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- preparation
- preparation according
- alcohol
- ceteares
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000009472 formulation Methods 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 6
- 208000035473 Communicable disease Diseases 0.000 claims 5
- 239000003995 emulsifying agent Substances 0.000 claims 5
- 150000002191 fatty alcohols Chemical class 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000002562 thickening agent Substances 0.000 claims 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- -1 stearyl alcohols Chemical class 0.000 claims 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
- 229960000735 docosanol Drugs 0.000 claims 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- 239000002953 phosphate buffered saline Substances 0.000 claims 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 2
- 229940068977 polysorbate 20 Drugs 0.000 claims 2
- 229940113124 polysorbate 60 Drugs 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940068968 polysorbate 80 Drugs 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims 2
- 229940042129 topical gel Drugs 0.000 claims 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 1
- 150000000211 1-dodecanols Chemical class 0.000 claims 1
- 150000000218 1-tetradecanols Chemical class 0.000 claims 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000005230 Leg Ulcer Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 208000024386 fungal infectious disease Diseases 0.000 claims 1
- 150000002398 hexadecan-1-ols Chemical class 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 229940043348 myristyl alcohol Drugs 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 229940055577 oleyl alcohol Drugs 0.000 claims 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 1
- 206010033072 otitis externa Diseases 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022147051A JP7470449B2 (ja) | 2017-06-12 | 2022-09-15 | ビスホスホシンゲル製剤及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762518262P | 2017-06-12 | 2017-06-12 | |
| US62/518,262 | 2017-06-12 | ||
| PCT/US2018/037151 WO2018231863A1 (en) | 2017-06-12 | 2018-06-12 | Bisphosphocin gel formulations and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147051A Division JP7470449B2 (ja) | 2017-06-12 | 2022-09-15 | ビスホスホシンゲル製剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523322A JP2020523322A (ja) | 2020-08-06 |
| JP2020523322A5 true JP2020523322A5 (enExample) | 2021-07-26 |
| JP7148994B2 JP7148994B2 (ja) | 2022-10-06 |
Family
ID=64562861
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567981A Active JP7148994B2 (ja) | 2017-06-12 | 2018-06-12 | ビスホスホシンゲル製剤及びその使用 |
| JP2022147051A Active JP7470449B2 (ja) | 2017-06-12 | 2022-09-15 | ビスホスホシンゲル製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022147051A Active JP7470449B2 (ja) | 2017-06-12 | 2022-09-15 | ビスホスホシンゲル製剤及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US11096954B2 (enExample) |
| EP (2) | EP3638251B1 (enExample) |
| JP (2) | JP7148994B2 (enExample) |
| KR (3) | KR20230031370A (enExample) |
| CN (1) | CN110753549A (enExample) |
| AU (3) | AU2018282905B2 (enExample) |
| BR (2) | BR112019026073B1 (enExample) |
| CA (1) | CA3066722A1 (enExample) |
| DK (1) | DK3638251T3 (enExample) |
| ES (1) | ES2981923T3 (enExample) |
| FI (1) | FI3638251T3 (enExample) |
| MX (1) | MX2019014772A (enExample) |
| PT (1) | PT3638251T (enExample) |
| WO (1) | WO2018231863A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006113505A2 (en) | 2005-04-15 | 2006-10-26 | Clarus Therapeutics, Inc. | Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
| US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
| US11795192B2 (en) | 2017-03-10 | 2023-10-24 | Lakewood Amedex, Inc. | Antimicrobial compounds, compositions, and uses thereof |
| US11377468B2 (en) | 2017-03-10 | 2022-07-05 | Lakewood Amedex, Inc. | Antimicrobial compounds, compositions, and uses thereof |
| KR102684529B1 (ko) * | 2017-03-10 | 2024-07-12 | 레이크우드 아메덱스, 인크. | 항미생물 화합물, 조성물, 및 그의 용도 |
| US12030908B2 (en) | 2017-03-10 | 2024-07-09 | Lakewood Amedex, Inc. | Antimicrobial compounds, compositions, and uses thereof |
| KR20230031370A (ko) | 2017-06-12 | 2023-03-07 | 레이크우드 아메덱스, 인크. | 비스포스포신 겔 제제 및 이의 용도 |
| MX2021004396A (es) * | 2018-10-17 | 2021-06-04 | Lakewood Amedex Inc | Metodos y composiciones para el tratamiento de la mucositis oral. |
| US11564933B2 (en) | 2019-04-12 | 2023-01-31 | Tolmar, Inc. | Methods of treating testosterone deficiency |
| WO2023004130A1 (en) * | 2021-07-22 | 2023-01-26 | Lakewood Amedex, Inc. | Methods for preparing bisphosphocins |
| WO2025179296A1 (en) * | 2024-02-22 | 2025-08-28 | Lakewood Amedex, Inc. | Crystalline forms of nu-3 and uses thereof |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105782A (en) | 1975-03-07 | 1978-08-08 | Yu Ruey J | Treatment of acne and dandruff |
| SE8004580L (sv) | 1980-06-19 | 1981-12-20 | Draco Ab | Farmaceutisk beredning |
| KR830005852A (ko) * | 1980-07-18 | 1983-09-14 | 미첼 페터 잭슨 | 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법 |
| US4421769A (en) * | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
| DE3542516A1 (de) | 1985-12-02 | 1987-06-04 | Henkel Kgaa | Desinfektionsmittel |
| US5266310A (en) | 1987-09-17 | 1993-11-30 | Boehringer Ingelheim International Gmbh | Stabilization of therapeutically active proteins in pharmaceutical preparations |
| DE3731255A1 (de) * | 1987-09-17 | 1989-04-06 | Boehringer Ingelheim Int | Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen |
| US5153230A (en) | 1989-10-06 | 1992-10-06 | Perfective Cosmetics, Inc. | Topical skin cream composition |
| US5167950A (en) | 1991-03-28 | 1992-12-01 | S. C. Johnson & Son | High alcohol content aerosol antimicrobial mousse |
| US5208015A (en) | 1991-07-23 | 1993-05-04 | Bristol-Myers Squibb Company | Topical anti-fungal agents having anti-inflammatory activity |
| DE4333385C2 (de) | 1993-09-30 | 1997-01-30 | Friedrich A Spruegel | Flächendesinfektions- und Reinigungsmittel |
| EP0748203A1 (en) * | 1994-03-11 | 1996-12-18 | The Procter & Gamble Company | LOW pH, HYDROLYTICALLY STABLE, COSMETIC COMPOSITIONS CONTAINING ACIDIC ACTIVES |
| FR2718022B1 (fr) | 1994-04-01 | 1996-04-26 | Roussel Uclaf | Compositions cosmétiques ou dermatologiques et leur préparation. |
| FR2722102B1 (fr) | 1994-07-11 | 1996-08-23 | Cird Galderma | Utilisation de particules creuses deformables dans une composition cosmetique et/ou dermatologique, contenant des matieres grasses |
| US5843998A (en) | 1997-06-30 | 1998-12-01 | Song; Jin | Skin blemish treatment |
| US7868162B2 (en) | 1998-12-30 | 2011-01-11 | Lakewood-Amedex, Inc. | Antimicrobial and antiviral compounds and methods for their use |
| US6627215B1 (en) | 1998-12-30 | 2003-09-30 | Oligos Etc. Inc. | Devices for improved wound management |
| US6211162B1 (en) | 1998-12-30 | 2001-04-03 | Oligos Etc. Inc. | Pulmonary delivery of protonated/acidified nucleic acids |
| US20020032164A1 (en) | 1998-12-30 | 2002-03-14 | Dale Roderic M. K. | Antimicrobial compounds and methods for their use |
| US6211349B1 (en) | 1998-12-30 | 2001-04-03 | Oligos Etc., Inc. | Protonated/acidified nucleic acids and methods of use |
| US6156294A (en) | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| EP1435970A4 (en) * | 2001-10-18 | 2005-05-04 | Ilex Products Inc | METHOD FOR TREATING THE SKIN WITH DIPHOSPHONATE DERIVATIVES |
| JP5711867B2 (ja) * | 2003-04-24 | 2015-05-07 | ガルデルマ・ソシエテ・アノニム | 皮膚科学的疾患の治療のためのアイバメクチンの使用 |
| CN1687100A (zh) * | 2005-04-05 | 2005-10-26 | 奥林格斯技术有限公司 | 修饰性核苷酸及其用途 |
| EP2149375A1 (en) | 2008-07-28 | 2010-02-03 | Despharma Kft. | Compositions for the treatment of dermatological diseases, and uses thereof |
| EP2419087B1 (en) | 2009-04-13 | 2013-01-23 | Sulur, Vanangamudi Subramaniam | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer and a process to make it |
| WO2015075406A1 (en) * | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
| FR3041540B1 (fr) | 2015-09-29 | 2018-10-26 | Galderma Research & Development | Composition nettoyante auto-moussante a rincer, contenant de l'ivermectine. |
| KR20230031370A (ko) | 2017-06-12 | 2023-03-07 | 레이크우드 아메덱스, 인크. | 비스포스포신 겔 제제 및 이의 용도 |
-
2018
- 2018-06-12 KR KR1020237004991A patent/KR20230031370A/ko not_active Ceased
- 2018-06-12 BR BR112019026073-0A patent/BR112019026073B1/pt not_active IP Right Cessation
- 2018-06-12 EP EP18816615.1A patent/EP3638251B1/en active Active
- 2018-06-12 DK DK18816615.1T patent/DK3638251T3/da active
- 2018-06-12 FI FIEP18816615.1T patent/FI3638251T3/fi active
- 2018-06-12 ES ES18816615T patent/ES2981923T3/es active Active
- 2018-06-12 US US16/006,660 patent/US11096954B2/en active Active
- 2018-06-12 KR KR1020267005083A patent/KR20260035292A/ko active Pending
- 2018-06-12 CA CA3066722A patent/CA3066722A1/en active Pending
- 2018-06-12 AU AU2018282905A patent/AU2018282905B2/en not_active Ceased
- 2018-06-12 EP EP23156658.9A patent/EP4241769A3/en active Pending
- 2018-06-12 KR KR1020207000424A patent/KR20200014904A/ko not_active Abandoned
- 2018-06-12 CN CN201880038759.5A patent/CN110753549A/zh active Pending
- 2018-06-12 MX MX2019014772A patent/MX2019014772A/es unknown
- 2018-06-12 PT PT188166151T patent/PT3638251T/pt unknown
- 2018-06-12 JP JP2019567981A patent/JP7148994B2/ja active Active
- 2018-06-12 BR BR122021011439-0A patent/BR122021011439B1/pt active IP Right Grant
- 2018-06-12 WO PCT/US2018/037151 patent/WO2018231863A1/en not_active Ceased
-
2020
- 2020-07-30 US US16/943,939 patent/US20200360415A1/en not_active Abandoned
-
2021
- 2021-08-09 US US17/396,989 patent/US12156883B2/en active Active
-
2022
- 2022-09-02 AU AU2022224829A patent/AU2022224829B2/en active Active
- 2022-09-15 JP JP2022147051A patent/JP7470449B2/ja active Active
- 2022-12-16 US US18/083,378 patent/US20230125677A1/en not_active Abandoned
-
2024
- 2024-04-05 AU AU2024202211A patent/AU2024202211B2/en active Active
- 2024-10-31 US US18/933,370 patent/US20250262234A1/en active Pending
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