JP2020521000A - 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ - Google Patents

標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ Download PDF

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JP2020521000A
JP2020521000A JP2020515282A JP2020515282A JP2020521000A JP 2020521000 A JP2020521000 A JP 2020521000A JP 2020515282 A JP2020515282 A JP 2020515282A JP 2020515282 A JP2020515282 A JP 2020515282A JP 2020521000 A JP2020521000 A JP 2020521000A
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peptide
molecule
mhc class
polypeptide
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JP2020521000A5 (enExample
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ヴァレンティン ブリュッテル,
ヴァレンティン ブリュッテル,
ヴィシュフーセン,ヨルク
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Julius Maximilians Universitaet Wuerzburg
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Priority to JP2023010057A priority Critical patent/JP2023052647A/ja
Priority to JP2025014951A priority patent/JP2025072445A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K39/39566Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/55Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/605MHC molecules or ligands thereof
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    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2319/00Fusion polypeptide

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2020515282A 2017-05-23 2018-05-18 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ Pending JP2020521000A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023010057A JP2023052647A (ja) 2017-05-23 2023-01-26 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ
JP2025014951A JP2025072445A (ja) 2017-05-23 2025-01-31 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17172444 2017-05-23
EP17172444.6 2017-05-23
PCT/EP2018/063100 WO2018215340A1 (en) 2017-05-23 2018-05-18 Combinations of mhc class ib molecules and peptides for targeted therapeutic immunomodulation

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JP2023010057A Division JP2023052647A (ja) 2017-05-23 2023-01-26 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ

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JP2020521000A true JP2020521000A (ja) 2020-07-16
JP2020521000A5 JP2020521000A5 (enExample) 2021-02-04

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JP2020515282A Pending JP2020521000A (ja) 2017-05-23 2018-05-18 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ
JP2023010057A Pending JP2023052647A (ja) 2017-05-23 2023-01-26 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ
JP2025014951A Pending JP2025072445A (ja) 2017-05-23 2025-01-31 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ

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JP2023010057A Pending JP2023052647A (ja) 2017-05-23 2023-01-26 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ
JP2025014951A Pending JP2025072445A (ja) 2017-05-23 2025-01-31 標的治療免疫調節のためのMHCクラスIb分子及びペプチドの組合せ

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US (2) US20200157175A1 (enExample)
EP (1) EP3630809A1 (enExample)
JP (3) JP2020521000A (enExample)
KR (2) KR102748741B1 (enExample)
CN (2) CN119185534A (enExample)
AU (1) AU2018274545B2 (enExample)
CA (1) CA3063959A1 (enExample)
WO (1) WO2018215340A1 (enExample)

Families Citing this family (8)

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CN112941030B (zh) * 2021-01-25 2023-08-08 吉林大学 一种抗原特异性Treg及其制备方法和应用
EP4249062A1 (en) 2022-03-24 2023-09-27 Julius-Maximilians-Universität Würzburg Mhc ib-mediated aquaporin 4 (aqp4)-specific immunosuppression as a novel treatment for nmo
CA3255287A1 (en) 2022-03-24 2023-09-28 Julius-Maximilians-Universität Würzburg MHO IB-mediated specific myelin suppression as a novel treatment for multiple sclerosis and anti-MOG antibody-associated disease
EP4249506A1 (en) 2022-03-24 2023-09-27 Julius-Maximilians-Universität Würzburg Mhc 1b-mediated alpha-synuclein-specific tolerance induction as a novel treatment for parkinson's disease
AU2023238308A1 (en) 2022-03-24 2024-10-10 Julius-Maximilians-Universität Würzburg Mhc ib-mediated islet-antigen-specific immunosuppression as a novel treatment for type 1 diabetes
WO2025061918A1 (en) 2023-09-22 2025-03-27 Julius-Maximilians-Universität Würzburg Mhc 1b-mediated alpha-synuclein-specific tolerance induction as a novel treatment for parkinson's disease
TW202519540A (zh) 2023-09-22 2025-05-16 德國符茲堡大學 MHC Ib媒介之髓磷脂特異性免疫抑制作為用於多發性硬化症及MOG抗體疾病之新穎治療
TW202530251A (zh) 2023-09-22 2025-08-01 德國符茲堡大學 MHC Ib媒介之水通道蛋白4(AQP4)特異性免疫抑制作為用於NMO之新穎治療

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JP2012507995A (ja) * 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Hla−gポリペプチドおよびその医薬的使用
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JP2010522695A (ja) * 2007-03-07 2010-07-08 ユーティーアイ リミテッド パートナーシップ 自己免疫状態の予防および治療のための組成物および方法
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