|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
EP1015469B2
(en)
|
1997-09-12 |
2015-11-18 |
Exiqon A/S |
Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues
|
|
AU5290499A
(en)
*
|
1998-08-03 |
2000-02-28 |
Novartis Ag |
Human htra serine protease
|
|
BRPI0008131B8
(pt)
|
1999-02-12 |
2021-05-25 |
Daiichi Sankyo Co Ltd |
composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno
|
|
ATE356824T1
(de)
|
1999-05-04 |
2007-04-15 |
Santaris Pharma As |
L-ribo-lna analoge
|
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
|
EP2284269B1
(en)
|
2002-11-18 |
2017-08-09 |
Roche Innovation Center Copenhagen A/S |
Antisense design
|
|
EP1888083B1
(en)
*
|
2005-05-24 |
2011-12-28 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to lmw-ptpase
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
DE602007009487D1
(de)
|
2006-01-27 |
2010-11-11 |
Isis Pharmaceutical Inc |
6-modifizierte bicyclische nukleinsäureanaloga
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
CA2651453C
(en)
|
2006-05-11 |
2014-10-14 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
MX2009000909A
(es)
|
2006-07-26 |
2009-02-04 |
Univ Yale |
Diagnostico y tratamiento de degeneracion macular relacionada con la edad.
|
|
US20100166743A1
(en)
*
|
2006-10-06 |
2010-07-01 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
|
DK2170917T3
(da)
|
2007-05-30 |
2012-10-08 |
Isis Pharmaceuticals Inc |
N-Substituerede bicycliske nukleinsyreanaloge med aminomethylenbro
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
TW200911290A
(en)
|
2007-07-02 |
2009-03-16 |
Alcon Res Ltd |
RNAI-mediated inhibition of HTRA1 for treatment of macular degeneration
|
|
AU2008272918B2
(en)
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
WO2009059317A2
(en)
*
|
2007-11-01 |
2009-05-07 |
University Of Iowa Research Foundation |
Predicting amd with snps within or near c2, factor b, plekha1, htra1, prelp, or loc387715
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
FR2965278B1
(fr)
*
|
2010-09-23 |
2014-10-10 |
Univ Caen Basse Normandie |
Procede d'obtention in vitro ou ex vivo de chondrocytes et leurs utilisations
|
|
EP2753631A1
(en)
|
2011-09-07 |
2014-07-16 |
Marina Biotech, Inc. |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013173637A1
(en)
*
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
WO2018087200A1
(en)
*
|
2016-11-11 |
2018-05-17 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|