JP2020523319A5 - - Google Patents

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Publication number
JP2020523319A5
JP2020523319A5 JP2019567691A JP2019567691A JP2020523319A5 JP 2020523319 A5 JP2020523319 A5 JP 2020523319A5 JP 2019567691 A JP2019567691 A JP 2019567691A JP 2019567691 A JP2019567691 A JP 2019567691A JP 2020523319 A5 JP2020523319 A5 JP 2020523319A5
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JP
Japan
Prior art keywords
seq
amino acid
acid sequence
sequence
fibrosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2019567691A
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English (en)
Japanese (ja)
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JP2020523319A (ja
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Priority claimed from PCT/US2018/036554 external-priority patent/WO2018227018A1/en
Publication of JP2020523319A publication Critical patent/JP2020523319A/ja
Publication of JP2020523319A5 publication Critical patent/JP2020523319A5/ja
Pending legal-status Critical Current

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JP2019567691A 2017-06-07 2018-06-07 免疫調節化合物の抗体コンジュゲートおよびその使用 Pending JP2020523319A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762516638P 2017-06-07 2017-06-07
US62/516,638 2017-06-07
PCT/US2018/036554 WO2018227018A1 (en) 2017-06-07 2018-06-07 Antibody conjugates of immune-modulatory compounds and uses thereof

Publications (2)

Publication Number Publication Date
JP2020523319A JP2020523319A (ja) 2020-08-06
JP2020523319A5 true JP2020523319A5 (https=) 2021-07-26

Family

ID=64567206

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019567691A Pending JP2020523319A (ja) 2017-06-07 2018-06-07 免疫調節化合物の抗体コンジュゲートおよびその使用

Country Status (7)

Country Link
US (1) US20200199247A1 (https=)
EP (1) EP3634485A4 (https=)
JP (1) JP2020523319A (https=)
CN (1) CN110891605A (https=)
AU (1) AU2018279105A1 (https=)
CA (1) CA3065852A1 (https=)
WO (1) WO2018227018A1 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11583593B2 (en) 2016-01-14 2023-02-21 Synthis Therapeutics, Inc. Antibody-ALK5 inhibitor conjugates and their uses
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
MX2020012679A (es) * 2018-05-25 2021-02-09 Silverback Therapeutics Inc Compuestos de amino-pirazincarboxamida, conjugados, y usos de los mismos.
CN111018857B (zh) * 2018-10-09 2023-06-02 嘉兴优博生物技术有限公司 靶向蛋白酶降解平台(ted)
EA202190986A1 (ru) 2018-11-26 2021-12-14 Фоти Севен, Инк. ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА К c-Kit
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
JP7682102B2 (ja) * 2019-05-10 2025-05-23 リビジェン バイオファーマ ホールディングス リミテッド ヒト化抗cd137抗体およびその使用
BR112021023345A2 (pt) 2019-05-20 2022-02-01 Pandion Operations Inc Imunotolerância com alvo em madcam
US20220267467A1 (en) * 2019-07-19 2022-08-25 WuXi Biologics Ireland Limited Polypeptide complex for conjugation and use thereof
WO2021023117A1 (zh) * 2019-08-02 2021-02-11 康方药业有限公司 抗ctla4-抗pd-1双特异性抗体及其用途
WO2021102332A1 (en) * 2019-11-22 2021-05-27 Silverback Therapeutics, Inc. Tgfbetar2 inhibitor-lrrc15 antibody conjugates and uses thereof
WO2021118968A1 (en) * 2019-12-12 2021-06-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody-drug conjugates specific for cd276 and uses thereof
JP2023509760A (ja) * 2020-01-08 2023-03-09 シンシス セラピューティクス,インコーポレイテッド Alk5阻害剤複合体およびその使用
TWI854088B (zh) * 2020-01-27 2024-09-01 英商梅迪繆思有限公司 用於治療腎臟疾病之抗αvβ8整聯蛋白抗體
EP4107187A4 (en) 2020-02-21 2024-07-03 Pandion Operations, Inc. TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR
JP7735291B2 (ja) 2020-02-21 2025-09-08 エーアールエス ファーマシューティカルズ、インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
AU2021246485A1 (en) * 2020-04-01 2022-11-17 The Regents Of The University Of California Immunotheranostic agent targeting mesenchymal stem cell-derived cancer cells and mesenchymal stem cell associated disease
CN113509557A (zh) * 2020-04-09 2021-10-19 嘉兴优博生物技术有限公司 靶向蛋白酶降解平台(ted)
EP4149627A4 (en) * 2020-05-14 2024-05-29 The General Hospital Corporation POLYPEPTIDE AGONISTS OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY
WO2021243136A2 (en) * 2020-05-29 2021-12-02 New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery Methods and compositions for treating, preventing the onset and/or slowing progression of osteoarthritis
EP4157883A4 (en) * 2020-06-02 2024-12-04 Children's Medical Center Corporation NANOBODY CONJUGATES (VHH) AND THEIR USES
JP2023532304A (ja) 2020-07-01 2023-07-27 エーアールエス ファーマシューティカルズ オペレーションズ,インク. 抗asgr1抗体コンジュゲートおよびその使用
KR102506295B1 (ko) * 2020-08-28 2023-03-08 국립암센터 디그옥시제닌에 대한 인간화 항체 및 이의 용도
CN114146095A (zh) * 2020-09-07 2022-03-08 是光隽恒(北京)生物科技有限公司 用于组织损伤修复的组合物及其制备方法和用途
CN116615442A (zh) * 2020-09-08 2023-08-18 优特力克斯有限公司 程序性细胞死亡1多肽变体
EP4247434A4 (en) * 2020-11-18 2024-10-23 Pandion Operations, Inc. THERAPEUTIC AGENTS TARGETING MADCAM AND THEIR USES
IL306129A (en) * 2021-04-07 2023-11-01 Mythic Therapeutics Inc Structures of antigen-binding proteins and antibodies and their uses
US20240209080A1 (en) 2021-04-10 2024-06-27 Profoundbio Us Co. Folr1 binding agents, conjugates thereof and methods of using the same
CA3216459A1 (en) 2021-04-23 2022-10-27 Profoundbio Us Co. Anti-cd70 antibodies, conjugates thereof and methods of using the same
CA3225636A1 (en) 2021-07-02 2023-01-05 Merck Patent Gmbh Anti-protac antibodies and complexes
TW202320857A (zh) 2021-07-06 2023-06-01 美商普方生物製藥美國公司 連接子、藥物連接子及其結合物及其使用方法
WO2023104134A1 (en) * 2021-12-09 2023-06-15 Genequantum Healthcare (Suzhou) Co., Ltd. Antibody-cytokine fusion proteins and applications thereof
US20260055119A9 (en) * 2021-12-30 2026-02-26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Tricyclic compound, method for preparing same, and use thereof
AU2023347072A1 (en) * 2022-09-20 2025-01-02 Currus Biologics Pty Ltd Bispecific polypeptides and uses thereof
WO2024138128A2 (en) * 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
CN121240880A (zh) 2022-12-27 2025-12-30 默克专利股份有限公司 Vhh抗protac抗体和复合物
CN121013863A (zh) * 2023-03-31 2025-11-25 艾菲赛尔治疗株式会社 Tnfr2结合多肽及使用方法
FR3147278A1 (fr) * 2023-03-31 2024-10-04 Avacta Life Sciences Limited Polypeptides de liaison au tnfr2 et procedes d'utilisation
FR3147292A1 (fr) * 2023-03-31 2024-10-04 Affyxell Therapeutics Co., Ltd. Cellules genetiquement modifiees dans lesquelles un acide nucleique codant pour des variantes de la proteine stefine a se liant specifiquement au tnfr2 ou une proteine de fusion comprenant celle-ci a ete introduite, et leurs utilisations
EP4713023A2 (en) * 2023-05-18 2026-03-25 Firefly Bio, Inc. Isoindolinone-glutarimide antibody conjugates, and uses thereof
WO2024243545A1 (en) * 2023-05-24 2024-11-28 President And Fellows Of Harvard College Compositions targeting endothelial cells and uses thereof
AR133955A1 (es) 2023-09-26 2025-11-19 Profoundbio Us Co Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos
WO2025149661A1 (en) 2024-01-10 2025-07-17 Genmab A/S Slitrk6 binding agents, conjugates thereof and methods of using the same
EP4595981A1 (en) * 2024-02-01 2025-08-06 Jack Elands Antibody-drug conjugates comprising an anti-integrin v 6 binding antibody
WO2025163120A1 (en) * 2024-02-01 2025-08-07 Adcytherix Sas ANTIBODY-DRUG CONJUGATES COMPRISING AN ANTI-INTEGRIN ΑVβ6 BINDING ANTIBODY
US20250381289A1 (en) 2024-02-29 2025-12-18 Genmab A/S Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same
WO2025216667A1 (en) * 2024-04-12 2025-10-16 Joint Stock Company «Biocad» Monoclonal antibody that specifically binds to bdca-2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1791565T3 (en) * 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
US8603483B2 (en) * 2004-12-09 2013-12-10 Janssen Biotech, Inc. Anti-integrin immunoconjugates, methods and uses
WO2011040973A2 (en) * 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd. Tnf-immunoconjugates with fibroblast activation protein antibodies and methods and uses thereof
CA2776037A1 (en) * 2009-10-02 2011-04-07 Ludwig Institute For Cancer Research Ltd Anti-fibroblast activation protein antibodies and methods and uses thereof
EP2608804A4 (en) * 2010-08-27 2015-03-11 Univ Miami TREATMENT OF KIDNEY DISEASES
EA201892619A1 (ru) * 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
KR102668696B1 (ko) * 2012-01-12 2024-05-29 예일 유니버시티 E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
WO2013111308A1 (ja) * 2012-01-26 2013-08-01 株式会社ヨロズ 湾曲中空パイプの製造方法
SG11201609372UA (en) * 2014-05-22 2016-12-29 Synthon Biopharmaceuticals Bv Site-specific conjugation of linker drugs to antibodies and resulting adcs
AR105654A1 (es) * 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
AU2016365117A1 (en) * 2015-11-30 2018-05-31 Abbvie Biotherapeutics Inc. Anti-huLRRC15 antibody drug conjugates and methods for their use
AU2016365114A1 (en) * 2015-11-30 2018-05-17 Abbvie Biotherapeutics Inc. Anti-huLRRC15 antibody drug conjugates and methods for their use
WO2019195278A1 (en) * 2018-04-02 2019-10-10 Silverback Therapeutics, Inc. Alk5 inhibitors, conjugates, and uses thereof
MX2020012679A (es) * 2018-05-25 2021-02-09 Silverback Therapeutics Inc Compuestos de amino-pirazincarboxamida, conjugados, y usos de los mismos.

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