JP2020522525A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020522525A5 JP2020522525A5 JP2019566909A JP2019566909A JP2020522525A5 JP 2020522525 A5 JP2020522525 A5 JP 2020522525A5 JP 2019566909 A JP2019566909 A JP 2019566909A JP 2019566909 A JP2019566909 A JP 2019566909A JP 2020522525 A5 JP2020522525 A5 JP 2020522525A5
- Authority
- JP
- Japan
- Prior art keywords
- human patient
- item
- pharmaceutical composition
- compound
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 146
- 229960005309 estradiol Drugs 0.000 claims description 51
- 239000008194 pharmaceutical composition Substances 0.000 claims description 49
- 238000002560 therapeutic procedure Methods 0.000 claims description 49
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 32
- 239000004381 Choline salt Substances 0.000 claims description 29
- 235000019417 choline salt Nutrition 0.000 claims description 29
- 206010046798 Uterine leiomyoma Diseases 0.000 claims description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 17
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims description 17
- 229960001652 norethindrone acetate Drugs 0.000 claims description 17
- 239000000583 progesterone congener Substances 0.000 claims description 16
- 201000010260 leiomyoma Diseases 0.000 claims description 15
- 229940011871 estrogen Drugs 0.000 claims description 12
- 239000000262 estrogen Substances 0.000 claims description 12
- 230000002175 menstrual effect Effects 0.000 claims description 9
- -1 2,3-difluoro-6-methoxybenzyloxy Chemical group 0.000 claims 8
- IIVUJUOJERNGQX-UHFFFAOYSA-N pyrimidine-5-carboxylic acid Chemical compound OC(=O)C1=CN=CN=C1 IIVUJUOJERNGQX-UHFFFAOYSA-N 0.000 claims 8
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical group C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 229960003575 estradiol acetate Drugs 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 2
- 238000000034 method Methods 0.000 description 251
- 210000002966 serum Anatomy 0.000 description 32
- 201000000736 Amenorrhea Diseases 0.000 description 24
- 206010001928 Amenorrhoea Diseases 0.000 description 24
- 231100000540 amenorrhea Toxicity 0.000 description 24
- 150000003248 quinolines Chemical class 0.000 description 24
- 229960003387 progesterone Drugs 0.000 description 16
- 239000000186 progesterone Substances 0.000 description 16
- 239000000126 substance Substances 0.000 description 14
- 229940035811 conjugated estrogen Drugs 0.000 description 10
- QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 description 10
- 229960004616 medroxyprogesterone Drugs 0.000 description 10
- FRQMUZJSZHZSGN-HBNHAYAOSA-N medroxyprogesterone Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FRQMUZJSZHZSGN-HBNHAYAOSA-N 0.000 description 10
- ZAHDXEIQWWLQQL-IHRRRGAJSA-N Deoxypyridinoline Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(O)=C(C[C@H](N)C([O-])=O)C(CC[C@H](N)C(O)=O)=C1 ZAHDXEIQWWLQQL-IHRRRGAJSA-N 0.000 description 9
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 8
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 8
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 description 8
- 229960004845 drospirenone Drugs 0.000 description 8
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 description 8
- 229960002568 ethinylestradiol Drugs 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 6
- KIQQMECNKUGGKA-NMYWJIRASA-N norgestimate Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(OC(C)=O)C#C)[C@@H]4[C@@H]3CCC2=C\1 KIQQMECNKUGGKA-NMYWJIRASA-N 0.000 description 6
- 229960000417 norgestimate Drugs 0.000 description 6
- 238000004319 19F solid-state nuclear magnetic resonance spectroscopy Methods 0.000 description 4
- 208000008035 Back Pain Diseases 0.000 description 4
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 4
- 208000000450 Pelvic Pain Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 229940053934 norethindrone Drugs 0.000 description 4
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 4
- 238000000634 powder X-ray diffraction Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 210000000689 upper leg Anatomy 0.000 description 4
- 238000004922 13C solid-state nuclear magnetic resonance spectroscopy Methods 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 0 CCc1c(*)ccc(OC)c1COc(cc(*(C(c1c(C(*)=O)[n]cc1*1)O)C1=O)c(*)c1)c1OC Chemical compound CCc1c(*)ccc(OC)c1COc(cc(*(C(c1c(C(*)=O)[n]cc1*1)O)C1=O)c(*)c1)c1OC 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 108010050808 Procollagen Proteins 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023043718A JP7485815B2 (ja) | 2017-06-05 | 2023-03-20 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762515232P | 2017-06-05 | 2017-06-05 | |
| US62/515,232 | 2017-06-05 | ||
| PCT/EP2018/064767 WO2018224497A1 (en) | 2017-06-05 | 2018-06-05 | Gonadotropin-releasing hormone antagonist dosing regimens for treating uterine fibroids and reducing menstrual blood loss |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023043718A Division JP7485815B2 (ja) | 2017-06-05 | 2023-03-20 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522525A JP2020522525A (ja) | 2020-07-30 |
| JP2020522525A5 true JP2020522525A5 (cg-RX-API-DMAC7.html) | 2021-07-26 |
| JP7292566B2 JP7292566B2 (ja) | 2023-06-19 |
Family
ID=62636157
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566909A Active JP7292566B2 (ja) | 2017-06-05 | 2018-06-05 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
| JP2023043718A Active JP7485815B2 (ja) | 2017-06-05 | 2023-03-20 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023043718A Active JP7485815B2 (ja) | 2017-06-05 | 2023-03-20 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
Country Status (18)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3384930A1 (en) | 2013-03-15 | 2018-10-10 | AbbVie Inc. | Compositions for use in treating heavy menstrual bleeding |
| MX2019014482A (es) | 2017-06-05 | 2020-08-17 | ObsEva SA | Régimenes de dosificación de antagonistas de hormona liberadora de gonadotropina para tratar miomas uterinos y reducir la menstruación. |
| KR20250117836A (ko) | 2017-06-05 | 2025-08-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 자궁내막증의 치료를 위한 고나도트로핀 방출 호르몬 길항제 투약 요법 |
| IL278082B2 (en) | 2018-04-19 | 2025-03-01 | Abbvie Inc | Methods of treating heavy menstrual bleeding |
| CA3107597A1 (en) * | 2018-08-01 | 2020-02-06 | Abbvie Inc. | Dosing regimens for elagolix |
| EP3873465B1 (en) | 2018-10-29 | 2025-01-15 | Kissei Pharmaceutical Co., Ltd. | Compositions and methods for the treatment of adenomyosis and rectovaginal endometriosis |
| EP3876943A2 (en) * | 2018-11-07 | 2021-09-15 | ObsEva S.A. | Compositions and methods for the treatment of estrogen-dependent disorders |
| US20220305017A1 (en) * | 2019-08-08 | 2022-09-29 | ObsEva S.A. | Compositions and methods for the treatment of estrogen-dependent disorders |
| CN114364384A (zh) * | 2019-08-08 | 2022-04-15 | 奥布赛瓦股份公司 | 用于治疗雌激素依赖性病症的GnRH拮抗剂 |
| KR20210155350A (ko) | 2020-06-15 | 2021-12-22 | 한상왕 | 녹차 추출물 및 비타민 d3를 유효성분으로 포함하는 자궁근종 개선용 조성물 |
| CN115232144B (zh) * | 2021-04-22 | 2024-04-02 | 长春金赛药业有限责任公司 | 含氮稠环类衍生物、药物组合物及其制备方法和应用 |
| KR102738115B1 (ko) | 2024-03-25 | 2024-12-05 | 한상왕 | 자궁근종 예방, 개선 또는 치료용 약학 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7109171B2 (en) * | 2000-02-28 | 2006-09-19 | Praecis Pharmaceuticals Inc. | Methods for treating FSH related conditions with GnRH antagonists |
| BRPI0617436B8 (pt) | 2005-10-19 | 2021-05-25 | Kissei Pharmaceutical | derivado heterocíclico fundido, composição farmacêutica compreendendo o mesmo e usos do dito derivado na prevenção ou tratamento de doença dependente de hormônio sexual e na regulação da reprodução, contracepção ou indução de ovulação |
| BR112012020110B1 (pt) | 2010-02-10 | 2021-06-08 | Kissei Pharmaceutical Co., Ltd. | composto derivado heterocíclico fusionado, composição farmacêutica que compreende o mesmo e uso terapêutico do dito composto |
| WO2014042176A1 (ja) | 2012-09-14 | 2014-03-20 | キッセイ薬品工業株式会社 | 縮合複素環誘導体の製造方法およびその製造中間体 |
| EP3384930A1 (en) * | 2013-03-15 | 2018-10-10 | AbbVie Inc. | Compositions for use in treating heavy menstrual bleeding |
| CA3025760A1 (en) | 2016-08-08 | 2018-02-15 | Kissei Pharmaceutical Co., Ltd. | Usage and dosage of therapeutic agents for endometriosis |
| DK3518933T4 (da) | 2016-09-30 | 2025-04-22 | Takeda Pharmaceuticals Co | Fremgangsmåder til behandling af uterusfibromer og endometriose |
| MX2019014482A (es) | 2017-06-05 | 2020-08-17 | ObsEva SA | Régimenes de dosificación de antagonistas de hormona liberadora de gonadotropina para tratar miomas uterinos y reducir la menstruación. |
| KR20250117836A (ko) | 2017-06-05 | 2025-08-05 | 깃세이 야쿠힌 고교 가부시키가이샤 | 자궁내막증의 치료를 위한 고나도트로핀 방출 호르몬 길항제 투약 요법 |
| EP3876943A2 (en) | 2018-11-07 | 2021-09-15 | ObsEva S.A. | Compositions and methods for the treatment of estrogen-dependent disorders |
-
2018
- 2018-06-05 MX MX2019014482A patent/MX2019014482A/es unknown
- 2018-06-05 JP JP2019566909A patent/JP7292566B2/ja active Active
- 2018-06-05 US US16/619,702 patent/US11759464B2/en active Active
- 2018-06-05 WO PCT/EP2018/064767 patent/WO2018224497A1/en not_active Ceased
- 2018-06-05 KR KR1020197038980A patent/KR102884301B1/ko active Active
- 2018-06-05 CN CN201880050807.2A patent/CN110996957A/zh active Pending
- 2018-06-05 ES ES18731976T patent/ES3018358T3/es active Active
- 2018-06-05 HR HRP20250390TT patent/HRP20250390T1/hr unknown
- 2018-06-05 SG SG11201911599XA patent/SG11201911599XA/en unknown
- 2018-06-05 PT PT187319769T patent/PT3634419T/pt unknown
- 2018-06-05 DK DK18731976.9T patent/DK3634419T3/da active
- 2018-06-05 HU HUE18731976A patent/HUE070907T2/hu unknown
- 2018-06-05 FI FIEP18731976.9T patent/FI3634419T3/fi active
- 2018-06-05 MX MX2023013582A patent/MX2023013582A/es unknown
- 2018-06-05 CA CA3066188A patent/CA3066188A1/en active Pending
- 2018-06-05 AU AU2018280741A patent/AU2018280741B2/en active Active
- 2018-06-05 EA EA201992812A patent/EA201992812A1/ru unknown
- 2018-06-05 PL PL18731976.9T patent/PL3634419T3/pl unknown
- 2018-06-05 EP EP24221894.9A patent/EP4509173A3/en active Pending
- 2018-06-05 EP EP18731976.9A patent/EP3634419B1/en active Active
-
2023
- 2023-03-20 JP JP2023043718A patent/JP7485815B2/ja active Active
- 2023-09-11 US US18/244,773 patent/US20240000785A1/en active Pending
-
2024
- 2024-03-14 AU AU2024201694A patent/AU2024201694A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020522525A5 (cg-RX-API-DMAC7.html) | ||
| US5468736A (en) | Hormone replacement therapy | |
| JP3113269B2 (ja) | 骨粗鬆症治療剤 | |
| KR100365879B1 (ko) | 프로게스테론길항제및게스타겐을포함하는자궁내막증식증또는자궁평활근종치료제 | |
| JP7292566B2 (ja) | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 | |
| JPH09502194A (ja) | 少なくとも１種のプロゲストーゲンおよび少なくとも１種のエストロゲンを含む、代替療法用製剤 | |
| JPS61178917A (ja) | 抗エストロゲンと担体よりなる組成物の製法 | |
| CA2746787A1 (en) | Method of increasing testosterone and related steroid concentrations in women | |
| HU214598B (hu) | Eljárás fogamzásgátló és hormonterápiához alkalmazható, ösztrogént és progesztint tartalmazó gyógyszerkészítmények előállítására | |
| JP2020522571A5 (cg-RX-API-DMAC7.html) | ||
| KR20000048981A (ko) | 에스트로겐 화합물 및 프로게스테론 화합물로 이루어진 호르몬 조성물 | |
| JP2003048836A (ja) | 効能を保持し無月経を引き起こす超低用量の経口避妊薬 | |
| EP0474374A1 (en) | Method for treatment of bone wasting diseases using a progestin | |
| JP3054780B2 (ja) | 受精の阻止及び防止方法 | |
| WO2000021511A2 (en) | Subcutaneous medroxyprogesterone acetate for treatment of menopause and endometriosis | |
| JP2005527574A (ja) | ホルモン補充療法におけるトリメゲストンと組み合わせた結合型エストロゲンの使用 | |
| RU2234321C2 (ru) | Применение антипрогестагенов в комбинированной терапии | |
| AU6621994A (en) | Method and composition for treatment of osteoporosis | |
| Briggs et al. | Clinical and biochemical investigations of a variable-dose combined type oral contraceptive | |
| JPH11501649A (ja) | 閉経周辺期及び閉経前期にある女性に対する徐放性避妊薬としての及びホルモン補充療法に使用する１月用注射薬 | |
| Gambhir et al. | 223. Chronic oral contraceptive therapy in man: Decrease of insulin binding | |
| Prema et al. | 222. Clinical trials with low dose injectable progestogen injection norethisterone 20 mg/monthly | |
| Tankeyoon et al. | 221. Metabolic effects of a long acting injectable steroid contraceptive | |
| MXPA01008772A (en) | Use of sex hormones to obtain a nasal pharmaceutical composition that is useful in the treatment of undesirable uterine bleeding | |
| CZ70099A3 (cs) | Transdermální terapeutický systém s estriolem, obsahujícím aktivní přísady |