JP2020521490A5 - - Google Patents

Info

Publication number

JP2020521490A5

JP2020521490A5 JP2019566198A JP2019566198A JP2020521490A5 JP 2020521490 A5 JP2020521490 A5 JP 2020521490A5 JP 2019566198 A JP2019566198 A JP 2019566198A JP 2019566198 A JP2019566198 A JP 2019566198A JP 2020521490 A5 JP2020521490 A5 JP 2020521490A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

seq

binding fragment

sequence defined

Prior art date

2018-05-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000427 antigen Substances 0.000 claims 36
• 102000036639 antigens Human genes 0.000 claims 36
• 108091007433 antigens Proteins 0.000 claims 36
• 239000012634 fragment Substances 0.000 claims 36
• 238000000034 method Methods 0.000 claims 34
• 238000004519 manufacturing process Methods 0.000 claims 19
• 210000004027 cell Anatomy 0.000 claims 17
• LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 13
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 13
• 235000018417 cysteine Nutrition 0.000 claims 13
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 13
• 229960003067 cystine Drugs 0.000 claims 13
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 11
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 11
• 239000006143 cell culture medium Substances 0.000 claims 6
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
• 235000001014 amino acid Nutrition 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 238000010923 batch production Methods 0.000 claims 2
• 238000009472 formulation Methods 0.000 claims 2
• 239000013628 high molecular weight specie Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• BYHQTRFJOGIQAO-GOSISDBHSA-N 3-(4-bromophenyl)-8-[(2R)-2-hydroxypropyl]-1-[(3-methoxyphenyl)methyl]-1,3,8-triazaspiro[4.5]decan-2-one Chemical compound C[C@H](CN1CCC2(CC1)CN(C(=O)N2CC3=CC(=CC=C3)OC)C4=CC=C(C=C4)Br)O BYHQTRFJOGIQAO-GOSISDBHSA-N 0.000 claims 1
• 230000002378 acidificating effect Effects 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 230000006240 deamidation Effects 0.000 claims 1
• 238000013467 fragmentation Methods 0.000 claims 1
• 238000006062 fragmentation reaction Methods 0.000 claims 1
• 238000006317 isomerization reaction Methods 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 239000002609 medium Substances 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
• 229920000053 polysorbate 80 Polymers 0.000 claims 1
• 229940068968 polysorbate 80 Drugs 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1