JP2020521000A - 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ - Google Patents
標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ Download PDFInfo
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- JP2020521000A JP2020521000A JP2020515282A JP2020515282A JP2020521000A JP 2020521000 A JP2020521000 A JP 2020521000A JP 2020515282 A JP2020515282 A JP 2020515282A JP 2020515282 A JP2020515282 A JP 2020515282A JP 2020521000 A JP2020521000 A JP 2020521000A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023010057A JP2023052647A (ja) | 2017-05-23 | 2023-01-26 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
| JP2025014951A JP2025072445A (ja) | 2017-05-23 | 2025-01-31 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17172444 | 2017-05-23 | ||
| EP17172444.6 | 2017-05-23 | ||
| PCT/EP2018/063100 WO2018215340A1 (en) | 2017-05-23 | 2018-05-18 | Combinations of mhc class ib molecules and peptides for targeted therapeutic immunomodulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010057A Division JP2023052647A (ja) | 2017-05-23 | 2023-01-26 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020521000A true JP2020521000A (ja) | 2020-07-16 |
| JP2020521000A5 JP2020521000A5 (enExample) | 2021-02-04 |
Family
ID=58778895
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515282A Pending JP2020521000A (ja) | 2017-05-23 | 2018-05-18 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
| JP2023010057A Pending JP2023052647A (ja) | 2017-05-23 | 2023-01-26 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
| JP2025014951A Pending JP2025072445A (ja) | 2017-05-23 | 2025-01-31 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023010057A Pending JP2023052647A (ja) | 2017-05-23 | 2023-01-26 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
| JP2025014951A Pending JP2025072445A (ja) | 2017-05-23 | 2025-01-31 | 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200157175A1 (enExample) |
| EP (1) | EP3630809A1 (enExample) |
| JP (3) | JP2020521000A (enExample) |
| KR (2) | KR102748741B1 (enExample) |
| CN (2) | CN119185534A (enExample) |
| AU (1) | AU2018274545B2 (enExample) |
| CA (1) | CA3063959A1 (enExample) |
| WO (1) | WO2018215340A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112941030B (zh) * | 2021-01-25 | 2023-08-08 | 吉林大学 | 一种抗原特异性Treg及其制备方法和应用 |
| EP4249062A1 (en) | 2022-03-24 | 2023-09-27 | Julius-Maximilians-Universität Würzburg | Mhc ib-mediated aquaporin 4 (aqp4)-specific immunosuppression as a novel treatment for nmo |
| CA3255287A1 (en) | 2022-03-24 | 2023-09-28 | Julius-Maximilians-Universität Würzburg | MHO IB-mediated specific myelin suppression as a novel treatment for multiple sclerosis and anti-MOG antibody-associated disease |
| EP4249506A1 (en) | 2022-03-24 | 2023-09-27 | Julius-Maximilians-Universität Würzburg | Mhc 1b-mediated alpha-synuclein-specific tolerance induction as a novel treatment for parkinson's disease |
| AU2023238308A1 (en) | 2022-03-24 | 2024-10-10 | Julius-Maximilians-Universität Würzburg | Mhc ib-mediated islet-antigen-specific immunosuppression as a novel treatment for type 1 diabetes |
| WO2025061918A1 (en) | 2023-09-22 | 2025-03-27 | Julius-Maximilians-Universität Würzburg | Mhc 1b-mediated alpha-synuclein-specific tolerance induction as a novel treatment for parkinson's disease |
| TW202519540A (zh) | 2023-09-22 | 2025-05-16 | 德國符茲堡大學 | MHC Ib媒介之髓磷脂特異性免疫抑制作為用於多發性硬化症及MOG抗體疾病之新穎治療 |
| TW202530251A (zh) | 2023-09-22 | 2025-08-01 | 德國符茲堡大學 | MHC Ib媒介之水通道蛋白4(AQP4)特異性免疫抑制作為用於NMO之新穎治療 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010522695A (ja) * | 2007-03-07 | 2010-07-08 | ユーティーアイ リミテッド パートナーシップ | 自己免疫状態の予防および治療のための組成物および方法 |
| JP2012507995A (ja) * | 2008-11-07 | 2012-04-05 | エイチエルエイ−ジー・テクノロジーズ | Hla−gポリペプチドおよびその医薬的使用 |
| JP2014513948A (ja) * | 2011-04-20 | 2014-06-19 | ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | β2ミクログロブリン欠損細胞 |
| US20150250862A1 (en) * | 2012-09-28 | 2015-09-10 | Dana-Farber Cancer Institute, Inc. | Targeted expansion of qa-1-peptide-specific regulatory cd8 t cells to ameliorate arthritis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1054688B1 (fr) | 1998-02-20 | 2004-06-30 | Commissariat A L'energie Atomique | Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications |
| FR2794977B1 (fr) | 1999-06-18 | 2003-10-31 | Commissariat Energie Atomique | Utilisation de compositions contenant des formes solubles d'hla-g dans le traitement de pathologies inflammatoires de la peau, et leur procede d'obtention |
| US9234174B2 (en) * | 2006-05-12 | 2016-01-12 | Ospedale San Raffaele S.R.L. | Tolerogenic dendritic cells, method for their production and uses therof |
| WO2009100135A2 (en) * | 2008-02-04 | 2009-08-13 | Medical College Georgia Research Institute, Inc. | Hla-g compositions and methods of use thereof |
| EP2730588A1 (en) * | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
| EP3209769B1 (en) * | 2014-10-24 | 2020-08-05 | The Board of Trustees of the Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
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2018
- 2018-05-18 AU AU2018274545A patent/AU2018274545B2/en active Active
- 2018-05-18 KR KR1020197038051A patent/KR102748741B1/ko active Active
- 2018-05-18 WO PCT/EP2018/063100 patent/WO2018215340A1/en not_active Ceased
- 2018-05-18 US US16/615,188 patent/US20200157175A1/en not_active Abandoned
- 2018-05-18 JP JP2020515282A patent/JP2020521000A/ja active Pending
- 2018-05-18 CA CA3063959A patent/CA3063959A1/en active Pending
- 2018-05-18 EP EP18725526.0A patent/EP3630809A1/en active Pending
- 2018-05-18 CN CN202411123693.3A patent/CN119185534A/zh active Pending
- 2018-05-18 KR KR1020247042945A patent/KR20250007053A/ko active Pending
- 2018-05-18 CN CN201880048884.4A patent/CN110945019B/zh active Active
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2023
- 2023-01-26 JP JP2023010057A patent/JP2023052647A/ja active Pending
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Patent Citations (4)
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| JP2010522695A (ja) * | 2007-03-07 | 2010-07-08 | ユーティーアイ リミテッド パートナーシップ | 自己免疫状態の予防および治療のための組成物および方法 |
| JP2012507995A (ja) * | 2008-11-07 | 2012-04-05 | エイチエルエイ−ジー・テクノロジーズ | Hla−gポリペプチドおよびその医薬的使用 |
| JP2014513948A (ja) * | 2011-04-20 | 2014-06-19 | ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | β2ミクログロブリン欠損細胞 |
| US20150250862A1 (en) * | 2012-09-28 | 2015-09-10 | Dana-Farber Cancer Institute, Inc. | Targeted expansion of qa-1-peptide-specific regulatory cd8 t cells to ameliorate arthritis |
Non-Patent Citations (1)
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| 生化学 (2009) VOL.81, NO.3, P.189-199, JPN7021005509, ISSN: 0004667449 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20250007053A (ko) | 2025-01-13 |
| KR102748741B1 (ko) | 2024-12-31 |
| WO2018215340A1 (en) | 2018-11-29 |
| US20230416338A1 (en) | 2023-12-28 |
| AU2018274545B2 (en) | 2023-09-21 |
| CA3063959A1 (en) | 2018-11-29 |
| AU2018274545A1 (en) | 2019-12-05 |
| KR20200021475A (ko) | 2020-02-28 |
| JP2023052647A (ja) | 2023-04-11 |
| CN119185534A (zh) | 2024-12-27 |
| CN110945019B (zh) | 2025-04-04 |
| EP3630809A1 (en) | 2020-04-08 |
| JP2025072445A (ja) | 2025-05-09 |
| CN110945019A (zh) | 2020-03-31 |
| US20200157175A1 (en) | 2020-05-21 |
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