JP2020523309A - ピラゾロピリミジンｐｄｅ９インヒビター - Google Patents

ピラゾロピリミジンｐｄｅ９インヒビター Download PDF

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Publication number
JP2020523309A
JP2020523309A JP2019567341A JP2019567341A JP2020523309A JP 2020523309 A JP2020523309 A JP 2020523309A JP 2019567341 A JP2019567341 A JP 2019567341A JP 2019567341 A JP2019567341 A JP 2019567341A JP 2020523309 A JP2020523309 A JP 2020523309A
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JP
Japan
Prior art keywords
ethyl
pyrazolo
cyclobutyl
dihydro
oxo
Prior art date
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Pending
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JP2019567341A
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English (en)
Japanese (ja)
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JP2020523309A5 (enExample
Inventor
アラサパン，アショーカ
コックス，ジェーソン・エム
ディベンハム，ジョン・エス
グオ，ジュイェン
ヘ，ジアファン
フサイン，ザヒド
ライ，ツォン
リ，デラン
メン，ドンファン
ラガバン，スバレカ
ティアガラジャン，シュリラーム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
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Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2020523309A publication Critical patent/JP2020523309A/ja
Publication of JP2020523309A5 publication Critical patent/JP2020523309A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019567341A 2017-06-08 2018-06-06 ピラゾロピリミジンｐｄｅ９インヒビター Pending JP2020523309A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762516903P 2017-06-08 2017-06-08
US62/516,903 2017-06-08
US201862665840P 2018-05-02 2018-05-02
US62/665,840 2018-05-02
PCT/US2018/036172 WO2018226771A1 (en) 2017-06-08 2018-06-06 Pyrazolopyrimidine pde9 inhibitors

Publications (2)

Publication Number Publication Date
JP2020523309A true JP2020523309A (ja) 2020-08-06
JP2020523309A5 JP2020523309A5 (enExample) 2021-07-26

Family

ID=62779024

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019567341A Pending JP2020523309A (ja) 2017-06-08 2018-06-06 ピラゾロピリミジンｐｄｅ９インヒビター

Country Status (13)

Country Link
US (2) US10934294B2 (enExample)
EP (1) EP3634964B1 (enExample)
JP (1) JP2020523309A (enExample)
KR (1) KR20200013758A (enExample)
CN (1) CN111051308A (enExample)
AU (1) AU2018281131B2 (enExample)
BR (1) BR112019025813A2 (enExample)
CA (1) CA3064938A1 (enExample)
MA (1) MA53841A (enExample)
MX (1) MX2019014597A (enExample)
RU (1) RU2019144010A (enExample)
TW (1) TW201902898A (enExample)
WO (1) WO2018226771A1 (enExample)

Families Citing this family (8)

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KR20200013758A (ko) 2017-06-08 2020-02-07 머크 샤프 앤드 돔 코포레이션 피라졸로피리미딘 pde9 억제제
WO2020123272A1 (en) * 2018-12-12 2020-06-18 Merck Sharp & Dohme Corp. Pyrazolopyrimidine pde9 inhibitors
US12247031B2 (en) 2018-12-12 2025-03-11 Merck Sharp & Dohme Llc Cyclobutyl pyrazolopyrimidine PDE9 inhibitors
CA3132895C (en) * 2019-03-08 2024-05-14 Transthera Sciences (Nanjing), Inc. Uses of phosphodiesterase inhibitors
WO2021253180A1 (en) * 2020-06-15 2021-12-23 Novartis Ag Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators
CN114773256B (zh) * 2022-03-23 2024-05-03 中国农业大学 一种4-氰基哌啶的合成方法
CN117582909B (zh) * 2024-01-19 2024-04-02 天津凯莱英医药科技发展有限公司 一种连续生产5-单硝酸异山梨酯的系统和方法
CN120329388B (zh) * 2025-04-30 2025-09-26 中日友好医院(中日友好临床医学研究所) 一种双靶点多肽及其在心衰治疗中的应用

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US5541187A (en) * 1992-03-30 1996-07-30 Sterling Winthrop Inc. 6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compositions and method of use thereof
JP2013533302A (ja) * 2010-08-12 2013-08-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ６−シクロアルキル−１，５−ジヒドロ−ピラゾロ（３，４−ｄ）ピリミジ−４−オン誘導体及びｐｄｅ９ａ阻害剤としてのその使用
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Also Published As

Publication number Publication date
KR20200013758A (ko) 2020-02-07
CN111051308A (zh) 2020-04-21
US11028092B2 (en) 2021-06-08
EP3634964A1 (en) 2020-04-15
CA3064938A1 (en) 2018-12-13
US20180354955A1 (en) 2018-12-13
EP3634964B1 (en) 2022-02-23
RU2019144010A3 (enExample) 2021-10-01
TW201902898A (zh) 2019-01-16
US10934294B2 (en) 2021-03-02
BR112019025813A2 (pt) 2020-07-07
RU2019144010A (ru) 2021-07-13
AU2018281131A1 (en) 2019-12-05
AU2018281131B2 (en) 2022-01-20
US20200140445A1 (en) 2020-05-07
WO2018226771A1 (en) 2018-12-13
MX2019014597A (es) 2020-02-05
MA53841A (fr) 2021-09-22

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