JP2020518629A - 骨髄増殖性腫瘍の治療方法 - Google Patents
骨髄増殖性腫瘍の治療方法 Download PDFInfo
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Abstract
Description
本出願は、2017年5月5日に出願された米国仮特許出願第62/502,456号、及び2017年7月20日に出願された米国仮特許出願第62/535,146号の優先権の利益を主張し、当該仮出願の各々の開示は、参照によりそれらの全体が本明細書に組み込まれる。
本明細書で使用される、「含む(comprising)」及び「含む(including)」という用語は区別することなく使用され得る。「含む(comprising)」及び「含む(including)」という用語は、記載された特徴または成分の存在を言及された通りに特定するものと解釈されるが、1つ以上の特徴、もしくは成分、またはその群の存在または追加を排除するものではない。さらに、「含む(comprising)」及び「含む(including)」という用語は、「〜からなる(consisting of)」という用語によって包含される例を含むことが意図される。したがって、「〜からなる(consisting of)」という用語は、より具体的な本発明の実施形態を提供するために「含む(comprising)」及び「含む(including)」という用語の代わりに使用され得る。
一実施形態において、化合物1は、以下の式を有する2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オール、またはその薬学的に許容される塩、溶媒和物、互変異性体、立体異性体、同位体置換体、プロドラッグ、代謝産物、もしくは多形体である。
一実施形態において、本明細書で提供される方法において利用される化合物は、対象に投与される前に、薬学的に許容される担体またはアジュバントと一緒に薬学的に許容される組成物へと製剤化される。別の実施形態において、かかる薬学的に許容される組成物は、本明細書に記載されるものを含む疾患または疾患症状のモジュレーションを達成するのに有効な量で、さらなる治療剤をさらに含む。
JAK2阻害剤
ある特定の実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、INCB018424(ルキソリチニブ)、TG101348、CYT387、AZD1480、SB1518(パクリチニブ)、XL019、NCB0−16562、NVP−BSK805、R723、ヒドロキシカルバミド、SAR302503、CP−690,550(タソシチニブ)、及びINCB16562から選択される。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、ルキソリチニブである。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、TG101348である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、CYT387である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、AZD1480である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、SB1518(パクリチニブ)である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、XL019である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、NCB0−16562である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、NVP−BSK805である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、R723である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、ヒドロキシカルバミドである。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、SAR302503である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、CP−690,550(タソシチニブ)である。
一実施形態において、本明細書で提供される方法で使用のためのJAK2阻害剤は、INCB16562である。
ルキソリチニブを含む薬学的組成物及び投与経路
ある特定の実施形態において、本明細書で提供される方法において投与を必要とする患者に投与するために、ルキソリチニブと、薬学的に許容される担体と、を含む、薬学的組成物が、本明細書で提供される。ある特定の実施形態において、薬学的組成物は、ルキソリチニブ及び希釈剤または溶媒を含む。ある特定の実施形態において、ルキソリチニブを含む薬学的組成物は、経口投与用である。
ある特定の実施形態において、薬学的組成物は、5〜25mgのルキソリチニブを含む。ある特定の実施形態において、薬学的組成物は、5、10、15、20、または25mgのルキソリチニブを含む。
ある特定の実施形態において、ルキソリチニブは、約5〜25mgの用量で1日1回または2回経口投与される。ある特定の実施形態において、ルキソリチニブは、約5、10、15、20、または25mgの用量で1日1回または2回経口投与される。
ある特定の実施形態において、ルキソリチニブは、ルキソリチニブ用に製剤化され、ルキソリチニブ用の添付文書に従って投与される。
化合物1は、本明細書で提供される対象におけるMPNまたはAMLのすべての治療の方法において使用され得る。
本明細書で提供される方法のある特定の実施形態において、治療される対象は、動物、例えば、哺乳動物または非ヒト霊長類である。特定の実施形態において、対象は、ヒト患者である。対象は、男性または女性であり得る。
トランスジェニック動物
この研究において使用される条件付きJAK2V617Fマウスは、Mullally et al.Physiological JAK2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells,Cancer Cell,2010;17:584−96に記載されている。条件付きトランスジェニックIDH1R132Hマウスは、Kwok−Kin Wong(Dana Farber Cancer Institute)によって提供され、条件付きIDH2R140Qマウスは、Craig B.Thompson(Memorial Sloan Kettering Cancer Center)によって提供される。
病理は、4% パラホルムアルデヒド(PFA)中の固定後に得た;血液塗抹標本及び骨髄サイトスピンは、殺傷日に実施した。切片は、必要に応じて、ヘマトキシリン及びエオシン染色またはWright Giemsa染色で染色した。CD34+染色は、CD34を用いて実施し、Ratモノクローナル抗体を、Bond(商標)Polymer Refine検出キット(カタログ番号DS9800)を用いてLeica Bond(商標)RXにおいて実施した。CD34(Abcam,カタログAb8158 1:50に希釈)で染色した切片を、20分間のクエン酸熱媒介性抗原回復、pH6(Leica Biosystem Epitope Retrieval 1、カタログ番号AR9961)を用いて前処置した。DABを、色原体として使用し、ヘマトキシリンで対比染色してマウントした。
解離した大腿骨及び脛骨を単離した。骨髄を、シリンジを用いて、または遠心分離の回転によって、PBS+2%BSAまたはRPMI+10% FCSに洗い流した。脾臓を、単離し、単一の細胞懸濁液を、スライドガラスを用いた機械的破砕によって作製した。すべての採取した細胞を、70mmの濾過器を通過した。赤血球(RBC)を、氷上で塩化アンモニウム−重炭酸カリウム溶解緩衝液中で10分間溶解した。細胞を、致死的に照射した(2×550 Rad) CD45.1宿主マウスに尾静脈注射を介して移植した。非競合的移植においては、1×106個の総細胞を移植し、薬物研究を含む競合的移植においては、1×106個の総ドナー細胞を、コンジェニックCD45.1ドナーから1×106個の細胞との混合物中で注射し、初期の移植の細胞においては、注射回数は、CD45.1ドナーからの300,000個の全骨髄細胞と共に約100,000個のMPPまたは300個のLT−HSCを注射するために分類した後、最低収率に基づいて決定した。
競合的移植から約2カ月後、末梢血分析を、ドナーキメリズムに対してHemaVet及びFACSによって実施した。マウスを、HCT(%)、WBC(K/uL)、ドナーキメリズム、及び体重を用いて一致させ、それらを、ランダム数発生器を用いて一致する群内でランダム化した。1日2回他で指示された場合を除いて、薬物を、21〜28日間、1日2回強制投与した。ルキソリチニブ(James Bradner,Dana Farber Cancer Institute)を、1kg当たり60mg投与し、2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オール(AG221)を、1kg当たり100mgまたは1kg当たり40mg投与した。最終用量を、殺処分する約1.5時間前に投与した。
細胞を、FACS緩衝液(リン酸緩衝生理食塩水(PBS)中の2% ウシ血清アルブミン)中の抗体で氷上で30分間染色した。ドナー及び支持キメリズムを、CD45.1(クローンA20、Biolegend)及びCD45.2(クローン104、BioLegend)に対する抗体を用いて評価した。
2HGを、Lu et al.,Expression of a homodimeric type I cytokine receptor is required for JAK2V617F−mediated transformation.Proceedings of the National Academy of Sciences of the United States of America 2005;102:18962−7によって記載されているように、80% 水性メタノールを用いて血清から抽出した。すべての抽出物を、4℃で、13,000rpmで回転させて、沈殿物を除去し、室温で乾燥させて、−80℃で保存した。代謝産物レベルは、多重反応モニタリングを用いた陰性モードエレクトロスプレー三連四重極質量分析計に連結されたイオン対逆相LCによって決定され、統合された溶出ピークを、Dang et al,Cancer−associated IDH1 mutations produce 2−hydroxyglutarate Nature 2009;462:739−44の絶対的定量に対する代謝産物の標準曲線と比較した。
CD45.2+LSK細胞を、氷冷FACS緩衝液に分類し、ペレット化し、フェノール−クロロホルムを用いたRNAの抽出までトリアゾール中で保存した。ライブラリを、SMARTer増幅(Clontech)を用いて生成し、ライブラリを増幅及び生成した。イルミナシークエンシングを、1試料当たり40×106の読み込みで50bpのPaired−Endを用いて実施した。
Memorial Sloan−Kettering Cancer Centerで施設内倫理委員会から承認を得た。Human Oncology Tissue Bankと協力して組織を採取し、すべての患者は、インフォームドコンセントに供給した。新鮮な末梢血を、ヘパリン化収集チューブに収集し、末梢血単核細胞(PBMC)の分離を、ヘタスターチを用いて行い、その後の赤血球細胞溶解によるフィコール勾配を行った。
冷凍または新鮮なPBMCを、3重のウェルにおいて、ペニシリン及びストレプトマイシンを用いてMethocult H4435(幹細胞)中に播種した。MPN患者細胞は、1ウェル当たり1,000個の細胞でCD34マイクロビーズ(Miltenyi)を用いた濃縮後に播種し、AML患者細胞は、1ウェル当たり100,000個の細胞で濃縮なしに播種した。AG221及びルキソリチニブを、400nMの濃度で試料に溶解し、DMSOを、対照に溶解した。
ヒト組織中の赤血球分化を観察するために、CD117/cKit(YB5.B8、eBiosciences)、CD34(581、BioLegend)、CD38(HIT2、BioLegend)、CD36(5−271、BioLegend)、CD71(OKT9、eBioscience)、及びCD235a(HIR2、eBioscience)の組み合わせで染色した。単球及び顆粒球性分化を観察するために、CD117/cKit、CD34、CD38、CD15(HI98、eBioscience)、CD14(HCD14、BioLegend)、及びCD16(3G8、BioLegend)に対する抗体を使用した。
データは、平均±SEMとして示す。Prismソフトウェアを用いて、すべてのデータの統計分析を行った。多重比較は、通常の一元配置ANOVAを用い、事後比較のためのTukey補正、及び多重補正したp値を用いて実施した。生存の比較は、ログ−ランク(Mantel−Cox)検定を用いて実施した。統計的相互作用は、二元配置ANOVAを用いて組み合わせたJAK2変異状態及びIDH1変異状態の影響に対して計算した。対(Paried)t検定は、処置前及び処置後にマウスにおける結果を比較するために使用した。P<0.05は、有意であるとみなした。*P<0.05、**P<0.01、***P<0.001、****P<0.0001。
IDH変異及びJAK2変異が協力して、造血幹/前駆細胞を形質転換するかどうかを評価するために、条件付きIDH1R132HまたはIDH2R140Q対立遺伝子を有するマウスが、Mullally et al.,Physiological JAK2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells,Cancer Cell 2010;17:584−96に記載されるJAK2V617F対立遺伝子と交差し、次いで、誘導性Mx1−cre対立遺伝子(Kuhn et al.,Science.1995 Sep 8;269(5229):1427−9)を使用して、造血細胞中のこれらの対立遺伝子の発現を誘導した。JAK2V617Fと一緒にIDH1R132HまたはIDH2R140Qの発現は、JAK2V617Fのみの全生存期間(それぞれ、平均生存期間156日及び359日)と同様の完全に浸透された致死的な疾患をもたらしたが、IDH1R132HまたはIDH2R140Q変異または野生型マウスと比較して、生存期間を減少させた(800日の未定義の平均生存期間;p<0.0001;図1A)。対照的に、移植研究において、IDH/JAK2変異細胞を移植したマウスは、JAK2変異細胞を移植したレシピエントと比較して、生存期間の著しい減少を示した(それぞれ、平均生存期間206日及び274日;p=0.0480;図1B)。殺処分時に、IDH1R132HまたはIDH2R140QとJAK2V617F変異との組み合わせを有するマウスは、JAK2変異対照と比較して、赤血球増加症(それぞれ、平均ヘマトクリット59%、65%)、白血球増加症(それぞれ、平均23.78K/uL、16.22K/uL;図1C、G)、及び脾腫(それぞれ、574.4mg、690.7mg;図1D、H)を示す。IDH1R132H及びIDH2R140Qマウスは、血清中の2HGの上昇したレベルを有し(図1E、I)、2HGレベルは、IDH1R132Hのみを用いたマウスと比較して、同時に起こるIDH1R132H及びJAK2V617Fを有するマウスにおいてより高く(p=0.0024)、これは、JAK2及びIDH1変異がより高い2HGレベルを促進するように相互に作用することを示唆した(p=0.0375;図1E)。JAK2V617Fと一緒に変異IDH1またはIDH2の発現は、JAK2V617Fマウスには見られないIDH/JAK2変異マウスにおけるオープンクロマチン及び大核による芽球様細胞の拡大を含む、JAK2V617Fマウスにおいて観察される以上に膵臓構造の破壊をもたらした。JAK2/IDH変異巨核球は、巨核球分化障害と一致するJAK2V617Fマウスにおける血小板前駆細胞と比較して免疫組織化学によりCD34の発現を増加させた(図1F、J)。
競合的移植において、IDH2R140Q変異骨髄細胞は、野生型細胞を競合することができ、変異IDH2によって誘導された自己再生で得られた増加は、同時に起こるIDH2R140Q及びJAK2V617F変異を有する細胞において維持されたことが見出された(図2A)。移植レシピエントは、赤血球増加症及び血小板増加症を含む一次マウスと同様の表現型を有した。IDH2R140QJAK2V617F骨髄移植したマウスにおいて、JAK2V617F変異細胞を移植したマウスと比較して、白血球増加症がより増加することが見出された(図6A)。
同時に起こるJAK2及びIDH変異を有するMPN患者が、疾患進行のリスクが高く、有害な臨床転帰を有する場合、JAK2阻害、IDH2阻害、及び組み合わせたJAK2/IDH2阻害が、JAK2/IDH2変異MPNを処置する際の有効性を決定するために試験した。マウスにCD45.2 JAK2/IDH2変異細胞及びCD45.1野生型細胞を移植し、レシピエントマウスがMPNを発症した後、マウスを、ビヒクル、IDH2阻害剤AG221、及び/またはJAKキナーゼ阻害剤ルキソリチニブ(INC18424)で処置した。相乗的または相加的毒性の証拠は、併用療法で観察されず、ルキソリチニブ療法は、AG221レベルを増加しなかった。IDH2R140QJAK2V617F変異細胞(平均1874ng/mL)を移植したマウスにおける血清2HGレベルは、標的阻害と一致する、単剤療法(平均744.4、p<0.0001)としてまたはルキソリチニブ(平均562.6ng/mL、p<0.0001)と組み合わせて投与される40〜100mg/kgの用量で経口AG221療法で減少した(図3A)。興味深いことには、ルキソリチニブ単剤療法はまた、血清2HGレベルをやや減少させた(平均1233ng/mL、p=0.0016;図3A)。疾患マウスにおける脾腫(ビヒクル平均289.1mg)は、AG221単剤療法(188.3mg、p=0.0040)またはルキソリチニブ単剤療法(101.3mg、p<0.0001)によって減少したが、脾腫は、併用療法により完全に消散した(59.53mg、p<0.0001、図3B)。AG221及びルキソリチニブによる併用療法はまた、いずれかの薬剤のみで観察された以上のある程度まで赤血球増加症(ヘマトクリット58.7%対37.61%、p=0.0028)及び白血球増加症(11.62K/uL対3.111K/uL、p=0.0069)を正規化した(図3C)。二重変異マウスの骨髄中の総LSK数(ビヒクル平均57.19×103)は、AG221単剤療法(36.43×103、ns)、ルキソリチニブ単剤療法(20.73×103、p=0.0266)、または併用処置(14.42×103、p=0.0090)によって減少し、幹/前駆細胞の減少は、同様の程度までLT−HSC、ST−HSC、及びMPPにおいて見られた(図3D;図6H)。併用処置は、いずれかの薬剤のみよりも多い程度まで二重変異マウスの骨髄中の総MP数(ビヒクル平均2.46×106対0.8863×106)を減少させ、この減少は、CMP、GMP、及びMEPを含むすべての測定したサブ集団において見られた(図3E、図6I)。
JAK2阻害剤が、実質的には、JAK2変異疾患の前臨床モデル(Quintas−Cardama et al.Preclinical characterization of the selective JAK1/2 inhibitor INCB018424:therapeutic implications for the treatment of myeloproliferative neoplasms,Blood.2010;115:3109−17を参照のこと)または臨床状況(Verstovsek et al.A double−blind,placebo−controlled trial of ruxolitinib for myelofibrosis.New England Journal of Medicine 2012;366:799−807及びVerstovsek et al.Safety and efficacy of INCB018424,a JAK1 and JAK2 inhibitor,in myelofibrosis.New England Journal of Medicine 2010;363:1117−27を参照のこと)における対立遺伝子負荷を減少させないため、研究は、単独でまたはJAK2阻害と組み合わせたIDH2阻害が、インビボでの疾患負荷を減少させ得るかどうかを評価するために行われた。レシピエントマウスにおけるIDH2R140QJAK2V617FMPN細胞(CD45.2+)の割合におけるAG221療法またはAG221/ルキソリチニブ併用療法への影響を評価した。
転写因子としてJAK2の役割、及び変異IDHが後成的状態を調節する能力(Xu et al.Oncometabolite 2−Hydroxyglutarate Is a Competitive Inhibitor of α−Ketoglutarate−Dependent Dioxygenases,Cancer Cell,2011;19:17−30及びFigueroa et al.,Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype,Disrupt TET2 Function,and Impair Hematopoietic Differentiation,Cancer Cell 2010;18:553−67を参照のこと)を考えると、インビボでの遺伝子発現における併用JAK2/IDH2変異の効果が研究された。さらに、併用IDH2/JAK2阻害の効果が研究された。変異CD45.2 LSKは、ビヒクル、AG221、ルキソリチニブ、または併用療法で処置されたJAK2/IDH2変異細胞を移植したレシピエントマウスから採取し、分類し、それらの転写生産は、RNAシークエンシングを通して、互いに及び野生型細胞と比較した。IDH2R140QJAK2V617F変異LSKは、野生型LSKと比較して、異なる遺伝子発現プロファイルを有した。この遺伝子発現プロファイルは、IL6/JAK/STAT3シグナル伝達(q=0.034、NES=1.9)及びインターフェロンガンマシグナル伝達(q=0.033,NES=1.9)遺伝子セットを含む、JAK−STATシグナル伝達に関連するMSigDB Hallmark遺伝子セットに対して濃縮した(図4A)。mTOR(q=0.005、NES=2.4)及び酸化的リン酸化反応(q=0.0047、NES=2.3;図4A)を含む、代謝に関連する遺伝子セットの濃縮発現が、観察された。最終的には、cMYC(q=0.004、NES=2.5)などのある特定の発がん性シグネチャは、JAK2/IDH2変異細胞中の発現を増加させた。同時に、これらのデータは、同時に起こるIDH2R140Q及びJAK2V617F変異が転写変化をもたらすことが示唆している。
JAK2/IDH2変異MPN細胞代謝におけるAG221、ルキソリチニブ、及び併用療法による処置の効果は、ビヒクル、ルキソリチニブ、もしくはAG221単剤療法または併用療法による処置から10日後に、マウス骨髄穿刺液から代謝産物を測定するために、LC/MSを用いて研究した。IDH阻害剤単剤療法による2HGレベルの減少が、まず、確認された(図4F)。IDH阻害剤単剤療法はまた、α−ケトグルタレート、クエン酸塩、コハク酸塩、フマル酸塩、及びリンゴ酸塩を含む、Krebのサイクル中間体のレベルも減少した(p<0.0252;図4G)。2HGレベルもまた、ルキソリチニブ阻害剤単剤療法で減少させ(図4F)、処置マウスの血清中で観察された結果と一致する(図3A)。ルキソリチニブ単剤療法はまた、クエン酸塩(p=0.0064)、フマル酸塩(p=0.0224)、及びリンゴ酸塩(p<0.0001;図4G)のプールサイズも減少した。血清中での観察と一致して、併用療法で処置したマウスは、2つの薬物の複合効果を支持する、野生型マウスと同様の2HGレベルを有した(図4F)。特に、併用処置マウスにおいて、グルタミンの座標増加を伴ったルキソリチニブ単剤療法(p=0.0026)及び併用療法(p=0.0049)によるグルタミン酸レベルの減少(図4H)が、観察された。これらのデータは、グルタミン酸塩/グルタミン代謝の調節においてJAK2変異経路とIDH2変異経路との間の潜在的な交差点を提供する。
IDH2R140Q及びJAK2V617F変異を有する臨床的に決定されたMPN及びMPN後AMLを有する患者からCD34+濃縮血液試料におけるメチルセルロースアッセイを実施した。この分析は、慢性期MPNから及び白血病性形質転換期間からの試料(PT 24、図5)が利用可能である患者を含んだ。患者のすべては、IDH阻害剤単剤療法によるコロニー数の増加を伴ってコロニー形成の特徴的パターンを示した。Wang et al.Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation,Science 2013:1−7によって記載されるように、この拡大は、赤血球分化の回復と一致するBFU−Eコロニーの存在を伴った(図5A)。形質学的試験において、この拡大はまた、対照と比較して、大きな高分化型コロニーの存在と関連した(図5B)。FACS分析は、IDH阻害剤処置が、未熟マーカーcKit/CD117の表面発現を減少したことを示した(図5C)。分化マーカーに関して、AG221で処置したほとんどの患者試料が、JAK2/IDH2変異MPN/AML細胞における分化の回復と一致する、赤血球マーカーCD235a(図5D)または骨髄性マーカーCD14の上方調節を示すことが見出された(図5E)。対照的に、単独でまたはIDH2阻害剤療法と組み合わせたJAK阻害剤療法は、コロニー出力を減少したことが観察された。併用処置は、IDH2阻害剤単剤療法で見られるコロニー数の増加を減衰させたが、ルキソリチニブ処置のみで見られなかった、c−Kit陽性コロニーの割合の減少及びCD235a/CD14陽性コロニーの割合の増加によって証明されるように、分化を促進するIDH2阻害の効果を依然として維持した。これらのデータは、併用JAK/IDH2阻害剤療法が、増殖を減衰し、分化を促進することによって共同的効果を有し得ることを示唆している。
Claims (50)
- 対象における骨髄増殖性腫瘍または急性骨髄性白血病を治療する方法であって、前記対象に、治療上有効な量の、以下の式を有する2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オール、
- 前記JAK2阻害剤が、ルキソリチニブ、TG101348、CYT387、レスタウルチニブ、AZD1480、パクリチニブ、XL019、NCB0−16562、NVP−BSK805、R723、ヒドロキシカルバミド、SAR302503、タソシチニブ、及びINCB16562から選択される、請求項1に記載の方法。
- 前記JAK2阻害剤が、ルキソリチニブである、請求項1または2に記載の方法。
- 前記骨髄増殖性腫瘍が、真性赤血球増加症、原発性または本態性血小板血症、原発性または突発性骨髄線維症、慢性骨髄性白血病、慢性好中球性白血病、若年性骨髄単球性白血病、慢性好酸球性白血病、及び好酸球増多症候群から選択される、請求項1〜3のいずれか1項に記載の方法。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140またはmIDH2−R172である、請求項1〜4のいずれか1項に記載の方法。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140である、請求項1〜5のいずれか1項に記載の方法。
- 前記IDH2の変異対立遺伝子が、mIDH2−R172である、請求項1〜5のいずれか1項に記載の方法。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140Q、mIDH2−R140W、mIDH2−R172K、またはmIDH2−R172Gである、請求項5に記載の方法。
- 前記JAK2の変異対立遺伝子が、mJAK2−V617Fである、請求項1〜8のいずれか1項に記載の方法。
- 化合物1が、約20〜2000mg/日の用量で投与される、請求項1〜9のいずれか1項に記載の方法。
- 化合物1が、約50〜500mg/日の用量で投与される、請求項1〜9のいずれか1項に記載の方法。
- 前記用量が、約60mg/日である、請求項11に記載の方法。
- 前記用量が、約100mg/日である、請求項11に記載の方法。
- 前記用量が、約150mg/日である、請求項11に記載の方法。
- 前記用量が、約200mg/日である、請求項11に記載の方法。
- 前記用量が、約300mg/日である、請求項11に記載の方法。
- 化合物1が、1日1回投与される、請求項1〜16のいずれか1項に記載の方法。
- 化合物1が、1〜25サイクルで投与される、請求項1〜17のいずれか1項に記載の方法。
- 化合物1が、28日サイクルで投与される、請求項1〜18のいずれか1項に記載の方法。
- 化合物1が、経口投与される、請求項1〜19のいずれか1項に記載の方法。
- 化合物1が、28日サイクルで、約100mg/日の用量で1日1回経口投与される、請求項20に記載の方法。
- 化合物1が、2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オールのメシル酸塩である、請求項1〜21のいずれか1項に記載の方法。
- ルキソリチニブが、約5〜25mgの用量で1日1回または2回投与される、請求項2または3に記載の方法。
- ルキソリチニブが、約5、10、15、20、または25mgの用量で1日1回または2回投与される、請求項2または3に記載の方法。
- ルキソリチニブが、経口投与される、請求項2、3、23、または24のいずれか1項に記載の方法。
- 対象における骨髄増殖性腫瘍または急性骨髄性白血病を治療する方法で使用のための化合物であって、前記化合物が、以下の式を有する2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オール、
- 前記JAK2阻害剤が、ルキソリチニブ、TG101348、CYT387、レスタウルチニブ、AZD1480、パクリチニブ、XL019、NCB0−16562、NVP−BSK805、R723、ヒドロキシカルバミド、SAR302503、タソシチニブ、及びINCB16562から選択される、請求項26に記載の使用のための化合物。
- 前記JAK2阻害剤が、ルキソリチニブである、請求項26または27に記載の使用のための化合物。
- 前記骨髄増殖性腫瘍が、真性赤血球増加症、原発性または本態性血小板血症、原発性または突発性骨髄線維症、慢性骨髄性白血病、慢性好中球性白血病、若年性骨髄単球性白血病、慢性好酸球性白血病、及び好酸球増多症候群から選択される、請求項26〜28のいずれか1項に記載の使用のための化合物。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140またはmIDH2−R172である、請求項26〜29のいずれか1項に記載の使用のための化合物。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140である、請求項26〜30のいずれか1項に記載の使用のための化合物。
- 前記IDH2の変異対立遺伝子が、mIDH2−R172である、請求項26〜30のいずれか1項に記載の使用のための化合物。
- 前記IDH2の変異対立遺伝子が、mIDH2−R140Q、mIDH2−R140W、mIDH2−R172K、またはmIDH2−R172Gである、請求項32に記載の使用のための化合物。
- 前記JAK2の変異対立遺伝子が、mJAK2−V617Fである、請求項26〜33のいずれか1項に記載の使用のための化合物。
- 化合物1が、約20〜2000mg/日の用量で投与される、請求項26〜34のいずれか1項に記載の使用のための化合物。
- 化合物1が、約50〜500mg/日の用量で投与される、請求項26〜34のいずれか1項に記載の使用のための化合物。
- 前記用量が、約60mg/日である、請求項36に記載の使用のための化合物。
- 前記用量が、約100mg/日である、請求項36に記載の使用のための化合物。
- 前記用量が、約150mg/日である、請求項36に記載の使用のための化合物。
- 前記用量が、約200mg/日である、請求項36に記載の使用のための化合物。
- 前記用量が、約300mg/日である、請求項36に記載の使用のための化合物。
- 化合物1が、1日1回投与される、請求項26〜41のいずれか1項に記載の使用のための化合物。
- 化合物1が、1〜25日サイクルで投与される、請求項26〜43のいずれか1項に記載の使用のための化合物。
- 化合物1が、28日サイクルで投与される、請求項26〜43のいずれか1項に記載の使用のための化合物。
- 化合物1が、経口投与される、請求項26〜44のいずれか1項に記載の使用のための化合物。
- 化合物1が、28日サイクルで、約100mg/日の用量で1日1回経口投与される、請求項45に記載の使用のための化合物。
- 化合物1が、2−メチル−1−[(4−[6−(トリフルオロメチル)ピリジン−2−イル]−6−{[2−(トリフルオロメチル)ピリジン−4−イル]アミノ}−1,3,5−トリアジン−2−イル)アミノ]プロパン−2−オールのメシル酸塩である、請求項26〜46のいずれか1項に記載の使用のための化合物。
- ルキソリチニブが、約5〜25mgの用量で1日1回または2回投与される、請求項27または28に記載の使用のための化合物。
- ルキソリチニブが、約5、10、15、20、または25mgの用量で1日1回または2回投与される、請求項27または28に記載の使用のための化合物。
- ルキソリチニブが、経口投与される、請求項27、28、48、または49のいずれか1項に記載の使用のための化合物。
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